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M. avium 104 MAV_5127 (-)

annotation: acyl-CoA dehydrogenase middle domain-containing protein
coordinates: 5280297 - 5281472
length: 391

DFSRVELSTQDAAFQESTRAFLAEHVTDEVRRRDRETGENFSEPVHVALGEAGYLESDWKLESEGGFDPV
RRRIFQLEIGRAHTPWFHWGTTAVVARLVKQFGAPELADAILPGVLSGKIRLCLGYTEPEGGSDVATCKT
RAVRDGSGWIINGSKMFTSNAQNAEYVFLLTNTDPRRPKHKNLTMFLVPLDSPGIEIQGIRTVDGDRTNI
VYYSDVRVDDLYRIGEVNGGWTVMRFALDAEHGITDPQDHGLQNISMLSEHGHLMAEAADGVAAILARPD
AAGRRPIDDESVKYRLGRGMARIEAAMSTPGMYGRVALIQTMREVSQELMDLLGTASALPTDTPGSPDDG
AIEFIFRHAVPAGIYGGTMEVFRNMIAQHELGLGRPSYGR*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. avium 104 MAV_5127 - - 100% (391) acyl-CoA dehydrogenase middle domain-containing protein
M. avium 104 MAV_1595 - e-155 67.61% (389) putative acyl-CoA dehydrogenase
M. avium 104 MAV_3008 - 3e-43 30.40% (421) putative acyl-CoA dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3534 fadE26 4e-36 29.78% (413) acyl-CoA dehydrogenase FADE26
M. gilvum PYR-GCK Mflv_4346 - 1e-148 65.04% (389) acyl-CoA dehydrogenase domain-containing protein
M. tuberculosis H37Rv Rv3504 fadE26 5e-36 29.78% (413) acyl-CoA dehydrogenase FADE26
M. leprae Br4923 MLBr_00737 fadE25 2e-11 28.10% (153) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_0615 - 5e-41 31.36% (405) putative acyl-CoA dehydrogenase
M. marinum M MMAR_4010 - 1e-154 65.81% (389) acyl-CoA dehydrogenase
M. smegmatis MC2 155 MSMEG_0578 - 1e-150 67.52% (391) acyl-CoA dehydrogenase middle domain-containing protein
M. thermoresistible (build 8) TH_2587 - 1e-159 68.88% (392) PUTATIVE acyl-CoA dehydrogenase domain protein
M. ulcerans Agy99 MUL_3874 - 1e-153 65.81% (389) acyl-CoA dehydrogenase
M. vanbaalenii PYR-1 Mvan_1998 - 1e-149 65.30% (389) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb3534|M.bovis_AF2122/97            ----------MRISYTPQQEELRRELRSYFATLMTPERREALSSVQGEYG
Rv3504|M.tuberculosis_H37Rv         ----------MRISYTPQQEELRRELRSYFATLMTPERREALSSVQGEYG
MAB_0615|M.abscessus_ATCC_1997      ----------MLIDLTPEQAKLQNDLRHYFSNLVTAEETREMMIDR----
MSMEG_0578|M.smegmatis_MC2_155      -------MDFSRVELSDEDTRFRDELRAFLAEIVTDEVIRRDRETG----
TH_2587|M.thermoresistible__bu      -------MDFSTVELSPEDQRFRAELRDFLTRHVTAEVIRRDRETG----
MAV_5127|M.avium_104                -------MDFSRVELSTQDAAFQESTRAFLAEHVTDEVRRRDRETG----
Mflv_4346|M.gilvum_PYR-GCK          -------MDFSRVQLSDDEQKFQDEVRTFLSEIVTDEVIRRDRETG----
Mvan_1998|M.vanbaalenii_PYR-1       -------MDFSRVELSDEDQKFLDEVRTFLGEIVTEDVIRRDRETG----
MMAR_4010|M.marinum_M               -------MDFSRVQISDADREFRETARSFLATHVTEEVRRHDRETG----
MUL_3874|M.ulcerans_Agy99           -------MDFSRVQISDADREFRETARSFLATHVTEEVRRHDRETG----
MLBr_00737|M.leprae_Br4923          MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRAR----
                                                .. .  .  :    *      :: .             

