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LLLEMAASGDPDRVAVVDGDIRLTTVDLSELADGGAGVIAASGASHVAYVGTGGVLLPLLLFSSARANTA FTPLNYRLSPEGLRELIDRLPSPLVVVDAEYRDIGAGFGQRVMTSDEFIEAARSTEPVSVFADPDDVAVV LFTSGTTSRPKAVELTHNNLTSYVTGTVEFGSADPADAALVCVPPYHIAGVGAALSNLYAGRAIVYLRRF DPHEWVRLVRDERVTTATVVPTMLSRIVAVLEEQSAELPTLRNFAYGGSKVARPLVRRALDLLPQVGFVN AYGLTETSSTIAVLTPEDHRLAHEARDDAVARRLTSVGRPVPGIEVQIRAEDGTVLGPGETGELFVRGPQ VSGRYTEIGSVLDDHGWFATRDVAMLDEDGYLFIGGRSDDTIIRGGENIAPSEVEDVLIEHPDVREVVVV GLDDAEWGQAIVAVIVPESGTAPAPERLREFARSKLRGSRTPDRIVFRDELPTTPTGKVLRREILEDLKP AAAEH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2574 | - | - | 100% (495) | feruloyl-CoA synthetase |
| M. avium 104 | MAV_1843 | - | 0.0 | 73.48% (494) | AMP-dependent synthetase and ligase |
| M. avium 104 | MAV_4950 | - | 0.0 | 71.72% (495) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3116 | fadD13 | 4e-50 | 28.12% (505) | chain-fatty-acid-CoA ligase |
| M. gilvum PYR-GCK | Mflv_2385 | - | 0.0 | 75.00% (488) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv3089 | fadD13 | 4e-50 | 28.12% (505) | chain-fatty-acid-CoA ligase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 3e-48 | 28.99% (507) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2539c | - | 1e-49 | 30.99% (513) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_0466 | - | 0.0 | 73.57% (488) | long-chain-fatty-acid-CoA ligase |
| M. smegmatis MC2 155 | MSMEG_4883 | - | 0.0 | 75.10% (490) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_2995 | - | 0.0 | 73.40% (485) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_1115 | - | 0.0 | 72.75% (488) | long-chain-fatty-acid-CoA ligase |
| M. vanbaalenii PYR-1 | Mvan_4263 | - | 0.0 | 73.16% (488) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2385|M.gilvum_PYR-GCK -----------------------------------------------MSI
Mvan_4263|M.vanbaalenii_PYR-1 -----------------------------------------------MSI
MSMEG_4883|M.smegmatis_MC2_155 -----------------------------------------------MSI
TH_2995|M.thermoresistible__bu --------------------------------------------------
MAV_2574|M.avium_104 --------------------------------------------------
MMAR_0466|M.marinum_M -----------------------------------------------MSV
MUL_1115|M.ulcerans_Agy99 -----------------------------------------------MSV
MLBr_02546|M.leprae_Br4923 -MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWG-DL
MAB_2539c|M.abscessus_ATCC_199 MPNNLRESLRQWGAAIP---AAVTSGAFTPVSPRALASLVRSFWQFGPTP
Mb3116|M.bovis_AF2122/97 ----------------------------------------------MKNI
Rv3089|M.tuberculosis_H37Rv ----------------------------------------------MKNI
Mflv_2385|M.gilvum_PYR-GCK SLLLEMATDAGPDRTAVVS--DDTRLTTAELSALADGGAGVIAAS---GA
Mvan_4263|M.vanbaalenii_PYR-1 SLLLEMAQDAGPDRTAVVS--DDLRLTTAELSALADGGAGVIAAS---GA
MSMEG_4883|M.smegmatis_MC2_155 SLLLEMASSGDPDRTAVVS--DDTRLTAGELSTLADGAAGVIAGS---GA
TH_2995|M.thermoresistible__bu -----MAVSGDPDRVAVID--RDVRLTTTELARLAGGGAQVIAGS---GV
MAV_2574|M.avium_104 -MLLEMAASGDPDRVAVVD--GDIRLTTVDLSELADGGAGVIAAS---GA
MMAR_0466|M.marinum_M SLLLEMAASASPDRIAVVS--GDLRLTTQQLSDLADGGAGAIAAS---DA
MUL_1115|M.ulcerans_Agy99 SLLLEMAASASPDRIAVVS--GDLRLKTQQLSDLADGGAGAIAAS---DA
MLBr_02546|M.leprae_Br4923 AMLPAMPARRSPHRAALID--EEGTLTYKELDRAAHALANGLIAKGVRGG
MAB_2539c|M.abscessus_ATCC_199 AMLLAASAIRFPDRAALID--DSGQLTYRDLQRRAEAVAAAVYARTPSAP
Mb3116|M.bovis_AF2122/97 GWMLRQRATVSPRLQAYVEPSTDVRMTYAQMNALANRCADVLTALGIAKG
Rv3089|M.tuberculosis_H37Rv GWMLRQRATVSPRLQAYVEPSTDVRMTYAQMNALANRCADVLTALGIAKG
* * :. . :. :: * * : .
