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VVCGRTPRERIELRPDDADPIVVPGPVHTDPGRVSGPVDVVLLAVKATQNAGAAGWLARLCGEHTVVVVL QNGVEQVEQVRPLCPDSPVIPGIVWYSATTQPQGWVRLRTEPALVLPSGPSAQAVAALLRDAGCRVDCDP DIITAAWRKLLTNALAGFMALSRRRSGMFRRDDVAALSRRYVAECLAVARAEGARLSDDVVDELVELFRR APEDMGTSILSDAEAHRPMEWDVRNGVIARKGRAHGLPTPISDVLVPLLAAASDGPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3448 | - | - | 100% (267) | 2-dehydropantoate 2-reductase |
| M. avium 104 | MAV_4625 | panE | 1e-16 | 28.79% (264) | 2-dehydropantoate 2-reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2603 | - | 1e-116 | 76.78% (267) | 2-dehydropantoate 2-reductase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv2573 | - | 1e-116 | 76.78% (267) | 2-dehydropantoate 2-reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3554 | - | 2e-18 | 31.44% (229) | ketopantoate reductase ApbA/PanE |
| M. marinum M | MMAR_2157 | apbA_1 | 1e-116 | 74.91% (267) | ketopantoate reductase, ApbA_1 |
| M. smegmatis MC2 155 | MSMEG_2919 | - | 3e-11 | 30.45% (243) | 2-dehydropantoate 2-reductase |
| M. thermoresistible (build 8) | TH_4612 | - | 4e-05 | 30.26% (152) | PUTATIVE putative 2-dehydropantoate 2-reductase |
| M. ulcerans Agy99 | MUL_1742 | apbA_1 | 1e-106 | 74.80% (246) | 2-dehydropantoate 2-reductase |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2157|M.marinum_M -------------------------------MLLCGHTARDSIELRP---
MUL_1742|M.ulcerans_Agy99 --------------------------------------------------
Mb2603|M.bovis_AF2122/97 ------------------------MHKAGYSPLLCGHTPRAGIELRR---
Rv2573|M.tuberculosis_H37Rv ------------------------MHKAGYSPLLCGHTPRAGIELRR---
MAV_3448|M.avium_104 --------------------------------MVCGRTPRERIELRP---
MSMEG_2919|M.smegmatis_MC2_155 MTDTTPHPVVVYGTGAVGGVIAAQLRLGGFDVTAVARGDHLRAIRAGGLK
TH_4612|M.thermoresistible__bu ---------VIVGSGAIGGTVGGLLARSGADVVLVARGAHAQALADRGLT
MAB_3554|M.abscessus_ATCC_1997 --------MLVFGAGGVGLYFSAVLAQAGHHVTIVGRPATVTAAGQSDLQ
MMAR_2157|M.marinum_M --DGASPIVVP-GPVHTDPQQLSG--PVDVLILAVKATQTGAAR------
MUL_1742|M.ulcerans_Agy99 --------MVP-GPVHTDPQQLSG--PVDVLIFAVKATQTGAAR------
Mb2603|M.bovis_AF2122/97 --DGADPIVVP-GPVHTSPREVAG--PVDVLILAVKATQNDAAR------
Rv2573|M.tuberculosis_H37Rv --DGADPIVVP-GPVHTSPREVAG--PVDVLILAVKATQNDAAR------
MAV_3448|M.avium_104 --DDADPIVVP-GPVHTDPGRVSG--PVDVVLLAVKATQNAGAA------
MSMEG_2919|M.smegmatis_MC2_155 LVTQAGERTVP-LPAAADAGEVDWS-DEPVVILAVKSHQTGAAL------
TH_4612|M.thermoresistible__bu LRTPDGTFEIG-VTAAADPAEVRLT-SRDVLVFATKTQHLEDALHAWVDR
MAB_3554|M.abscessus_ATCC_1997 LTTSSGVLAVSGIHVVADIAEARIDPTADLIIVAVKAWQVSAAA------
: . :. . :::.*.*: : *
MMAR_2157|M.marinum_M -----EWLARLCGEHTVVAVLQNGVEQVEQVRP----------HCPSSSI
MUL_1742|M.ulcerans_Agy99 -----EWLARLCGEHTVVAVLQNGVEQVEQVQP----------HCPSSSI
Mb2603|M.bovis_AF2122/97 -----PWLTRLCDERTVVAVLQNGVEQVEQVQP----------HCPSSAV
Rv2573|M.tuberculosis_H37Rv -----PWLTRLCDERTVVAVLQNGVEQVEQVQP----------HCPSSAV
MAV_3448|M.avium_104 -----GWLARLCGEHTVVVVLQNGVEQVEQVRP----------LCPDSPV
MSMEG_2919|M.smegmatis_MC2_155 -----DDLATHAPAHTAIFAAQNGVANEMAILRRFADVYGVTVMLPAAHL
