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MDRDQLIDLTRRALKLARDKTTDLAPHQHAVDACEYTSLDRHERDRAMVLDSPQLVGYSSELPGPGTYCT KTVMGRSILLTRAADGAVRAFDNVCLHRQSRVATGCGTALRFTCPYHGWTYDNGGRLVGLPGREGFPGIA VGSDGLTELPATEFAGFLWVSLHPAARLDVPAHLGPLAGELQSWGIGRWSPLGEKVLDSPINWKLAADTF AENYHFATVHRRTFATIARSNCTVFDSYGPHHRLIFPLNTILELENVPEGQWDPFHHMVVIYALFPNVVL SVTIANGELFRIYPGDRPGSSITVHQNSTPLDLSDESVATGAQAVFDYAHATVRDEDYRLAETLQTNFES GARQRLVFGRNEPGLQHRHITWAQALKTPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3964 | - | - | 100% (380) | ring-hydroxylating dioxygenase, large terminal subunit |
| M. marinum M | MMAR_0230 | - | 3e-33 | 26.45% (363) | dioxygenase |
| M. marinum M | MMAR_0307 | - | 1e-21 | 31.31% (198) | dioxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3186c | - | 1e-18 | 25.72% (346) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_2470 | - | 8e-22 | 30.13% (229) | Rieske (2Fe-2S) domain-containing protein |
| M. tuberculosis H37Rv | Rv3161c | - | 2e-18 | 25.43% (346) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4370c | - | 3e-16 | 29.55% (220) | putative large terminal subunit of phenylpropionate dioxygenase |
| M. avium 104 | MAV_1644 | - | 0.0 | 82.45% (376) | Rieske (2Fe-2S) domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0293 | - | 1e-20 | 31.37% (204) | Rieske (2Fe-2S) domain-containing protein |
| M. thermoresistible (build 8) | TH_3877 | - | 3e-22 | 30.13% (229) | PUTATIVE Rieske (2Fe-2S) domain protein |
| M. ulcerans Agy99 | MUL_3820 | - | 0.0 | 97.37% (380) | ring-hydroxylating dioxygenase, large terminal subunit |
| M. vanbaalenii PYR-1 | Mvan_4910 | - | 3e-64 | 36.12% (371) | Rieske (2Fe-2S) domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3964|M.marinum_M ----MD---RDQLIDLTRRALKLARDKTTDLAPHQHAVDACEYTSLDRHE
MUL_3820|M.ulcerans_Agy99 ----MD---RDQLIDLTRRALKLARDKTTDLAPHQHAVDAREYTSLDRHE
MAV_1644|M.avium_104 ----MQ---HDQLIDLTRRALKLARDRTTDLAPTAHVVDARDYTCVQRHQ
Mvan_4910|M.vanbaalenii_PYR-1 MTAIADGPVSNQDEELTRRALRHAVDKTTDMADRELRVPLHYYRDPKITE
Mb3186c|M.bovis_AF2122/97 --------MLSTDNRAELGDILTDIGDYLDDNPPALSLPPAAYTSSELWQ
Rv3161c|M.tuberculosis_H37Rv --------MLSTDNRAELGDILTDIGDYLDDNPPALSLPPAAYTSSELWQ
Mflv_2470|M.gilvum_PYR-GCK ----------MPKWPKPAEGSWTEHYPELGTGPVSFRDS----TSPEFYE
TH_3877|M.thermoresistible__bu ----------MKKWPKPAEGSWTEHYPELGTGPVSFRDS----TSPEFYE
MSMEG_0293|M.smegmatis_MC2_155 ---------MATKWPKPAEGSWTEHYPELGTGPISFRDS----TSREFYA
MAB_4370c|M.abscessus_ATCC_199 MASLPRPVAVAQGALCRPQALVRDIDVSGLVDSHGGLLDRVIFTDGELYR
.
