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PLTYQDFPSLRFEPGEHGVLNLVLDSPGLNSVGPQMHRDLADVWPVIDRDPDVRVVLVRGEGKAFSSGGS FELIDETIGDYEGRIRIMREARDLVLNLVNLDKPVVSAIRGPAVGAGLVVALLADISVASATAKIIDGHT KLGVAAGDHAAICWPLLVGMAKAKYYLLTCETLSGEEAERIGLVSTCVDDDEVLPTATRLAENLAQGAQN AIRWTKRSLNHWYRMFGPTFETSLGLEFLGFTGPDVQEGLAAHRQKRPARFTDRTEGP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2037 | echA15 | - | 100% (269) | enoyl-CoA hydratase EchA15 |
| M. marinum M | MMAR_4790 | - | 1e-29 | 32.90% (231) | enoyl-CoA hydratase |
| M. marinum M | MMAR_2278 | echA12 | 9e-26 | 32.93% (246) | enoyl-CoA hydratase, EchA12 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2698 | echA15 | 1e-134 | 88.35% (266) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2395 | - | 7e-29 | 33.33% (192) | enoyl-CoA hydratase/isomerase |
| M. tuberculosis H37Rv | Rv2679 | echA15 | 1e-134 | 88.35% (266) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_01241 | - | 3e-24 | 31.37% (255) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_2737c | - | 3e-22 | 31.20% (234) | enoyl-CoA hydratase |
| M. avium 104 | MAV_3574 | - | 1e-128 | 84.35% (262) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_5620 | - | 3e-31 | 32.75% (229) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_3709 | - | 8e-41 | 38.52% (257) | PUTATIVE enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_3313 | echA15 | 1e-151 | 97.77% (269) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_4253 | - | 6e-29 | 33.66% (205) | enoyl-CoA hydratase/isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2037|M.marinum_M ---MPLT-----YQDFPSLRFE----PGEHGVLNLVLDSPGLNSVGPQMH
MUL_3313|M.ulcerans_Agy99 ---MPLT-----YQDFPSLRFE----PGERGVLNLVLDSPGLNSVGPQMH
Mb2698|M.bovis_AF2122/97 ---MPVT-----YDDFPSLRCEIHDQPGHEGVLELVLDSPGLNSVGPHMH
Rv2679|M.tuberculosis_H37Rv ---MPVT-----YDDFPSLRCEIHDQPGHEGVLELVLDSPGLNSVGPHMH
MAV_3574|M.avium_104 ---MPVSHPPVDYHDFPSLRCE----LGDDGVLTVVLDSPGLNSVGPQMH
MLBr_01241|M.leprae_Br4923 MSQTDASCTIAELPYRSVTDLVVLDFPRPEVALITLNRPGRMNSMALDLM
MAB_2737c|M.abscessus_ATCC_199 ------------------MSFVLVDRPRPEIALVTLNRPERMNAMAFDVM