TH_4612|M.thermoresistible__bu PVHHGDTVVGTAGSTLPVLTALNGVVAEEMALRFFARVFGVCVWMPAAHV
MAB_3554|M.abscessus_ATCC_1997 -----TAIAPLVGAHTIVLPLQNGIEAADDLAN---------VIGPQHVL
:. : **: * :
MMAR_2157|M.marinum_M VAGSVWFAAETQPGGWVRLRGDAALVL----P-TGAAAETLAGLLRAAGC
MUL_1742|M.ulcerans_Agy99 VAGSVWFAAETQPGGWVRLRGDAALVL----P-TGAAAETLAGLLRAAGC
Mb2603|M.bovis_AF2122/97 VPAIVWCSAETQPQGWVRLRGEAALVV----P-TGPAAEQFAGLLRGAGA
Rv2573|M.tuberculosis_H37Rv VPAIVWCSAETQPQGWVRLRGEAALVV----P-TGPAAEQFAGLLRGAGA
MAV_3448|M.avium_104 IPGIVWYSATTQPQGWVRLRTEPALVL----P-SGPSAQAVAALLRDAGC
MSMEG_2919|M.smegmatis_MC2_155 EPGVVVQQSHPLAGILDLGRYPSG---------ADAVAHDVAAMLRASQF
TH_4612|M.thermoresistible__bu VPGEVIVRSWPVAGQFHISRWPADLAD----AEDDRLLSDIAATWTPAGL
MAB_3554|M.abscessus_ATCC_1997 GCSCVVIAKRTKPWAVTCLGAHAHLEIGPISDSFAGELTSLVAALHQAHI
. * . . . ... :
MMAR_2157|M.marinum_M RVDCDPDFTTVIWRKLVLNALAGLMALS--GRRSGMFRRDDIAELSRHYV
MUL_1742|M.ulcerans_Agy99 RVDCDLDFTTVIWRKLVLNALAGLMALS--GRRSGMFRRDDIAELSRHYV
Mb2603|M.bovis_AF2122/97 TVDCDPDFTTAAWRKLLVNALAGFMVLS--GRRSAMFRRDDVAALSRRYV
Rv2573|M.tuberculosis_H37Rv TVDCDPDFTTAAWRKLLVNALAGFMVLS--GRRSAMFRRDDVAALSRRYV
MAV_3448|M.avium_104 RVDCDPDIITAAWRKLLTNALAGFMALS--RRRSGMFRRDDVAALSRRYV
MSMEG_2919|M.smegmatis_MC2_155 LSEVRPDIMAWKHRKLIMNLGNGVTAIFRPGPAADELAAQARAEAEEVLG
TH_4612|M.thermoresistible__bu LVARPPDVAPWKYRKLLANLANAVVALTGSGRGDPVVIAAAQREGEAVLR
MAB_3554|M.abscessus_ATCC_1997 SVTLSSDIRATLWRKFMLISSYGGVGVLCRQPVGVTSTTPETAALIRDAM
*. . **:: . :
MMAR_2157|M.marinum_M AECLAVARAEGARLDDDVIDEMVDLFASAPEDMGTSILADREAHRRLEWD
MUL_1742|M.ulcerans_Agy99 AECLAVARAEGARLDDDVIDEMVDLFASAPEDMGTSILADREAHRRLEWD
Mb2603|M.bovis_AF2122/97 AECLAVARAEGARLDDDVVDEVVRLVRSAPQDMGTSMLADRAAHRPLEWD
Rv2573|M.tuberculosis_H37Rv AECLAVARAEGARLDDDVVDEVVRLVRSAPQDMGTSMLADRAAHRPLEWD
MAV_3448|M.avium_104 AECLAVARAEGARLSDDVVDELVELFRRAPEDMGTSILSDAEAHRPMEWD
MSMEG_2919|M.smegmatis_MC2_155 AAGIPVVPPEQDTERRGRFLAGR----VRDDVHGSTWQSVARGHTEVETD
TH_4612|M.thermoresistible__bu HAGIEFVPAEVEREARRHGPRDRDVADAGDVVANSTWQSLARNSGSVETD
MAB_3554|M.abscessus_ATCC_1997 FEVLAVGQAHGVALSHQDVDSMMAVFHAFDPLTTSSMHRDLLEGRPSELE
: . .. :: * :
MMAR_2157|M.marinum_M LRNGVIIRKARAHGLATPISQVLVPLLAAASDGPG---------------
MUL_1742|M.ulcerans_Agy99 LRNGVIIRKARAHGLATPISQVLVPLLAAASDGPG---------------
Mb2603|M.bovis_AF2122/97 LRNGVIVRKARAHGLATPISDVLVPLLAAASDGPG---------------
Rv2573|M.tuberculosis_H37Rv LRNGVIVRKARAHGLATPISDVLVPLLAAASDGPG---------------
MAV_3448|M.avium_104 VRNGVIARKGRAHGLPTPISDVLVPLLAAASDGPG---------------
MSMEG_2919|M.smegmatis_MC2_155 YFNGEIALQARLIGRSAPVNEYLQRVTADHARHGRPP---RSLDAAEALS
TH_4612|M.thermoresistible__bu YLNGEIVRIAHRHGMTAPVNAGLARLARAAARDGHPPGRYSGGELAEALG
MAB_3554|M.abscessus_ATCC_1997 HQSGAVLRYGRAVGVTTPIHWCIYASQLPAEIAARKPTEHAP--------
.* : .: * .:*: :
MMAR_2157|M.marinum_M ---------------
MUL_1742|M.ulcerans_Agy99 ---------------
Mb2603|M.bovis_AF2122/97 ---------------
Rv2573|M.tuberculosis_H37Rv ---------------
MAV_3448|M.avium_104 ---------------
MSMEG_2919|M.smegmatis_MC2_155 HITAGAAAPEHL---
TH_4612|M.thermoresistible__bu LVGEALGADVMVEGR
MAB_3554|M.abscessus_ATCC_1997 ---------------