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MPDWTAAQLPSFAGRTVIVTGANAGLGEVTARELARVGGHVILAVRNTDKGRAAADRMAGVATGRVEVRE LDLQDLASVRRFADGIDTVDVLVNNAGIMATKHAVTVDGFEGQIGTNHLGHFALTNLLLPKLTDRVVTVS SLMHHFGYISLKDLNFRSRPYSAWLAYSQSKLANLLFTSELQRRLDAVPSSLRALAAHPGWSHTNLQGNS GRKLGDAAVLAVDRIVSTDADFGARQTLYAVSQDLPGDTFVGPRFGLYGRTQPTWRNWPAKRAGTAAALW ELSEELTGTSFRSDPDLRRGRAAGPPSPRRPPGAVTKLVLSATPRGVGGYAMSDANLAAVLALCAALASA VGNVVRQRSAQEVTDKPVGHLALFGMLLRDTRWWLGGLGDIGSYVLLAAALDRGSVLLVMSLQVTALLFA LPIYARMTHHPITGREWAWALLLAVALAVLIAVGDPTGGQQRAPLQTWLVVAAVIGPLLVLGLLGARVWA DRPVAALLLAAVAGSLLAMFAVLMKGVVDILEHNPGQLWRSFELYALVFCGVAGMIYHQSAYRAGALTAS LPTIIVAKPVVGGILGIIVLRETLVAGGWEWVVLAVTAVVVIVATVGLARGEAASMSAGAGRDVRPTDRP KAASQA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4124 | - | - | 100% (636) | dehydrogenase |
| M. avium 104 | MAV_1153 | - | e-117 | 75.26% (291) | retinol dehydrogenase 13 |
| M. avium 104 | MAV_3622 | - | 5e-93 | 62.94% (286) | hypothetical protein MAV_3622 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2748c | - | 8e-70 | 51.20% (291) | hypothetical protein Mb2748c |
| M. gilvum PYR-GCK | Mflv_1940 | - | 1e-112 | 71.13% (291) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2729c | - | 1e-68 | 50.52% (291) | hypothetical protein Rv2729c |
| M. leprae Br4923 | MLBr_00315 | - | 3e-51 | 44.41% (304) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1144c | - | 4e-84 | 58.62% (290) | short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_1984 | - | 7e-87 | 57.44% (289) | hypothetical protein MMAR_1984 |
| M. smegmatis MC2 155 | MSMEG_5430 | - | 1e-111 | 71.13% (291) | retinol dehydrogenase 13 |
| M. thermoresistible (build 8) | TH_3199 | - | 1e-114 | 71.63% (289) | PUTATIVE retinol dehydrogenase 13 |
| M. ulcerans Agy99 | MUL_3372 | - | 4e-87 | 57.44% (289) | hypothetical protein MUL_3372 |
| M. vanbaalenii PYR-1 | Mvan_4786 | - | 1e-112 | 71.13% (291) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5430|M.smegmatis_MC2_155 ----MTQWTSADLPSFRGRTVVITG---ANSGLGLVTARELARVGAKVIV
TH_3199|M.thermoresistible__bu ------MWTAADLPSFSDRTVIVTG---ANSGLGLVTARELARVGARVII
Mflv_1940|M.gilvum_PYR-GCK ----MSDWTAADLPSFAGRTVIVTG---ANSGLGLVTARELARVGATTIL
Mvan_4786|M.vanbaalenii_PYR-1 ----MSDWTAADLPSFAGRTVIVTG---ANSGLGLITARELARVGARTIL