Mflv_2395|M.gilvum_PYR-GCK ---------MYGMP--DEID----VTADGDLRIITLNRPDDLNAVNDNLH
Mvan_4253|M.vanbaalenii_PYR-1 ---------MYGMP--EEID----VRADGALRIITLNRPDDLNAVNDNLH
MSMEG_5620|M.smegmatis_MC2_155 --------MNYDVP--DELS----VSTDGPVRIVTINRETDLNSVNEKLH
TH_3709|M.thermoresistible__bu ----MTTSEIATLPGYEEFAPWLLVEKRGAVHVVSINRPEAFNAVNEEVH
: : :*:: .:
MMAR_2037|M.marinum_M RDLADVWPVIDRDPDVRVVLVRGEGKAFSSGGSFELIDET-----IGDYE
MUL_3313|M.ulcerans_Agy99 RDLTDVWPVIDRDPDVRVVLVRGEGKAFSSGGSFELIDET-----IGDYE
Mb2698|M.bovis_AF2122/97 RDLADIWPVIDRDPAVRVVLVRGEGKAFSSGGSFDLIAET-----IGDYQ
Rv2679|M.tuberculosis_H37Rv RDLADIWPVIDRDPAVRVVLVRGEGKAFSSGGSFDLIAET-----IGDYQ
MAV_3574|M.avium_104 RDLADIWPVIDRDPAVRAVLVRGEGKAFSSGGSFDLIDET-----IGDYQ
MLBr_01241|M.leprae_Br4923 KSLKQVLKRITYDHSVRVVVLTGAGRGFCSGADQKFTAPVPQVEGLTQPV
MAB_2737c|M.abscessus_ATCC_199 LPFKQMLVDISHDNDVRAVVITGAGKGFCSGADQKSAGPIPHIGGLTQPT
Mflv_2395|M.gilvum_PYR-GCK VGLAKIWEELNEDPGARAAVITGAGRAFSAGGDFHYLDELR-----RDEA
Mvan_4253|M.vanbaalenii_PYR-1 VGLAKIWEELNEDAGARAAVITGAGRAFSAGGDFNYLDELR-----NDEA
MSMEG_5620|M.smegmatis_MC2_155 WALANVWRQLAADKDAKVVVLTGAGRAFSAGGDLGWITTFL-----DDPV
TH_3709|M.thermoresistible__bu HAFATIWRRLTDDEDVRAVVTTGVGKAFSAGGDMVMFGRLI-----EDPV
: : : * .:..: * *:.*.:*.. :
MMAR_2037|M.marinum_M GRIRIMREARDLVLNLVNLDKPVVSAIRGPAVGAGLVVALLADISVASAT
MUL_3313|M.ulcerans_Agy99 GRIRIMREARDLVLSLVNLDKPVVSAIRGPAVGARLVVALLADISVASAT
Mb2698|M.bovis_AF2122/97 GRLRIMREARDLVLNLVNFDKPVVSAIRGPAVGAGLVVALLADISVAGRA
Rv2679|M.tuberculosis_H37Rv GRLRIMREARDLVLNLVNFDKPVVSAIRGPAVGAGLVVALLADISVAGRA
MAV_3574|M.avium_104 GRVRIMREARDLVHNMINCDTPVVSAIRGPAVGAGLVVALLADISVAGRT
MLBr_01241|M.leprae_Br4923 RALRAMELLEEVILALRRLHQPVIAAINGPAIGGGLCLALAADVRVASTR
MAB_2737c|M.abscessus_ATCC_199 IALRSMELLDEVILTLRRMHQPVIAAINGAAIGGGLCLALACDVRVASQD
Mflv_2395|M.gilvum_PYR-GCK LRQKTIKHGRDLVIGMVRCRIPVIAAVNGPAVGLGCSLAALSDVVYIAEN
Mvan_4253|M.vanbaalenii_PYR-1 LRQKTIKHGRDLVIGMVRCRIPVVAAVNGPAVGLGCSLAALSDVVYIAEN
MSMEG_5620|M.smegmatis_MC2_155 ARDESIREGAQIIEEMLRFPLPVIAAVNGPAVGLGCSVALLCDILLISED
TH_3709|M.thermoresistible__bu ARQFQITEARTVFLEVINFPKPLVSAVNGPAVGLGCSIALLSDFLVMGRS
: :. : . *:::*:.*.*:* :* .*. .