MMAR_3964|M.marinum_M RDRAMVLD-SPQLVGYSSELPGPGTYCTK--TVMGRSILLTRAADGAVRA
MUL_3820|M.ulcerans_Agy99 RDRAMVLD-SPQLVGYSSELPGPDTYRTK--TIMGRSILLTRAADRAVRA
MAV_1644|M.avium_104 QDRAMLLA-SPQLVGYVSELPAPGTYCTK--TVMGRSVLLTRTSDGSVKA
Mvan_4910|M.vanbaalenii_PYR-1 IEESQVLRRVPLAIVPSAQIPAVNDYVVR--SVLGDSLLVTRDRDGVSHV
Mb3186c|M.bovis_AF2122/97 LERERIFNRSWMLVAHVDQLAKTGDYVT--VSVAGEPVMVVRDVDGQLHA
Rv3161c|M.tuberculosis_H37Rv LERERIFNRSWMLVAHVDQVAKTGDYVT--VSVAGEPVMVVRDVDGQLHA
Mflv_2470|M.gilvum_PYR-GCK LEREAVFKRAWLNVGRVEELPRVGSYLTKDIDAARTSVIVVKGRDGQIRA
TH_3877|M.thermoresistible__bu LEREAVFKRAWLHVGRVEELPRAGSYLTKNIDVAKTSVIVVRGRDEQIRA
MSMEG_0293|M.smegmatis_MC2_155 LEREAIFKRAWLNISRVEETPDAGSYITRRVEAADASLLLVKGADGRIRA
MAB_4370c|M.abscessus_ATCC_199 QELRRVFAPSWLFLAHADQFHRPGDFFTT--YMGEDPVIVSMDKNRRIRA
: :: : : . : . .::: : :.
MMAR_3964|M.marinum_M FDNVCLHRQSRVATGC-------GTALRFTCPYHGWTYDNGGRLVGLPGR
MUL_3820|M.ulcerans_Agy99 FDNVCLHRQSRVATGC-------GTALRFTCPYHGWTYDNGGRLVGLPGR
MAV_1644|M.avium_104 FNNVCLHRQSQVATGC-------GTASRFSCPYHAWTYDNTGRLVGLPGR
Mvan_4910|M.vanbaalenii_PYR-1 FLNYCRHRGAKPACGA-------GNTSRFTCPYHAWSYKNTGELFTVPGK
Mb3186c|M.bovis_AF2122/97 LSPICRHRLMLMVEPG------AGRIDTLTCQYHLWRYGLDGRLRGAPHM
Rv3161c|M.tuberculosis_H37Rv LSPICRHRLMLMVEPG------AGRIDTLTCQYHLWRYGLDGRLRGAPHM
Mflv_2470|M.gilvum_PYR-GCK FHNVCRHRGNKLVWNDFPSEEVKGACRQFTCKYHGWRYGLDGELTFVQQP
TH_3877|M.thermoresistible__bu FYNICRHRGNKLVWNDYPHEEVKGACRQFTCKYHGWRYDLKGDLTFVQQE
MSMEG_0293|M.smegmatis_MC2_155 FHNVCRRRGHTVAAPDFRATELRNTGTEFACGHCGWRYGLDGSLIAAPDA
MAB_4370c|M.abscessus_ATCC_199 FLNSCRHRGARVCRAD------YGVTRGFTCTYHGWAYDLEGKLISVPNE
: * :* . ::* : * * * *
MMAR_3964|M.marinum_M EGFPG-IAVGSDGLTELP-ATEFAGFLWVSLHPA---ARLDVPAHLGPLA
MUL_3820|M.ulcerans_Agy99 EGFPG-IAVGSDGLTELP-ATEFAGFLWVSLHPA---ARLDVPAHLGPLA
MAV_1644|M.avium_104 EGFPD-VTLRSAGLTELP-ATEFAGFLWVSLDPG---ATLDVATHLGPLA
Mvan_4910|M.vanbaalenii_PYR-1 AGFDS-MDKADYGLVELP-NQERHGFIWAVLTAG---ATIDVDAHLGAIG
Mb3186c|M.bovis_AF2122/97 AANLD-FNRRECRLPQFA-VATWNGLVWINLDAD---AEP-IAAHLDLTD
Rv3161c|M.tuberculosis_H37Rv AANLD-FNRRECRLPQFA-VATWNGLVWINLDAD---AEP-IAAHLDLTD
Mflv_2470|M.gilvum_PYR-GCK GEFFG-LDTAKYGLKSVH-CDVWNGFIFINFDAE---PRQTLREFLGPMI
TH_3877|M.thermoresistible__bu SEFFD-LDTARYGLKPVN-CDVWNGFIFINFDPE---PKWSLREFLGPMI
MSMEG_0293|M.smegmatis_MC2_155 DRFTG-FDATELGLAEVH-CDVWAGFVFVNFDTT---PRQSLREFLGPMV
MAB_4370c|M.abscessus_ATCC_199 EGYPDSFSTDDWGLVEVPHVDSYHGLIFGTWNPAPVGLRESLGDMAWYMD