Mflv_2385|M.gilvum_PYR-GCK RHVAYVGTGGALLPLLLFASARAAVPVTPLNYRLSAEGLRALLDRLPDPL
Mvan_4263|M.vanbaalenii_PYR-1 RHVAYVGAGGAMLPLLLFASARAAVPVTPLNYRLSADGLRALLDRLPDPL
MSMEG_4883|M.smegmatis_MC2_155 AHVAYVGTGGALLPLLLFASARAAIPFTPLNYRLSAEGLRELVDRLPTPL
TH_2995|M.thermoresistible__bu QHVAYVGLGGAMLPLLIFASTHATVPFTPLNYRLSAEGLHQLIERLPSPL
MAV_2574|M.avium_104 SHVAYVGTGGVLLPLLLFSSARANTAFTPLNYRLSPEGLRELIDRLPSPL
MMAR_0466|M.marinum_M QHVVYVGTGGAMLPLLIFASARAGLPFTSINYRLSADGIAALIRRLPRPL
MUL_1115|M.ulcerans_Agy99 QHVVYVGTGGAMLPLLIFASARAGLPFTSINYRLSADGIAALIRRLPRPL
MLBr_02546|M.leprae_Br4923 DGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKV
MAB_2539c|M.abscessus_ATCC_199 RSVGIICRNHRGFAESMLAGAQLGAELVFINTELTPQQLGAILQRHEPDV
Mb3116|M.bovis_AF2122/97 DRVALLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKV
Rv3089|M.tuberculosis_H37Rv DRVALLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKV
: : . : . :: :* .:: : : :
Mflv_2385|M.gilvum_PYR-GCK VVVDDEYRDAVGDSYR-TMGSREFFEASRTAEP-------AAEFADPDS-
Mvan_4263|M.vanbaalenii_PYR-1 VVVDDEYRDAVGDGYR-TIGSAEFLDAARTAEP-------AAEFADPDA-
MSMEG_4883|M.smegmatis_MC2_155 VIADGEYAGMLAGAGRPVLTSEEFLSQARTADP-------AAEFADPDA-
TH_2995|M.thermoresistible__bu VIADDEYVDAVAGTGKQVMRSSEFVEAARAAEP-------LEGFADPDS-
MAV_2574|M.avium_104 VVVDAEYRDIGAGFGQRVMTSDEFIEAARSTEP-------VSVFADPDD-
MMAR_0466|M.marinum_M VVVDERYRDTIAADQS--LSSQQFLELAGRAEP-------VAEFPDPDS-
MUL_1115|M.ulcerans_Agy99 VVVDERYRETIAADQS--LSSQQFLELAGRAEP-------VAEFPDPDS-
MLBr_02546|M.leprae_Br4923 IIYDDEYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIARSSS
MAB_2539c|M.abscessus_ATCC_199 LVYDDEYSQAVEESQYQGLRVLAWRENPQENR------LTLDSLADQHHP
Mb3116|M.bovis_AF2122/97 VIYGAPSAPVIDAIRAQADPPGTVTDWIGADSLAERLRSAAADEPAVECG
Rv3089|M.tuberculosis_H37Rv VIYGAPSAPVIDAIRAQADPPGTVTDWIGADSLAERLRSAAADEPAVECG
:: .
