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TKNSDHRCYDELFIGGQWRKPANPQQLDVISPHSEQPIGHAQAAGPEDVDAAVAAARRAFDHGPWPRMSH AERMAKVEQLATIYAAHMDEMADLITDEMGSPRSFSRMGQGAAAATLIHLTLAAARDFPWTERRQGVLGE VHLHRAPVGVVGAIVPWNVPQFLIMPKLIPALIAGCTVIVKPAPETPLDALWLAEMIEQLELPPGVVSVL PGGTDVGEALVRHPGVDKVAFTGSSAVGRRIAALCGERLKRVSLELGGKSAAIILDDADIDKTVAGLKSA GLMNNGQACVAQTRILVSDRKHDEVVDALAAMMAELNVGDPADESTDIGPLVAQRQQRRVQEYIKSGRSE GARMVLGGEDSPAGRGWYVRPTLFADATNDMRIAREEIFGPVLTVLRYRDEDDAIRIANETDYGLAGSVW TADVAHGLEVAAAVRTGTYGINMYTLDIGAPFGGFKQSGIGREFGPEGLHEYVELQTLVCKGQLPPL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1643 | - | - | 100% (488) | aldehyde dehydrogenase |
| M. avium 104 | MAV_3969 | - | e-150 | 59.03% (454) | aldehyde dehydrogenase |
| M. avium 104 | MAV_4946 | - | e-124 | 48.95% (474) | aldehyde dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 8e-94 | 42.08% (461) | aldehyde dehydrogenase NAD dependant AldA |
| M. gilvum PYR-GCK | Mflv_0428 | - | 1e-131 | 49.29% (491) | betaine-aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 1e-126 | 47.99% (473) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 1e-58 | 31.13% (453) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4484 | - | 1e-136 | 50.53% (473) | aldehyde dehydrogenase |
| M. marinum M | MMAR_3965 | - | 0.0 | 81.15% (488) | NAD-dependent aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0309 | - | 1e-138 | 52.22% (473) | aldehyde dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_3080 | - | 1e-156 | 58.77% (473) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_1122 | - | 1e-124 | 47.78% (473) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0240 | - | 1e-133 | 51.35% (483) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1643|M.avium_104 --------MTKNSDHRCYDELFIGGQWRKPANPQQLDVISPHSEQPIGHA
MMAR_3965|M.marinum_M --------MTADSTHRSFHELFIGGRWCKPTIAEPITVISPHSEEPIGRA
TH_3080|M.thermoresistible__bu ---------------VHPEELFIGGEWATPSSAQRIEVISPHTEEPVAAV
Mflv_0428|M.gilvum_PYR-GCK ---MTQS----TAFRTEWDKLFIGGKWVEPASSEVIEVRSPATGDVVGKV
Mvan_0240|M.vanbaalenii_PYR-1 ---MTQS----TTFRTEWDKLFIGGKWVEPATSDVIEVHSPATGELVGKV
MSMEG_0309|M.smegmatis_MC2_155 MTAMTQTAPAATAATTNWDKLFIGGQWVEPSSSEIIEVFSPATGEKVGQA
Rv0223c|M.tuberculosis_H37Rv ----------MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKV
MUL_1122|M.ulcerans_Agy99 -----------MGEKTEYDKLFIGGRWTEPSTSEVIEVHCPATGEYVGKV