MLBr_00315|M.leprae_Br4923 ----MAKWTTADIPDQTGRVAVITG---ANTGLGYQTALALAEHGAHVVL
MAB_1144c|M.abscessus_ATCC_199 MSKSTATWSAAKLPSFEGRTVIITG---ANSGLGLETARELARVGAHVIM
MAV_4124|M.avium_104 ----MPDWTAAQLPSFAGRTVIVTG---ANAGLGEVTARELARVGGHVIL
Mb2748c|M.bovis_AF2122/97 ----MASVEFATILALGAALLAGIGYVTLQRSARQVTAEEYVGHLTLFHL
Rv2729c|M.tuberculosis_H37Rv ----MASVEFATILALGAALLAGIGYVTLQRSARQVTAEEYVGHFTLFHL
MMAR_1984|M.marinum_M ----MTTTEIAAVLALGAAFASALGNVTRQRSAQEITDEQ-VGHLELFWL
MUL_3372|M.ulcerans_Agy99 ----MTTTEIAAVLALGAAFASALGNVTRQRSAQEITDEQ-VGHLELFWL
* : * : . * . :
MSMEG_5430|M.smegmatis_MC2_155 AVRNLDKGTAAAETMPG----GIVEVRKLDLQDLASVHEFADTVE----T
TH_3199|M.thermoresistible__bu AVRNTTKGEAAAEQMTGP-GHGPVEVRALDLQNLASVREFAAGVEG---D
Mflv_1940|M.gilvum_PYR-GCK AVRNLDKGRAAADSMSG-----DVEVRRLDLQDLSSVREFADGVD----S
Mvan_4786|M.vanbaalenii_PYR-1 AVRNLDKGNTAAATMTG-----DVEVRSLDLQNLASVRAFADGVD----S
MLBr_00315|M.leprae_Br4923 AVRNLDKGKDAAARITATSAQNNVALQELDLASLESVRAAAKQLRSDYDH
MAB_1144c|M.abscessus_ATCC_199 AVRNTEKGNAAQASIKGS-----TEVRQVDVADLASVRAFADTVEG----
MAV_4124|M.avium_104 AVRNTDKGRAAADRMAG-VATGRVEVRELDLQDLASVRRFADGIDT----
Mb2748c|M.bovis_AF2122/97 SLRHALWWLGSLAAVAS----FTLQAIALTMGSVVLVQSLQATALL----
Rv2729c|M.tuberculosis_H37Rv SLRHALWWLGSLAAVAS----FTLQAIALTMGSVVLVQSLQATALL----
MMAR_1984|M.marinum_M SLRDSRWWLGALGAIAN----YLLQAAALTLGSVVLVSALQVTALL----
MUL_3372|M.ulcerans_Agy99 SLRDSRWWLGALGAIAN----YLLQAAALTLGSVVLVSALQVTALL----
::*. : : : : .: *
MSMEG_5430|M.smegmatis_MC2_155 VDVLVNNAGIMAVPLARTVDGFESQIGTNHLGHFALTNLLLPKIS----D
TH_3199|M.thermoresistible__bu VDVLVNNAGIMAVPLARTVDGFESQIGTNHLGHFALTNLLLPQIT----D
Mflv_1940|M.gilvum_PYR-GCK VDVLVNNAGIMAVPYALTADGFESQIGTNHLGHFALTNLLLPKIS----D
Mvan_4786|M.vanbaalenii_PYR-1 VDVLVNNAGIMAVPYAQTVDGFESQIGTNHLGHFALTNLLLPKIS----D
MLBr_00315|M.leprae_Br4923 IDLLINNAGVMWTPKSTTKDGFELQFGTNHLGHFAFTGLLLDRLLPIVGS
MAB_1144c|M.abscessus_ATCC_199 ADILVNNAGIMMVPPAKTVDGFESQIGTNHLGAFALTNLLLPKLT----D
MAV_4124|M.avium_104 VDVLVNNAGIMATKHAVTVDGFEGQIGTNHLGHFALTNLLLPKLT----D
Mb2748c|M.bovis_AF2122/97 FALLIDAR--LTHHRCTPREWMWAVLLAGAVAVIVMSGNPAAGTTRAPFS
Rv2729c|M.tuberculosis_H37Rv FALLIDAR--LTHHRCTPREWMWAVLLAGAVAVIVMSGNPAAGTTRAPFS
MMAR_1984|M.marinum_M FALPIYAR--VTRRRVTRWEWTWAVLLAVSLAVVVIVGDPDVGVSRGSLA
MUL_3372|M.ulcerans_Agy99 FALPIYAR--VTRRRVTRWEWTWAVLLAVSLAVVVIVGDPDVGVSRGSLA
: : : : : : :. ..: .