Mflv_2385|M.gilvum_PYR-GCK ---------VGVVLFTSGTTSKPKAVELTH--TNLTSYIMGTVEFASAEP
Mvan_4263|M.vanbaalenii_PYR-1 ---------VGVVLFTSGTTSKPKAVELSH--ANLTSYIMGTVEFASAEP
MSMEG_4883|M.smegmatis_MC2_155 ---------VAVVLFTSGTTSRPKAVELTH--NNLTSYITGTVEFGSAAP
TH_2995|M.thermoresistible__bu ---------VGIVLFTSGTTSRPKAVELTH--NNLTSYVTGTVEFADADA
MAV_2574|M.avium_104 ---------VAVVLFTSGTTSRPKAVELTH--NNLTSYVTGTVEFGSADP
MMAR_0466|M.marinum_M ---------VAIVLFTSGTTSQPKAVELTH--SNLTSYVTTTVEFGCAAP
MUL_1115|M.ulcerans_Agy99 ---------VAIVLFTSGTTSQPKAVELTH--SNLTSYVTTTVEFGCAAP
MLBr_02546|M.leprae_Br4923 APAPKVRKRASIIILTSGTTGTPKGANRNT-PASLAPLGG-ILSKVPFRA
MAB_2539c|M.abscessus_ATCC_199 KPPP-VRRPVKLTLLTSGTTGLAKGVPRAIKPRQLALMCVTAMATVRLRS
Mb3116|M.bovis_AF2122/97 G------DDNLFIMYTSGTTGHPKGVVHTH--ESVHSAASSWASTIDVRY
Rv3089|M.tuberculosis_H37Rv G------DDNLFIMYTSGTTGHPKGVVHTH--ESVHSAASSWASTIDVRY
. : *****. .*.. .:
Mflv_2385|M.gilvum_PYR-GCK DDAALICVPPYHIAGVSAALSNLYAGRKMVYLRHFDAEKWVRLVADEGVT
Mvan_4263|M.vanbaalenii_PYR-1 DDAALICVPPYHIAGVSAALSNLYAGRKMVYLTQFDAGRWVDLVTGEGVT
MSMEG_4883|M.smegmatis_MC2_155 EDAALICVPPYHIAGVSAAMSNLYAGRKMVYLRNFDAHRWVELVRTEGVT
TH_2995|M.thermoresistible__bu EDAALVCVPPYHIAGVGAALSNLYAGRKIVCLSRFDPAEWVRLVADEKVT
MAV_2574|M.avium_104 ADAALVCVPPYHIAGVGAALSNLYAGRAIVYLRRFDPHEWVRLVRDERVT
MMAR_0466|M.marinum_M SDAALICVPPYHIAGVSAVLSNLYAGRKMVYLTNFDAHEWVRLTNAEQVT
MUL_1115|M.ulcerans_Agy99 SDAALICVPPYHIAGVSAVLSNLYAGRKMVYLNNFDAHEWVRLTNAEQVT
MLBr_02546|M.leprae_Br4923 HEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKPATVLEDIEKHQAT
MAB_2539c|M.abscessus_ATCC_199 RDRVLVAPPFFHGFGLAALLGPLALGGTVMCRRRFDAQQAMTDIRRQRVT
Mb3116|M.bovis_AF2122/97 RDRLLLPLPMFHVAALTTVIFSAMRGVTLISMPQFDATKVWSLIVEERVC
Rv3089|M.tuberculosis_H37Rv RDRLLLPLPMFHVAALTTVIFSAMRGVTLISMPQFDATKVWSLIVEERVC
: *: * :* . * :: .*.. . .