MAB_4484|M.abscessus_ATCC_1997 --------------MTNYDKLFIGGVWTEPATDQVIEVISPATGQKVGQC
Mb0791|M.bovis_AF2122/97 ----------MALWGDGISALLIDGKLSD-GRAGTFPTVNPATEEVLGVA
MLBr_02573|M.leprae_Br4923 ---------------------------------MSIATINPATGETVKTF
: . * : : :
MAV_1643|M.avium_104 QAAGPEDVDAAVAAARRAFDHGPWPRMSHAERMAKVEQLATIYAAHMDEM
MMAR_3965|M.marinum_M PAAGPDEVEAAVAAARRAFDYGPWPRLDPDERIRKVEELAAIYASHLDDM
TH_3080|M.thermoresistible__bu AAACPDDVDRAVAAARAAFDTGPWPRMDPAERVAVIRGLAERYGERRSEL
Mflv_0428|M.gilvum_PYR-GCK PLASAADVDAACAAAREAFDNGPWPQMSPTERAEVLGRAVKLMEERADEL
Mvan_0240|M.vanbaalenii_PYR-1 PLASAADVDAACAAAREAFDNGPWPHMSPAERGEILGRAVKIMEERADEL
MSMEG_0309|M.smegmatis_MC2_155 PLATKADVDAACAAARKAFDEGPWPRMTPQEREAVLAKATALIEESADEF
Rv0223c|M.tuberculosis_H37Rv PMAAAADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLF
MUL_1122|M.ulcerans_Agy99 PLAAAADVDAAVAAARAAFDNGPWPSTPPKERATVIANALKLLEERKDHF
MAB_4484|M.abscessus_ATCC_1997 PLASPADVDAAVSAARRAFDNGPWPRLTPHERQAVLQKAVSLLESRKDEI
Mb0791|M.bovis_AF2122/97 ADADAEDMGRAIEAARRAFDSTDWSRN-TELRVRCVRQLRDAMQQHVEEL
MLBr_02573|M.leprae_Br4923 TPTTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQS
: :: * * ** : * .
MAV_1643|M.avium_104 ADLITDEMGSPRSFSRMGQGAAAATLIHLTLA-AARDFPWTERRQGVLG-
MMAR_3965|M.marinum_M ADLITAEMGSPHSFSRLGQAAGAAGLMQLALA-AGRNFPWVERRQGIRG-
TH_3080|M.thermoresistible__bu AELITAQIGAPISFAQRAQVGLPWTMMSAFCT-LAENHPWQQTRAGMYGA
Mflv_0428|M.gilvum_PYR-GCK KFLLAAETGQPPTIVDMMQYGAAMSSFQFYAG-AADKFTWQDIRDGVYG-
Mvan_0240|M.vanbaalenii_PYR-1 KFLLAAETGQPPTIVDMMQYGAAMSSFQFYAG-AADKFTWQDIRDGVYG-
MSMEG_0309|M.smegmatis_MC2_155 KTLLKLETGQPQTIVDMMQYGAAMSTLQFYAS-AADKFAWKDIRDGIYG-
Rv0223c|M.tuberculosis_H37Rv TKLLAAETGQPPTIIETMHWMGSMGAMNYFAG-AADKVTWTETRTGSYG-
MUL_1122|M.ulcerans_Agy99 AKLFADETGQPPMTVETMHWMGSIGALNFFAGPAVDQVRWKEIRNGSYG-
MAB_4484|M.abscessus_ATCC_1997 CKAIADETGAPPMVIETLQWMGGFGAIQYYAN-AADAVKWKELRNGAYG-
Mb0791|M.bovis_AF2122/97 RELTISEVGAPRMLTASAQLEGPVGDLSFAAD-TAESYPWKQDLGEASPL
MLBr_02573|M.leprae_Br4923 AALMTLEMG-KTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVG-
: * . :
MAV_1643|M.avium_104 ----EVHLHRAPVGVVGAIVPWNVPQFLIMPKLIPALIAGCTVIVKPAPE
MMAR_3965|M.marinum_M ----QAHLRRAPVGVVGAIVPWNVPQFLIMPKLIPALIAGCTVIIKPAPE
TH_3080|M.thermoresistible__bu ----DVHVRREPVGVVAAIVPWNMPQFLIVTKLIPALLAGCTVVLKPAPE
Mflv_0428|M.gilvum_PYR-GCK ----QTLVVREPVGVVGAVTAWNVPFFLAANKLGPALLAGCTVVLKPAAE
Mvan_0240|M.vanbaalenii_PYR-1 ----QTLVVREPVGVVGAVTAWNVPFFLAANKLGPALLAGCTVVLKPAAE