MSMEG_5430|M.smegmatis_MC2_155 RVVTVSSMMHW-IGRINLRDLNWKARPYSAWLAYGQSKLANLMFTSELQR
TH_3199|M.thermoresistible__bu RVVTVSSLMHW-FGYLSLNDLNWKARPYSAWLAYAQSKLANLLFTSELQR
Mflv_1940|M.gilvum_PYR-GCK RVVTVSSMMHL-FGRINLNDLNWKSRPYLAWPAYGQSKLANLLFTSELQR
Mvan_4786|M.vanbaalenii_PYR-1 RVVTVSSMMHL-MGRVNLKDLNWKSRPYLAWPAYGQSKLANLLFTGELQR
MLBr_00315|M.leprae_Br4923 RVITVSSLSHRLFADIHFNDLQWECN-YNRVAAYGQSKLANLLFTYELQR
MAB_1144c|M.abscessus_ATCC_199 RVIAVSSVAHR-AGKIDLTDLNYERRRYTRAGAYGASKLANLLFTKELQR
MAV_4124|M.avium_104 RVVTVSSLMHH-FGYISLKDLNFRSRPYSAWLAYSQSKLANLLFTSELQR
Mb2748c|M.bovis_AF2122/97 TWAVVAVVVVP-AVVLCVVGARIASGSLSAVLLAVASSATLAVFTVLTKG
Rv2729c|M.tuberculosis_H37Rv TWAVVAVVVVP-AVVLCVVGARIASGSLSAVLLAVASSATLAVFTVLTKG
MMAR_1984|M.marinum_M TWMVVASVLGP-VMVFCVLGARIWSGSVAAVLLAVVSGCSLALFAVLTKA
MUL_3372|M.ulcerans_Agy99 TWMVVASVLGP-VMVFCVLGARIWSGSVAAVLLAVVSGCSLALFAVLTKA
.*: : . . . . * : :*: :
MSMEG_5430|M.smegmatis_MC2_155 RLVASGSSVRALAAHPGYSATNLQGHSGNRFGTAAAALGNRHLATDVTFG
TH_3199|M.thermoresistible__bu RLDTVGSPVRAVAAHPGYSSTNLQGHTGRRFGDALARIGNRYLATDAEFG
Mflv_1940|M.gilvum_PYR-GCK RLSRAGSPVRAVAAHPGYSATNLQGHSGNPLGEKIARAGNR-MATDADFG
Mvan_4786|M.vanbaalenii_PYR-1 RLAAAGSPVRAVAAHPGYSATNLQGHSGNPLGEKIARAGNR-IATDADFG
MLBr_00315|M.leprae_Br4923 RLATRQTTI-AVAAHPGGSRTELTRTLPALIAPIFSVAELF-LTQDAATG
MAB_1144c|M.abscessus_ATCC_199 RLSAAGSPVRALTVHPGVAATELQSHSGNPIFELALKTGNL-FAQNAAHG
MAV_4124|M.avium_104 RLDAVPSSLRALAAHPGWSHTNLQGNSGRKLGDAAVLAVDRIVSTDADFG
Mb2748c|M.bovis_AF2122/97 VVTELGEGFATLIRTPELYAWILVLPIGLMLQQSSLRVGALTASLPTITV
Rv2729c|M.tuberculosis_H37Rv VVTELGEGFATLIRTPALYAWILVLPIGLMLQQSSLRVGALTASLPTITV
MMAR_1984|M.marinum_M VVEVVGGGAGALFRAPEFYVWIAAALGGMIFQQSSFRAGTLTASLPTVVV
MUL_3372|M.ulcerans_Agy99 VVEVVGGGAGALFRAPEFYVWIAAALGGMIFQQSSFRAGTLTASLPTVVV
: :: * : : .
MSMEG_5430|M.smegmatis_MC2_155 ARQTLYAVS-QDLPGDTFVGPR-----FGQWGPTGSVGRSPLARRTDTQR
TH_3199|M.thermoresistible__bu ARQTLYAVA-RDVPGDSFIGPR-----FAMHGPTEQVGRSPLARSAGTAR
Mflv_1940|M.gilvum_PYR-GCK ARQTLYAVA-RDVAGDSFIGPR-----FTMFGPTVTTWRSPLARNRTTAA
Mvan_4786|M.vanbaalenii_PYR-1 ARQTLYAVA-ADIPGDSFIGPR-----FSMFGPTVATWRSPLARDRGKAA
MLBr_00315|M.leprae_Br4923 ALPTLRAATDAAVLGGQYFGPDG---FAEIRGHPKVVASNGKSHDVDRQL
MAB_1144c|M.abscessus_ATCC_199 ALPTLYAAS-QDLPGDTYIGPDG---PFEAKGYPTRVGRSGRAQDTETAK
MAV_4124|M.avium_104 ARQTLYAVS-QDLPGDTFVGPR-----FGLYGRTQPTWRNWPAKRAGTAA
Mb2748c|M.bovis_AF2122/97 ARPVIASVLGITVLDEVLHTGRVALVALVAVVVVVVVATVALAR---DEV
Rv2729c|M.tuberculosis_H37Rv ARPVIASVLGITVLDEVLHTGRVALVALVAAVVVVVVATVALAR---DEV
MMAR_1984|M.marinum_M AKPLMGAVLGMVVLGETLDTTGPGLVVVAFGVVLVLVATIALARGEAEKV
MUL_3372|M.ulcerans_Agy99 AKPLMGAVLGMVVLGETLDTTGPGLVVVAFGVVLVLVATIALARGEAEKV
* : :. : . . ::
MSMEG_5430|M.smegmatis_MC2_155 ALWELSEQLTGTTYPL----------------------------------
TH_3199|M.thermoresistible__bu ALWELSEQLTDTKFPL----------------------------------
Mflv_1940|M.gilvum_PYR-GCK QLWTLSEQLTGVEFPL----------------------------------
Mvan_4786|M.vanbaalenii_PYR-1 GLWTLSEQLTGTEFPL----------------------------------
MLBr_00315|M.leprae_Br4923 RLWAVSEELTGVVYPVG---------------------------------
MAB_1144c|M.abscessus_ATCC_199 GLWRLSEQLTGVSFPL----------------------------------
MAV_4124|M.avium_104 ALWELSEELTGTSFRSDPDLRRGRAAGPPSPRRPPGAVTKLVLSATPRGV
Mb2748c|M.bovis_AF2122/97 AMMTVSAGELGAAG-QLAVR------------------------------
Rv2729c|M.tuberculosis_H37Rv AMMTVSAGELGAAG-QLAVR------------------------------
MMAR_1984|M.marinum_M AEEAVESGHIPATMPHRAVTMHFGPADDDVQTDRLRRAPAG---------
MUL_3372|M.ulcerans_Agy99 AEEAVESGHIPATMPHRAVTMHFGPADDDVQTDRLRRAPAG---------
:. .
