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KAVTWHGKRDVRVDSVPDPKIEQPTDAIIEVTSTNICGSDLHLYEILGAFMKPGDILGHEPMGVVREVGT ETGDLRVGDRVVIPFQICCGSCYMCGQQLYTQCETTQVRDQGMGAALFGYSELYGEVPGGQAELLRVPQA QFTHIKVPVGPPDSRFVYLSDVLPTAWQAVAYADIPDGGTVAVLGLGPIGDMASRIADHLGYRVIAVDLV PERLGRAAQRGIHTIDLARLDAGLGDAIRDLTDGRGADSVIDAVGMEAHGSPAAKLAQQVAGVLPDALGK RLMQTAGVDRLSALYSAIDAVRRGGTISLIGVYGGMADPLPMLTLFDKQVTLRMGQANVKRWVDDIMPLL TDDDPLGVDDFATHVLPLERAPHAYEIFQKKQDGAVKVILKP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4101 | - | - | 100% (393) | S-(hydroxymethyl)glutathione dehydrogenase |
| M. avium 104 | MAV_2804 | - | 3e-54 | 37.47% (395) | zinc-binding dehydrogenase |
| M. avium 104 | MAV_5022 | - | 2e-16 | 31.17% (231) | oxidoreductase, zinc-binding dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1929 | - | 5e-32 | 36.80% (269) | dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1966 | - | 0.0 | 79.39% (393) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1895 | - | 5e-49 | 35.28% (394) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 2e-18 | 32.10% (243) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_1869c | - | 4e-15 | 31.40% (242) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. marinum M | MMAR_2790 | - | 8e-50 | 35.62% (393) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6616 | - | 0.0 | 81.17% (393) | S-(hydroxymethyl)glutathione dehydrogenase |
| M. thermoresistible (build 8) | TH_2319 | - | 8e-91 | 68.03% (244) | S-(hydroxymethyl)glutathione dehydrogenase |
| M. ulcerans Agy99 | MUL_2962 | - | 3e-50 | 35.62% (393) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4749 | - | 0.0 | 82.44% (393) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1929|M.bovis_AF2122/97 --------------------------------------------------
Rv1895|M.tuberculosis_H37Rv -------MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLH
MMAR_2790|M.marinum_M -------MRTVVIDGPGSIRVDNRPDPALPGSDGVIVAVSAAGICGSDLH
MUL_2962|M.ulcerans_Agy99 -------MRTVVIDGPGSIRVDNRPDPALPGSDGVIVVVSAAGICGSDLH
Mflv_1966|M.gilvum_PYR-GCK -------MKAVTWHGRRDVRVDTVADPKIEQPTDAIIEVTSTNICGSDLH
Mvan_4749|M.vanbaalenii_PYR-1 -------MRAVTWHGRRDVRVDSVPDPKIEEPTDAIIEVTSTNICGSDLH
MSMEG_6616|M.smegmatis_MC2_155 -------MKAVTWHGRRDVRVDNVPDPKIEQPTDAIIEVTSTNICGSDLH
MAV_4101|M.avium_104 -------MKAVTWHGKRDVRVDSVPDPKIEQPTDAIIEVTSTNICGSDLH
TH_2319|M.thermoresistible__bu ----------VTWHGRRKVSVDTVPDPAIMEPTDAIIRVTSTNICGSDLH
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDP---GPGEAVVDVTACGVCHTDLT
MAB_1869c|M.abscessus_ATCC_199 ----------------MELVDIVIPDP---GPGEVVVKVQACGVCHTDLT
Mb1929|M.bovis_AF2122/97 --------------------------------------------------
