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VAGSTPLAPMIGPDAITPRAAVRSPKTAELVAGTLRRMVVEGQLKDGDFLPNEAELMSHFGVSRPTLREA VRVLESERLVEVRRGSRTGARVRVPGPEIVARPVGLLLELSGADIADLLVARSAIEPMAARLLAENGTEE QFAELDRMLEEHIPSDWQSDRLAETTGDFHRRVVELSGNATLGIIAGMLHEITVRHHQFLFREHRPVSKS DYDKLMRSYRKLMQIMRSGDGDAAEAHWRTHLDTARALMLQGLESVKVRDVMG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5201 | - | - | 100% (263) | regulatory protein GntR, HTH |
| M. smegmatis MC2 155 | MSMEG_2605 | - | 3e-24 | 31.98% (222) | transcriptional regulator, GntR family protein |
| M. smegmatis MC2 155 | MSMEG_0895 | - | 1e-23 | 32.78% (241) | GntR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3086c | - | 2e-15 | 27.71% (231) | GntR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2114 | - | 1e-114 | 79.09% (263) | GntR domain-containing protein |
| M. tuberculosis H37Rv | Rv3060c | - | 2e-15 | 27.71% (231) | GntR family transcriptional regulator |
| M. leprae Br4923 | MLBr_01188 | - | 7e-10 | 36.05% (86) | hypothetical protein MLBr_01188 |
| M. abscessus ATCC 19977 | MAB_4644c | - | 7e-12 | 31.82% (198) | GntR family transcriptional regulator |
| M. marinum M | MMAR_3975 | - | 4e-29 | 33.99% (253) | FadR family transcriptional regulator |
| M. avium 104 | MAV_2542 | - | 4e-82 | 62.02% (258) | regulatory protein GntR, HTH |
| M. thermoresistible (build 8) | TH_0492 | - | 9e-64 | 70.12% (164) | regulatory protein GntR, HTH |
| M. ulcerans Agy99 | MUL_3832 | - | 2e-29 | 33.99% (253) | FadR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4590 | - | 1e-115 | 80.77% (260) | GntR domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3975|M.marinum_M --------MTALGIGPDPRRRLSAPRIAEIVADELRRQIIDGELADGDLL
MUL_3832|M.ulcerans_Agy99 --------MTALGIGPDPRRRLSAPRIAEIVADELRRQIIDGELADGDLL
MLBr_01188|M.leprae_Br4923 -------------------------------------------------M
Mb3086c|M.bovis_AF2122/97 --------------MSTEPDAVWTDKRASKIARRIEADIVRRGWPIGASL
Rv3060c|M.tuberculosis_H37Rv --------------MSTEPDAVWTDKRASKIARRIEADIVRRGWPIGASL
Mflv_2114|M.gilvum_PYR-GCK MARSTPLAPMIGPDAVASRTAVRSPKTAELVAGTLRRMVVEGQLKDGDFL
Mvan_4590|M.vanbaalenii_PYR-1 MTRNTPLAPMIGPDAVASRAAVRSPKTAELVAGTLRRMVVEGQLKDGDFL
MSMEG_5201|M.smegmatis_MC2_155 MAGSTPLAPMIGPDAITPRAAVRSPKTAELVAGTLRRMVVEGQLKDGDFL
TH_0492|M.thermoresistible__bu --------------------------------------------------
MAV_2542|M.avium_104 MPKREPLAPMATS---QNNGAVRSPKTAEIVADTLRRMIVEGQLKDGDFL
MAB_4644c|M.abscessus_ATCC_199 -----------------MHPRLSSQSLAEQVANILAAQIGDGRWSTGAKL
MMAR_3975|M.marinum_M PRQEVLVEQFNVSLVSLREALRILETEGLVSVRRGNRGGAVVHAPAKTSA
MUL_3832|M.ulcerans_Agy99 PRQEVLVEQFNVSLVSLREALRILETEGLVSVRRGNRGGAVVHAPAKASA
MLBr_01188|M.leprae_Br4923 PRQEALVEPLNVSLLSFREALQIMDTERLISLRRGNRGSVVVHTPTRTSA
Mb3086c|M.bovis_AF2122/97 GSESALQQRFCVSRSVLREAVRLVEHHQVARMRRGPNGGLFICEPNAGPA
Rv3060c|M.tuberculosis_H37Rv GSESALQQRFCVSRSVLREAVRLVEHHQVARMRRGPNGGLFICEPNAGPA
Mflv_2114|M.gilvum_PYR-GCK PNEAELMAHFGVSRPTLREAVRVLESERLVEVRRGSRTGARVRVPGPEIV
Mvan_4590|M.vanbaalenii_PYR-1 PNEAELMAHFGVSRPTLREAVRVLESERLVEVRRGSRTGARVRVPGPEIV
