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MAKDLVATVPDLSGKLAIITGANSGLGFGLARRLSAAGADVIMAIRNRAKGEAAVEEIRTAVPDAKLTIK ALDLSSLASVAALGEQLMADGRPIDLLINNAGVMTPPERVTTADGFELQFGSNHLGHFALTAHLLPLLRA AQRARVVSLSSLAARRGRIHFDDLQFERSYAPMTAYGQSKLAVLMFARELDRRSRAAGWGIISNAAHPGL TKTNLQIAGPSHGRDKPALMERLYKTSWRFAPFLWQEIEEGILPALYAAATPQADGGAFYGPRGRYEVAG GGVREAKVPAAARNDADSKRLWEVSEQLTGVSYPKSR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2263 | - | - | 100% (317) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0068 | - | 3e-66 | 48.43% (318) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0439c | - | 4e-61 | 46.28% (309) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2286 | - | 1e-179 | 100.00% (317) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0151 | - | 4e-62 | 45.69% (313) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00315 | - | 7e-60 | 45.91% (318) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3070 | - | 1e-82 | 54.25% (306) | short chain dehydrogenase |
| M. marinum M | MMAR_3355 | - | 1e-160 | 88.29% (316) | oxidoreductase |
| M. avium 104 | MAV_2969 | - | 1e-109 | 62.06% (311) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2212 | - | 7e-87 | 54.49% (312) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4179 | - | 6e-65 | 47.23% (307) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1288 | - | 1e-160 | 87.97% (316) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1061 | - | 3e-91 | 56.11% (319) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2263|M.tuberculosis_H37Rv ----MAKDLVATVPDLSGKLAIITGANSGLGFGLARRLSAAGADVIMAIR
Mb2286|M.bovis_AF2122/97 ----MAKDLVATVPDLSGKLAIITGANSGLGFGLARRLSAAGADVIMAIR
MMAR_3355|M.marinum_M ----MASDLIATVPDLSGKLAIVTGANSGLGFGLARRLSAAGADVVMAIR
MUL_1288|M.ulcerans_Agy99 ----MASDLIATVPDLSGKLAIVTGANSGLGFGLARRLSAAGADVVMAIR
MAV_2969|M.avium_104 ----MKPNLTLEIPDLRGKFAVVTGANSGLGFGLAKRLAAAGAEVVLAVR
MAB_3070|M.abscessus_ATCC_1997 ---MPRTPYDVDIPDLSGQRAVVTGASDGIGLEIAMKLAGAGADVFMPVR
MSMEG_2212|M.smegmatis_MC2_155 ---MPRKPIDVTLPDLSGRRAVVTGASDGIGLGIAARLAAAGADVILPVR
Mvan_1061|M.vanbaalenii_PYR-1 MDHMTRK-ATVDARDLHGKLAVITGGSDGIGFGLAGRLAAAGAEVILPVR
Mflv_0151|M.gilvum_PYR-GCK ---MTSKWTAADVPDQSGRVAVVTGANTGIGYETAEVLAGKGARVVIAVR
TH_4179|M.thermoresistible__bu ---MTGKWTARDVPDQTGRTAVITGANTGLGFETAKVLAEKGAHVVLAVR
MLBr_00315|M.leprae_Br4923 ----MAKWTTADIPDQTGRVAVITGANTGLGYQTALALAEHGAHVVLAVR
* *: *::**.. *:* * *: ** *.:.:*
Rv2263|M.tuberculosis_H37Rv NRAKGEAAVEEIRTAVPDAKLTIKALDLSSLASVAALGEQLMADGRPIDL
Mb2286|M.bovis_AF2122/97 NRAKGEAAVEEIRTAVPDAKLTIKALDLSSLASVAALGEQLMADGRPIDL
