For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VPVSHPPVDYHDFPSLRCELGDDGVLTVVLDSPGLNSVGPQMHRDLADIWPVIDRDPAVRAVLVRGEGKA FSSGGSFDLIDETIGDYQGRVRIMREARDLVHNMINCDTPVVSAIRGPAVGAGLVVALLADISVAGRTAK LIDGHTKLGVAAGDHAAICWPLLVGMAKAKYYLLTCETLLGEEAERIGLVSLCVDDDDVLSTAAGIAGKL AQGAQHAIQWTKRSLNHWYRTMGPTFETSVGLEFLSFSGPDVQEGLAAHREKRAARFTGGSAT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3574 | - | - | 100% (273) | enoyl-CoA hydratase |
| M. avium 104 | MAV_1818 | - | 1e-37 | 39.11% (225) | enoyl-CoA hydratase |
| M. avium 104 | MAV_2558 | - | 9e-37 | 38.60% (228) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2698 | echA15 | 1e-126 | 83.77% (265) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2395 | - | 9e-32 | 33.06% (242) | enoyl-CoA hydratase/isomerase |
| M. tuberculosis H37Rv | Rv2679 | echA15 | 1e-126 | 83.77% (265) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 3e-23 | 30.56% (252) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_1185c | - | 1e-18 | 27.10% (262) | enoyl-CoA hydratase |
| M. marinum M | MMAR_2037 | echA15 | 1e-127 | 84.35% (262) | enoyl-CoA hydratase EchA15 |
| M. smegmatis MC2 155 | MSMEG_5620 | - | 9e-31 | 32.75% (229) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_3709 | - | 4e-39 | 40.35% (228) | PUTATIVE enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_3313 | echA15 | 1e-125 | 82.82% (262) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_4253 | - | 2e-32 | 33.20% (244) | enoyl-CoA hydratase/isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2395|M.gilvum_PYR-GCK ---------MYGMP--DEID----VTADGDLRIITLNRPDDLNAVNDNLH
Mvan_4253|M.vanbaalenii_PYR-1 ---------MYGMP--EEID----VRADGALRIITLNRPDDLNAVNDNLH
MSMEG_5620|M.smegmatis_MC2_155 --------MNYDVP--DELS----VSTDGPVRIVTINRETDLNSVNEKLH
TH_3709|M.thermoresistible__bu MTTS----EIATLPGYEEFAPWLLVEKRGAVHVVSINRPEAFNAVNEEVH
MMAR_2037|M.marinum_M MPLT-----YQDFPS-LRFE----PGEHGVLNLVLDSP--GLNSVGPQMH
MUL_3313|M.ulcerans_Agy99 MPLT-----YQDFPS-LRFE----PGERGVLNLVLDSP--GLNSVGPQMH
Mb2698|M.bovis_AF2122/97 MPVT-----YDDFPS-LRCEIHDQPGHEGVLELVLDSP--GLNSVGPHMH
Rv2679|M.tuberculosis_H37Rv MPVT-----YDDFPS-LRCEIHDQPGHEGVLELVLDSP--GLNSVGPHMH
MAV_3574|M.avium_104 MPVSHPPVDYHDFPS-LRCE----LGDDGVLTVVLDSP--GLNSVGPQMH
MLBr_02402|M.leprae_Br4923 ----------MKYDT-------ILVDGYQRVGIITLNRPQALNALNSQMM
MAB_1185c|M.abscessus_ATCC_199 -------MTSHNFET-------ILTERIDRVAVITLNRPKALNALNSQVM
: :: . :*::. .:
Mflv_2395|M.gilvum_PYR-GCK VGLAKIWEELNEDPGARAAVITGAGRAFSAGGDFHYLDELRRDEALRQKT
Mvan_4253|M.vanbaalenii_PYR-1 VGLAKIWEELNEDAGARAAVITGAGRAFSAGGDFNYLDELRNDEALRQKT
