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GDVLHVTVYILAGLAAVEAGALAVLWRRLVRSRAELDELRQRTDARNWLLAGGREAVKTVWNTANLVRKE GFGAAVRSSIEELADWAEVERPDLARVTPDGRVVILFTDIEESTALNERIGDRAWVKLISSHDKLVSDLV RRQSGHVVKSQGDGFMVAFARPEQAVRCGIELQRALRRNANRKRHEEIRVRIGIHMGRSVRRGDDLFGRN VAMAARVAAQAAGGEILVSQPVRDALSRSDGIRFDDGREVELKGFSGTYRLFAVLASPDPG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1250 | - | - | 100% (272) | adenylate and guanylate cyclase catalytic domain-containing protein |
| M. avium 104 | MAV_5228 | - | 5e-23 | 39.63% (164) | hydrolase, alpha/beta hydrolase fold family protein |
| M. avium 104 | MAV_3122 | - | 2e-14 | 32.65% (147) | adenylate and guanylate cyclase catalytic domain-containing |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1151c | - | 3e-64 | 79.87% (149) | hypothetical protein Mb1151c |
| M. gilvum PYR-GCK | Mflv_2091 | - | 1e-88 | 64.48% (259) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv1120c | - | 7e-65 | 80.54% (149) | hypothetical protein Rv1120c |
| M. leprae Br4923 | MLBr_01399 | - | 5e-16 | 31.95% (169) | hypothetical protein MLBr_01399 |
| M. abscessus ATCC 19977 | MAB_2330 | - | 1e-13 | 32.04% (181) | putative purine cyclase-like protein |
| M. marinum M | MMAR_4340 | - | 1e-119 | 77.41% (270) | hypothetical protein MMAR_4340 |
| M. smegmatis MC2 155 | MSMEG_4477 | - | 5e-21 | 40.62% (160) | hydrolase, alpha/beta hydrolase fold family protein |
| M. thermoresistible (build 8) | TH_1244 | - | 7e-96 | 67.79% (267) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0150 | - | 1e-103 | 78.79% (231) | hypothetical protein MUL_0150 |
| M. vanbaalenii PYR-1 | Mvan_4613 | - | 4e-87 | 64.48% (259) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4613|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1244|M.thermoresistible__bu --------------------------------------------------
MMAR_4340|M.marinum_M --------------------------------------------------
MUL_0150|M.ulcerans_Agy99 --------------------------------------------------
Mb1151c|M.bovis_AF2122/97 --------------------------------------------------
Rv1120c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1250|M.avium_104 --------------------------------------------------
MLBr_01399|M.leprae_Br4923 --------------------------------------------------
MAB_2330|M.abscessus_ATCC_1997 -------------------------------------------------M
MSMEG_4477|M.smegmatis_MC2_155 MAETSYASCGDLSLAYQLFGDGPIPLVFVGPFVGHVELFWTVPEFKSFFD
Mflv_2091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4613|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1244|M.thermoresistible__bu ------------------------VAARPLPLAVAAAPGSPIPRRVGQDG
MMAR_4340|M.marinum_M --------------------------------------------------