MSMEG_0309|M.smegmatis_MC2_155 ----QTLVLKEPVGVVGAVVAWNVPFFLAANKLGPALLAGCTIVLKPAAE
Rv0223c|M.tuberculosis_H37Rv ----QSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAE
MUL_1122|M.ulcerans_Agy99 ----QTIVHREPIGVVGAIVAWNVPLFLAINKLGPAPLAGCTVVLKPAAE
MAB_4484|M.abscessus_ATCC_1997 ----QTLVTREPAGVVAAIAAWNVPLFLALNKIGPAFLAGCAVVLKPAAE
Mb0791|M.bovis_AF2122/97 GIATRRTLAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPD
MLBr_02573|M.leprae_Br4923 --ASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASN
. *** *: .**.* ** ** . ::* *.:
MAV_1643|M.avium_104 TPLDALWLAEMIEQLE-LPPGVVSVLPGG-TDVGEALVRHPGVDKVAFTG
MMAR_3965|M.marinum_M TPLDALWLAEMIEQIE-LPEGVVSVLPGG-PSVGEALVRHPGVDKIAFTG
TH_3080|M.thermoresistible__bu SPLDALLLAELIADSG-IPSGVVNVLPGP-AGVGERLVRHPGVDKVSFTG
Mflv_0428|M.gilvum_PYR-GCK TPLSVFAMAEMFVEAG-LPEGVLSIVPGG-PETGQALTANPNLDKYTFTG
Mvan_0240|M.vanbaalenii_PYR-1 TPLSVFAMAEMFVEAG-LPEGVLSIVPGG-PETGQALTANPNLDKYTFTG
MSMEG_0309|M.smegmatis_MC2_155 TPLTTNLMAQKFLEAG-LPEGVLSVVPGG-PETGRALTDNPALDKFTFTG
Rv0223c|M.tuberculosis_H37Rv TPLTANALAEVFAEVG-LPEGVLSVVPGG-IETGQALTSNPDIDMFTFTG
MUL_1122|M.ulcerans_Agy99 TPLTANALAEVFAEAG-LPEGVLSVVPGG-VETGQALTSNPGVDLFTFTG
MAB_4484|M.abscessus_ATCC_1997 TPLSSFILAEVFAEAG-VPEGVLSVVPGG-AETGRALTNNPDVDVFSFTG
Mb0791|M.bovis_AF2122/97 TPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFTG
MLBr_02573|M.leprae_Br4923 VPQCALYLADVIARGG-FPEDCFQTLLIS-ANGVEAILRDPRVAAATLTG
* :.: : .* . .. : : .* : ::**
MAV_1643|M.avium_104 SSAVGRRIAALCGERLKRVSLELGGKSAAIILDDADIDKTVAGLKSAGLM
MMAR_3965|M.marinum_M SSATGRRIAALCGEGLKRVSLELGGKSAAIILDDADIGKTVAGLKTAGLM
TH_3080|M.thermoresistible__bu STAAGRAVAAAAAAGLKRVSLELGGKSAAVVLSDADPAAVATAVRSASLS
Mflv_0428|M.gilvum_PYR-GCK SSGVGKEIAKIAADKLKPCTLELGGKSAAIILEDADLDSTLPMLVFSGLM
Mvan_0240|M.vanbaalenii_PYR-1 SSGVGKEIAKIAADKLKPCTLELGGKSAAIILEDADLDSTLPMLVFSGLM
MSMEG_0309|M.smegmatis_MC2_155 SSAVGKEIGKIAAEKLKPCTLELGGKSAAIILEDADLDSTLPMLLFSGLM
Rv0223c|M.tuberculosis_H37Rv SSAVGREVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVM
MUL_1122|M.ulcerans_Agy99 SSAVGKEIGRRAAEMLKPCTLELGGKSAAILLEDVDLSTAVPMMVFSGIM
MAB_4484|M.abscessus_ATCC_1997 STAVGKEIAEIAAKNLKKVTLELGGKSAAIVLEDADLAAALPMLVFSGLM
Mb0791|M.bovis_AF2122/97 STATGRAVMADAAATIKKVFLELGGKSAFVVLDDADLAAASAVSAFSACM
MLBr_02573|M.leprae_Br4923 SEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQ
* .*: : .. :* *****... ::: ..* . . .