Mb3534|M.bovis_AF2122/97            VGNVYRETIAQMGRDGWLALGWPKEYGGQGRSAMDQLIFTDEAAIAGAP-
Rv3504|M.tuberculosis_H37Rv         VGNVYRETIAQMGRDGWLALGWPKEYGGQGRSAMDQLIFTDEAAIAGAP-
MAB_0615|M.abscessus_ATCC_1997      HGSSYEAVVRRMGQDGWLGVGWPKEYGGHGFGPLEQQIFMNEVMRADVP-
MSMEG_0578|M.smegmatis_MC2_155      -ENFDESVHLALGGAGYLAADYRCADDG-GFSAVRRRIWELEIGRAHTPW
TH_2587|M.thermoresistible__bu      -DNFDEGVHTALGAAGYLEKDFRSEAEG-GWNALRRRIWELEIGRAHTPW
MAV_5127|M.avium_104                -ENFSEPVHVALGEAGYLESDWKLESEG-GFDPVRRRIFQLEIGRAHTPW
Mflv_4346|M.gilvum_PYR-GCK          -DNFDEGVHLALGAAGYLDRDWNPATER-PFSRVERRIWELEKRRAHVPW
Mvan_1998|M.vanbaalenii_PYR-1       -DNFDEGVHLALGAAGYLERDWNPDSDR-AFTRVQRRIWELEKRRAHVPW
MMAR_4010|M.marinum_M               -DNFHEGLHLALGAAGYLAAEWKPEADG-GFSRVRRRIWELEKRRAHVPW
MUL_3874|M.ulcerans_Agy99           -DNFHEGLHLALGAAGYLAAEWKPEADG-GFSRVRRRIWELEKRRAHVPW
MLBr_00737|M.leprae_Br4923          ---FPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASA
                                         .     :.  *:                :   *   *   . .. 

Mb3534|M.bovis_AF2122/97            VPFLTINSVAPT-IMAYGTDEQKRFFLPRIAAGDLHFSIGYSEPGAGTDL
Rv3504|M.tuberculosis_H37Rv         VPFLTINSVAPT-IMAYGTDEQKRFFLPRIAAGDLHFSIGYSEPGAGTDL
MAB_0615|M.abscessus_ATCC_1997      MPLVTLQTVGPT-LQKYGTEEQKKKFLPGILAGEIHFAIGYTEPEAGTDL
MSMEG_0578|M.smegmatis_MC2_155      FHWGTTAMAAHT-VEKFGTPELVEEVLPGVLSGRVRICLGYTEPEGGSDV
TH_2587|M.thermoresistible__bu      FHWGTTAMVAQS-VEKFGTPELRDEVIPGVLTGEIRLCLGYTEPEGGSDV
MAV_5127|M.avium_104                FHWGTTAVVARL-VKQFGAPELADAILPGVLSGKIRLCLGYTEPEGGSDV
Mflv_4346|M.gilvum_PYR-GCK          VTSGTTAMITKS-VEKFGSPELKDEVLPRVYSGHVRLCLGYTEPEGGSDV
Mvan_1998|M.vanbaalenii_PYR-1       VTSGTTAMIAKS-VERFGSPELKDEVMPKVYSGHVRLCLGYTEPEGGSDV
MMAR_4010|M.marinum_M               VTWGTTAMVARS-VAKFGSPELVEEVLPGVFSGHVRMCLGYTEPEGGSDV
MUL_3874|M.ulcerans_Agy99           VTWGTTAMVARS-VAKFGSPELVEEVLPGVFSGHVRMCLGYTEPEGGSDV
MLBr_00737|M.leprae_Br4923          SLIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDA
                                        :        :   *: *    .:* : :     . . :*  .*:* 

Mb3534|M.bovis_AF2122/97            ANLRTTAVRDGD--DYVVNGQKMWTSLIQYADYVWLAVRTNPESSGAKKH
Rv3504|M.tuberculosis_H37Rv         ANLRTTAVRDGD--DYVVNGQKMWTSLIQYADYVWLAVRTNPESSGAKKH
MAB_0615|M.abscessus_ATCC_1997      ASLRTTAVRDGD--HYVVNGQKIFTTGAHQAQYIWLACRTDP---SAPKH
MSMEG_0578|M.smegmatis_MC2_155      ATCKTRAVRDGD--AWIINGSKMFTSNAHNAQYVFLVTNTDP---EAPKH
TH_2587|M.thermoresistible__bu      ATCRTRAVREADGSSWIINGAKMFTSNAHHAQYVFLLTNTDP---AAPKH
MAV_5127|M.avium_104                ATCKTRAVRDGS--GWIINGSKMFTSNAQNAEYVFLLTNTDP---RRPKH
Mflv_4346|M.gilvum_PYR-GCK          ATCKTRAVRDGS--SWVINGSKMFTTGAHNCQYVFLITNTDP---SAPKH
Mvan_1998|M.vanbaalenii_PYR-1       ATCKTRAVRDGD--SWVINGSKMFTTGAHNCQYVFLITNTDP---SAPKH
MMAR_4010|M.marinum_M               ATCKTRALRDGD--SWLINGSKMFTTGAHNCQYVFLITNTDP---QARKH
MUL_3874|M.ulcerans_Agy99           ATCKTRALRDGD--SWLINGSKMFTTGAHNCQYVFLITNTDP---QARKH
MLBr_00737|M.leprae_Br4923          ASMRTRAKADGD--DWILNGFKCWITNGGKSTWYTVMAVTDP----DKGA
                                    *. :* *  :..   :::** * : :    . :  :   *:*        

