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MPLTYQDFPSLRFEPGERGVLNLVLDSPGLNSVGPQMHRDLTDVWPVIDRDPDVRVVLVRGEGKAFSSGG SFELIDETIGDYEGRIRIMREARDLVLSLVNLDKPVVSAIRGPAVGARLVVALLADISVASATAKIIDGH TKLGVAAGDHAAICWPLLVGMAKAKYYLLTCETLSGEEAERISLVSTCVDDDEVLPTATRLAEDLAQGAQ NAIRWTKRSLNHWYRMFGPTFETSLGLEFLGFTGPDVQEGLAAHRQKRPARFTDRTEGP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3313 | echA15 | - | 100% (269) | enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_0359 | - | 3e-27 | 31.17% (231) | enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_1480 | echA12 | 6e-24 | 31.71% (246) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2698 | echA15 | 1e-131 | 86.84% (266) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2395 | - | 1e-26 | 31.77% (192) | enoyl-CoA hydratase/isomerase |
| M. tuberculosis H37Rv | Rv2679 | echA15 | 1e-131 | 86.84% (266) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 6e-23 | 31.33% (249) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_2737c | - | 1e-20 | 30.34% (234) | enoyl-CoA hydratase |
| M. marinum M | MMAR_2037 | echA15 | 1e-151 | 97.77% (269) | enoyl-CoA hydratase EchA15 |
| M. avium 104 | MAV_3574 | - | 1e-125 | 82.82% (262) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_5620 | - | 7e-29 | 31.44% (229) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_3709 | - | 7e-40 | 38.13% (257) | PUTATIVE enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_4253 | - | 1e-26 | 32.20% (205) | enoyl-CoA hydratase/isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3313|M.ulcerans_Agy99 MPLT-----YQDFPSLRFE--------PGERGVLNLVLDSP-GLNSVGPQ
MMAR_2037|M.marinum_M MPLT-----YQDFPSLRFE--------PGEHGVLNLVLDSP-GLNSVGPQ
Mb2698|M.bovis_AF2122/97 MPVT-----YDDFPSLRCEIHD----QPGHEGVLELVLDSP-GLNSVGPH
Rv2679|M.tuberculosis_H37Rv MPVT-----YDDFPSLRCEIHD----QPGHEGVLELVLDSP-GLNSVGPH
MAV_3574|M.avium_104 MPVSHPPVDYHDFPSLRCE--------LGDDGVLTVVLDSP-GLNSVGPQ
MLBr_02402|M.leprae_Br4923 ----------MKYDTILVDG---------YQRVGIITLNRPQALNALNSQ
MAB_2737c|M.abscessus_ATCC_199 ------------MSFVLVDRP--------RPEIALVTLNRPERMNAMAFD
Mflv_2395|M.gilvum_PYR-GCK -----------MYGMP--DEID----VTADGDLRIITLNRPDDLNAVNDN
Mvan_4253|M.vanbaalenii_PYR-1 -----------MYGMP--EEID----VRADGALRIITLNRPDDLNAVNDN
MSMEG_5620|M.smegmatis_MC2_155 ----------MNYDVP--DELS----VSTDGPVRIVTINRETDLNSVNEK
TH_3709|M.thermoresistible__bu ------MTTSEIATLPGYEEFAPWLLVEKRGAVHVVSINRPEAFNAVNEE
: : : :: :*:: .