MSMEG_5201|M.smegmatis_MC2_155 PNEAELMSHFGVSRPTLREAVRVLESERLVEVRRGSRTGARVRVPGPEIV
TH_0492|M.thermoresistible__bu -------------------------------------------------V
MAV_2542|M.avium_104 PYEAELMDHFQVSRPSLREAVRVLESDRLVEVRRGSRTGARVRVPGPEIV
MAB_4644c|M.abscessus_ATCC_199 PGEVALCEEFGVSRATVREAIRDLKTKGLVSTRQG--AGVFVTSDRP---
MMAR_3975|M.marinum_M AYMLGLLLQSESVAVSDLGAALQELEPACAALAAQRPDRADTLVPELKRV
MUL_3832|M.ulcerans_Agy99 AYMLGLLLQSESVAVSDLGAALQELEPACAALAAQRPDRADTLVPELKRV
MLBr_01188|M.leprae_Br4923 AYMLGLLLQSKSIALADLGAALQELEPACAALAAQ---------------
Mb3086c|M.bovis_AF2122/97 TRAVVIYLEYLGTTIGDLLGARLVLEPLAASLAAE--HIDE---PGIERL
Rv3060c|M.tuberculosis_H37Rv TRAVVIYLEYLGTTIGDLLGARLVLEPLAASLAAE--HIDE---PGIERL
Mflv_2114|M.gilvum_PYR-GCK ARPAGLLLELSGATIADLLTAKSAIEPMAARLLAE--SGSAAAFDELEQL
Mvan_4590|M.vanbaalenii_PYR-1 ARPAGLLLELSGATIADLLTAKSGIEPMAARLLAE--SGSPEAFDELERM
MSMEG_5201|M.smegmatis_MC2_155 ARPVGLLLELSGADIADLLVARSAIEPMAARLLAE--NGTEEQFAELDRM
TH_0492|M.thermoresistible__bu ARPAALLLELSGATVADVMVARSGTEPMAARLLAE--SGNTEAFDELEKM
MAV_2542|M.avium_104 ARPAGFLLEMAGTTLADVMTARMGIEPYAARLLAE--DGTAAAHRELREL
MAB_4644c|M.abscessus_ATCC_199 --LGQWDRVLAAAEIDAVVEIRRLLEVQAAGLAAERRNRSDVAAIRRALV
. : : * .* * *:
MMAR_3975|M.marinum_M NEAMSEHLDDGAMFTEIGRQFHDLIVRGCGNHTIIAVVGSLETLWTSHEQ
MUL_3832|M.ulcerans_Agy99 NEAMSEHLDDGAMFTEIGRQFHDLIVRGCGNHTIIAVVGSLETLWTSHEQ
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 RAVLRAEERWRPGLPPPPEQFYRVLAEQSKNPVLQLFIDILMRLTKRYVQ
Rv3060c|M.tuberculosis_H37Rv RAVLRAEERWRPGLPPPPEQFYRVLAEQSKNPVLQLFIDILMRLTKRYVQ
Mflv_2114|M.gilvum_PYR-GCK LEELVADSHQSPRLAEATGAFHLRVVQLSGNATLSIVAGMLHEITVRHTA
Mvan_4590|M.vanbaalenii_PYR-1 LEELAADSHKSSRLAEATGLFHLRVVQLSGNATLSIVAGMLHEITVRHTA
MSMEG_5201|M.smegmatis_MC2_155 LEEHIPSDWQSDRLAETTGDFHRRVVELSGNATLGIIAGMLHEITVRHHQ
TH_0492|M.thermoresistible__bu LTEHIPAGYESGRLAETTGDFHLRVVQLSGNTTLSIIAGMLHEITVRHTE
MAV_2542|M.avium_104 IEE-IPAAWETGKLGAASTALHRRLVELSGNATLTVIVGMLHEIFERHMT
MAB_4644c|M.abscessus_ATCC_199 ARAKAESAGDDIEYVDADLEFHRAVVAAVHNPLLDELFDSFSVRMR----
MMAR_3975|M.marinum_M Q----------------------WADESAARGTYPSLTKRRAVLNTHIKL
MUL_3832|M.ulcerans_Agy99 Q----------------------WADESAARGTYPSLAKRRAVLNAHIKL
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 KSGTQSAGEAVEAAGQVHNEHSDIVAAVTAGDSAWAKTLSERHVEAVAGW
Rv3060c|M.tuberculosis_H37Rv KSGTQSAGEAVEAAGQVHNEHSDIVAAVTAGDSAWAKTLSERHVEAVAGW
Mflv_2114|M.gilvum_PYR-GCK -------------------------FVFNERR-PVSKADYETLLRSYRRL
Mvan_4590|M.vanbaalenii_PYR-1 -------------------------FVFNERR-PVSKADYDTLLRSYRKL
MSMEG_5201|M.smegmatis_MC2_155 -------------------------FLFREHR-PVSKSDYDKLMRSYRKL
TH_0492|M.thermoresistible__bu -------------------------VALRGER-SLSKTDYDKLIRSYRRL
MAV_2542|M.avium_104 -------------------------AAFLSVQNVVPKAQYNKLMRSYTRL
MAB_4644c|M.abscessus_ATCC_199 ---------------------------EAMLALLAGSAERPHDQEHHQWL
MMAR_3975|M.marinum_M TETIAEGDVDRARRIAGRHLADTQTYVLSGRAEQRIYALSPQALSRPRDM
MUL_3832|M.ulcerans_Agy99 TETIAEGDVDRARRIAGRHLADTQTYVLSGRAEQRIYALSPQALSRPRDM
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 LQQHQRGNDAAVRNGGRAREPRRAQQLILGAPRGKLAEVLAATIGDDIAA