MUL_0150|M.ulcerans_Agy99 --------------------------------------------------
Mb1151c|M.bovis_AF2122/97 --------------------------------------------------
Rv1120c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1250|M.avium_104 --------------------------------------------------
MLBr_01399|M.leprae_Br4923 -MPPSAKSTYP-------------GQVEGAPHDGTPSAPQEPDEDTVTVP
MAB_2330|M.abscessus_ATCC_1997 DVEPSGLDAEPDGEFDSGIRKRRRGRTRGPVRHDSAQVTDGIDTTADEVP
MSMEG_4477|M.smegmatis_MC2_155 QLASFCRVAIFDKAGTGLSDPVPKVRTLDDRAAEIEAVMDAVGFDDAVVL
Mflv_2091|M.gilvum_PYR-GCK ----MLILVCVLAVLAAGLGIALAVQTRRLTSARQEAEELRHR-------
Mvan_4613|M.vanbaalenii_PYR-1 ------MALLVLAAVVVGLAVALAVQSRRLRTARQEADELRRR-------
TH_1244|M.thermoresistible__bu AVTQIAIVVVALAGLALAEAVALAVLWGRLRRERRAADELRRR-------
MMAR_4340|M.marinum_M MTDALHIAVYVLAGVAALEAAALIALWRLLARARQENDELRQR-------
MUL_0150|M.ulcerans_Agy99 ---------------------------------------MRQR-------
Mb1151c|M.bovis_AF2122/97 --------------------------------------------------
Rv1120c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1250|M.avium_104 MGDVLHVTVYILAGLAAVEAGALAVLWRRLVRSRAELDELRQR-------
MLBr_01399|M.leprae_Br4923 APALIRRSSVSMP-NAAQWLHTTNRSPRLVAMVRRARRLLPGD-------
MAB_2330|M.abscessus_ATCC_1997 STESASRHFARASRTAGSWFRKMDRDPAVVAALRRARRSLPGD-------
MSMEG_4477|M.smegmatis_MC2_155 AMSEGGPASILFAANRPGRVRTLVAYGSFATMAGCRWEDLDGDPVDIRAR
Mflv_2091|M.gilvum_PYR-GCK --LDTRQLLVSGGTKAVKTVWQTANILRKDGFGAAVRSSIEEL-------
Mvan_4613|M.vanbaalenii_PYR-1 --LDTRQMLVTGSTKAVKTVWQTANILRRDGFGAAVRSSIEEL-------
TH_1244|M.thermoresistible__bu --LDTRTTLMAGGREAVRTVWQTANILRTDGLGAAARSSIEDL-------
MMAR_4340|M.marinum_M --ADSRNWLLTGGREAVKTVWQTANLMRKEGFGAAVRSSIEDL-------
MUL_0150|M.ulcerans_Agy99 --ADSRNWLLTGGREAVKTVWQTANLMRKEGFGAAVRSSIEDL-------
Mb1151c|M.bovis_AF2122/97 --------MLSGGREAVKTVWQTANLVRKEGFGAAVRSSIEDP-------
Rv1120c|M.tuberculosis_H37Rv --------MLSGGREAVKTVWQTANLVRKEGFGAAVRSSIEDP-------
MAV_1250|M.avium_104 --TDARNWLLAGGREAVKTVWNTANLVRKEGFGAAVRSSIEEL-------
MLBr_01399|M.leprae_Br4923 --PDFGDPLSTAGEGGPRAAARAADRLLGDRGAASREVSLSVL-------
MAB_2330|M.abscessus_ATCC_1997 --PYFGDPLSTSGFGGASAVARAADRLVTDRDTAVREFGFGAL-------
MSMEG_4477|M.smegmatis_MC2_155 SVAEMGDEYAPTVEQVIHFQEQARAVRGQWGSGAAVRCAMPSMGSMRQLG
. .: * . .:
Mflv_2091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4613|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1244|M.thermoresistible__bu --------------------------------------------------
MMAR_4340|M.marinum_M --------------------------------------------------
MUL_0150|M.ulcerans_Agy99 --------------------------------------------------
Mb1151c|M.bovis_AF2122/97 --------------------------------------------------