MUL_3313|M.ulcerans_Agy99 MHRDLTDVWPVIDRDPDVRVVLVRGEGKAFSSGGSFELIDET--IGDYEG
MMAR_2037|M.marinum_M MHRDLADVWPVIDRDPDVRVVLVRGEGKAFSSGGSFELIDET--IGDYEG
Mb2698|M.bovis_AF2122/97 MHRDLADIWPVIDRDPAVRVVLVRGEGKAFSSGGSFDLIAET--IGDYQG
Rv2679|M.tuberculosis_H37Rv MHRDLADIWPVIDRDPAVRVVLVRGEGKAFSSGGSFDLIAET--IGDYQG
MAV_3574|M.avium_104 MHRDLADIWPVIDRDPAVRAVLVRGEGKAFSSGGSFDLIDET--IGDYQG
MLBr_02402|M.leprae_Br4923 MMNEITNAAKELDIDPDVGAILITGSPKVFAAGADIKEMASLTFTDAFDA
MAB_2737c|M.abscessus_ATCC_199 VMLPFKQMLVDISHDNDVRAVVITGAGKGFCSGADQKSAGPIPHIGGLTQ
Mflv_2395|M.gilvum_PYR-GCK LHVGLAKIWEELNEDPGARAAVITGAGRAFSAGGDFHYLDELR--RDEAL
Mvan_4253|M.vanbaalenii_PYR-1 LHVGLAKIWEELNEDAGARAAVITGAGRAFSAGGDFNYLDELR--NDEAL
MSMEG_5620|M.smegmatis_MC2_155 LHWALANVWRQLAADKDAKVVVLTGAGRAFSAGGDLGWITTFL--DDPVA
TH_3709|M.thermoresistible__bu VHHAFATIWRRLTDDEDVRAVVTTGVGKAFSAGGDMVMFGRLI--EDPVA
: : : * . . : * : *.:*..
MUL_3313|M.ulcerans_Agy99 RIRIMREAR---DLVLSLVNLDKPVVSAIRGPAVGARLVVALLADISVAS
MMAR_2037|M.marinum_M RIRIMREAR---DLVLNLVNLDKPVVSAIRGPAVGAGLVVALLADISVAS
Mb2698|M.bovis_AF2122/97 RLRIMREAR---DLVLNLVNFDKPVVSAIRGPAVGAGLVVALLADISVAG
Rv2679|M.tuberculosis_H37Rv RLRIMREAR---DLVLNLVNFDKPVVSAIRGPAVGAGLVVALLADISVAG
MAV_3574|M.avium_104 RVRIMREAR---DLVHNMINCDTPVVSAIRGPAVGAGLVVALLADISVAG
MLBr_02402|M.leprae_Br4923 DFFSAWG---------KLAAVRTPMIAAVAGYALGGGCELAMMCDLLIAA
MAB_2737c|M.abscessus_ATCC_199 PTIALRSMELLDEVILTLRRMHQPVIAAINGAAIGGGLCLALACDVRVAS
Mflv_2395|M.gilvum_PYR-GCK RQKTIKHGR---DLVIGMVRCRIPVIAAVNGPAVGLGCSLAALSDVVYIA
Mvan_4253|M.vanbaalenii_PYR-1 RQKTIKHGR---DLVIGMVRCRIPVVAAVNGPAVGLGCSLAALSDVVYIA
MSMEG_5620|M.smegmatis_MC2_155 RDESIREGA---QIIEEMLRFPLPVIAAVNGPAVGLGCSVALLCDILLIS
TH_3709|M.thermoresistible__bu RQFQITEAR---TVFLEVINFPKPLVSAVNGPAVGLGCSIALLSDFLVMG
: *:::*: * *:* :* .*. .