Rv1895|M.tuberculosis_H37Rv FYEGEYPFTEP-VALGHEAVGTIVEAGPQVRTVGVGDLVMVSSVAGCGVC
MMAR_2790|M.marinum_M FYEGEYPLAEP-VALGHEAVGTVVEKGPDVHTVEVGDQVMVSSVAGCGAC
MUL_2962|M.ulcerans_Agy99 FYEGEYPLAEP-VALGHEAVGTVVEKGPDVHTVEVGDQVMVSSVAGCGAC
Mflv_1966|M.gilvum_PYR-GCK LYEVLGAFMSEGDVLGHEPMGIVREVGAEVSNLSVGDRVVIPFQISCGHC
Mvan_4749|M.vanbaalenii_PYR-1 LYEVLGAFMNEGDILGHEPMGVVREVGSAVSNLAVGDRVVIPFQISCGHC
MSMEG_6616|M.smegmatis_MC2_155 LYEVLGAFMNEGDILGHEPMGIVREVGSAVDGLSVGDRVVIPFQISCGHC
MAV_4101|M.avium_104 LYEILGAFMKPGDILGHEPMGVVREVGTETGDLRVGDRVVIPFQICCGSC
TH_2319|M.thermoresistible__bu LYEVLSAFMSPGDILGHEAMGVVEEVGPEVGALQAGDRVVIPFNISCGTC
MLBr_01784|M.leprae_Br4923 YREGGINDRYP-FLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAVCGQC
MAB_1869c|M.abscessus_ATCC_199 YREGGINDEFP-FLLGHEAAGIVETVGEGVTTVEPGDFVILNWRAVCGVC
Mb1929|M.bovis_AF2122/97 -----------------------MIFG----AGVLGGAQADLLAVPAADF
Rv1895|M.tuberculosis_H37Rv PGCETHDPVMCFS--------GPMIFG----AGVLGGAQADLLAVPAADF
MMAR_2790|M.marinum_M AGCATRDPAMCVS--------GPQIFG----SGALGGAQADLLAVPAADF
MUL_2962|M.ulcerans_Agy99 AGCATRDPAMCVS--------GPQIFG----SGALGGAQADLLAVPATDF
Mflv_1966|M.gilvum_PYR-GCK FMCDMKLYTQCETTQVREQGMGAALFGFSELYGSVPGGQAEYLRVPQAQF
Mvan_4749|M.vanbaalenii_PYR-1 FMCDRKLYTQCETTQVRDQGMGAALFGYSELYGSVPGGQAEYLRVPQAQF
MSMEG_6616|M.smegmatis_MC2_155 FMCDQKLYTQCETTQVREQGMGAALFGYSELYGSVPGGQAQYLRVPQAQF
MAV_4101|M.avium_104 YMCGQQLYTQCETTQVRDQGMGAALFGYSELYGEVPGGQAELLRVPQAQF
TH_2319|M.thermoresistible__bu WMCAQGLQSQCETTQNRDQGTGAALFGYSKLYGEVAGGQAEYLRVPQAQY
MLBr_01784|M.leprae_Br4923 RACKRGRPSYCFDTFN--AQQKMTLIDGTELTPALGIGAFADKTLVHSGQ
MAB_1869c|M.abscessus_ATCC_199 RACKRGRPQYCFDTFN--AAQKMTLTDGTELTPALGIGAFIEKTLVHAGQ
: . : . : :
Mb1929|M.bovis_AF2122/97 QVLKIPEGITTEQALLLTDNLATGWAAAQRADISFGSAVAVIGLGAVGLC
Rv1895|M.tuberculosis_H37Rv QVLKIPEGITTEQALLLTDNLATGWAAAQRADISFGSAVAVIGLGAVGLC
MMAR_2790|M.marinum_M QVLKIPAAITTEQALLLTDNLATGWAAARRADILFGATVAVIGLGAVGLC
MUL_2962|M.ulcerans_Agy99 QVLKIPAAITTEQALLLTDNLATGWAAARRADIPFGATVAVIGLGAVGLC
Mflv_1966|M.gilvum_PYR-GCK THIKVPEGPDDSRFVYLSDVLPTAWQSVAYADIPDGGTVTVIGLGPIGDM
Mvan_4749|M.vanbaalenii_PYR-1 THIKVPDGPPDSRFVYLSDVLPTAWQAVAYADVPDGGTVTVLGLGPIGDM
MSMEG_6616|M.smegmatis_MC2_155 THIKVPDGPPDSRYVYLSDVLPTAWQSVAYAEIPKGGTVTVLGLGPIGDM
MAV_4101|M.avium_104 THIKVPVGPPDSRFVYLSDVLPTAWQAVAYADIPDGGTVAVLGLGPIGDM
TH_2319|M.thermoresistible__bu THITVPHDGPDDRYVYLSDVLPTAWQGVEYAAVPDGGTLVVLGLGPIGSM
MLBr_01784|M.leprae_Br4923 CTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTVAVIGCGGVGDA
MAB_1869c|M.abscessus_ATCC_199 CTKVDPTADPAVVGLLGCGVMAGLGAAVNTGNVGRDDTVAVIGCGGVGDA
* : . :. . . : . ::.*:* * :*