MSMEG_5620|M.smegmatis_MC2_155 WALANVWRQLAADKDAKVVVLTGAGRAFSAGGDLGWITTFLDDPVARDES
TH_3709|M.thermoresistible__bu HAFATIWRRLTDDEDVRAVVTTGVGKAFSAGGDMVMFGRLIEDPVARQFQ
MMAR_2037|M.marinum_M RDLADVWPVIDRDPDVRVVLVRGEGKAFSSGGSFELIDETIGDYEGRIRI
MUL_3313|M.ulcerans_Agy99 RDLTDVWPVIDRDPDVRVVLVRGEGKAFSSGGSFELIDETIGDYEGRIRI
Mb2698|M.bovis_AF2122/97 RDLADIWPVIDRDPAVRVVLVRGEGKAFSSGGSFDLIAETIGDYQGRLRI
Rv2679|M.tuberculosis_H37Rv RDLADIWPVIDRDPAVRVVLVRGEGKAFSSGGSFDLIAETIGDYQGRLRI
MAV_3574|M.avium_104 RDLADIWPVIDRDPAVRAVLVRGEGKAFSSGGSFDLIDETIGDYQGRVRI
MLBr_02402|M.leprae_Br4923 NEITNAAKELDIDPDVGAILITGSPKVFAAGADIKEMASLTFTDAFDADF
MAB_1185c|M.abscessus_ATCC_199 NEVTTAAAEFDADHGIGAIIITGSEKAFAAGADIKEMSEQSFSDMFGSDF
.: : * . : * :.*::*..: :
Mflv_2395|M.gilvum_PYR-GCK IKHGRDLVIGMVRCRIPVIAAVNGPAVGLGCSLAALSDVVYIAENAFFAD
Mvan_4253|M.vanbaalenii_PYR-1 IKHGRDLVIGMVRCRIPVVAAVNGPAVGLGCSLAALSDVVYIAENAFFAD
MSMEG_5620|M.smegmatis_MC2_155 IREGAQIIEEMLRFPLPVIAAVNGPAVGLGCSVALLCDILLISEDAYLAD
TH_3709|M.thermoresistible__bu ITEARTVFLEVINFPKPLVSAVNGPAVGLGCSIALLSDFLVMGRSSYLAD
MMAR_2037|M.marinum_M MREARDLVLNLVNLDKPVVSAIRGPAVGAGLVVALLADISVASATAKIID
MUL_3313|M.ulcerans_Agy99 MREARDLVLSLVNLDKPVVSAIRGPAVGARLVVALLADISVASATAKIID
Mb2698|M.bovis_AF2122/97 MREARDLVLNLVNFDKPVVSAIRGPAVGAGLVVALLADISVAGRAAKIID
Rv2679|M.tuberculosis_H37Rv MREARDLVLNLVNFDKPVVSAIRGPAVGAGLVVALLADISVAGRAAKIID
MAV_3574|M.avium_104 MREARDLVHNMINCDTPVVSAIRGPAVGAGLVVALLADISVAGRTAKLID
MLBr_02402|M.leprae_Br4923 FSAWG----KLAAVRTPMIAAVAGYALGGGCELAMMCDLLIAADTAKFGQ
MAB_1185c|M.abscessus_ATCC_199 FSAWG----KLGAVRTPTIAAVSGYALGGGCELAMMCDVIIAAENATFGQ
: : * ::*: * *:* :* :.*. . : : :
Mflv_2395|M.gilvum_PYR-GCK PHVSIGLVAADGGPLVWGSQISLLQAKEFALTGVRIKAQKAVELGLANHV
Mvan_4253|M.vanbaalenii_PYR-1 PHVSIGLVAADGGPLVWGSQISLLQAKEFALTGVRIKAQRAVELGLANHV
MSMEG_5620|M.smegmatis_MC2_155 PHVSVGLVAGDGGAALWPLLTPIMRSREFLYTGDRIDAGKAVELGLASRS
TH_3709|M.thermoresistible__bu PHVAVGLVAGDGGAAMLPLLIGLMKAKQYVLLGDRITPEEAEKLNLVTKV
MMAR_2037|M.marinum_M GHTKLGVAAGDHAAICWPLLVGMAKAKYYLLTCETLSGEEAERIGLVSTC
MUL_3313|M.ulcerans_Agy99 GHTKLGVAAGDHAAICWPLLVGMAKAKYYLLTCETLSGEEAERISLVSTC
Mb2698|M.bovis_AF2122/97 GHTKLGVAAGDHAAICWPLLVGMAKAKYYLLTCEPLSGEEAERIGLVSIC
Rv2679|M.tuberculosis_H37Rv GHTKLGVAAGDHAAICWPLLVGMAKAKYYLLTCEPLSGEEAERIGLVSIC
MAV_3574|M.avium_104 GHTKLGVAAGDHAAICWPLLVGMAKAKYYLLTCETLLGEEAERIGLVSLC
MLBr_02402|M.leprae_Br4923 PEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSRV
MAB_1185c|M.abscessus_ATCC_199 PEIKLGVLPGMGGSQRLTRAIGKAKAMDMILTGRNMDAAEAERSGLVSRV
. :*: .. .. :: : .* . .*..