MAV_1643|M.avium_104 NNGQACVAQTRILVSDRKHDEVVDALAAMMAELNVGDPADESTDIGPLVA
MMAR_3965|M.marinum_M NNGQACVAQTRILVSERRHDEVVDALADMMSALQVGDPADEKTDVGPLVA
TH_3080|M.thermoresistible__bu NSGQICNALTRILMPAGRAAEFTDALAAEMESLVIGDPTDAETQIGPLVA
Mflv_0428|M.gilvum_PYR-GCK NSGQACVGQTRILAPRSRYDEVIEKLGEAVRNMAPGLPDNPAAMIGPLIS
Mvan_0240|M.vanbaalenii_PYR-1 NSGQACVGQTRILAPRSRYDEVVEKLAAAAAGMAPGLPDNPAAMIGPLIS
MSMEG_0309|M.smegmatis_MC2_155 NSGQACVGQTRILAPRSRYDEVVEKVAAGVAAMQVGVPDDPAAMVGPLIS
Rv0223c|M.tuberculosis_H37Rv NAGQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLIS
MUL_1122|M.ulcerans_Agy99 NTGQACVGQTRILAPRSRYEEIVEAVSAFVQTLPVGPPSDPAAQIGSLIS
MAB_4484|M.abscessus_ATCC_1997 NAGQGCVNQTRVLAPRSRYDEVVDGIVGMVSLMGVGLPDDPATQVGPLIT
Mb0791|M.bovis_AF2122/97 HAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLIS
MLBr_02573|M.leprae_Br4923 NNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLAT
: ** * .*.: * : * * : : *.* :
MAV_1643|M.avium_104 QRQQRRVQEYIKSGRSEGARMVLGGEDSPA--GRGWYVRPTLFADATNDM
MMAR_3965|M.marinum_M QRQQRRVRDYIRSGQQEGARIVLGGQDSPQ--DRGWYVRPTLFTDATNDM
TH_3080|M.thermoresistible__bu RRQQERVRGYIEAGCAEGARLVTGGPGLPAGVDRGWYVQPTLFADADNSM
Mflv_0428|M.gilvum_PYR-GCK EKQRDRVEGYIKKGIEEGARVITGG-GRPEGLDSGWFVEPTVFADVDNSM
Mvan_0240|M.vanbaalenii_PYR-1 EKQRDRVEGYIKKGIEEGARVVTGG-GRPEGLDSGWYVQPTVFADVDNSM
MSMEG_0309|M.smegmatis_MC2_155 EKQRERVEGYIKKGIEEGARLVTGG-GRPEGLDSGWFVQPTVFADVDNSM
Rv0223c|M.tuberculosis_H37Rv EKQRTRVEGYIAKGIEEGARLVCGG-GRPEGLDNGFFIQPTVFADVDNKM
MUL_1122|M.ulcerans_Agy99 EKQRARVEGYIAKGIEEGARLVSGG-GRPESLDNGFFVQPTVFADVDNKM
MAB_4484|M.abscessus_ATCC_1997 EKQRTRVEGYIAKGIAEGARLAYGG-KRPEGLDGGYFVQPTIFADVDNSM
Mb0791|M.bovis_AF2122/97 ARQRDRVQGYLDLAVAEGGRFACGG-ARPADREVGFYIEPTVIAGLTNDA
MLBr_02573|M.leprae_Br4923 ESGRAQVEQQVDAAAAAGAVIRCGG-KRPD--RPGWFYPPTVITDITKDM
: :*. : . *. . ** * *:: **:::. :.
