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MRTVVVDSQRSIRVDTRPDPRLPGPDGVIVDVTASAICGSDLHFLDGHYPIDQPVPIGHEAVGVVVETGS DVTRFTNGDRVLVSSVTGCGRCAGCLTLDPVKCVHGPQIFGTGLLGGAQSDLLAVPAADFQLLAVPDGIG TEEALLLTDNLPTGWAAAKRADIPVGGTVAVIGAGAVGQCALRSALALGAARVFAVDPVVARRERAAAAG ATPMDSPAAQTILEATDGLGADSVIDAVGTDASIDDALAGVRTGGTVSVVGVHDLTPYPLPALVCLLRSL TLRMTTAPVQQTWAELVPLLQAGRLSVDGIFTDAMPLAEAEAAYAAAFSRSGEHLKVHLVP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4517 | - | - | 100% (341) | alcohol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1966 | - | 9e-48 | 34.43% (395) | alcohol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3148 | - | 2e-42 | 34.31% (376) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1929 | - | 9e-91 | 73.39% (233) | dehydrogenase |
| M. tuberculosis H37Rv | Rv1895 | - | 1e-131 | 68.62% (341) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 1e-25 | 30.61% (330) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_0983c | - | 7e-32 | 33.04% (336) | zinc-containing alcohol dehydrogenase |
| M. marinum M | MMAR_2790 | - | 1e-130 | 69.32% (339) | dehydrogenase |
| M. avium 104 | MAV_2804 | - | 1e-132 | 69.21% (341) | zinc-binding dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6616 | - | 2e-47 | 33.92% (395) | S-(hydroxymethyl)glutathione dehydrogenase |
| M. thermoresistible (build 8) | TH_2319 | - | 8e-29 | 36.67% (210) | S-(hydroxymethyl)glutathione dehydrogenase |
| M. ulcerans Agy99 | MUL_2962 | - | 1e-131 | 69.32% (339) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1841 | - | 1e-162 | 82.99% (341) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01784|M.leprae_Br4923 ------MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHT
MAB_0983c|M.abscessus_ATCC_199 MRIRSAVLHAAPIERPYRDTHPLKVIELELDPPGPGEVLVRIEAAGLCHS
Mflv_4517|M.gilvum_PYR-GCK ----------MRTVVVDSQRSIRVDTRPDPRLPGPDGVIVDVTASAICGS
Mvan_1841|M.vanbaalenii_PYR-1 ----------MRAVVIDSERRIRVETRPDPQLPGPDGAIVEVTATAICGS
Mb1929|M.bovis_AF2122/97 --------------------------------------------------
Rv1895|M.tuberculosis_H37Rv ----------MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGS
MMAR_2790|M.marinum_M ----------MRTVVIDGPGSIRVDNRPDPALPGSDGVIVAVSAAGICGS
MUL_2962|M.ulcerans_Agy99 ----------MRTVVIDGPGSIRVDNRPDPALPGSDGVIVVVSAAGICGS
MAV_2804|M.avium_104 ----------MRTVVVDGPRSIRVDTRPDPVLPGPDGAIVEVSAAGICGS
MSMEG_6616|M.smegmatis_MC2_155 ----------MKAVTWHGRRDVRVDNVPDPKIEQPTDAIIEVTSTNICGS
TH_2319|M.thermoresistible__bu -------------VTWHGRRKVSVDTVPDPAIMEPTDAIIRVTSTNICGS
MLBr_01784|M.leprae_Br4923 DLTYREGGINDRYP-FLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAVC
MAB_0983c|M.abscessus_ATCC_199 DLSVVDGNRIRPVP-MALGHEAAGVIAAVGPGVRDVSPGDHVVLVYVPSC
Mflv_4517|M.gilvum_PYR-GCK DLHFLDGHYPIDQP-VPIGHEAVGVVVETGSDVTRFTNGDRVLVSSVTGC
Mvan_1841|M.vanbaalenii_PYR-1 DLHFLEGHYPIDQP-VSIGHEAVGVVVETGTTVAGFKVGDRVLVSSVAGC
Mb1929|M.bovis_AF2122/97 --------------------------------------------------
Rv1895|M.tuberculosis_H37Rv DLHFYEGEYPFTEP-VALGHEAVGTIVEAGPQVRTVGVGDLVMVSSVAGC
MMAR_2790|M.marinum_M DLHFYEGEYPLAEP-VALGHEAVGTVVEKGPDVHTVEVGDQVMVSSVAGC
MUL_2962|M.ulcerans_Agy99 DLHFYEGEYPLAEP-VALGHEAVGTVVEKGPDVHTVEVGDQVMVSSVAGC
MAV_2804|M.avium_104 DLHFYEADFPMPDP-IALGHEAIGTVVEAGPQVRNVKVGDQVMVSSVAGC
MSMEG_6616|M.smegmatis_MC2_155 DLHLYEVLGAFMNEGDILGHEPMGIVREVGSAVDGLSVGDRVVIPFQISC
TH_2319|M.thermoresistible__bu DLHLYEVLSAFMSPGDILGHEAMGVVEEVGPEVGALQAGDRVVIPFNISC
MLBr_01784|M.leprae_Br4923 GQCRACKRGRPSYCFDTF-NAQQKMTLIDG---------TELTPALGIGA
MAB_0983c|M.abscessus_ATCC_199 GACRYCSSGRPALCPDAA-AANGRGDLIRGGTRLHDLDGTEVRHHLGVSG
Mflv_4517|M.gilvum_PYR-GCK GRCAGCLTLDPVKCVHGP-QIFGTG--LLG----------------GAQS
Mvan_1841|M.vanbaalenii_PYR-1 GRCAGCRTQDPVKCVQGP-QIFGSG--LLG----------------GAQA
Mb1929|M.bovis_AF2122/97 -------------------MIFGAG--VLG----------------GAQA
Rv1895|M.tuberculosis_H37Rv GVCPGCETHDPVMCFSGP-MIFGAG--VLG----------------GAQA
MMAR_2790|M.marinum_M GACAGCATRDPAMCVSGP-QIFGSG--ALG----------------GAQA
MUL_2962|M.ulcerans_Agy99 GACAGCATRDPAMCVSGP-QIFGSG--ALG----------------GAQA
MAV_2804|M.avium_104 GSCAGCATRDPVLCHSGF-QIFGGG--VLG----------------GAQA
MSMEG_6616|M.smegmatis_MC2_155 GHCFMCDQKLYTQCETTQVREQGMGAALFG-------YSELYGSVPGGQA
TH_2319|M.thermoresistible__bu GTCWMCAQGLQSQCETTQNRDQGTGAALFG-------YSKLYGEVAGGQA
* * .
MLBr_01784|M.leprae_Br4923 FADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTV
MAB_0983c|M.abscessus_ATCC_199 FADHAVVDRNSVVVIDENVPLDTAALFGCAMLTGFGAVTHTASVRPGDSV
Mflv_4517|M.gilvum_PYR-GCK DLLAVPAADFQLLAVPDGIGTEEALLLTDNLPTGWAAAKR-ADIPVGGTV
Mvan_1841|M.vanbaalenii_PYR-1 DLMAVPAADFQLLAIPDGIDTEQALLLTDNLATGWAAAKR-ADIPVGGTV
Mb1929|M.bovis_AF2122/97 DLLAVPAADFQVLKIPEGITTEQALLLTDNLATGWAAAQR-ADISFGSAV
Rv1895|M.tuberculosis_H37Rv DLLAVPAADFQVLKIPEGITTEQALLLTDNLATGWAAAQR-ADISFGSAV
MMAR_2790|M.marinum_M DLLAVPAADFQVLKIPAAITTEQALLLTDNLATGWAAARR-ADILFGATV
MUL_2962|M.ulcerans_Agy99 DLLAVPATDFQVLKIPAAITTEQALLLTDNLATGWAAARR-ADIPFGATV
MAV_2804|M.avium_104 DLLAVPAADFQLLKIPEGISTEQALLLTDNLATGWAAAQR-ADIPFGGTV
MSMEG_6616|M.smegmatis_MC2_155 QYLRVPQAQFTHIKVPDGPPDSRYVYLSDVLPTAWQSVAY-AEIPKGGTV
TH_2319|M.thermoresistible__bu EYLRVPQAQYTHITVPHDGPDDRYVYLSDVLPTAWQGVEY-AAVPDGGTL
. : : : :. .. * : . ::