MMAR_2037|M.marinum_M AKIIDGHTKLGVAAGDH-AAICWPLLVGMAKAKYYLLTCETLSGEEAERI
MUL_3313|M.ulcerans_Agy99 AKIIDGHTKLGVAAGDH-AAICWPLLVGMAKAKYYLLTCETLSGEEAERI
Mb2698|M.bovis_AF2122/97 AKIIDGHTKLGVAAGDH-AAICWPLLVGMAKAKYYLLTCEPLSGEEAERI
Rv2679|M.tuberculosis_H37Rv AKIIDGHTKLGVAAGDH-AAICWPLLVGMAKAKYYLLTCEPLSGEEAERI
MAV_3574|M.avium_104 AKLIDGHTKLGVAAGDH-AAICWPLLVGMAKAKYYLLTCETLLGEEAERI
MLBr_01241|M.leprae_Br4923 AYFRAAGINNGLSASELGLSYLLPRAVGSSRAFEIMLSGRDVGAEEAEQI
MAB_2737c|M.abscessus_ATCC_199 AYFRAAGINNGLTASELGLSYLLPRAIGTSRASDIMLTGRDVDADEAERI
Mflv_2395|M.gilvum_PYR-GCK AFFADPHVSIGLVAADG-GPLVWGSQISLLQAKEFALTGVRIKAQKAVEL
Mvan_4253|M.vanbaalenii_PYR-1 AFFADPHVSIGLVAADG-GPLVWGSQISLLQAKEFALTGVRIKAQRAVEL
MSMEG_5620|M.smegmatis_MC2_155 AYLADPHVSVGLVAGDG-GAALWPLLTPIMRSREFLYTGDRIDAGKAVEL
TH_3709|M.thermoresistible__bu SYLADPHVAVGLVAGDG-GAAMLPLLIGLMKAKQYVLLGDRITPEEAEKL
: : *: *.: . :: : .* .:
MMAR_2037|M.marinum_M GLVSTCVDDDEVLPTATRLAENLAQGAQNAIRWTKRSLN---HWYRMFGP
MUL_3313|M.ulcerans_Agy99 SLVSTCVDDDEVLPTATRLAEDLAQGAQNAIRWTKRSLN---HWYRMFGP
Mb2698|M.bovis_AF2122/97 GLVSICVDDDDVLPTATRLAERLAAGAQNAIRWTKRSLN---HWYRMFGP
Rv2679|M.tuberculosis_H37Rv GLVSICVDDDDVLPTATRLAERLAAGAQNAIRWTKRSLN---HWYRMFGP
MAV_3574|M.avium_104 GLVSLCVDDDDVLSTAAGIAGKLAQGAQHAIQWTKRSLN---HWYRTMGP
MLBr_01241|M.leprae_Br4923 GLVSYRVSDDRLLDTCYSIAARMATFSRSGTELTKRALWGGLDAASLDKH
MAB_2737c|M.abscessus_ATCC_199 GLVSRKVASESLLEECYAIGERIAGFSRPGIELTKRTIWSGLDAASLESH
Mflv_2395|M.gilvum_PYR-GCK GLANHVVD--DPVGEAIACAKKIMALPQQAVEATKRLMN--IQLEKSVMA
Mvan_4253|M.vanbaalenii_PYR-1 GLANHVVD--DPVAEAIACAKKLIELPQQAVEATKRLMN--IQLEKSVMA
MSMEG_5620|M.smegmatis_MC2_155 GLASRSVAPGQLRSEAMTLAHRLAKQPVEALQGTKRVVN--MYLSQVLSG
TH_3709|M.thermoresistible__bu NLVTKVAEDDAVLDDALAIGERLAALPPQALRATKVAMN--MHLSRAALG
.*.. . . . : . . . ** :
MMAR_2037|M.marinum_M TFETSLGLEFLGFTGPDVQEGLAAHRQKRPARF-TDRTEGP---
MUL_3313|M.ulcerans_Agy99 TFETSLGLEFLGFTGPDVQEGLAAHRQKRPARF-TDRTEGP---
Mb2698|M.bovis_AF2122/97 AFETSLGLEFIGFGGPDVREGLAAHREKRPARFGADPDPGAGS-
Rv2679|M.tuberculosis_H37Rv AFETSLGLEFIGFGGPDVREGLAAHREKRPARFGADPDPGAGS-
MAV_3574|M.avium_104 TFETSVGLEFLSFSGPDVQEGLAAHREKRAARFTGGSAT-----
MLBr_01241|M.leprae_Br4923 MQSESLAQLFIALHTSNFEEAAAPCTEKRPTVLVDARGCATSPG
MAB_2737c|M.abscessus_ATCC_199 MHQEGLGQLYVRLLTDNFEEATAARKEKRPAEFRDKR-------
Mflv_2395|M.gilvum_PYR-GCK SLDYANLAEYVSFGTADFNRIVDGLIAKN---------------
Mvan_4253|M.vanbaalenii_PYR-1 SLDYANLAEYVSFGTADFNKIVDGLIAKK---------------
MSMEG_5620|M.smegmatis_MC2_155 PLQAGFAAEQVSMRSDDHRARLLAFKKKAHK-------------
TH_3709|M.thermoresistible__bu ILEYALAEEYTSFTTPEFQERVAAFRAKSNK-------------
. . : : . *