Rv1120c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1250|M.avium_104 --------------------------------------------------
MLBr_01399|M.leprae_Br4923 --------------------------------------------------
MAB_2330|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4477|M.smegmatis_MC2_155 MFERLCASPGMARATFEAAFRIDVRPILPTIAAPTLVIHARDDPAVPVQC
Mflv_2091|M.gilvum_PYR-GCK ----------ADWAEVERPDLARLSLNGR---------------------
Mvan_4613|M.vanbaalenii_PYR-1 ----------ADWAEVERPDLARLAPNGR---------------------
TH_1244|M.thermoresistible__bu ----------ADWAEVERPDLARLAANGK---------------------
MMAR_4340|M.marinum_M ----------ADWAEVERPDLARVTPDGR---------------------
MUL_0150|M.ulcerans_Agy99 ----------ADWAEVERPDLARVTPDGR---------------------
Mb1151c|M.bovis_AF2122/97 ----------ADWAEVERPDLARVTPDAR---------------------
Rv1120c|M.tuberculosis_H37Rv ----------ADWAEVERPDLARVTPDGR---------------------
MAV_1250|M.avium_104 ----------ADWAEVERPDLARVTPDGR---------------------
MLBr_01399|M.leprae_Br4923 ----------QVWQALT-EAIARRPVNPE---------------------
MAB_2330|M.abscessus_ATCC_1997 ----------QIWQAFT-EKVSKQPANRE---------------------
MSMEG_4477|M.smegmatis_MC2_155 SRYLADHISGARWLEVDGVDHAPWFTEADRVLTEIEEFVTGNHAAPHNSH
* . : :
Mflv_2091|M.gilvum_PYR-GCK ---LTIMFSDIEESTALNERIGDRAFVRLIGRHDKSVRKFVDKHEGHVVK
Mvan_4613|M.vanbaalenii_PYR-1 ---VAIMFSDIEESTALNERIGDRAFVRLLGRHDKPVRRHVDAHDGYVVK
TH_1244|M.thermoresistible__bu ---VVILFSDIEGSTALNNRIGDRAWVRLIDRHSRLVRRFVKKHDGYVIK
MMAR_4340|M.marinum_M ---VVILFSDIEESTALNERIGDRAWVKLIGAHDKMVHEFVHRHGGHVVK
MUL_0150|M.ulcerans_Agy99 ---VVILFSDIEESTVLNERIGNRAWVKLIGAHDKMVHEFVHRHGGHVVK
Mb1151c|M.bovis_AF2122/97 ---VVILFSDIEESTALDERIGDRTWVKLIGAHDKLVHELVRRWSGHMVT
Rv1120c|M.tuberculosis_H37Rv ---VVILFSDIEESTALDERIGDRTWVKLIGAHDKLVHELVRRWSGHMVT
MAV_1250|M.avium_104 ---VVILFTDIEESTALNERIGDRAWVKLISSHDKLVSDLVRRQSGHVVK
MLBr_01399|M.leprae_Br4923 ---VTLVFTDLVGFSGWSLQAGDEATLALLRQVARAVESPLLDAGGHIVK
MAB_2330|M.abscessus_ATCC_1997 ---VTLVFTDLVGFSGWALEAGDEATLKLLRRVASVSEPPLLSAGGQVVK
MSMEG_4477|M.smegmatis_MC2_155 RALRTVLFTDIVASTQHAASNGDERWRAVLQRFGEVTEELSGRFGGVVVK
.::*:*: : *:. :: * ::.
Mflv_2091|M.gilvum_PYR-GCK SQGDGFMVAFAKPEQAVRCGLDIQHSLA-----RRPNDIRVRMGVHTGKS
Mvan_4613|M.vanbaalenii_PYR-1 SQGDGFMVAFARPEQAVRCGLAIQHSLD-----KRPNGIRVRIGIHVGKS
TH_1244|M.thermoresistible__bu SQGDGFMVAFARPEQAVRCSVELQRALR-----KRPDRIRVRIGIHLGRS
MMAR_4340|M.marinum_M SQGDGFMIAFARAEQAVRCGLDIQRALSREAKRKPRNGIRVRIGIHMGRS
MUL_0150|M.ulcerans_Agy99 SQGDGFMIAFARAEQAVRCGLDIQHALSREAKRKPRNGIRVRIGIHMGRS
Mb1151c|M.bovis_AF2122/97 SQGDGFMIAFARAEQAVRCGIDIQDALRNSAKRKRNQGIRVRIGTTWG--
Rv1120c|M.tuberculosis_H37Rv SQGDGFMIAFARAEQAVRCGIDIQDALRNSAKRKRNQGIRVRIGTTWG--
