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TSTWSPDRLGDLGDKRIIVTGATNGVGLGTTRALVRAGAHVILAVRNTDLGARRAAEVGGTTTVVEVDLA DMSSVRAFPGRLTAAGIDDVDILINNAGALTQRRTETVDGFETTLGTNLLGPFALTNLLLGRVRSQVIIV GSDAHRMATLRLDDMHLRRNRWTPLGAYGRAKLAVMLWGLELDRRQRVARSPVVTHLTHPGWVASNLPNV SQTRLMSVIQRGVTTVADRFAASIDEGAAPTLYCISEPIPPGSYVGVEGRLGLRGAPVLIGRSAVACDYE TAAAVVDFAERETGTAIPY*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6557 | - | - | 100% (300) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5430 | - | 1e-44 | 37.04% (297) | retinol dehydrogenase 13 |
| M. smegmatis MC2 155 | MSMEG_0863 | - | 4e-38 | 35.48% (310) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0069 | - | 9e-39 | 35.60% (309) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2288 | - | 1e-111 | 65.66% (297) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0068 | - | 2e-38 | 35.28% (309) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00315 | - | 8e-37 | 34.85% (307) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1144c | - | 3e-60 | 42.95% (298) | short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0757 | - | 2e-35 | 33.87% (313) | dehydrogenase/reductase |
| M. avium 104 | MAV_3824 | - | 1e-121 | 73.15% (298) | dehydrogenase |
| M. thermoresistible (build 8) | TH_3199 | - | 2e-46 | 38.21% (301) | PUTATIVE retinol dehydrogenase 13 |
| M. ulcerans Agy99 | MUL_1391 | - | 8e-35 | 33.87% (313) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4378 | - | 1e-112 | 65.89% (299) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0757|M.marinum_M MSANGKAKSHWSASDIPDQSGRVVVVTGANTGLGYHTAEALAGRGAHVVL
MUL_1391|M.ulcerans_Agy99 MSAKGKAKSHWSASDIPDQSGRVVVVTGANTGLGYHTAEALADRGAHVVL
Mb0069|M.bovis_AF2122/97 -------MTKWTAADIPDQTGRTAVITGANTGLGFETAAALAAHGAHVVL
Rv0068|M.tuberculosis_H37Rv -------MTKWTAADIPDQTGRTAVITGANTGLGFETAAALAAHGAHVVL
MLBr_00315|M.leprae_Br4923 -------MAKWTTADIPDQTGRVAVITGANTGLGYQTALALAEHGAHVVL
MAB_1144c|M.abscessus_ATCC_199 ---MSKSTATWSAAKLPSFEGRTVIITGANSGLGLETARELARVGAHVIM
TH_3199|M.thermoresistible__bu ---------MWTAADLPSFSDRTVIVTGANSGLGLVTARELARVGARVII
MSMEG_6557|M.smegmatis_MC2_155 ------MTSTWSPDRLGDLGDKRIIVTGATNGVGLGTTRALVRAGAHVIL
MAV_3824|M.avium_104 ------MTIPWTPDRLGDLTGKRVIVTGATNGVGLGTARALAKAGAEVIL
Mflv_2288|M.gilvum_PYR-GCK -MASTRTAATWTPARLGDMSGQRIIVTGATNGVGLATATALARAGAQVIL
Mvan_4378|M.vanbaalenii_PYR-1 ------MATMWSPARLGDMSGQRIIVTGATNGVGLATATALARAGAHVIL
*:. : . .: ::***..*:* *: *. **.*::
MMAR_0757|M.marinum_M AVRNPEKGNAAVAQIVAAKPQADVTLQALDLSSLDSVRSAADALRSAY-P
MUL_1391|M.ulcerans_Agy99 AVRNPEKGNAAVAQIVAAKPQADVTLQALDLSSLDSVRSAADALRSAY-P
Mb0069|M.bovis_AF2122/97 AVRNLDKGKQAAARITEATPGAEVELQELDLTSLASVRAAAAQLKSDH-Q
Rv0068|M.tuberculosis_H37Rv AVRNLDKGKQAAARITEATPGAEVELQELDLTSLASVRAAAAQLKSDH-Q
MLBr_00315|M.leprae_Br4923 AVRNLDKGKDAAARITATSAQNNVALQELDLASLESVRAAAKQLRSDY-D
MAB_1144c|M.abscessus_ATCC_199 AVRNTEKGNAAQASIKG-----STEVRQVDVADLASVRAFADTVEG----
TH_3199|M.thermoresistible__bu AVRNTTKGEAAAEQMTGPG-HGPVEVRALDLQNLASVREFAAGVEGD---
