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REYLKHYIDGRWVDPVRPNALEVDNPTTEEISGRIALGSSADVDLAVTAARRAFATWSQTTREERLELLG AIMAEYQKRAGDLAEAVTEEMGAPAGLASGPQVNLGIGHLATTVDALKNFAFEEQHGSTLVVKEPIGVCG LITPWNWPINQIACKVFPALATGNTMVLKPSEVAPYSAQIFTEIIDAAGVPAGVYNLVYGDGPGVGASIS SHPDIDMVSFTGSTRAGIEIARNAAPTVKRVTQELGGKSPNIVLDDDDFAKSVAAGTSVMMVNSGQSCNA PSRMLVPNSRMDEAIAVARETAAAVKVGDPSDKTAIGPVASKAQFDKIQGLIQKGIDEGATLVIGGTGRP DGIDKGYYVKPTVFANVTNDMTIAREEIFGPVLCILGYDDLDQAVEIGNDTEYGLAGYVSGADLDKARAV ARRIRAGSVAINHGFDMAAPFGGYKRSGNGREWGPFAFDEFLEVKAALGYAPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4953 | - | - | 100% (474) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2878 | - | e-113 | 46.97% (462) | betaine-aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0240 | - | e-102 | 43.27% (483) | betaine-aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 3e-92 | 40.17% (473) | aldehyde dehydrogenase NAD dependant AldA |
| M. gilvum PYR-GCK | Mflv_1797 | - | 0.0 | 93.67% (474) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 6e-96 | 40.99% (483) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 6e-45 | 29.49% (451) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4484 | - | 9e-99 | 43.19% (477) | aldehyde dehydrogenase |
| M. marinum M | MMAR_4928 | aldA | 2e-95 | 41.77% (474) | NAD-dependent aldehyde dehydrogenase, AldA |
| M. avium 104 | MAV_5202 | - | 0.0 | 76.37% (474) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0455 | - | 0.0 | 85.84% (473) | aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_4605 | - | 0.0 | 79.11% (474) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_0477 | aldA | 3e-94 | 41.35% (474) | NAD-dependent aldehyde dehydrogenase, AldA |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4928|M.marinum_M -MALLADGVSSLFIDGKRCE-GAAGTFATVNPATEETLGVAADADAGDMD
MUL_0477|M.ulcerans_Agy99 -MALLADGVSSLFIDGKRCE-GAAGTFATVNPATEETLGVAADAVAGDMD
Mb0791|M.bovis_AF2122/97 -MALWGDGISALLIDGKLSD-GRAGTFPTVNPATEEVLGVAADADAEDMG
Mvan_4953|M.vanbaalenii_PYR-1 -----MREYLKHYIDGRWVDPVRPNALEVDNPTTEEISGRIALGSSADVD
Mflv_1797|M.gilvum_PYR-GCK -----MREYLKHYIDGQWVDPVRPNALDVDNPATEEVSGKIALGSSADVD
MSMEG_0455|M.smegmatis_MC2_155 -----MREYLKFYIDGRWVDPVEPRTLDVDNPTTEQVAGRIAIGAAADVD