Mflv_2395|M.gilvum_PYR-GCK VD--DPVGEAIACAKKIMALPQQAVEATKRLMNIQLEKSVMASLDYANLA
Mvan_4253|M.vanbaalenii_PYR-1 VD--DPVAEAIACAKKLIELPQQAVEATKRLMNIQLEKSVMASLDYANLA
MSMEG_5620|M.smegmatis_MC2_155 VAPGQLRSEAMTLAHRLAKQPVEALQGTKRVVNMYLSQVLSGPLQAGFAA
TH_3709|M.thermoresistible__bu AEDDAVLDDALAIGERLAALPPQALRATKVAMNMHLSRAALGILEYALAE
MMAR_2037|M.marinum_M VDDDEVLPTATRLAENLAQGAQNAIRWTKRSLN-HWYRMFGPTFETSLGL
MUL_3313|M.ulcerans_Agy99 VDDDEVLPTATRLAEDLAQGAQNAIRWTKRSLN-HWYRMFGPTFETSLGL
Mb2698|M.bovis_AF2122/97 VDDDDVLPTATRLAERLAAGAQNAIRWTKRSLN-HWYRMFGPAFETSLGL
Rv2679|M.tuberculosis_H37Rv VDDDDVLPTATRLAERLAAGAQNAIRWTKRSLN-HWYRMFGPAFETSLGL
MAV_3574|M.avium_104 VDDDDVLSTAAGIAGKLAQGAQHAIQWTKRSLN-HWYRTMGPTFETSVGL
MLBr_02402|M.leprae_Br4923 VLADDLLPEAKAVATTISQMSRSATRMAKEAVNRSFESTLAEGLLHERRL
MAB_1185c|M.abscessus_ATCC_199 VATESLLDEAKAVAKTISEMSLSASMMAKEAVNRAFESSLAEGLLFERRI
. * . : . * :* :* :
Mflv_2395|M.gilvum_PYR-GCK EYVSFGTADFNRIVDGLIAKN--------------
Mvan_4253|M.vanbaalenii_PYR-1 EYVSFGTADFNKIVDGLIAKK--------------
MSMEG_5620|M.smegmatis_MC2_155 EQVSMRSDDHRARLLAFKKKAHK------------
TH_3709|M.thermoresistible__bu EYTSFTTPEFQERVAAFRAKSNK------------
MMAR_2037|M.marinum_M EFLGFTGPDVQEGLAAHRQKRPARF-TDRTEGP--
MUL_3313|M.ulcerans_Agy99 EFLGFTGPDVQEGLAAHRQKRPARF-TDRTEGP--
Mb2698|M.bovis_AF2122/97 EFIGFGGPDVREGLAAHREKRPARFGADPDPGAGS
Rv2679|M.tuberculosis_H37Rv EFIGFGGPDVREGLAAHREKRPARFGADPDPGAGS
MAV_3574|M.avium_104 EFLSFSGPDVQEGLAAHREKRAARFTGGSAT----
MLBr_02402|M.leprae_Br4923 FHSTFVTDDQSEGMAAFIEKRAPQFTHR-------
MAB_1185c|M.abscessus_ATCC_199 FHSAFGTADQSEGMAAFVEKRPANFIHR-------
: : : . *