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YGMPEEIDVRADGALRIITLNRPDDLNAVNDNLHVGLAKIWEELNEDAGARAAVITGAGRAFSAGGDFNY LDELRNDEALRQKTIKHGRDLVIGMVRCRIPVVAAVNGPAVGLGCSLAALSDVVYIAENAFFADPHVSIG LVAADGGPLVWGSQISLLQAKEFALTGVRIKAQRAVELGLANHVVDDPVAEAIACAKKLIELPQQAVEAT KRLMNIQLEKSVMASLDYANLAEYVSFGTADFNKIVDGLIAKK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4253 | - | - | 100% (254) | enoyl-CoA hydratase/isomerase |
| M. vanbaalenii PYR-1 | Mvan_2877 | - | 4e-25 | 34.31% (204) | enoyl-CoA hydratase/isomerase |
| M. vanbaalenii PYR-1 | Mvan_4083 | - | 1e-24 | 33.96% (212) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2698 | echA15 | 1e-28 | 31.15% (244) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2395 | - | 1e-135 | 94.86% (253) | enoyl-CoA hydratase/isomerase |
| M. tuberculosis H37Rv | Rv2679 | echA15 | 2e-28 | 31.15% (244) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 2e-23 | 30.52% (249) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_1185c | - | 1e-25 | 32.64% (239) | enoyl-CoA hydratase |
| M. marinum M | MMAR_4790 | - | 1e-103 | 72.83% (254) | enoyl-CoA hydratase |
| M. avium 104 | MAV_0867 | - | 1e-105 | 74.70% (253) | enoyl-CoA hydratase/isomerase family protein |
| M. smegmatis MC2 155 | MSMEG_4873 | - | 2e-97 | 68.92% (251) | enoyl-CoA hydratase/isomerase |
| M. thermoresistible (build 8) | TH_2529 | - | 1e-100 | 69.69% (254) | PUTATIVE enoyl-CoA hydratase/isomerase |
| M. ulcerans Agy99 | MUL_0359 | - | 1e-104 | 73.23% (254) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4253|M.vanbaalenii_PYR-1 ---MYGMPEEIDVRADG-----ALRIITLNRPDDLNAVNDNLHVGLAKIW
Mflv_2395|M.gilvum_PYR-GCK ---MYGMPDEIDVTADG-----DLRIITLNRPDDLNAVNDNLHVGLAKIW
MSMEG_4873|M.smegmatis_MC2_155 ------MPDEIEVRAEG-----DIRVITLNRPEALNAVNDSLHEGLAHLW
TH_2529|M.thermoresistible__bu ---MYDMPPEIDVRADG-----DIRIITLNRPDALNAVNDPLHEGLAKLW
MMAR_4790|M.marinum_M ---MYDMPTEIDVRAEG-----ALRIITLNRPDALNAVNDNLHVGLAGLW
MUL_0359|M.ulcerans_Agy99 ---MYDMPTEIDVRAEG-----ALRIITLNRPDALNAVNDNLHVGLAGLW
MAV_0867|M.avium_104 ---MYDMPTEIDVRADG-----ALRIITLNRPDSLNSVNDDLHVGLARLW
MLBr_02402|M.leprae_Br4923 -----MKYDTILVDGYQ-----RVGIITLNRPQALNALNSQMMNEITNAA
MAB_1185c|M.abscessus_ATCC_199 --MTSHNFETILTERID-----RVAVITLNRPKALNALNSQVMNEVTTAA
