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MEPSRRWGDDRAILDDEEARRRILEAAGRCIVRRGNTQFRMGEVADEAGVSRSTVYRYFPGRDDVLLGLM LRRVDHALAESVRSLPAPEDPVRSVPQMVLARVESVDGNPLNEALFAAESTAMASALQKGSEPLVELLLR HYGPLLERWKAAGLLYPDVDFRSVVQWLHTATLFLLAPSWRYRPHADKRRFVEQFVVRALVPQIRQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5275 | - | - | 100% (206) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_4189 | - | 2e-12 | 32.47% (194) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_1403 | - | 2e-12 | 27.81% (187) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0482c | - | 6e-08 | 25.52% (192) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3024 | - | 2e-13 | 29.03% (186) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1255c | - | 2e-08 | 25.81% (186) | transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_01733 | - | 6e-08 | 26.70% (206) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4765 | - | 2e-11 | 28.71% (202) | putative regulatory protein TetR |
| M. marinum M | MMAR_3161 | - | 3e-14 | 29.65% (199) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_2106 | - | 3e-13 | 29.70% (202) | putative transcriptional regulator |
| M. thermoresistible (build 8) | TH_1262 | - | 4e-12 | 29.23% (195) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_4487 | - | 5e-08 | 26.88% (186) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_3399 | - | 3e-58 | 52.53% (198) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_5275|M.avium_104 --------------------------------------MEPS---RRWGD
Mvan_3399|M.vanbaalenii_PYR-1 --------------------------------------MPTSRARRNWGD
MAB_4765|M.abscessus_ATCC_1997 -----------------------------------------MARRRGWDG
MSMEG_2106|M.smegmatis_MC2_155 -----------------------------------------MARRRGWDG
TH_1262|M.thermoresistible__bu ------------------------------------------MRTHGWGG
Mflv_3024|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3161|M.marinum_M ----------------------------------------------MRWG
Rv1255c|M.tuberculosis_H37Rv ---------------------------------------------MAGTD
MUL_4487|M.ulcerans_Agy99 ---------------------------------------------MGRTD
Mb0482c|M.bovis_AF2122/97 ----------------------------------MAERIPAVTVKTDGRK
MLBr_01733|M.leprae_Br4923 MTRRSIHTRKPLKWSGCAGQHVRSGKVFDVGRISLSYPSMKPGVKIDARS
MAV_5275|M.avium_104 DRAILDDEEARRRILEAAGRCIVRRGNTQFRMGEVADEAGVSRSTVYRYF
Mvan_3399|M.vanbaalenii_PYR-1 DRALLNDEEARDRLLDAAERCVARRGDTQIRMSEVADAANVVRSTVYRYY
MAB_4765|M.abscessus_ATCC_1997 -QPPSSDEEAAERIVAAAVKLIGETG-SAVSLADVAAELGVIRQTVYRYF
MSMEG_2106|M.smegmatis_MC2_155 -RPPANDEEASARIVEAAVALISETG-SDVSIADVAASLGVIRQTVYRYF
TH_1262|M.thermoresistible__bu -SAPASDEEAIARILEAAKRTIEERG-AEFSIADVARAVGVTRQTVYRYF
Mflv_3024|M.gilvum_PYR-GCK --------MARDRLLDAAETCLQSKGLSGTTMEDIARQAGVSRATVYRYF
MMAR_3161|M.marinum_M AAAPSDRDSARDRLLDAAERCLESCGVVGTTMEDIGRTAGVSRATVYRYF
Rv1255c|M.tuberculosis_H37Rv WLSARRTELAADRILDAAERLFTQRDPASIGMNEIAKAAGCSRATLYRYF
MUL_4487|M.ulcerans_Agy99 WLAAHRSEVAADRILDAAERLYTEHDPASIGMNEIARAAGCSRATLYRYF
Mb0482c|M.bovis_AF2122/97 RRWHQHKVERRNELVDGTIEAIRRHG-RFLSMDEIAAEIGVSKTVLYRYF
MLBr_01733|M.leprae_Br4923 ERWREHRKKVRGEIVDAAFRALDRLG-PEVSVREIAEEAGTAKPKIYRHF
.:: .: . : ::. . : :**::