Mb1929|M.bovis_AF2122/97 ALRSAFIHGAATVFAVDRVKGRLQ--RAATWGATPIPS-----PAAETIL
Rv1895|M.tuberculosis_H37Rv ALRSAFIHGAATVFAVDRVKGRLQ--RAATWGATPIPS-----PAAETIL
MMAR_2790|M.marinum_M AVRSALAQGAATVFAVDRVQGRLQ--RASEWGATAVAS-----PAAEAIV
MUL_2962|M.ulcerans_Agy99 AVRSALAQGAATVFAVDRVQGRLQ--RAAEWGATAVAS-----PAAEAIV
Mflv_1966|M.gilvum_PYR-GCK AARIAQHKG-HTVFAVDFVPERLA--RAKARGIHTIDASALDGSVGDEVR
Mvan_4749|M.vanbaalenii_PYR-1 AARIAQHLG-YQVFAVDLVPERLD--RAIARGIHTIDASIVDGSVGDEVR
MSMEG_6616|M.smegmatis_MC2_155 AARIAHHLG-YEVFAVDRIPERLR--RAADRGIQAIDLGAIDEPLGDVIR
MAV_4101|M.avium_104 ASRIADHLG-YRVIAVDLVPERLG--RAAQRGIHTIDLARLDAGLGDAIR
TH_2319|M.thermoresistible__bu ACRIAAHRGNCRVIGVDRVPERIEKVRPYCADVLNVDTDDVEAAVREQTG
MLBr_01784|M.leprae_Br4923 AISGAALVGANRIIAVDIDDTKLE--WARTFGATHTVNALEL-EVVKTIQ
MAB_1869c|M.abscessus_ATCC_199 AIAGARLAGARKIIAIDTDDTKLA--WAKDFGATDTINARKVDDVVTAIQ
* * * ::.:* :: . .
Mb1929|M.bovis_AF2122/97 AATRGRGADSVIDAVGTDASMS----------------------------
Rv1895|M.tuberculosis_H37Rv AATRGRGADSVIDAVGTDASMS----------------------------
MMAR_2790|M.marinum_M AATGGRGADSVIDAVGTDASMT----------------------------
MUL_2962|M.ulcerans_Agy99 AATSGRGADSVIDAVDTDASMT----------------------------
Mflv_1966|M.gilvum_PYR-GCK RLTSGRGSDSVIDAVGMEAHGSPVAKAVQDATAFLPGAIAKP------MM
Mvan_4749|M.vanbaalenii_PYR-1 RLTGGRGSDSVIDAVGMEAHGSPVAKFAQQATALLPDAVAKP------MM
MSMEG_6616|M.smegmatis_MC2_155 SMTHGRGTDAVIDAVGMEAHGSPVAKIMQTAAAALPDAVAKP------MM
MAV_4101|M.avium_104 DLTDGRGADSVIDAVGMEAHGSPAAKLAQQVAGVLPDALGKR------LM
TH_2319|M.thermoresistible__bu GXXVQTPPDPRRQSADCENHADQHGRPEHPPEELHHQADDQRQRRHERDA
MLBr_01784|M.leprae_Br4923 DLTSGFGVDVVIDTVGRPETWK----------------------------
MAB_1869c|M.abscessus_ATCC_199 ELTDEFGADVVIDAVGRPETWK----------------------------
* ::..
Mb1929|M.bovis_AF2122/97 ------------DALNAVRPGGTVSVVGVHD-LQPFPLPALTCLLRSITL
Rv1895|M.tuberculosis_H37Rv ------------DALNAVRPGGTVSVVGVHD-LQPFPVPALTCLLRSITL
MMAR_2790|M.marinum_M ------------DALNAVRAGGTVSVVGVHD-LQPFPLPALTCLLRSITL
MUL_2962|M.ulcerans_Agy99 ------------DALNAVRAGGTVSVVGVHD-LQPFPLPALTCLLRSITL
Mflv_1966|M.gilvum_PYR-GCK KKAGVDRLDALYTAIDCVRRGGTLSVIGVYG-GMADPMPILTMFDKQIQV
Mvan_4749|M.vanbaalenii_PYR-1 QKAGVDRLDALYTAIDCVRRGGTLSLIGVYG-GMADPMPMLTLFDKQIQV
MSMEG_6616|M.smegmatis_MC2_155 ENAGVDRLDALYSAIDTVRRGGTISLIGVYG-GTADPIPMLTLFDKQIQL
MAV_4101|M.avium_104 QTAGVDRLSALYSAIDAVRRGGTISLIGVYG-GMADPLPMLTLFDKQVTL
TH_2319|M.thermoresistible__bu ATAGSPPLPSPWPDRTTTHR-HTWRRLGGME-LLRDVVVLLHIVGFAVTF
MLBr_01784|M.leprae_Br4923 ------------QAFYARDLAGTVVLVGVPTPDMRLDMPLLDFFSHGGSL
MAB_1869c|M.abscessus_ATCC_199 ------------QAFYARDLAGTVVLVGVPTPDMTLEMPLIDFFSRGGSL
* :* : : . .