TH_4605|M.thermoresistible__bu VEDEGMREYLKFYIDGAWVDPVDLKTLDVDDPATEEVSGRIAIGSATDVD
MAV_5202|M.avium_104 -----MREYLKFYIDGQWVDPVRPNTFDVENPATEQVCGKISLGSAADVD
Rv0223c|M.tuberculosis_H37Rv -MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPMAAAADVD
MAB_4484|M.abscessus_ATCC_1997 -----MTNYDKLFIGGVWTEPATDQVIEVISPATGQKVGQCPLASPADVD
MLBr_02573|M.leprae_Br4923 ------------------------MSIATINPATGETVKTFTPTTQDEVE
: . *:* : . ::
MMAR_4928|M.marinum_M RAIEAARRAFDDTDWSRNT-ELRVRCVRQLRDAMREHIEELRALTISEVG
MUL_0477|M.ulcerans_Agy99 RAIEAARRAFDDTDWSRNT-ELRVRCVRQLRDAMREHIEELRALTISEVG
Mb0791|M.bovis_AF2122/97 RAIEAARRAFDSTDWSRNT-ELRVRCVRQLRDAMQQHVEELRELTISEVG
Mvan_4953|M.vanbaalenii_PYR-1 LAVTAARRAFA--TWSQTTREERLELLGAIMAEYQKRAGDLAEAVTEEMG
Mflv_1797|M.gilvum_PYR-GCK LAVTAARRAFG--TWSQTTREERLELLGAIMAEYQNRAADLADAVHEEMG
MSMEG_0455|M.smegmatis_MC2_155 AAVEAARKAFT--TWSQTSRDERLAVLGAILDEYQKRAIDLADAVGEEMG
TH_4605|M.thermoresistible__bu NAVRAARRAFP--AWSQSSREERLELLQGILAEYQKRSADLADAVHEEMG
MAV_5202|M.avium_104 VAVGAARRAFG--RWSQSSREDRLDLLQAILAEYQKRADDLAAAVTEEIG
Rv0223c|M.tuberculosis_H37Rv AAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLFTKLLAAETG
MAB_4484|M.abscessus_ATCC_1997 AAVSAARRAFDNGPWPRLTPHERQAVLQKAVSLLESRKDEICKAIADETG
MLBr_02573|M.leprae_Br4923 DAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQSAALMTLEMG
*: * * : . * . * *
MMAR_4928|M.marinum_M APRMLTAAAQLEGPVNDLAFSADTAESYSWKQDLGAAAPMGIPTRRTVVR
MUL_0477|M.ulcerans_Agy99 APRMLTAAAQLEGPVNDLAFSADTAESYSWKQDLGAAAPMGIPTRRTVVR
Mb0791|M.bovis_AF2122/97 APRMLTASAQLEGPVGDLSFAADTAESYPWKQDLGEASPLGIATRRTLAR
Mvan_4953|M.vanbaalenii_PYR-1 APAGLASGPQVNLGIGHLATTVDALKNFAFEEQH---------GSTLVVK
Mflv_1797|M.gilvum_PYR-GCK APASLASGPQVNLGIGHLATAIDALKNFQFEEQH---------GSTLVVK
MSMEG_0455|M.smegmatis_MC2_155 APASLAAGPQVRMGLGHLTTSIEALKKFQFEEQY---------GSTLVVK
TH_4605|M.thermoresistible__bu APPSLAKGPQVNMGLGHLTTAIDVLKNFSFEEQR---------GATLVVK
MAV_5202|M.avium_104 APPSLAAGPQVFLGIGHLTTAIEVLKNFAFTEQR---------GATLIAR
Rv0223c|M.tuberculosis_H37Rv QPPTIIETMHWMGSMGAMNYFAGAADKVTWTETRTGSY-----GQSIVSR
MAB_4484|M.abscessus_ATCC_1997 APPMVIETLQWMGGFGAIQYYANAADAVKWKELRNGAY-----GQTLVTR
MLBr_02573|M.leprae_Br4923 KTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVG---ASKALARY
. . .