Mb2698|M.bovis_AF2122/97 MPVTYDDFPSLRCEIHDQPGHEGVLELVLDSP-GLNSVGPHMHRDLADIW
Rv2679|M.tuberculosis_H37Rv MPVTYDDFPSLRCEIHDQPGHEGVLELVLDSP-GLNSVGPHMHRDLADIW
: : :.*: * **::. : ::
Mvan_4253|M.vanbaalenii_PYR-1 EELNEDAGARAAVITGAGRAFSAGGDFNYLDELRNDEALRQKTIKHGRDL
Mflv_2395|M.gilvum_PYR-GCK EELNEDPGARAAVITGAGRAFSAGGDFHYLDELRRDEALRQKTIKHGRDL
MSMEG_4873|M.smegmatis_MC2_155 TRLSEDYDARAAVITGAGRAFSAGGDFAYLQELGEDPKLRAKTILHGREI
TH_2529|M.thermoresistible__bu DRLSEDYDARAAVLTGAGRAFSAGGDYAYLAELGEDPRLRAKTLQHGREI
MMAR_4790|M.marinum_M RRLSEDRSARAAVLTGAGRAFSAGGDFAYLAELSQDADLRAKTIAHGRDI
MUL_0359|M.ulcerans_Agy99 RRLSEDRSARAAVLTGAGRAFSAGGDFAYLAELAQDADLRAKTIAHGRDI
MAV_0867|M.avium_104 QRLTDDPTARAAVITGAGRAFSAGGDFGYLKELSADADLRAKTIRDGREI
MLBr_02402|M.leprae_Br4923 KELDIDPDVGAILITGSPKVFAAGADIKEMASLTFTDAFDADFFSAWG--
MAB_1185c|M.abscessus_ATCC_199 AEFDADHGIGAIIITGSEKAFAAGADIKEMSEQSFSDMFGSDFFSAWG--
Mb2698|M.bovis_AF2122/97 PVIDRDPAVRVVLVRGEGKAFSSGGSFDLIAETIGDYQGRLRIMREARDL
Rv2679|M.tuberculosis_H37Rv PVIDRDPAVRVVLVRGEGKAFSSGGSFDLIAETIGDYQGRLRIMREARDL
: * . :: * :.*::*.. : . :
Mvan_4253|M.vanbaalenii_PYR-1 VIGMVRCRIPVVAAVNGPAVGLGCSLAALSDVVYIAENAFFADPHVSIGL
Mflv_2395|M.gilvum_PYR-GCK VIGMVRCRIPVIAAVNGPAVGLGCSLAALSDVVYIAENAFFADPHVSIGL
MSMEG_4873|M.smegmatis_MC2_155 VLGMTRCRVPVVAAVNGPAVGLGCSLVALSDIVYIAPQAYLADPHVQVGL
TH_2529|M.thermoresistible__bu VLGMTRCRVPVVAAVNGPAVGLGCSLVALSDIVYIAPDAYLADPHVQVGL
MMAR_4790|M.marinum_M VLGMARCRVPVVAAVNGPAVGLGCSLVALSDIVYIAPDAYLADPHVQVGL
MUL_0359|M.ulcerans_Agy99 VLGMARCRVPVVAAVNGPAVGLGCSLVALSDIVYIAPDAYLADPHVQVGL
MAV_0867|M.avium_104 VLGMARCRIPVVAAVNGPAVGLGCSLVALSDIVYIAENAYLADPHVQVGL
MLBr_02402|M.leprae_Br4923 --KLAAVRTPMIAAVAGYALGGGCELAMMCDLLIAADTAKFGQPEIKLGV
MAB_1185c|M.abscessus_ATCC_199 --KLGAVRTPTIAAVSGYALGGGCELAMMCDVIIAAENATFGQPEIKLGV
Mb2698|M.bovis_AF2122/97 VLNLVNFDKPVVSAIRGPAVGAGLVVALLADISVAGRAAKIIDGHTKLGV
Rv2679|M.tuberculosis_H37Rv VLNLVNFDKPVVSAIRGPAVGAGLVVALLADISVAGRAAKIIDGHTKLGV
: * ::*: * *:* * :. :.*: . * : : . .:*:
Mvan_4253|M.vanbaalenii_PYR-1 VAADGGPLVWGSQISLLQAKEFALTGVRIKAQRAVELGLAN--HVVDDPV
Mflv_2395|M.gilvum_PYR-GCK VAADGGPLVWGSQISLLQAKEFALTGVRIKAQKAVELGLAN--HVVDDPV
MSMEG_4873|M.smegmatis_MC2_155 VAADGGPITWPLHISLLLAKEYALTGARIPAQRAVELGLAN--HLSDDPV