MLBr_01784|M.leprae_Br4923 AVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFGATHTVNALE
MAB_0983c|M.abscessus_ATCC_199 AVLGLGGVGLAVVMSAAAAGAGEVLAIDPVPAKRELALELGATSACAPDE
Mflv_4517|M.gilvum_PYR-GCK AVIGAGAVGQCALRSALALGAARVFAVDPVVARRERAAAAGATPMDSPAA
Mvan_1841|M.vanbaalenii_PYR-1 AVIGAGAVGQCALRSAYALGAATVFAVDPVAARRDRAAAAGARAVPAPAA
Mb1929|M.bovis_AF2122/97 AVIGLGAVGLCALRSAFIHGAATVFAVDRVKGRLQRAATWGATPIPSPAA
Rv1895|M.tuberculosis_H37Rv AVIGLGAVGLCALRSAFIHGAATVFAVDRVKGRLQRAATWGATPIPSPAA
MMAR_2790|M.marinum_M AVIGLGAVGLCAVRSALAQGAATVFAVDRVQGRLQRASEWGATAVASPAA
MUL_2962|M.ulcerans_Agy99 AVIGLGAVGLCAVRSALAQGAATVFAVDRVQGRLQRAAEWGATAVASPAA
MAV_2804|M.avium_104 AVIGLGAVGLCALRSALFQGAATVFAVDQVDGRLARAARWGATPLKAPAL
MSMEG_6616|M.smegmatis_MC2_155 TVLGLGPIGDMAARIAHHLG-YEVFAVDRIPERLRRAADRGIQAIDLG--
TH_2319|M.thermoresistible__bu VVLGLGPIGSMACRIAAHRGNCRVIGVDRVPERIEKVRPYCADVLNVDTD
.*:* * :* . * * ::.:* : .
MLBr_01784|M.leprae_Br4923 LEVVKTIQDLT-----------------------SGFGVDVVIDTVGRPE
MAB_0983c|M.abscessus_ATCC_199 APG----------------------------------GHDWVFEVVGSAA
Mflv_4517|M.gilvum_PYR-GCK QTILEATD---------------------------GLGADSVIDAVGTDA
Mvan_1841|M.vanbaalenii_PYR-1 AAILEATG---------------------------GLGVDSVIDAVGTDT
Mb1929|M.bovis_AF2122/97 ETILAATR---------------------------GRGADSVIDAVGTDA
Rv1895|M.tuberculosis_H37Rv ETILAATR---------------------------GRGADSVIDAVGTDA
MMAR_2790|M.marinum_M EAIVAATG---------------------------GRGADSVIDAVGTDA
MUL_2962|M.ulcerans_Agy99 EAIVAATS---------------------------GRGADSVIDAVDTDA
MAV_2804|M.avium_104 EAILAATG---------------------------GRGADAVIDAVATDA
MSMEG_6616|M.smegmatis_MC2_155 ----AIDEPLG--------DVIR--------SMTHGRGTDAVIDAVGMEA
TH_2319|M.thermoresistible__bu DVEAAVREQTGGXXVQTPPDPRRQSADCENHADQHGR-PEHPPEELHHQA
: : :
MLBr_01784|M.leprae_Br4923 TWKQAFYARDLAGTVVLVGVPTPDMR---------LDMPLLDFFSHGGSL
MAB_0983c|M.abscessus_ATCC_199 VLEQAYALTGRGGGTVSVGLPHPDAR---------ISLPALNIVAEGRSI
Mflv_4517|M.gilvum_PYR-GCK SIDDALAGVRTGGTVSVVGVHDLTP----------YPLPALVCLLRSLTL
Mvan_1841|M.vanbaalenii_PYR-1 SLDDALACVRTGGTVSIVGVHDLQP----------YPLPALVCLLRSLTI
Mb1929|M.bovis_AF2122/97 SMSDALNAVRPGGTVSVVGVHDLQP----------FPLPALTCLLRSITL
Rv1895|M.tuberculosis_H37Rv SMSDALNAVRPGGTVSVVGVHDLQP----------FPVPALTCLLRSITL
MMAR_2790|M.marinum_M SMTDALNAVRAGGTVSVVGVHDLQP----------FPLPALTCLLRSITL
MUL_2962|M.ulcerans_Agy99 SMTDALNAVRAGGTVSVVGVHDLQP----------FPLPALTCLLRSITL
MAV_2804|M.avium_104 SLTEALNAVRPGGTVSVVGVHDMNP----------FPLNALGCLIRSITL
MSMEG_6616|M.smegmatis_MC2_155 HGSPVAKIMQTAAAALPDAVAKPMMENAGVD-----RLDALYSAIDTVRR
TH_2319|M.thermoresistible__bu DDQRQRRHERDAATAGSPPLPSPWPDRTTTHRHTWRRLGGMELLRDVVVL
.. . : : :
