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VASTRTAATWTPARLGDMSGQRIIVTGATNGVGLATATALARAGAQVILAVRNLELGAQRAAEMGGDTSV VELDLADQSSVRAFPSLFDGDVDVLINNAGAVAQHRTDTVDGFENTLGTNFLGPFALTNLLYGRVRSKIV NVGSDAHKTASINFDDPHLRTDKWSPFPAYARSKLAVMLWGLELDRRLRAAGSPVTTYLTHPGWVSSNLA KVSDTRLMTRVHSVVTAAANVIGNDLDAGAAPSLYCLTEPIPPGSYVGIAGRFGFKGPPTLSGRAPVACD YADARRLWEFAERETGTALPI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2288 | - | - | 100% (301) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_1940 | - | 6e-56 | 42.81% (292) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_0143 | - | 9e-44 | 38.74% (302) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0069 | - | 6e-43 | 37.22% (309) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0068 | - | 1e-42 | 36.89% (309) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00315 | - | 3e-37 | 35.39% (308) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1144c | - | 2e-57 | 40.27% (298) | short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_3355 | - | 2e-37 | 35.48% (310) | oxidoreductase |
| M. avium 104 | MAV_3824 | - | 1e-113 | 67.12% (292) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6557 | - | 1e-111 | 65.66% (297) | dehydrogenase |
| M. thermoresistible (build 8) | TH_3199 | - | 8e-54 | 41.22% (296) | PUTATIVE retinol dehydrogenase 13 |
| M. ulcerans Agy99 | MUL_1288 | - | 2e-37 | 35.48% (310) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4378 | - | 1e-152 | 90.14% (294) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_1144c|M.abscessus_ATCC_199 --MSKSTATWSAAKLPSFEGRTVIITGANSGLGLETARELARVGAHVIMA
TH_3199|M.thermoresistible__bu --------MWTAADLPSFSDRTVIVTGANSGLGLVTARELARVGARVIIA
Mb0069|M.bovis_AF2122/97 ------MTKWTAADIPDQTGRTAVITGANTGLGFETAAALAAHGAHVVLA
Rv0068|M.tuberculosis_H37Rv ------MTKWTAADIPDQTGRTAVITGANTGLGFETAAALAAHGAHVVLA
MLBr_00315|M.leprae_Br4923 ------MAKWTTADIPDQTGRVAVITGANTGLGYQTALALAEHGAHVVLA
MMAR_3355|M.marinum_M ------MASDLIATVPDLSGKLAIVTGANSGLGFGLARRLSAAGADVVMA
MUL_1288|M.ulcerans_Agy99 ------MASDLIATVPDLSGKLAIVTGANSGLGFGLARRLSAAGADVVMA
Mflv_2288|M.gilvum_PYR-GCK MASTRTAATWTPARLGDMSGQRIIVTGATNGVGLATATALARAGAQVILA
Mvan_4378|M.vanbaalenii_PYR-1 -----MATMWSPARLGDMSGQRIIVTGATNGVGLATATALARAGAHVILA
MAV_3824|M.avium_104 -----MTIPWTPDRLGDLTGKRVIVTGATNGVGLGTARALAKAGAEVILA
MSMEG_6557|M.smegmatis_MC2_155 -----MTSTWSPDRLGDLGDKRIIVTGATNGVGLGTTRALVRAGAHVILA
: . .: ::***..*:* : * ** *::*
MAB_1144c|M.abscessus_ATCC_199 VRNTEKGNAAQASIKG-----STEVRQVDVADLASVRAFADTVEG-----
TH_3199|M.thermoresistible__bu VRNTTKGEAAAEQMTGPG-HGPVEVRALDLQNLASVREFAAGVEGD----
Mb0069|M.bovis_AF2122/97 VRNLDKGKQAAARITEATPGAEVELQELDLTSLASVRAAAAQLKSDH-QR
Rv0068|M.tuberculosis_H37Rv VRNLDKGKQAAARITEATPGAEVELQELDLTSLASVRAAAAQLKSDH-QR
MLBr_00315|M.leprae_Br4923 VRNLDKGKDAAARITATSAQNNVALQELDLASLESVRAAAKQLRSDY-DH
MMAR_3355|M.marinum_M IRNRAKGEAAIEEIRSAVPDAKLSIKALDLSSLASVAALGDQLNSEG-RP
MUL_1288|M.ulcerans_Agy99 IRNRAKGEAAIEEIRSAVPDAKLSTKALDLSSLASVAALGDQLNSEG-RP
Mflv_2288|M.gilvum_PYR-GCK VRNLELGAQRAAEMGG-----DTSVVELDLADQSSVRAFPSLFDGD----
Mvan_4378|M.vanbaalenii_PYR-1 VRNLELGAQRAAEMGG-----DTSVVKLDLADQSSVRAFPGLVDGD----
MAV_3824|M.avium_104 VRNTELGKQRAAQMGG-----STAVEKLDLADLSSVRAFADRIEAP----
MSMEG_6557|M.smegmatis_MC2_155 VRNTDLGARRAAEVGG-----TTTVVEVDLADMSSVRAFPGRLTAAGIDD
:** * : :*: . ** . .