MMAR_4928|M.marinum_M EAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAVLGE
MUL_0477|M.ulcerans_Agy99 EAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAVLGE
Mb0791|M.bovis_AF2122/97 EAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAALGE
Mvan_4953|M.vanbaalenii_PYR-1 EPIGVCGLITPWNWPINQIACKVFPALATGNTMVLKPSEVAPYSAQIFTE
Mflv_1797|M.gilvum_PYR-GCK EPIGVCGLITPWNWPINQIACKVFPALATGNTMVLKPSEVAPYSAQIFTE
MSMEG_0455|M.smegmatis_MC2_155 EPIGVCGLITPWNWPINQIACKVFPALATGCTMVLKPSEVAPFSAQIFTE
TH_4605|M.thermoresistible__bu EPIGVCGLITPWNWPLNQIACKVFPALATGCTMVLKPSEVAPYSGQIFTE
MAV_5202|M.avium_104 EPIGVCGLITPWNWPINQVAVKVYPALATGCTVVLKPSEVAPFSSYIFAE
Rv0223c|M.tuberculosis_H37Rv EPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLTANALAE
MAB_4484|M.abscessus_ATCC_1997 EPAGVVAAIAAWNVPLFLALNKIGPAFLAGCAVVLKPAAETPLSSFILAE
MLBr_02573|M.leprae_Br4923 QPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCALYLAD
:. ** : .** * **: :* . :** : .* . : :
MMAR_4928|M.marinum_M LIADCTDIPPGVVNIVTSSEHGLGALLAKDPRVDMVSFTGSTATGRSVMA
MUL_0477|M.ulcerans_Agy99 LIADCTDIPPGVVNIVTSSEHGLGALLAKDPRVDMVSFTGSTATGRSVMA
Mb0791|M.bovis_AF2122/97 IIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFTGSTATGRAVMA
Mvan_4953|M.vanbaalenii_PYR-1 IIDAAG-VPAGVYNLVYGDGPGVGASISSHPDIDMVSFTGSTRAGIEIAR
Mflv_1797|M.gilvum_PYR-GCK ILDAAG-VPAGVYNLVYGDGPGVGAAISSHPEIDMVSFTGSTRAGIEVAR
MSMEG_0455|M.smegmatis_MC2_155 IIEAAG-VPAGVYNLVYGDGPGVGSALSSHPDIDMVSFTGSTRAGIDVAR
TH_4605|M.thermoresistible__bu ILDTAG-VPAGVYNMVFGDGPGVGVALSSHPDVDLVSFTGSTRAGVDVAR
MAV_5202|M.avium_104 ILAAAG-VPAGVFNLVNGDGPGVGAALASHPDIDLVSFTGSTRAGVEVAR
Rv0223c|M.tuberculosis_H37Rv VFAEVG-LPEGVLSVVPG-GIETGQALTSNPDIDMFTFTGSSAVGREVGR
MAB_4484|M.abscessus_ATCC_1997 VFAEAG-VPEGVLSVVPG-GAETGRALTNNPDVDVFSFTGSTAVGKEIAE
MLBr_02573|M.leprae_Br4923 VIARGG-FPEDCFQTLLISANGVEAILR-DPRVAAATLTGSEPAGQAVGA
:: .* . . : : .* : ::*** .* :
MMAR_4928|M.marinum_M DGAATIKRMFLELGGKSAFIVLDDADLAAASSVSAFTASMHAGQGCAITT
MUL_0477|M.ulcerans_Agy99 DGAATIKRMFLELGGKSAFIVLDDADLAAASSVSAFTASMHAGQGCAITT
Mb0791|M.bovis_AF2122/97 DAAATIKKVFLELGGKSAFVVLDDADLAAASAVSAFSACMHAGQGCAITT
Mvan_4953|M.vanbaalenii_PYR-1 NAAPTVKRVTQELGGKSPNIVLDDDDFAKSVAAGTSVMMVNSGQSCNAPS
Mflv_1797|M.gilvum_PYR-GCK NAAPTVKRVTQELGGKSPNIVLDDDDFAKSVAAGTSVMMVNSGQSCNAPS
MSMEG_0455|M.smegmatis_MC2_155 NAAPTVKRVTQELGGKSPNIVLDDADFAKSVAAGVSAMMTNSGQSCNAPS
TH_4605|M.thermoresistible__bu NAAPTVKRVTQELGGKSANIVLDDADFAKSVTAGVTTMMLNSGQSCNAPS
MAV_5202|M.avium_104 NAAPTVKRVTQELGGKSPNIVLDDGGFADAVRAGVANMMPNSGQSCNAPS
Rv0223c|M.tuberculosis_H37Rv RAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQT
MAB_4484|M.abscessus_ATCC_1997 IAAKNLKKVTLELGGKSAAIVLEDADLAAALPMLVFSGLMNAGQGCVNQT
MLBr_02573|M.leprae_Br4923 IAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQNNGQSCIAAK
.. :* ****... ::: . .: : . : **.* .