Mb1929|M.bovis_AF2122/97 ---RMTMAPVQRTWPE-------LIPLLQ----------SGRLDVDGIFT
Rv1895|M.tuberculosis_H37Rv ---RMTMAPVQRTWPE-------LIPLLQ----------SGRLDVDGIFT
MMAR_2790|M.marinum_M ---RLTIAPVQRTWSE-------LIPLLE----------SGRLDVDGIFT
MUL_2962|M.ulcerans_Agy99 ---RLTIAPVQRTWSE-------LIPLLE----------SGRLDVDGIFT
Mflv_1966|M.gilvum_PYR-GCK ---RMGQANVKRWVDD-------ILPLLT---------DEDPLGVDTFAT
Mvan_4749|M.vanbaalenii_PYR-1 ---RMGQANVKKWVDD-------IMPLLT---------DSDPLGVDTFAT
MSMEG_6616|M.smegmatis_MC2_155 ---RMGQANVKRWVDD-------IMPLLG---------DDDPLGVDDFAT
MAV_4101|M.avium_104 ---RMGQANVKRWVDD-------IMPLLT---------DDDPLGVDDFAT
TH_2319|M.thermoresistible__bu GA-WTAEAVARRFRTTRLMDYGLLLSLITGLALAAPWPAGIVLNYPKIGL
MLBr_01784|M.leprae_Br4923 KSSWYGDCLPERDFPT-------LVDLYL----------QGRLPLGKFVS
MAB_1869c|M.abscessus_ATCC_199 KSSWYGDCLPERDFPT-------LVSLYQ----------QGRLPLDRFVS
. .: :: * * :
Mb1929|M.bovis_AF2122/97 TTLPLDEAAKGYATARARSGEELKVLLTP---------------------
Rv1895|M.tuberculosis_H37Rv TTLPLDEAAKGYATARARSGEELRFCLRPDSRDVLGAHETVDLYVHVRRC
MMAR_2790|M.marinum_M TSLPLDEAAKGYSIAGSRSGNDVKVLLKV---------------------
MUL_2962|M.ulcerans_Agy99 TSLPLDEAAKGYSIAGSRSGNDVKVLLKV---------------------
Mflv_1966|M.gilvum_PYR-GCK HTLPLDQAPHAYEIFQKKQDGAVKVILKP---------------------
Mvan_4749|M.vanbaalenii_PYR-1 HVLPMEEAPHAYKIFQQKQDGAVKVILQP---------------------
MSMEG_6616|M.smegmatis_MC2_155 HILPIDEAPHAYEIFQKKQDGAVKIILKP---------------------
MAV_4101|M.avium_104 HVLPLERAPHAYEIFQKKQDGAVKVILKP---------------------
TH_2319|M.thermoresistible__bu KLVLLVALGAVLGIGGAHQRRTGNPVPRPLFVTAGVLSFAAAAVAVLW--
MLBr_01784|M.leprae_Br4923 ERIGLGDVEEAFHKIHGGKVLRSVVML-----------------------
MAB_1869c|M.abscessus_ATCC_199 ERIGIESIEAAFEKMHHGEVLRSVVVL-----------------------
: : .
Mb1929|M.bovis_AF2122/97 ----------------------
Rv1895|M.tuberculosis_H37Rv QSVADLQLEGAADGVDGPSMLN
MMAR_2790|M.marinum_M ----------------------
MUL_2962|M.ulcerans_Agy99 ----------------------
Mflv_1966|M.gilvum_PYR-GCK ----------------------
Mvan_4749|M.vanbaalenii_PYR-1 ----------------------
MSMEG_6616|M.smegmatis_MC2_155 ----------------------
MAV_4101|M.avium_104 ----------------------
TH_2319|M.thermoresistible__bu ----------------------
MLBr_01784|M.leprae_Br4923 ----------------------
MAB_1869c|M.abscessus_ATCC_199 ----------------------