MAB_1144c|M.abscessus_ATCC_199 ADILVNNAGIMMVP-PAKTVDGFESQIGTNHLGAFALTNLLLPKLT----
TH_3199|M.thermoresistible__bu VDVLVNNAGIMAVP-LARTVDGFESQIGTNHLGHFALTNLLLPQIT----
Mb0069|M.bovis_AF2122/97 IDLLINNAGVMYTP-RQTTADGFEMQFGTNHLGHFALTGLLIDRLLPVAG
Rv0068|M.tuberculosis_H37Rv IDLLINNAGVMYTP-RQTTADGFEMQFGTNHLGHFALTGLLIDRLLPVAG
MLBr_00315|M.leprae_Br4923 IDLLINNAGVMWTP-KSTTKDGFELQFGTNHLGHFAFTGLLLDRLLPIVG
MMAR_3355|M.marinum_M IDILINNAGVMTPPERDTTADGFELQFGSNHLGHFALTAHVLPLLRAAQG
MUL_1288|M.ulcerans_Agy99 IDILINNAGVMTPPERDTTADGFELQFGSNHLGHFALTAHVLPLLRAAQG
Mflv_2288|M.gilvum_PYR-GCK VDVLINNAGAVAQH-RTDTVDGFENTLGTNFLGPFALTNLLYGRVR----
Mvan_4378|M.vanbaalenii_PYR-1 VDVLINNAGQVAQH-RSDTVDGFEITLGTNFLGPFALTNLMFGRVR----
MAV_3824|M.avium_104 VDILINNAGALTDR-RTETVDGFEMTLGTNLLGPFALTNLLLPKVR----
MSMEG_6557|M.smegmatis_MC2_155 VDILINNAGALTQR-RTETVDGFETTLGTNLLGPFALTNLLLGRVR----
*:*:**** : * **** :*:* ** **:* : :
MAB_1144c|M.abscessus_ATCC_199 DRVIAVSSVAHR-AGKIDLTDLNYERRRYTRAGAYGASKLANLLFTKELQ
TH_3199|M.thermoresistible__bu DRVVTVSSLMHW-FGYLSLNDLNWKARPYSAWLAYAQSKLANLLFTSELQ
Mb0069|M.bovis_AF2122/97 SRVVTISSVGHRIRAAIHFDDLQWERR-YRRVAAYGQAKLANLLFTYELQ
Rv0068|M.tuberculosis_H37Rv SRVVTISSVGHRIRAAIHFDDLQWERR-YRRVAAYGQAKLANLLFTYELQ
MLBr_00315|M.leprae_Br4923 SRVITVSSLSHRLFADIHFNDLQWECN-YNRVAAYGQSKLANLLFTYELQ
MMAR_3355|M.marinum_M ARVVSLSSLAAR-RGRIHFDDLQFEKS-YAAMTAYGQSKLAVLMFARELD
MUL_1288|M.ulcerans_Agy99 ARVVSLSSLAAR-RGRIHFDDLQFEKS-YAAMTAYGQSKLAVLMFARELD
Mflv_2288|M.gilvum_PYR-GCK SKIVNVGSDAHK-TASINFDDPHLRTDKWSPFPAYARSKLAVMLWGLELD
Mvan_4378|M.vanbaalenii_PYR-1 SKIVNVGSDAHK-SASLAFDDLHLRSRRWSSFPAYARSKLAVMLWGLELD
MAV_3824|M.avium_104 SQIINVGSDAHR-SATLHLDDLHLRRHKWTRLGAYAQSKLAVMLWGLELD
MSMEG_6557|M.smegmatis_MC2_155 SQVIIVGSDAHR-MATLRLDDMHLRRNRWTPLGAYGRAKLAVMLWGLELD
::: :.* . : : * : . : **. :*** ::: **:
MAB_1144c|M.abscessus_ATCC_199 RRLSAAGSPVRALTVHPGVAATELQSH-------SGNPIFELALK--TGN
TH_3199|M.thermoresistible__bu RRLDTVGSPVRAVAAHPGYSSTNLQGH-------TGRRFGDALAR--IGN
Mb0069|M.bovis_AF2122/97 RR-LAPGGTTIAVASHPGVSNTELVRN-------MPRPLVAVAAI---LA
Rv0068|M.tuberculosis_H37Rv RR-LAPGGTTIAVASHPGVSNTEVVRN-------MPRPLVAVAAI---LA