MMAR_4928|M.marinum_M RLVVPRARYDEAVAIAAGTMSSIKPGDPDDARTVCGPLISQRQRDRVQGY
MUL_0477|M.ulcerans_Agy99 RLVVPRARYDEAVAIAAGTMSSIKPGDPDDARTVCGPLISQRQRDRVEGY
Mb0791|M.bovis_AF2122/97 RLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLISARQRDRVQGY
Mvan_4953|M.vanbaalenii_PYR-1 RMLVPNSRMDEAIAVARETAAAVKVGDPSD-KTAIGPVASKAQFDKIQGL
Mflv_1797|M.gilvum_PYR-GCK RMLVPNSRMDEAIAVARETAGAVKVGDPGD-QSAIGPVASRAQFEKIQGL
MSMEG_0455|M.smegmatis_MC2_155 RMLVPNSRMGEAITIARGTAAAVKVGDPSD-KKAIGPVASKAQFDKIQGL
TH_4605|M.thermoresistible__bu RMLVPNSRMDEAIEIARETAAQVAVGDPDN-KTAIGPVVSRVQFDKIQRL
MAV_5202|M.avium_104 RMLVPASRMAEAISIAREVAEQVQVGDPDD-ATAIGPVASRAQFEKVQRL
Rv0223c|M.tuberculosis_H37Rv RILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTRVEGY
MAB_4484|M.abscessus_ATCC_1997 RVLAPRSRYDEVVDGIVGMVSLMGVGLPDDPATQVGPLITEKQRTRVEGY
MLBr_02573|M.leprae_Br4923 RFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGRAQVEQQ
*.:. * : : * * : **: : :::
MMAR_4928|M.marinum_M LDLAIAEGGTFACGG-GRPAGRQVGYFIEPTVIAGLTNDARPAREEIFGP
MUL_0477|M.ulcerans_Agy99 LDLAIAEGGTFACGG-GRPAGRQVGYFIEPTVIAGLTTDARPAREEIFGP
Mb0791|M.bovis_AF2122/97 LDLAVAEGGRFACGG-ARPADREVGFYIEPTVIAGLTNDARVAREEIFGP
Mvan_4953|M.vanbaalenii_PYR-1 IQKGIDEGATLVIGGTGRPDGIDKGYYVKPTVFANVTNDMTIAREEIFGP
Mflv_1797|M.gilvum_PYR-GCK IQKGIDEGATLVVGGTGRPDGVDKGYYVKPTVFANVTNDMTIAREEIFGP
MSMEG_0455|M.smegmatis_MC2_155 IQKGIDEGATLVAGGTGRPDGLDTGYYVKPTVFADVTNDMTIAREEIFGP
TH_4605|M.thermoresistible__bu IQQGIDEGATVVVGGPGRPDGLEVGYYVKPTVFANVKNDMTIAREEIFGP
MAV_5202|M.avium_104 IQQGIDEGATVVAGGPGRPAGLDQGYYVKPTVFADVTNDMTIAREEIFGP
Rv0223c|M.tuberculosis_H37Rv IAKGIEEGARLVCGG-GRPEGLDNGFFIQPTVFADVDNKMTIAQEEIFGP
MAB_4484|M.abscessus_ATCC_1997 IAKGIAEGARLAYGG-KRPEGLDGGYFVQPTIFADVDNSMTIAQEEIFGP
MLBr_02573|M.leprae_Br4923 VDAAAAAGAVIRCGG-KRPD--RPGWFYPPTVITDITKDMALYTDEVFGP
: . *. . ** ** *:: **:::.: .. :*:***
MMAR_4928|M.marinum_M VLTVLAHDGDDDAVRIANDSPYGLSGTVYGGDPQRAADVAARLRVGTVNV
MUL_0477|M.ulcerans_Agy99 VLTVLAHDGDDDAVRIANDSPYGLSGTVYGGDPQRAADVAARLRVGAVNV