TH_2529|M.thermoresistible__bu VAADGGPITWPLHISLLLAKEYALTGARIPAQRAVELGLAN--HLSEDPV
MMAR_4790|M.marinum_M VAADGGPLTWPLHISLMLAKEYALTGQRIAAQRAVELGLVN--HVAADPV
MUL_0359|M.ulcerans_Agy99 VAADGGPLTWPLHISLMLAKEYALTGQRIAAQRAVELGLAN--HVAADPV
MAV_0867|M.avium_104 VAADGGPLTWPLHISLLLAKEYALTGTRISAQRAVELGLAN--HVADDPV
MLBr_02402|M.leprae_Br4923 LPGMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSRVVLADDLL
MAB_1185c|M.abscessus_ATCC_199 LPGMGGSQRLTRAIGKAKAMDMILTGRNMDAAEAERSGLVSRVVATESLL
Mb2698|M.bovis_AF2122/97 AAGDHAAICWPLLVGMAKAKYYLLTCEPLSGEEAERIGLVSICVDDDDVL
Rv2679|M.tuberculosis_H37Rv AAGDHAAICWPLLVGMAKAKYYLLTCEPLSGEEAERIGLVSICVDDDDVL
.. .. :. * ** : . .* . **.. . :
Mvan_4253|M.vanbaalenii_PYR-1 AEAIACAKKLIELPQQAVEATKRLMNIQLEKSVMASLDYANLAEYVSFGT
Mflv_2395|M.gilvum_PYR-GCK GEAIACAKKIMALPQQAVEATKRLMNIQLEKSVMASLDYANLAEYVSFGT
MSMEG_4873|M.smegmatis_MC2_155 AEAIEAAQKMAKLPRQSLEATKRLLNLHMEQAVLATLDFGNTAEEQSFRT
TH_2529|M.thermoresistible__bu ADAVAAARKMSRMPRQALEATKRLLNIHMERAVMATLDYGNTAEAQSFET
MMAR_4790|M.marinum_M AEAVACAQRIMKLPQQAVESTKRVLNIHLERAVLASLDYALSAEHQSFTT
MUL_0359|M.ulcerans_Agy99 AEAVACAQRIVKLPQQAVESTKRVLNIHLERAVLASLDYALSAEHQSFTT
MAV_0867|M.avium_104 AEAIACAQKILELPQQAVESTKRVLNIHLERAVLASLDYALSAESQSFVT
MLBr_02402|M.leprae_Br4923 PEAKAVATTISQMSRSATRMAKEAVNRSFESTLAEGLLHERRLFHSTFVT
MAB_1185c|M.abscessus_ATCC_199 DEAKAVAKTISEMSLSASMMAKEAVNRAFESSLAEGLLFERRIFHSAFGT
Mb2698|M.bovis_AF2122/97 PTATRLAERLAAGAQNAIRWTKRSLN-HWYRMFGPAFETSLGLEFIGFGG
Rv2679|M.tuberculosis_H37Rv PTATRLAERLAAGAQNAIRWTKRSLN-HWYRMFGPAFETSLGLEFIGFGG
* * : . .: :*. :* . : *
Mvan_4253|M.vanbaalenii_PYR-1 ADFNKIVDGLIAKK--------------
Mflv_2395|M.gilvum_PYR-GCK ADFNRIVDGLIAKN--------------
MSMEG_4873|M.smegmatis_MC2_155 EDFKAIVAGLNARKN-------------
TH_2529|M.thermoresistible__bu EDFRNIVAGLNARRN-------------
MMAR_4790|M.marinum_M EDFRSIVTRLTAPKN-------------
MUL_0359|M.ulcerans_Agy99 EDFRSIVTRLTAPKN-------------
MAV_0867|M.avium_104 EDFRSIVTKL-ADKN-------------
MLBr_02402|M.leprae_Br4923 DDQSEGMAAFIEKRAPQFTHR-------
MAB_1185c|M.abscessus_ATCC_199 ADQSEGMAAFVEKRPANFIHR-------
Mb2698|M.bovis_AF2122/97 PDVREGLAAHREKRPARFGADPDPGAGS
Rv2679|M.tuberculosis_H37Rv PDVREGLAAHREKRPARFGADPDPGAGS
* : .