. . * . *::: . :
MMAR_3964|M.marinum_M GELQSWGIGRWSPLGEKVLDSPINWKLAADTFAENYHFATVHRR-TFATI
MUL_3820|M.ulcerans_Agy99 GELQSWGIGRWSPLGEKVLGSPIDWKLATDTFAENYHFATVHRR-TFATI
MAV_1644|M.avium_104 DELDSWGIGRWSPLGEKVLDCAINWKLAIDTFAENYHFATVHRQ-TFATI
Mvan_4910|M.vanbaalenii_PYR-1 PELELMNYASYGYHTEKEFQSQVSWKGALEAFAEGYHFPFVHGESVIGQN
Mb3186c|M.bovis_AF2122/97 DEFAGYRLGEMVQVESWSHEWRANWKVAAENGHENYHVLGLHRQTLEPFV
Rv3161c|M.tuberculosis_H37Rv DEFAGYRLGEMVQVESWSHEWRANWKVAAENGHENYHVLGLHRQTLEPFV
Mflv_2470|M.gilvum_PYR-GCK TALDDYPFELMTERYDFVAHNNSNWKIFADAFQEYYHVPSLHSQQVPTEV
TH_3877|M.thermoresistible__bu TALDDYPFGLMTERYEFEAHNNSNWKIFADAFQEYYHVPSLHSQQVPSAV
MSMEG_0293|M.smegmatis_MC2_155 TGLDDYPFEKLTERYDWVAHNNSNWKIFADAFQEYYHVPSLHTQQVPPEV
MAB_4370c|M.abscessus_ATCC_199 AMLDHDSEGTVVVGGVHKWVLDGNWKLAAEQFATDWYHVNMSHASALMVM
: .** : :: :
MMAR_3964|M.marinum_M ARSN----CTVFDSYG--------PHHRLIFPLNTILELENVPEG-----
MUL_3820|M.ulcerans_Agy99 ARSN----CTVFDSYG--------PHHRLIFPLNTILELENVPEG-----
MAV_1644|M.avium_104 ARSN----CTVFDSYG--------PHHRLVFPLNTILELDDIPED-----
Mvan_4910|M.vanbaalenii_PYR-1 TLPN----TGVYDEYG--------KHHRIGFPFNWVTNLADDASG-----
Mb3186c|M.bovis_AF2122/97 PGG------GDLDVR---------QYSRWALRLRVPFTVPVEAKS-----
Rv3161c|M.tuberculosis_H37Rv PGG------GDLDVR---------QYSRWALRLRVPFTVPVEAKS-----
Mflv_2470|M.gilvum_PYR-GCK RQPNATFECGHFQIDGPHRLVSTAGTRRWLLAPEYMYPVERATHSGLVGP
TH_3877|M.thermoresistible__bu RQPNATFECGHFQIDGPHRLVSTAGTRRWLMPPEYMYPVERATRSGLVGP
MSMEG_0293|M.smegmatis_MC2_155 RDPNAGFTCGHFQIDGPHRLVSTAGTRRWLLAPEYMYPIERATQSGLVGP
MAB_4370c|M.abscessus_ATCC_199 APQGKAPKDEIVHRTGRQYVDPNGHGAGFPVHPKNRFDARVVHQWTDYGA
. . .
MMAR_3964|M.marinum_M --------------QWDPFHHMVVIYALFPNVVLSVTIANGELFRIYPGD
MUL_3820|M.ulcerans_Agy99 --------------QWDPFHHMVVIYALFPNVVLSVTIANGELFRIYPGD
MAV_1644|M.avium_104 --------------QWNPFHNMVVIYALFPNIVLSVTIANGELFRVYPGD
Mvan_4910|M.vanbaalenii_PYR-1 --------------SWDPHQNMGVIYWIYPNLILANSPIGVEIIDILPAG
Mb3186c|M.bovis_AF2122/97 ------------LQLNEVQKSNLVVLWTFPNSALAIAGERVVWFGFIPQS
Rv3161c|M.tuberculosis_H37Rv ------------LQLNEVQKSNLVVLWTFPNSALAIAGERVVWFGFIPQS
Mflv_2470|M.gilvum_PYR-GCK WRTPET-HQSAGLNPGGIEPWGITNFQIFPNLEILIYHGWYLLYRYWPTS
TH_3877|M.thermoresistible__bu WRTPKT-HFSAGLNPGGIEPWGITNFQIFPNLEILIYHGWYLLYQYWPTS
MSMEG_0293|M.smegmatis_MC2_155 WRTPDIGKLPTGLNPGGIEPWGISNFQIFPNIEILIYGGWYLLYRYWPTS
MAB_4370c|M.abscessus_ATCC_199 LRERLG-------EARVQGPLTNGHATVFPNLSYLPVNGSVRIW--HPKG
:** * .