MUL_3313|M.ulcerans_Agy99 ATAKIIDGHTKLGVAA-GDHAAICWPLLVGMAKAKYYLLTCETLSGEEAE
MMAR_2037|M.marinum_M ATAKIIDGHTKLGVAA-GDHAAICWPLLVGMAKAKYYLLTCETLSGEEAE
Mb2698|M.bovis_AF2122/97 RAAKIIDGHTKLGVAA-GDHAAICWPLLVGMAKAKYYLLTCEPLSGEEAE
Rv2679|M.tuberculosis_H37Rv RAAKIIDGHTKLGVAA-GDHAAICWPLLVGMAKAKYYLLTCEPLSGEEAE
MAV_3574|M.avium_104 RTAKLIDGHTKLGVAA-GDHAAICWPLLVGMAKAKYYLLTCETLLGEEAE
MLBr_02402|M.leprae_Br4923 DTAKFGQPEIKLGVLP-GMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAE
MAB_2737c|M.abscessus_ATCC_199 QDAYFRAAGINNGLTASELGLSYLLPRAIGTSRASDIMLTGRDVDADEAE
Mflv_2395|M.gilvum_PYR-GCK ENAFFADPHVSIGLVA-ADGGPLVWGSQISLLQAKEFALTGVRIKAQKAV
Mvan_4253|M.vanbaalenii_PYR-1 ENAFFADPHVSIGLVA-ADGGPLVWGSQISLLQAKEFALTGVRIKAQRAV
MSMEG_5620|M.smegmatis_MC2_155 EDAYLADPHVSVGLVA-GDGGAALWPLLTPIMRSREFLYTGDRIDAGKAV
TH_3709|M.thermoresistible__bu RSSYLADPHVAVGLVA-GDGGAAMLPLLIGLMKAKQYVLLGDRITPEEAE
: : *: . . :: : .*
MUL_3313|M.ulcerans_Agy99 RISLVSTCVDDDEVLPTATRLAEDLAQGAQNAIRWTKRSLN---HWYRMF
MMAR_2037|M.marinum_M RIGLVSTCVDDDEVLPTATRLAENLAQGAQNAIRWTKRSLN---HWYRMF
Mb2698|M.bovis_AF2122/97 RIGLVSICVDDDDVLPTATRLAERLAAGAQNAIRWTKRSLN---HWYRMF
Rv2679|M.tuberculosis_H37Rv RIGLVSICVDDDDVLPTATRLAERLAAGAQNAIRWTKRSLN---HWYRMF
MAV_3574|M.avium_104 RIGLVSLCVDDDDVLSTAAGIAGKLAQGAQHAIQWTKRSLN---HWYRTM
MLBr_02402|M.leprae_Br4923 RSGLVSRVVLADDLLPEAKAVATTISQMSRSATRMAKEAVNRSFESTLAE
MAB_2737c|M.abscessus_ATCC_199 RIGLVSRKVASESLLEECYAIGERIAGFSRPGIELTKRTIWSGLDAASLE
Mflv_2395|M.gilvum_PYR-GCK ELGLANHVVD--DPVGEAIACAKKIMALPQQAVEATKRLMN--IQLEKSV
Mvan_4253|M.vanbaalenii_PYR-1 ELGLANHVVD--DPVAEAIACAKKLIELPQQAVEATKRLMN--IQLEKSV
MSMEG_5620|M.smegmatis_MC2_155 ELGLASRSVAPGQLRSEAMTLAHRLAKQPVEALQGTKRVVN--MYLSQVL
TH_3709|M.thermoresistible__bu KLNLVTKVAEDDAVLDDALAIGERLAALPPQALRATKVAMN--MHLSRAA
. .*.. . . . : . . . :* :
MUL_3313|M.ulcerans_Agy99 GPTFETSLGLEFLGFTGPDVQEGLAAHRQKRPARF-TDRTEGP--
MMAR_2037|M.marinum_M GPTFETSLGLEFLGFTGPDVQEGLAAHRQKRPARF-TDRTEGP--
Mb2698|M.bovis_AF2122/97 GPAFETSLGLEFIGFGGPDVREGLAAHREKRPARFGADPDPGAGS
Rv2679|M.tuberculosis_H37Rv GPAFETSLGLEFIGFGGPDVREGLAAHREKRPARFGADPDPGAGS
MAV_3574|M.avium_104 GPTFETSVGLEFLSFSGPDVQEGLAAHREKRAARFTGGSAT----
MLBr_02402|M.leprae_Br4923 GLLHER--RLFHSTFVTDDQSEGMAAFIEKRAPQFTHR-------
MAB_2737c|M.abscessus_ATCC_199 SHMHQEGLGQLYVRLLTDNFEEATAARKEKRPAEFRDKR------
Mflv_2395|M.gilvum_PYR-GCK MASLDYANLAEYVSFGTADFNRIVDGLIAKN--------------
Mvan_4253|M.vanbaalenii_PYR-1 MASLDYANLAEYVSFGTADFNKIVDGLIAKK--------------
MSMEG_5620|M.smegmatis_MC2_155 SGPLQAGFAAEQVSMRSDDHRARLLAFKKKAHK------------
TH_3709|M.thermoresistible__bu LGILEYALAEEYTSFTTPEFQERVAAFRAKSNK------------
: : : . *