MAV_1250|M.avium_104 SQGDGFMVAFARPEQAVRCGIELQRALRRNANRKRHEEIRVRIGIHMGRS
MLBr_01399|M.leprae_Br4923 RMGDGIMAVFRDPSVAVQAVLAATEAMKS--VEVGGYTPRIRVGIHTGRP
MAB_2330|M.abscessus_ATCC_1997 RMGDGIMAVFDDPVTALRAIIPARDALKN--VEIQGYTPVMRIGIHAGTP
MSMEG_4477|M.smegmatis_MC2_155 STGDGHLSTFEGPTHAIRYAEALRSDAET-------LGIQIRAAIHTGEC
*** : .* . *:: :* . *
Mflv_2091|M.gilvum_PYR-GCK VLRGDDVFGRNVAMAARVAAAADGGEILVSSAVHRALADCEDLA------
Mvan_4613|M.vanbaalenii_PYR-1 VLRGDDLFGRNVAMAARVAAEADGGEVLVSSAVRDALTDADDIV------
TH_1244|M.thermoresistible__bu VRRGDDLFGRNVALAARVAGAAEGGEVLVSQAVRDALNSAGDAGSDEVAG
MMAR_4340|M.marinum_M VRRGDDLFGRNVAMAARVAGQAGGGQILVSEPVRDAVRDCGDIR------
MUL_0150|M.ulcerans_Agy99 VRRGDDLFGRNVAMAARVAGQAVGGQILVSEPVRDAVRDCGDIR------
Mb1151c|M.bovis_AF2122/97 ARCG------TVTICSAATSQ-----------------------------
Rv1120c|M.tuberculosis_H37Rv ARCG------TVTICSAATSQ-----------------------------
MAV_1250|M.avium_104 VRRGDDLFGRNVAMAARVAAQAAGGEILVSQPVRDALSRSDGIR------
MLBr_01399|M.leprae_Br4923 QRLAADWLGVDVNIAARVMERATKGGIMISGPTLDLIPQSDLKELGIITR
MAB_2330|M.abscessus_ATCC_1997 QRIGSDWLGVDVNIAARVMESAAKGGLAISQPALAKVPLAFLDHMGLTPT
MSMEG_4477|M.smegmatis_MC2_155 ELLGDDIGGIAVHIAARILGQARAGEILVSRTVRDLVVGSGTSF------
. * :.:
Mflv_2091|M.gilvum_PYR-GCK --FDEQRDVELKGFSGSHTLYPVRSASASR--------------------
Mvan_4613|M.vanbaalenii_PYR-1 --VDGERDAHLKGFSGSHTLYSVRSASASR--------------------
TH_1244|M.thermoresistible__bu FDVDDGREVSLKGFPGRHRLFAVRGQAGFRPRPRPE--------------
MMAR_4340|M.marinum_M --VDDGRDVELKGFSGSYRLFGVETAPECEPD------------------
MUL_0150|M.ulcerans_Agy99 --VDDGRDVELKGFSGSYRLFGVETAPECEPD------------------
Mb1151c|M.bovis_AF2122/97 --------------------------------------------------
Rv1120c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1250|M.avium_104 --FDDGREVELKGFSGTYRLFAVLASPDPG--------------------
MLBr_01399|M.leprae_Br4923 RVRKPMFTSKFTGIPPDMVIYRIKARRELTASDETAQTNSLT--------
MAB_2330|M.abscessus_ATCC_1997 PVRRPLFSSRPAGVPENMKMYLLETRRQLPAPGDDGRV------------
MSMEG_4477|M.smegmatis_MC2_155 ---ADRGNVELRGVPGTWQLLAVGDGAGGGSPAGSVEALLAAEPTPAART
Mflv_2091|M.gilvum_PYR-GCK ---------------------------------
Mvan_4613|M.vanbaalenii_PYR-1 ---------------------------------
TH_1244|M.thermoresistible__bu ---------------------------------
MMAR_4340|M.marinum_M ---------------------------------
MUL_0150|M.ulcerans_Agy99 ---------------------------------
Mb1151c|M.bovis_AF2122/97 ---------------------------------
Rv1120c|M.tuberculosis_H37Rv ---------------------------------
MAV_1250|M.avium_104 ---------------------------------
MLBr_01399|M.leprae_Br4923 ---------------------------------
MAB_2330|M.abscessus_ATCC_1997 ---------------------------------
MSMEG_4477|M.smegmatis_MC2_155 ATRRADRAVAAVAKRTPWALRGVARLTMSATRR