MSMEG_6557|M.smegmatis_MC2_155 AVRNTDLGARRAAEVGG-----TTTVVEVDLADMSSVRAFPGRLTAAGID
MAV_3824|M.avium_104 AVRNTELGKQRAAQMGG-----STAVEKLDLADLSSVRAFADRIEAP---
Mflv_2288|M.gilvum_PYR-GCK AVRNLELGAQRAAEMGG-----DTSVVELDLADQSSVRAFPSLFDGD---
Mvan_4378|M.vanbaalenii_PYR-1 AVRNLELGAQRAAEMGG-----DTSVVKLDLADQSSVRAFPGLVDGD---
**** * : . : :*: . *** . . .
MMAR_0757|M.marinum_M RIDLLINNAGVMWTPKQVTKDGFEMQFGTNHLGHFALTGLLLDHLLPVPG
MUL_1391|M.ulcerans_Agy99 RIDLLINNAGVMWTPKQVTKDGFEMQFGTNHLGHFALTGLLLDHLLPVPG
Mb0069|M.bovis_AF2122/97 RIDLLINNAGVMYTPRQTTADGFEMQFGTNHLGHFALTGLLIDRLLPVAG
Rv0068|M.tuberculosis_H37Rv RIDLLINNAGVMYTPRQTTADGFEMQFGTNHLGHFALTGLLIDRLLPVAG
MLBr_00315|M.leprae_Br4923 HIDLLINNAGVMWTPKSTTKDGFELQFGTNHLGHFAFTGLLLDRLLPIVG
MAB_1144c|M.abscessus_ATCC_199 -ADILVNNAGIMMVPPAKTVDGFESQIGTNHLGAFALTNLLLPKLT----
TH_3199|M.thermoresistible__bu -VDVLVNNAGIMAVPLARTVDGFESQIGTNHLGHFALTNLLLPQIT----
MSMEG_6557|M.smegmatis_MC2_155 DVDILINNAGALTQRRTETVDGFETTLGTNLLGPFALTNLLLGRVR----
MAV_3824|M.avium_104 -VDILINNAGALTDRRTETVDGFEMTLGTNLLGPFALTNLLLPKVR----
Mflv_2288|M.gilvum_PYR-GCK -VDVLINNAGAVAQHRTDTVDGFENTLGTNFLGPFALTNLLYGRVR----
Mvan_4378|M.vanbaalenii_PYR-1 -VDVLINNAGQVAQHRSDTVDGFEITLGTNFLGPFALTNLMFGRVR----
*:*:**** : * **** :*** ** **:*.*: ::
MMAR_0757|M.marinum_M SRVITVSSLGHRIRAAIHFDDLQWERS-YNRVAAYGQSKLANLLFTYELQ
MUL_1391|M.ulcerans_Agy99 SRVITVSSLGHRIRAAIHFDDLQWERS-YNRVAAYGQSKLANLLFTYELQ
Mb0069|M.bovis_AF2122/97 SRVVTISSVGHRIRAAIHFDDLQWERR-YRRVAAYGQAKLANLLFTYELQ
Rv0068|M.tuberculosis_H37Rv SRVVTISSVGHRIRAAIHFDDLQWERR-YRRVAAYGQAKLANLLFTYELQ
MLBr_00315|M.leprae_Br4923 SRVITVSSLSHRLFADIHFNDLQWECN-YNRVAAYGQSKLANLLFTYELQ
MAB_1144c|M.abscessus_ATCC_199 DRVIAVSSVAHRA-GKIDLTDLNYERRRYTRAGAYGASKLANLLFTKELQ
TH_3199|M.thermoresistible__bu DRVVTVSSLMHWF-GYLSLNDLNWKARPYSAWLAYAQSKLANLLFTSELQ
MSMEG_6557|M.smegmatis_MC2_155 SQVIIVGSDAHRM-ATLRLDDMHLRRNRWTPLGAYGRAKLAVMLWGLELD
MAV_3824|M.avium_104 SQIINVGSDAHRS-ATLHLDDLHLRRHKWTRLGAYAQSKLAVMLWGLELD
Mflv_2288|M.gilvum_PYR-GCK SKIVNVGSDAHKT-ASINFDDPHLRTDKWSPFPAYARSKLAVMLWGLELD
Mvan_4378|M.vanbaalenii_PYR-1 SKIVNVGSDAHKS-ASLAFDDLHLRSRRWSSFPAYARSKLAVMLWGLELD
.::: :.* * . : : * : . : **. :*** :*: **:
MMAR_0757|M.marinum_M RRLAADSQAATIAVAAHPGGSNTELARNLPRMLVPLAN----ILGPALFQ