MLBr_00315|M.leprae_Br4923 RR-LATRQTTIAVAAHPGGSRTELTRT-------LPALIAPIFSV---AE
MMAR_3355|M.marinum_M RRSRAAGWGVMSNAAHPGLTKTNLQISGPSHGREKPALMQRFYTTSWRFA
MUL_1288|M.ulcerans_Agy99 RRSRAAGWGVMSNAAHPGLTKTNLQISGPSHGREKPALMQRFYTTSWRFA
Mflv_2288|M.gilvum_PYR-GCK RRLRAAGSPVTTYLTHPGWVSSNLAKVS------DTRLMTRVHSVVTAAA
Mvan_4378|M.vanbaalenii_PYR-1 RRLRTAGSPVTTYLTHPGWVSSNLAKVS------DTALMTRVHSAVTAVA
MAV_3824|M.avium_104 RRLRAAGSPIVTQLTHPGWVASNLSNLG------DAPLKAAAHKAVKMVA
MSMEG_6557|M.smegmatis_MC2_155 RRQRVARSPVVTHLTHPGWVASNLPNVS------QTRLMSVIQRGVTTVA
** . : *** :::
MAB_1144c|M.abscessus_ATCC_199 -LFAQNAAHGALPTLYAASQ-DLPGDTYIGPDGPFEAKG-YPTRVGRSGR
TH_3199|M.thermoresistible__bu RYLATDAEFGARQTLYAVAR-DVPGDSFIGPR--FAMHG-PTEQVGRSPL
Mb0069|M.bovis_AF2122/97 P-LMQDAELGALPTLRAATDPAVRGGQYFGPDGFGEIRG-YPKVVASSAQ
Rv0068|M.tuberculosis_H37Rv P-LMQDAELGALPTLRAATDPAVRGGQYFGPDGFGEIRG-YPKVVASSAQ
MLBr_00315|M.leprae_Br4923 LFLTQDAATGALPTLRAATDAAVLGGQYFGPDGFAEIRG-HPKVVASNGK
MMAR_3355|M.marinum_M PFLWQEIEDGILPALYAAVTPQAEGGAFYGPRGFYEAAGGGVRAAKVPAR
MUL_1288|M.ulcerans_Agy99 PFLWQEIEDGILPALYAAVTPQAEGGAFYGPRGFYEAAGGGVRAAKVPAR
Mflv_2288|M.gilvum_PYR-GCK NVIGNDLDAGAAPSLYCLTEPIPPG-SYVGIAGRFGFKG-PPTLSGRAPV
Mvan_4378|M.vanbaalenii_PYR-1 NVIGNDIDAGAAPTLYCLTEPIPPG-SYVGIAGRLGFKG-PPTLSGRAPV
MAV_3824|M.avium_104 DRLANDIDEGAAPTLYCISEPIPPG-SYVGVSGRFGLRG-GPVLIGRTPL
MSMEG_6557|M.smegmatis_MC2_155 DRFAASIDEGAAPTLYCISEPIPPG-SYVGVEGRLGLRG-APVLIGRSAV
: . * :* . * : * *
MAB_1144c|M.abscessus_ATCC_199 AQDTETAKGLWRLSEQLTGVSFPL--
TH_3199|M.thermoresistible__bu ARSAGTARALWELSEQLTDTKFPL--
Mb0069|M.bovis_AF2122/97 SHDEQLQRRLWAVSEELTGVVYPVG-
Rv0068|M.tuberculosis_H37Rv SHDEQLQRRLWAVSEELTGVVYPVG-
MLBr_00315|M.leprae_Br4923 SHDVDRQLRLWAVSEELTGVVYPVG-
MMAR_3355|M.marinum_M AGNDADCQRLWEVSERLTGVGYPTSS
MUL_1288|M.ulcerans_Agy99 AGNDADCQRLWEVSERLTGVGYPTSS
Mflv_2288|M.gilvum_PYR-GCK ACDYADARRLWEFAERETGTALPI--
Mvan_4378|M.vanbaalenii_PYR-1 ACDYADAQRLWEFAERETGTTLPA--
MAV_3824|M.avium_104 ACDYDTAARLVAFAERETGTELRV--
MSMEG_6557|M.smegmatis_MC2_155 ACDYETAAAVVDFAERETGTAIPY--
: . : .:*. *..