MLBr_01784|M.leprae_Br4923 KSSW---------------------------------YGDCLPERDFPTL
MAB_0983c|M.abscessus_ATCC_199 LGSY---------------------------------MGSAQPQQDIPAM
Mflv_4517|M.gilvum_PYR-GCK R------------------------------------MTTAPVQQTWAEL
Mvan_1841|M.vanbaalenii_PYR-1 R------------------------------------LTTAPVQQTWPEL
Mb1929|M.bovis_AF2122/97 R------------------------------------MTMAPVQRTWPEL
Rv1895|M.tuberculosis_H37Rv R------------------------------------MTMAPVQRTWPEL
MMAR_2790|M.marinum_M R------------------------------------LTIAPVQRTWSEL
MUL_2962|M.ulcerans_Agy99 R------------------------------------LTIAPVQRTWSEL
MAV_2804|M.avium_104 R------------------------------------MTTAPVQRTWPEL
MSMEG_6616|M.smegmatis_MC2_155 GGTISLIGVYGG-TADPIP------MLTLFDKQIQLRMGQANVKRWVDDI
TH_2319|M.thermoresistible__bu LHIVGFAVTFGAWTAEAVARRFRTTRLMDYGLLLSLITGLALAAPWPAGI
. :
MLBr_01784|M.leprae_Br4923 VD------------LYLQGRLPLGKFVSERIGLGDVEEAFHKIHGGKVLR
MAB_0983c|M.abscessus_ATCC_199 LA------------LWRAGRLPVEKLKSDDLPLSDINIALDALAEGQAVR
Mflv_4517|M.gilvum_PYR-GCK VP------------LLQAGRLSVDGIFTDAMPLAEAEAAYAAAFSRSGEH
Mvan_1841|M.vanbaalenii_PYR-1 IP------------LLQAGRLSVDGIFTGALPLDDAERAYAAAFSRSAEH
Mb1929|M.bovis_AF2122/97 IP------------LLQSGRLDVDGIFTTTLPLDEAAKGYATARARSGEE
Rv1895|M.tuberculosis_H37Rv IP------------LLQSGRLDVDGIFTTTLPLDEAAKGYATARARSGEE
MMAR_2790|M.marinum_M IP------------LLESGRLDVDGIFTTSLPLDEAAKGYSIAGSRSGND
MUL_2962|M.ulcerans_Agy99 IP------------LLESGRLDVDGIFTTSLPLDEAAKGYSIAGSRSGND
MAV_2804|M.avium_104 IP------------LLQSGRLDVDGIFTTTMPLDEAAIGYATAGSRSGDD
MSMEG_6616|M.smegmatis_MC2_155 MP-----------LLGDDDPLGVDDFATHIL--PIDEAPHAYEIFQKKQD
TH_2319|M.thermoresistible__bu VLNYPKIGLKLVLLVALGAVLGIGGAHQRRTGNPVPRPLFVTAGVLSFAA
: : * : .
MLBr_01784|M.leprae_Br4923 SVVML---------------------------------------------
MAB_0983c|M.abscessus_ATCC_199 QILRPGVSA-----------------------------------------
Mflv_4517|M.gilvum_PYR-GCK LKVHLVP-------------------------------------------
Mvan_1841|M.vanbaalenii_PYR-1 LKVQLIP-------------------------------------------
Mb1929|M.bovis_AF2122/97 LKVLLTP-------------------------------------------
Rv1895|M.tuberculosis_H37Rv LRFCLRPDSRDVLGAHETVDLYVHVRRCQSVADLQLEGAADGVDGPSMLN
MMAR_2790|M.marinum_M VKVLLKV-------------------------------------------
MUL_2962|M.ulcerans_Agy99 VKVLLKV-------------------------------------------
MAV_2804|M.avium_104 VKILLKP-------------------------------------------
MSMEG_6616|M.smegmatis_MC2_155 GAVKIILKP-----------------------------------------
TH_2319|M.thermoresistible__bu AAVAVLW-------------------------------------------
.