Mb3534|M.bovis_AF2122/97            RGISVLIVPTTAEGFSWTPVHTMAGP---DTSATYYSDVRVPVANRVGEE
Rv3504|M.tuberculosis_H37Rv         RGISVLIVPTTAEGFSWTPVHTMAGP---DTSATYYSDVRVPVANRVGEE
MAB_0615|M.abscessus_ATCC_1997      KGISILIVDTKDPGYSWTPIITNDGAH--HTNATYYTDVRVPVEMLVGEE
MSMEG_0578|M.smegmatis_MC2_155      NSLTMFLVPLGTPGVEIQGIRTVDGD---RTNITYYSDVRVSDRYRVGDV
TH_2587|M.thermoresistible__bu      QSLTMFLVPLDTPGIEIGPIRTVDGD---RTNIVYYSDVRVDDHYRIGEV
MAV_5127|M.avium_104                KNLTMFLVPLDSPGIEIQGIRTVDGD---RTNIVYYSDVRVDDLYRIGEV
Mflv_4346|M.gilvum_PYR-GCK          KSLTMFLVPLDTPGVEIQGIRTVDGD---RTNIVYYSDVRVDDRYRLGEV
Mvan_1998|M.vanbaalenii_PYR-1       KSLTMFLVPLDSPGVEIQGIRTVDGD---RTNIVYYSDVRVDDRYRLGEV
MMAR_4010|M.marinum_M               KSLTMFLVPLDSAGIEIQGIRTVDGD---RTNIVYYSDVRIDDKYRLGAV
MUL_3874|M.ulcerans_Agy99           KSLTMFLVPLDSAGIEIQGIRTVDGD---RTNIVYYSDVRIDDKYRLGAV
MLBr_00737|M.leprae_Br4923          NGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEP
                                    ..:: ::*     * .     .  *     *.  *: . *:     :*  

Mb3534|M.bovis_AF2122/97            NAGWKLVTNQLNHERVALVSPAP--IFGCLREVREWAQNTKDAGGTRLID
Rv3504|M.tuberculosis_H37Rv         NAGWKLVTNQLNHERVALVSPAP--IFGCLREVREWAQNTKDAGGTRLID
MAB_0615|M.abscessus_ATCC_1997      NAGWKLITTQLNHERVSLGPSGR--IAGMYDRVYEWAS-KPGPDGVAPLS
MSMEG_0578|M.smegmatis_MC2_155      NGGWGVLRGALDVEHGTFERDTH--GLQKIATMTEHITLMAEALDLVAAQ
TH_2587|M.thermoresistible__bu      NGGWTVLREALNVEHGTVERDSQ--GLQKLATMTEHALLTAEGLDWAVAV
MAV_5127|M.avium_104                NGGWTVMRFALDAEHGITDPQDH--GLQNISMLSEHGHLMAEAADGVAAI
Mflv_4346|M.gilvum_PYR-GCK          NGGWTVVREPLNAEHGDVAAADD--GLADVSIMMHQAMFMAKAVDTAAQK
Mvan_1998|M.vanbaalenii_PYR-1       NDGWTVVREPLNAEHGAVDAADD--GLQDVSIMMHQAMFMAAAVDKAAQK
MMAR_4010|M.marinum_M               NGGWTVLREPLNVEHGAVAAAPD--GLQDTSIMMHQAGSMAEAVDRAASC
MUL_3874|M.ulcerans_Agy99           NGGWTVLREPLNVEHGAVAAAPD--GLQDTSIMMHQAGSMAEAVDRAASC
MLBr_00737|M.leprae_Br4923          GTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTF
                                    . *:      *:  :                                   