MAV_1643|M.avium_104 RIAREEIFGPVLTVLRYRDEDDAIRIANETDYGLAGSVWTADVAHGLEVA
MMAR_3965|M.marinum_M CIAREEIFGPVLTVLTYRDEQDAIRIANDSDYGLAGSVWTADTAHGLEIA
TH_3080|M.thermoresistible__bu RIAREEIFGPVLTVIPYPDEDAAVAIANDSDYGLAGSVFTADTERGLAIA
Mflv_0428|M.gilvum_PYR-GCK TIAQEEIFGPVLSVIPYEDEDDAVRIANDSVYGLAGSVYTTDNDRALKIA
Mvan_0240|M.vanbaalenii_PYR-1 TIAQEEIFGPVLAVIPYEDEDDAVRIANDSVYGLAGSVYTTDNDRALKIA
MSMEG_0309|M.smegmatis_MC2_155 TIAQEEIFGPVLVVIPFEDEDDAVRIANDSVYGLAGSVYTTDHAKGVEIA
Rv0223c|M.tuberculosis_H37Rv TIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIKIS
MUL_1122|M.ulcerans_Agy99 TIAQEEIFGPVLVVIPYDTKEDAIKIANDSVYGLAGSVWTSNVPKGIEIS
MAB_4484|M.abscessus_ATCC_1997 TIAQEEIFGPVLSIIAYDSVDEAVKIANDSNYGLAGSVWTTDVQKGLEVA
Mb0791|M.bovis_AF2122/97 RVAREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARIA
MLBr_02573|M.leprae_Br4923 ALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFI
: :*:**** : : *: *** : :**....: : . .
MAV_1643|M.avium_104 AAVRTGTYGINM-YTLDIGAPFGGFKQSGIGREFGPEGLHEYVELQTLVC
MMAR_3965|M.marinum_M AAVRTGTYGINM-YTLDISAPFGGFKQSGIGREFGPEGLAEYVELQTVLC
TH_3080|M.thermoresistible__bu ARIRTGTFGVNQGYTMDPFAPFGGVKGSGYGRELGPEGIDAYTDVKSISV
Mflv_0428|M.gilvum_PYR-GCK RRIRTGTYAVNM-YAFDPCAPFGGYKNSGIGRENGWEGIEAYCEQKSILL
Mvan_0240|M.vanbaalenii_PYR-1 RRIRTGTYAVNM-YAFDPCAPFGGFKNSGIGRENGWEGIEAYCEPKSILL
MSMEG_0309|M.smegmatis_MC2_155 SKVRTGTYGINM-YAFDPGAPFGGYKNSGIGRECGPEGIAGYCESKSVLL
Rv0223c|M.tuberculosis_H37Rv QQIRTGTYGINW-YAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVLL
MUL_1122|M.ulcerans_Agy99 EKIRTGTYAINW-YAFDPCCPFGGYKNSGIGRENGPEGVEHFTQQKSVLM
MAB_4484|M.abscessus_ATCC_1997 AQIRTGTYGINW-YAFDPSCPFGGYKQSGIGRENGPEGIEEYCELKSVLL
Mb0791|M.bovis_AF2122/97 SRLRVGTVNVNGGVWYCADAPFGGYKQSGIGREMGLLGFEEYLEAKLIAT
MLBr_02573|M.leprae_Br4923 DNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWI
: .* :* **** * ** *** . *. : : : :
MAV_1643|M.avium_104 KGQLPPL--------
MMAR_3965|M.marinum_M SGKMPPLRGFEEPAG
TH_3080|M.thermoresistible__bu APASTT---------
Mflv_0428|M.gilvum_PYR-GCK PFGYTPPAS------
Mvan_0240|M.vanbaalenii_PYR-1 PFGYTPAT-------
MSMEG_0309|M.smegmatis_MC2_155 PFGYTPE--------
Rv0223c|M.tuberculosis_H37Rv PMGYTVA--------
MUL_1122|M.ulcerans_Agy99 PMGYTLES-------
MAB_4484|M.abscessus_ATCC_1997 PMGYTLESI------
Mb0791|M.bovis_AF2122/97 AAN------------
MLBr_02573|M.leprae_Br4923 A--------------