MAV_5275|M.avium_104 PGRDDVLLGLMLRRVDH-ALAESVRSLPAPEDPVRSVPQMVLARVESVD-
Mvan_3399|M.vanbaalenii_PYR-1 PSRDDLLLGLVLRRVDR-ACTRWIRELRRPQDAAASIRELVLLPAASVDS
MAB_4765|M.abscessus_ATCC_1997 PTADALMHAASLASVDG-FLDRLTHVVRGITDPAEALTEGVLYTLEEVT-
MSMEG_2106|M.smegmatis_MC2_155 PTADALMRAAAIASVDG-FLDRLTAHVRGITDPAEAMTDGVLYTLEEVS-
TH_1262|M.thermoresistible__bu PSTDALLVAAAMHAAGD-FLDRLAVHLQGITDPVEAVAEAIATTLEWLP-
Mflv_3024|M.gilvum_PYR-GCK PSRESVVSGVIVRAAQR-YLHRISGRISAHTDLGSAILDFVAVTVRAARR
MMAR_3161|M.marinum_M PNREAVMSGVIIRAAER-YLDRINPRIAEHTDLGSALVDFVEYTVEAARR
Rv1255c|M.tuberculosis_H37Rv DSREALRTAYVHRETRR-LGREIMVKIADVVEPAERLLVSITTTLRMVRD
MUL_4487|M.ulcerans_Agy99 ESREALRTAYVHRETLR-LGREIMQQIGDIDDPRDQLITSITATLRMVRQ
Mb0482c|M.bovis_AF2122/97 VDKNDLTTAVMMRFTQTTLIPNMIAALSADMDGFELTREIIRVYVETVAA
MLBr_01733|M.leprae_Br4923 TDKSDLFEAIGIRLRDMLWAAIFPAIDLATDSAREIIRRSVDEYVSLVDK
. : . . :
MAV_5275|M.avium_104 GNPLNEALFAAESTAMASALQKGSEPLVELLLRHYGPLLERWKAAGLL-Y
Mvan_3399|M.vanbaalenii_PYR-1 GDPVNLALYAGESTGLATVLEAGAQSVTEIVAGNLKPLFKAWKDEGQI-Y
MAB_4765|M.abscessus_ATCC_1997 -RTPHLGIMMSEPYAHSHTSDMTSDEAQAFGLRMLDRFDVDWVQYG---Y
MSMEG_2106|M.smegmatis_MC2_155 -RTPHLGIVLSEPYLHANSGSLASDEAQDFGMRMLKRFDVDWAAYG---Y
TH_1262|M.thermoresistible__bu -EDTHIGLLVAPGRPTAHTESVTSDVAIDFANRMLRRFDVDWAAVG---Y
Mflv_3024|M.gilvum_PYR-GCK EPIIGVLFGSDDELAGVGLAEGTSVALFELVADFLRPVFAAHWDQL---E
MMAR_3161|M.marinum_M EEIIGLLFGSDEELAGVGLAAGTSTSLFELVTEFLRPIFRRHWSYV---E
Rv1255c|M.tuberculosis_H37Rv NPALAAWFTTTRPPIG-GEMAGRSEVIAALAAAFLNSLGP---------D
MUL_4487|M.ulcerans_Agy99 RPALAAWFASTRPPIG-GELAGQSEVIAGLAAAFLQSLGP---------E
Mb0482c|M.bovis_AF2122/97 QPEPYRFVMANSSASKSKVIADSERIIARMLAVMLRRRMQEAGMDTG--G
MLBr_01733|M.leprae_Br4923 HPNVLRVFIQGRFSAQSEATVRTLDEGREITLTMAEMFNNELREMELNRA
. :
MAV_5275|M.avium_104 PDVDFRSVVQWLH-TATLFLLAPSWRYRPHADKRRFVEQFVVRALVPQIR
Mvan_3399|M.vanbaalenii_PYR-1 PDLDLNETVQWMS-ATSSFLLTPTWRHRSPAAKRRFVDRYLLRALIR---
MAB_4765|M.abscessus_ATCC_1997 DDAAKRELVEFALRIMLSFFVSPNEATRSRDELRGFLKRWLGGAVLAQGR
MSMEG_2106|M.smegmatis_MC2_155 DEAAQRELVEFTLRIMLSFFVAPNEATRSREELRRFIRRWLGGALLAQPR
TH_1262|M.thermoresistible__bu SDADLDELAEHLLRVIQSFVIDPGRPPRDGQSLRAYLRRWVGAAVTGAR-
Mflv_3024|M.gilvum_PYR-GCK AGVSVDDAAEWILRTILSLLSVRGPRHRSPEGLDAFLRRFLLPALLADTQ
MMAR_3161|M.marinum_M PGVSVDDAAEWVLRTILSLLTVRGPRERSRDGLRTFLSRFLLPAILAS-D
Rv1255c|M.tuberculosis_H37Rv DPTTVERRARWVVRMLTSLLMFPG---RDEADERAMIAEFVVPIVTPASA
MUL_4487|M.ulcerans_Agy99 APAAVERRARWTVRVIVSLLMFPG---QDEADERAMLEEFVAPVVTPFPT
Mb0482c|M.bovis_AF2122/97 VEPWAYLIVGGVQLATHSWMSDPRMSSDELIDYLTMLSWSALCGIVEAGG
MLBr_01733|M.leprae_Br4923 ASELAAFAAFGSVASATEWWLGPEPDSPRRMPREQFVAHLTIIMMAVIVG
. : :
MAV_5275|M.avium_104 Q-------------------------
Mvan_3399|M.vanbaalenii_PYR-1 --------------------------
MAB_4765|M.abscessus_ATCC_1997 --------------------------
MSMEG_2106|M.smegmatis_MC2_155 ATAAPSSST-----------------
TH_1262|M.thermoresistible__bu --------------------------
Mflv_3024|M.gilvum_PYR-GCK RCVTATIAE-----------------
MMAR_3161|M.marinum_M HCRPM---------------------
Rv1255c|M.tuberculosis_H37Rv AARKAGHPGPE---------------
MUL_4487|M.ulcerans_Agy99 RR------------------------
Mb0482c|M.bovis_AF2122/97 SLEKFREQPHPSPIVPAWGQV-----
MLBr_01733|M.leprae_Br4923 TAETLGISMNPDRPIHDAVPLDRSAS