Rv3060c|M.tuberculosis_H37Rv LQQHQRGNDAAVRNGGRAREPRRAQQLILGAPRGKLAEVLAATIGDDIAA
Mflv_2114|M.gilvum_PYR-GCK LQFLRSRDADGAEAHWRRHLDKTRELLLAGLESVPVRDVMG---------
Mvan_4590|M.vanbaalenii_PYR-1 MQFLRAGDAVGAEAHWRKHLDTTRELLLTGLESVPVRDVMG---------
MSMEG_5201|M.smegmatis_MC2_155 MQIMRSGDGDAAEAHWRTHLDTARALMLQGLESVKVRDVMG---------
TH_0492|M.thermoresistible__bu LKLVRAGDGAAAEAHWRTHLDTARQLMLEGLETIRVRDIMG---------
MAV_2542|M.avium_104 ADLVAARDGAEAEAHWRRHMENASAELLKGHEKTKVRDIMH---------
MAB_4644c|M.abscessus_ATCC_199 FDAIVDGSTRRAVELATDQLQHVRMR------------------------
MMAR_3975|M.marinum_M RRP-----------------------------------------------
MUL_3832|M.ulcerans_Agy99 RRP-----------------------------------------------
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 SGWQVGSVFGTETALLERYQVSRAVLREAVRLLEYHAIAHMRRGPGGGLV
Rv3060c|M.tuberculosis_H37Rv SGWQVGSVFGTETALLERYQVSRAVLREAVRLLEYHAIAHMRRGPGGGLV
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4590|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5201|M.smegmatis_MC2_155 --------------------------------------------------
TH_0492|M.thermoresistible__bu --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3975|M.marinum_M --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 VTTPQPQASIDTIALYLQYRKPSREDLRCVRDAIEIDNVAKVVKRRSEPE
Rv3060c|M.tuberculosis_H37Rv VTTPQPQASIDTIALYLQYRKPSREDLRCVRDAIEIDNVAKVVKRRSEPE
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4590|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5201|M.smegmatis_MC2_155 --------------------------------------------------
TH_0492|M.thermoresistible__bu --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3975|M.marinum_M --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 VASFLDTLGRPRLDNPTDDVRAAAVEEFRFHVGLARAAGNTMLDLFLLIL
Rv3060c|M.tuberculosis_H37Rv VASFLDTLGRPRLDNPTDDVRAAAVEEFRFHVGLARAAGNTMLDLFLLIL
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4590|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5201|M.smegmatis_MC2_155 --------------------------------------------------
TH_0492|M.thermoresistible__bu --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3975|M.marinum_M --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 VELFRRHLSSTEQALPTWSDVVAVGHAHVRILEAIGSGDDSLARCRTRRH
Rv3060c|M.tuberculosis_H37Rv VELFRRHLSSTEQALPTWSDVVAVGHAHVRILEAIGSGDDSLARCRTRRH
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4590|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5201|M.smegmatis_MC2_155 --------------------------------------------------
TH_0492|M.thermoresistible__bu --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3975|M.marinum_M ---------
MUL_3832|M.ulcerans_Agy99 ---------
MLBr_01188|M.leprae_Br4923 ---------
Mb3086c|M.bovis_AF2122/97 LDAAASWWL
Rv3060c|M.tuberculosis_H37Rv LDAAASWWL
Mflv_2114|M.gilvum_PYR-GCK ---------
Mvan_4590|M.vanbaalenii_PYR-1 ---------
MSMEG_5201|M.smegmatis_MC2_155 ---------
TH_0492|M.thermoresistible__bu ---------
MAV_2542|M.avium_104 ---------
MAB_4644c|M.abscessus_ATCC_199 ---------