MMAR_3355|M.marinum_M NRAKGEAAIEEIRSAVPDAKLSIKALDLSSLASVAALGDQLNSEGRPIDI
MUL_1288|M.ulcerans_Agy99 NRAKGEAAIEEIRSAVPDAKLSTKALDLSSLASVAALGDQLNSEGRPIDI
MAV_2969|M.avium_104 DPAKGDQAVAAIRRAVPQAKLTIRQLDLSSLRSVAALGEQLTAEGRPIDI
MAB_3070|M.abscessus_ATCC_1997 NLRKGQAAVSRIRALHPRAHLTLAELDLSSLVSIADLGEKLCAEGTPIHL
MSMEG_2212|M.smegmatis_MC2_155 NEIKGKAAIAAVRQTNAAAKVSLRELDLSSLASVAALGKSLLEEAQPIHL
Mvan_1061|M.vanbaalenii_PYR-1 NADKGRRAADAIRTTTPDARISTRPMDLSSLQSVADLADELLREGRPIHL
Mflv_0151|M.gilvum_PYR-GCK DAGKGQKALDAITRKHPGAAVSLQELDLSSLGSVRRATDALRSAHPRIDL
TH_4179|M.thermoresistible__bu DPDKGRRAADRITAAAPHADVTVRQLDLTSLDNIRRAADDLRAGYPRIDL
MLBr_00315|M.leprae_Br4923 NLDKGKDAAARITATSAQNNVALQELDLASLESVRAAAKQLRSDYDHIDL
: ** * : . :: :**:** .: . * *.:
Rv2263|M.tuberculosis_H37Rv LINNAGVMTPPERVTTADGFELQFGSNHLGHFALTAHLLPLLRAAQRARV
Mb2286|M.bovis_AF2122/97 LINNAGVMTPPERVTTADGFELQFGSNHLGHFALTAHLLPLLRAAQRARV
MMAR_3355|M.marinum_M LINNAGVMTPPERDTTADGFELQFGSNHLGHFALTAHVLPLLRAAQGARV
MUL_1288|M.ulcerans_Agy99 LINNAGVMTPPERDTTADGFELQFGSNHLGHFALTAHVLPLLRAAQGARV
MAV_2969|M.avium_104 LINNAGVMAPPRRQQTSDGFELQFGTNHLGHFALTGRLLALLRAADSARV
MAB_3070|M.abscessus_ATCC_1997 LINNAGVMTPPERQTTADGFELQFGTNHLGHFALTGHLLPLLRAGR-ARV
MSMEG_2212|M.smegmatis_MC2_155 LINNAGVMTPPERRTTTDGFESQFGTNHLGHFALVAHLLPLLRAGG-ARV
Mvan_1061|M.vanbaalenii_PYR-1 LINNAGVMNPPSRQTTVDGFELQWGTNHLGHFALTARLLPLLTAGA-ARV
Mflv_0151|M.gilvum_PYR-GCK LINNAGVMYPP-KQVTRDGFELQFGTNHLGHFAFTGLLLDNLLDVPGSRV
TH_4179|M.thermoresistible__bu LINNAGVMYPP-RQTTRDGFELQFGTNHLGHFALTGQLLDNILPVDGSRV
MLBr_00315|M.leprae_Br4923 LINNAGVMWTP-KSTTKDGFELQFGTNHLGHFAFTGLLLDRLLPIVGSRV
******** .* : * **** *:*:*******:.. :* : :**
Rv2263|M.tuberculosis_H37Rv VSLSSLAAR-RGRIHFDDLQFERSYAPMTAYGQSKLAVLMFARELDRRSR
Mb2286|M.bovis_AF2122/97 VSLSSLAAR-RGRIHFDDLQFERSYAPMTAYGQSKLAVLMFARELDRRSR
MMAR_3355|M.marinum_M VSLSSLAAR-RGRIHFDDLQFEKSYAAMTAYGQSKLAVLMFARELDRRSR
MUL_1288|M.ulcerans_Agy99 VSLSSLAAR-RGRIHFDDLQFEKSYAAMTAYGQSKLAVLMFARELDRRSR
MAV_2969|M.avium_104 VTVSSIAAT-QRKLDFADVNAEHGYQPMYSYGVAKLAQLMFAVELDWRSR
MAB_3070|M.abscessus_ATCC_1997 TSHTSIAAR-SGEINWDDLNWERGYDGMRAYRQSKIACGLFGLELSRLSN
MSMEG_2212|M.smegmatis_MC2_155 TSQVSVAAN-QHAINWDDLNWERSYDGAKAYSQSKIAFGLFGLELDRRSH
Mvan_1061|M.vanbaalenii_PYR-1 TTQSSISAA-RHAINWDDLNFEKSYAVGKAYSQSKIANLMFGLELDRRSR
Mflv_0151|M.gilvum_PYR-GCK VTVASLAHKNLADIHFDDLQWERKYNRVAAYGQSKLANLMFTYELQRRLA
TH_4179|M.thermoresistible__bu VTVASIAHRNMADIHFDDLQWERGYHRVAAYGQSKLANLMFAYELQRRLS
MLBr_00315|M.leprae_Br4923 ITVSSLSHRLFADIHFNDLQWECNYNRVAAYGQSKLANLLFTYELQRRLA
: *:: :.: *:: * * :* :*:* :* **.