MMAR_3964|M.marinum_M RPGSSITVHQNSTPLDLSDESVATGAQAVFDYAHATVRDEDYRLAETLQT
MUL_3820|M.ulcerans_Agy99 RPGSSITVHQNSTPLDLSDESVATGAQAVFDYAHATVRDEDYRLAETLQT
MAV_1644|M.avium_104 RPGRSITVHQNATPQDLSDESVAAGVQAVFDYAHATVRDEDYRLVESLQA
Mvan_4910|M.vanbaalenii_PYR-1 EPTRCSVRHSWMGRVPATTDEMREMYDQVYDSVHAAVVDEDFAMLPQCGE
Mb3186c|M.bovis_AF2122/97 IDRVQVLGGVLTTPELAADAAATA---QTSQFVMAMINDEDR--LGLEAV
Rv3161c|M.tuberculosis_H37Rv IDRVQVLGGVLTTPELAADAAATA---QTSQFVMAMINDEDR--LGLEAV
Mflv_2470|M.gilvum_PYR-GCK HNTHKFEAYNAFHPARTVRERVEH---EVASVVLKEFALQDAGMLGGTQA
TH_3877|M.thermoresistible__bu YNTHRFEAYTAFHPARTVRERIEH---EVASVVLKEFALQDAGMLGGTQA
MSMEG_0293|M.smegmatis_MC2_155 HNTHRYEAFTYFHPARTVRERIEH---EVAAVVLKEFALQDAGMLGGTQA
MAB_4370c|M.abscessus_ATCC_199 PDKMEVWAWTIVDRSMPEEVRDAQRLYNLRTFGPTGIFEQDDGENWSEVQ
. :*
MMAR_3964|M.marinum_M NFESG-----ARQRLVFGRNEPGLQHRHITWAQALKTPG-----------
MUL_3820|M.ulcerans_Agy99 NLESG-----ARQRLVFGRNEPGLQHRHITWAQALETPG-----------
MAV_1644|M.avium_104 NLESG-----ARDHLVFGRNEPGLQHRHITWAKALAASTG----------
Mvan_4910|M.vanbaalenii_PYR-1 GVRHG-----QHDHMIIGRNEIGVQHMVKVFAQELGVALS----------
Mb3186c|M.bovis_AF2122/97 QVGAGSRF-AERGHLSSKEWPGMLAFYRNLAMALVGDHPGAS--------
Rv3161c|M.tuberculosis_H37Rv QVGAGSRF-AERGHLSSKEWPGMLAFYRNLAMALVGDHPGAS--------
Mflv_2470|M.gilvum_PYR-GCK ALEYGLGE-PIVDDYPLNDQEILVRHLHHVAVDWVDRYKAERDAQRAERD
TH_3877|M.thermoresistible__bu ALEYGLDE-PIVDEFPLSDQEILVRHLHKVVVDWVEEYQSE-------RT
MSMEG_0293|M.smegmatis_MC2_155 ALEY-----DVIDDYPLNDQEILVRHLHKVAVDWVEAYQRE-------PA
MAB_4370c|M.abscessus_ATCC_199 SISRGFVTNSVALNYQMGLDSEREDGRHPGLTSELYSDAAGRSFYARWRD
. :
MMAR_3964|M.marinum_M ------------
MUL_3820|M.ulcerans_Agy99 ------------
MAV_1644|M.avium_104 ------------
Mvan_4910|M.vanbaalenii_PYR-1 ------------
Mb3186c|M.bovis_AF2122/97 ------------
Rv3161c|M.tuberculosis_H37Rv ------------
Mflv_2470|M.gilvum_PYR-GCK PVGV--------
TH_3877|M.thermoresistible__bu AVGV--------
MSMEG_0293|M.smegmatis_MC2_155 PAGV--------
MAB_4370c|M.abscessus_ATCC_199 LMNTKAWHEEHV