Mb3534|M.bovis_AF2122/97            SEWVQLNLARVHAKAEVLKLINWELASSQSGPKDAGPSPADASAAKVFGT
Rv3504|M.tuberculosis_H37Rv         SEWVQLNLARVHAKAEVLKLINWELASSQSGPKDAGPSPADASAAKVFGT
MAB_0615|M.abscessus_ATCC_1997      HEDVRRVLGEMKAVWRLNELLNWQVASS-----GDDISMADAAATKILAT
MSMEG_0578|M.smegmatis_MC2_155      APGDG----------ASRFRLGRGIACT------EAAMSTPDMYGRVAIA
TH_2587|M.thermoresistible__bu      AASPGPDGRRLLDDESVQYRLGRSVARL------EAALSTPAEYGRVAIA
MAV_5127|M.avium_104                LARPDAAGRRPIDDESVKYRLGRGMARI------EAAMSTPGMYGRVALI
Mflv_4346|M.gilvum_PYR-GCK          STIPDPNGRRLIDDGAVAYRLGRSVARL------EASLSAPSIFGRVALA
Mvan_1998|M.vanbaalenii_PYR-1       STIPDPNGRRLIDDGSVAYRLGRSVARL------EASLSAPSIFGRVALA
MMAR_4010|M.marinum_M               VMRPDPDGRRPIDDTSVAYRLGRSVARM------EAALSAPSIFGRVAIA
MUL_3874|M.ulcerans_Agy99           VMRPDPDGRRPIDDTSVAYRLGRSVARM------EAALSAPSIFGRVAIA
MLBr_00737|M.leprae_Br4923          QSIQFMLADMAMKVEAARLIVYAAAARAE---RGEPDLGFISAASKCFAS
                                                        :    *                   :    

Mb3534|M.bovis_AF2122/97            ELATEAYRLLMEVLGTAATLRQNSPGALLRGRVERMHRACLILTFGGGTN
Rv3504|M.tuberculosis_H37Rv         ELATEAYRLLMEVLGTAATLRQNSPGALLRGRVERMHRACLILTFGGGTN
MAB_0615|M.abscessus_ATCC_1997      EWIQKLGRLSEGVVGRYGDPADANTAETLE-WLDAQTKRHLVITFGGGVN
MSMEG_0578|M.smegmatis_MC2_155      QTMRDVTPDLMDILGPA--------GALTDG-VEYIFRLAGPTGIYGGTL
TH_2587|M.thermoresistible__bu      QMMRDITPELMDVLGAASALPVDTTGAAADGAVEYLFRLASPVAIYGGTV
MAV_5127|M.avium_104                QTMREVSQELMDLLGTASALPTDTPGSPDDGAIEFIFRHAVPAGIYGGTM
Mflv_4346|M.gilvum_PYR-GCK          QTMRDISPDLMDILGTASALPVGTDGAADDGAAEYVYRFAPLVGIYGGTL
Mvan_1998|M.vanbaalenii_PYR-1       QTMRDISPDLMDVMGAASALPVGTDGAADDGASEYIYRFAPLVGIYGGTL
MMAR_4010|M.marinum_M               QTMRDISPDLMDILGSAAALPFGTDGAVDDGGAEYVYRFAPLVGIYGGTL
MUL_3874|M.ulcerans_Agy99           QTMRDISPDLMDILGSAAALPFGTDGAVDDGGAEYVYRFAPLVGIYGGTH
MLBr_00737|M.leprae_Br4923          DIAMEVTTDAVQLFGGAG--------YTSDFPVERFMRDAKITQIYEGTN
                                    :   .       :.*                  :   :      :  *. 

Mb3534|M.bovis_AF2122/97            EVQRDIIGMVALGLPRANR--------
Rv3504|M.tuberculosis_H37Rv         EVQRDIIGMVALGLPRANR--------
MAB_0615|M.abscessus_ATCC_1997      EVMREMVSTAGLGTPRVPR--------
MSMEG_0578|M.smegmatis_MC2_155      EVFRNMIAQHGLGLGKPNYAQPVKKVS
TH_2587|M.thermoresistible__bu      EVFRNMIAQHALGLGKPSYGTPVKR--
MAV_5127|M.avium_104                EVFRNMIAQHELGLGRPSYGR------
Mflv_4346|M.gilvum_PYR-GCK          EVFRNMIAQYVLGLGKPNYSPPRKAS-
Mvan_1998|M.vanbaalenii_PYR-1       EVFRNMIAQYALGLGKPNYSPVKT---
MMAR_4010|M.marinum_M               EVFRNMIAQHVLGLGKPSY-PHRT---
MUL_3874|M.ulcerans_Agy99           EVFRNMIAQHVLGLGKPSY-PHRT---
MLBr_00737|M.leprae_Br4923          QIQRVVMSRALLR--------------
                                    :: * ::.   *

species	id	gene	e-value	identity (len)	annotation
M. avium 104	MAV_5127	-	-	100% (391)	acyl-CoA dehydrogenase middle domain-containing protein
M. avium 104	MAV_1595	-	e-155	67.61% (389)	putative acyl-CoA dehydrogenase
M. avium 104	MAV_3008	-	3e-43	30.40% (421)	putative acyl-CoA dehydrogenase