Rv2263|M.tuberculosis_H37Rv AAGWGIISNAAHPGLTKTNLQIAGPSHGRDKPALMERLYKTSWRFAPFLW
Mb2286|M.bovis_AF2122/97 AAGWGIISNAAHPGLTKTNLQIAGPSHGRDKPALMERLYKTSWRFAPFLW
MMAR_3355|M.marinum_M AAGWGVMSNAAHPGLTKTNLQISGPSHGREKPALMQRFYTTSWRFAPFLW
MUL_1288|M.ulcerans_Agy99 AAGWGVMSNAAHPGLTKTNLQISGPSHGREKPALMQRFYTTSWRFAPFLW
MAV_2969|M.avium_104 LGGWGLMSNAAHPGLAKTNL-LSGASYGSSAPTLQARLTRLTWRLLPFMW
MAB_3070|M.abscessus_ATCC_1997 TAGWGITSNIAHPGVAPTSLLAARPEVGRTKDTTEVRMIRWLSARG-LIV
MSMEG_2212|M.smegmatis_MC2_155 AHGWGITSNLSHPGLAPTNLLAARPDTGRAQDDWKLRLIRTLSSRG-ILF
Mvan_1061|M.vanbaalenii_PYR-1 HAGWGITSNVAHPGVTATNLLAAQPHMGRDGDTLSVRLIRRLAGLG-ILT
Mflv_0151|M.gilvum_PYR-GCK ARGAPTIAVAAHPGISNTELMRHVPGTSLPG----------VMKLAGLVT
TH_4179|M.thermoresistible__bu AKNAPTISVAAHPGVSNTELTRYIPGARLPG----------VSLLAGLLT
MLBr_00315|M.leprae_Br4923 TR-QTTIAVAAHPGGSRTELTRTLPALIAPI----------FSVAELFLT
: :*** : *.* . ::
Rv2263|M.tuberculosis_H37Rv QEIEEGILPALYAAATPQADGGAFYGPRGRYEVAGGGVREAKVPAAARND
Mb2286|M.bovis_AF2122/97 QEIEEGILPALYAAATPQADGGAFYGPRGRYEVAGGGVREAKVPAAARND
MMAR_3355|M.marinum_M QEIEDGILPALYAAVTPQAEGGAFYGPRGFYEAAGGGVRAAKVPARAGND
MUL_1288|M.ulcerans_Agy99 QEIEDGILPALYAAVTPQAEGGAFYGPRGFYEAAGGGVRAAKVPARAGND
MAV_2969|M.avium_104 LDIDEAVKPTLYAAVSPDAQGARYYGPRGFYETARGGVTFARVPPLARSE
MAB_3070|M.abscessus_ATCC_1997 GTVASATLPALMAAVAPEATDGGFYGPRW-PGSAGGPPGPQKLWKPLHSI
MSMEG_2212|M.smegmatis_MC2_155 GTVHTAQLPALYAAASPHAKRGGFYGPRG-PGHLGGPPGEQRLYSRLRNN
Mvan_1061|M.vanbaalenii_PYR-1 QTVDQGLLPALYAATHPDAEGGKFYGPSG-FQHLSGAPAEQQVYGPARDA
Mflv_0151|M.gilvum_PYR-GCK NTPAVGALPTVRAATDPGVTGGQYYGPSG-FNEMVGHPVLVTSNKKSHDV
TH_4179|M.thermoresistible__bu NSPAVGALATLRAATDPEVKGGQYYGPDG-FQEIRGHPVLVGSSAKSRDE
MLBr_00315|M.leprae_Br4923 QDAATGALPTLRAATDAAVLGGQYFGPDG-FAEIRGHPKVVASNGKSHDV
. .:: **. . . . ::** * .
Rv2263|M.tuberculosis_H37Rv ADSKRLWEVSEQLTGVSYPKSR---
Mb2286|M.bovis_AF2122/97 ADSKRLWEVSEQLTGVSYPKSR---
MMAR_3355|M.marinum_M ADCQRLWEVSERLTGVGYPTSS---
MUL_1288|M.ulcerans_Agy99 ADCQRLWEVSERLTGVGYPTSS---
MAV_2969|M.avium_104 PEMARLWRLSEQLSGVDYPG-----
MAB_3070|M.abscessus_ATCC_1997 RNASRLWQASQELTGVTFT------
MSMEG_2212|M.smegmatis_MC2_155 DEAQRIWEISEKLTDMSFPTA----
Mvan_1061|M.vanbaalenii_PYR-1 ADAARLWRVSEQLAGAQFALPRAGA
Mflv_0151|M.gilvum_PYR-GCK AVQQRLWTVSEELTGVKYGV-----
TH_4179|M.thermoresistible__bu DIQRRLWTVSEELTGVTFPV-----
MLBr_00315|M.leprae_Br4923 DRQLRLWAVSEELTGVVYPVG----
*:* *:.*:. :