Mb0791|M.bovis_AF2122/97 VLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARIASRLRVGTVNV
Mvan_4953|M.vanbaalenii_PYR-1 VLCILGYDDLDQAVEIGNDTEYGLAGYVSGADLDKARAVARRIRAGSVAI
Mflv_1797|M.gilvum_PYR-GCK VLCILGYDDLDQAVAIGNDTEYGLAGYVSGSDLEQARAVARRIRAGSVAI
MSMEG_0455|M.smegmatis_MC2_155 VLCILGYDDLDQAVEIANDTEYGLAGYVSGADLETARAVARRIRAGSVAI
TH_4605|M.thermoresistible__bu VLCILGYDDLDDAIEIANDTDYGLAGYVSGSDLEQARALARRIRAGSIAI
MAV_5202|M.avium_104 VLCILGYDDLDHAVRLANDTDYGLAGYVSGADLDTAREVAGKIRAGWVTI
Rv0223c|M.tuberculosis_H37Rv VLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIKISQQIRTGTYGI
MAB_4484|M.abscessus_ATCC_1997 VLSIIAYDSVDEAVKIANDSNYGLAGSVWTTDVQKGLEVAAQIRTGTYGI
MLBr_02573|M.leprae_Br4923 VASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIVAGQVFI
* : :.*: :.* : :**.. . : . .: .* :
MMAR_4928|M.marinum_M NGGVWYCADAPFGGYKQSGIGREMGLAGFEEYLETKLIA-----TAAN--
MUL_0477|M.ulcerans_Agy99 NGGVWYCADAPFGGYKQSGIGREMGLAGFEEYLETKLIA-----TAAN--
Mb0791|M.bovis_AF2122/97 NGGVWYCADAPFGGYKQSGIGREMGLLGFEEYLEAKLIA-----TAAN--
Mvan_4953|M.vanbaalenii_PYR-1 N--HGFDMAAPFGGYKRSGNGREWGPFAFDEFLEVKAAL---GYAPA---
Mflv_1797|M.gilvum_PYR-GCK N--HGFDMAAPFGGYKRSGNGREWGPFAFDEFLEVKAAL---GYAPA---
MSMEG_0455|M.smegmatis_MC2_155 N--HGFDLSAPFGGYKRSGNGREWGHFGFDEYLETKAAM---GYAPPQ--
TH_4605|M.thermoresistible__bu N--HGFDLNAPFGGYKRSGNGREWSDYGFHEYLETKAIL---GYSPS---
MAV_5202|M.avium_104 N--HAFDLNAPFGGYKRSGNGREWSDFGFHEYLEVKSIL---GYAPAQAD
Rv0223c|M.tuberculosis_H37Rv NW-YAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVLLPMGYTVA---
MAB_4484|M.abscessus_ATCC_1997 NW-YAFDPSCPFGGYKQSGIGRENGPEGIEEYCELKSVLLPMGYTLESI-
MLBr_02573|M.leprae_Br4923 NGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA---------
* **** *.** *** . .. .: : *
MMAR_4928|M.marinum_M -
MUL_0477|M.ulcerans_Agy99 -
Mb0791|M.bovis_AF2122/97 -
Mvan_4953|M.vanbaalenii_PYR-1 -
Mflv_1797|M.gilvum_PYR-GCK -
MSMEG_0455|M.smegmatis_MC2_155 -
TH_4605|M.thermoresistible__bu -
MAV_5202|M.avium_104 R
Rv0223c|M.tuberculosis_H37Rv -
MAB_4484|M.abscessus_ATCC_1997 -
MLBr_02573|M.leprae_Br4923 -