MUL_1391|M.ulcerans_Agy99 RRLAADSQAATIAVAAHPGDSNTELARNLPRMLVPLAN----ILGPALFQ
Mb0069|M.bovis_AF2122/97 RRLAPG--GTTIAVASHPGVSNTELVRNMPRPLVAVAA----ILAP-LMQ
Rv0068|M.tuberculosis_H37Rv RRLAPG--GTTIAVASHPGVSNTEVVRNMPRPLVAVAA----ILAP-LMQ
MLBr_00315|M.leprae_Br4923 RRLATR--QTTIAVAAHPGGSRTELTRTLPALIAPIFS----VAELFLTQ
MAB_1144c|M.abscessus_ATCC_199 RRLSAAG-SPVRALTVHPGVAATELQSHSGNPIFELALK---TGN-LFAQ
TH_3199|M.thermoresistible__bu RRLDTVG-SPVRAVAAHPGYSSTNLQGHTGRRFGDALAR---IGNRYLAT
MSMEG_6557|M.smegmatis_MC2_155 RRQRVAR-SPVVTHLTHPGWVASNLPNVSQTRLMSVIQRGVTTVADRFAA
MAV_3824|M.avium_104 RRLRAAG-SPIVTQLTHPGWVASNLSNLGDAPLKAAAHKAVKMVADRLAN
Mflv_2288|M.gilvum_PYR-GCK RRLRAAG-SPVTTYLTHPGWVSSNLAKVSDTRLMTRVHSVVTAAANVIGN
Mvan_4378|M.vanbaalenii_PYR-1 RRLRTAG-SPVTTYLTHPGWVSSNLAKVSDTALMTRVHSAVTAVANVIGN
** . : *** ::: : :
MMAR_0757|M.marinum_M SAQMGALPTLRAATDPSVAGGQYYGPDGFAEQRGHPKIVQSSAQSHDEDL
MUL_1391|M.ulcerans_Agy99 SAQMGALPTLRTATDPSAAGGQYYGPDGFAEQRGHPKIVQSSAQSHDEDL
Mb0069|M.bovis_AF2122/97 DAELGALPTLRAATDPAVRGGQYFGPDGFGEIRGYPKVVASSAQSHDEQL
Rv0068|M.tuberculosis_H37Rv DAELGALPTLRAATDPAVRGGQYFGPDGFGEIRGYPKVVASSAQSHDEQL
MLBr_00315|M.leprae_Br4923 DAATGALPTLRAATDAAVLGGQYFGPDGFAEIRGHPKVVASNGKSHDVDR
MAB_1144c|M.abscessus_ATCC_199 NAAHGALPTLYAASQ-DLPGDTYIGPDGPFEAKGYPTRVGRSGRAQDTET
TH_3199|M.thermoresistible__bu DAEFGARQTLYAVAR-DVPGDSFIGPR--FAMHGPTEQVGRSPLARSAGT
MSMEG_6557|M.smegmatis_MC2_155 SIDEGAAPTLYCISEPIPPG-SYVGVEGRLGLRGAPVLIGRSAVACDYET
MAV_3824|M.avium_104 DIDEGAAPTLYCISEPIPPG-SYVGVSGRFGLRGGPVLIGRTPLACDYDT
Mflv_2288|M.gilvum_PYR-GCK DLDAGAAPSLYCLTEPIPPG-SYVGIAGRFGFKGPPTLSGRAPVACDYAD
Mvan_4378|M.vanbaalenii_PYR-1 DIDAGAAPTLYCLTEPIPPG-SYVGIAGRLGFKGPPTLSGRAPVACDYAD
. ** :* : * : * :* . : .
MMAR_0757|M.marinum_M QRRLWTVSEELTGVSFPV-
MUL_1391|M.ulcerans_Agy99 QRRLWTVSEELTGVSFPV-
Mb0069|M.bovis_AF2122/97 QRRLWAVSEELTGVVYPVG
Rv0068|M.tuberculosis_H37Rv QRRLWAVSEELTGVVYPVG
MLBr_00315|M.leprae_Br4923 QLRLWAVSEELTGVVYPVG
MAB_1144c|M.abscessus_ATCC_199 AKGLWRLSEQLTGVSFPL-
TH_3199|M.thermoresistible__bu ARALWELSEQLTDTKFPL-
MSMEG_6557|M.smegmatis_MC2_155 AAAVVDFAERETGTAIPY-
MAV_3824|M.avium_104 AARLVAFAERETGTELRV-
Mflv_2288|M.gilvum_PYR-GCK ARRLWEFAERETGTALPI-
Mvan_4378|M.vanbaalenii_PYR-1 AQRLWEFAERETGTTLPA-
: .:*. *..