MSMEG_5430|M.smegmatis_MC2_155 --------------------------------------------------
TH_3199|M.thermoresistible__bu --------------------------------------------------
Mflv_1940|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4786|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00315|M.leprae_Br4923 --------------------------------------------------
MAB_1144c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4124|M.avium_104 GGYAMSDANLAAVLALCAALASAVGNVVRQRSAQEVTDKPVGHLALFGML
Mb2748c|M.bovis_AF2122/97 --------------------------------------------------
Rv2729c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1984|M.marinum_M --------------------------------------------------
MUL_3372|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5430|M.smegmatis_MC2_155 --------------------------------------------------
TH_3199|M.thermoresistible__bu --------------------------------------------------
Mflv_1940|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4786|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00315|M.leprae_Br4923 --------------------------------------------------
MAB_1144c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4124|M.avium_104 LRDTRWWLGGLGDIGSYVLLAAALDRGSVLLVMSLQVTALLFALPIYARM
Mb2748c|M.bovis_AF2122/97 --------------------------------------------------
Rv2729c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1984|M.marinum_M --------------------------------------------------
MUL_3372|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5430|M.smegmatis_MC2_155 --------------------------------------------------
TH_3199|M.thermoresistible__bu --------------------------------------------------
Mflv_1940|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4786|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00315|M.leprae_Br4923 --------------------------------------------------
MAB_1144c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4124|M.avium_104 THHPITGREWAWALLLAVALAVLIAVGDPTGGQQRAPLQTWLVVAAVIGP
Mb2748c|M.bovis_AF2122/97 --------------------------------------------------
Rv2729c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1984|M.marinum_M --------------------------------------------------
MUL_3372|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5430|M.smegmatis_MC2_155 --------------------------------------------------
TH_3199|M.thermoresistible__bu --------------------------------------------------
Mflv_1940|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4786|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00315|M.leprae_Br4923 --------------------------------------------------
MAB_1144c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4124|M.avium_104 LLVLGLLGARVWADRPVAALLLAAVAGSLLAMFAVLMKGVVDILEHNPGQ
Mb2748c|M.bovis_AF2122/97 --------------------------------------------------
Rv2729c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1984|M.marinum_M --------------------------------------------------
MUL_3372|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5430|M.smegmatis_MC2_155 --------------------------------------------------
TH_3199|M.thermoresistible__bu --------------------------------------------------
Mflv_1940|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4786|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00315|M.leprae_Br4923 --------------------------------------------------
MAB_1144c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4124|M.avium_104 LWRSFELYALVFCGVAGMIYHQSAYRAGALTASLPTIIVAKPVVGGILGI
Mb2748c|M.bovis_AF2122/97 --------------------------------------------------
Rv2729c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1984|M.marinum_M --------------------------------------------------
MUL_3372|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5430|M.smegmatis_MC2_155 --------------------------------------------------
TH_3199|M.thermoresistible__bu --------------------------------------------------
Mflv_1940|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4786|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00315|M.leprae_Br4923 --------------------------------------------------
MAB_1144c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4124|M.avium_104 IVLRETLVAGGWEWVVLAVTAVVVIVATVGLARGEAASMSAGAGRDVRPT
Mb2748c|M.bovis_AF2122/97 --------------------------------------------------
Rv2729c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1984|M.marinum_M --------------------------------------------------
MUL_3372|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5430|M.smegmatis_MC2_155 ---------
TH_3199|M.thermoresistible__bu ---------
Mflv_1940|M.gilvum_PYR-GCK ---------
Mvan_4786|M.vanbaalenii_PYR-1 ---------
MLBr_00315|M.leprae_Br4923 ---------
MAB_1144c|M.abscessus_ATCC_199 ---------
MAV_4124|M.avium_104 DRPKAASQA
Mb2748c|M.bovis_AF2122/97 ---------
Rv2729c|M.tuberculosis_H37Rv ---------
MMAR_1984|M.marinum_M ---------
MUL_3372|M.ulcerans_Agy99 ---------