Mflv_2385|M.gilvum_PYR-GCK SATVVPTMLDRIVTVLET--TDTALPTLRTLAYGGSKVPLPLVRKALSLL
Mvan_4263|M.vanbaalenii_PYR-1 SATVVPTMLDRIVSVLET--RGTTLPTLRTLAYGGSKVPLPLVRKALSLL
MSMEG_4883|M.smegmatis_MC2_155 SATVVPTMLDRIVTALET--TRAELPTLRNLAYGGSKVALPLVRKALELM
TH_2995|M.thermoresistible__bu TATVVPTMLDRIVTELEA--RPRELPSLRNLAYGGSKVGLPLVRKALELL
MAV_2574|M.avium_104 TATVVPTMLSRIVAVLEE--QSAELPTLRNFAYGGSKVARPLVRRALDLL
MMAR_0466|M.marinum_M TATVVPTMLDRIVAVLET--GEHKLPSLRNLAYGGSKVGLPLVRRALELL
MUL_1115|M.ulcerans_Agy99 TATVVPTMLDRIVAVLET--GEHKLPSLRNLAYGCSKVGLPLVRRALELL
MLBr_02546|M.leprae_Br4923 AMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRALEEL
MAB_2539c|M.abscessus_ATCC_199 VLMAVPVMLQRILALADLDRRDARQLSLRMIVTGAAPISSSTVSGVLEAF
Mb3116|M.bovis_AF2122/97 IGGAVPAILNFMRQVPEF--AELDAPDFRYFITGGAPMPEALIK--IYAA
Rv3089|M.tuberculosis_H37Rv IGGAVPAILNFMRQVPEF--AELDAPDFRYFITGGAPMPEALIK--IYAA
.**.:*. : : :* . . : : :
Mflv_2385|M.gilvum_PYR-GCK PDVGFVNAYGLTETSSTIAVLTPDDHRAALAAADDAALRRLGSVGQPVPG
Mvan_4263|M.vanbaalenii_PYR-1 PAVGFVNAYGLTETSSTIAVLTPDDHRAALAASDEAAIRRLGSVGQPVPG
MSMEG_4883|M.smegmatis_MC2_155 PNVGFVNAYGLTETSSTIAVLGPDDHRAALASDDPGVTRRLGSVGQVVPG
TH_2995|M.thermoresistible__bu PDVGFVNAYGLTETSSTIAVLGPEDHRIALASDDEKVVRRLGSVGQPVPG
MAV_2574|M.avium_104 PQVGFVNAYGLTETSSTIAVLTPEDHRLAHEARDDAVARRLTSVGRPVPG
MMAR_0466|M.marinum_M PDVGFVNAYGLTETSSTIAVLTPDDHRAAQSAAAAGLARRLGSVGRPVPG
MUL_1115|M.ulcerans_Agy99 PDVGFVNAYRLTETSSTIAVLTPDDHRAAQSAAAAGLARRLGSVGRPVPG
MLBr_02546|M.leprae_Br4923 GPV-IYNMYGSTEIA------------FATIAGPKDLQINSATVGPVVKG
MAB_2539c|M.abscessus_ATCC_199 GPI-LVNGYGSTEAG------------VVAIASPKDLVASPNTIGRTALG
Mb3116|M.bovis_AF2122/97 KNIEVVQGYALTESCG-----------GGTLLLSEDALRKAGSAGRATMF
Rv3089|M.tuberculosis_H37Rv KNIEVVQGYALTESCG-----------GGTLLLSEDALRKAGSAGRATMF
: . : * ** : * .
Mflv_2385|M.gilvum_PYR-GCK IEVEVRAEDGTVLGPGETGELFVRGEQVSGKYTDIGS-----VLDENGWF
Mvan_4263|M.vanbaalenii_PYR-1 IEVEIRADDGTVLGAGETGELFVRGEQVSGKYTDIGS-----VLDEQGWF
MSMEG_4883|M.smegmatis_MC2_155 IEVQIRGEDGTVLGPGETGELFVRGEQVSGRYTEIGS-----VLDEDGWF
TH_2995|M.thermoresistible__bu IEIQIRSKNGEVLGPGETGELFVRGPQVSGRYTGIGS-----VLDDDGWF
MAV_2574|M.avium_104 IEVQIRAEDGTVLGPGETGELFVRGPQVSGRYTEIGS-----VLDDHGWF
MMAR_0466|M.marinum_M VELQIRGQDGRVLGPGETGELFVRGGQVSGRYTGIGS-----VLDGHGWF
MUL_1115|M.ulcerans_Agy99 VELQIRGQDGRVLGPGETGELFVRGEQVSGRYTGIGS-----VLDGHGWF
MLBr_02546|M.leprae_Br4923 VKVKILDDSGKEVPRGQVGRIFVGNAFPFEGYTGGGG-----KQIIDGLL
MAB_2539c|M.abscessus_ATCC_199 VSVRILREDRRPAAPGETGMIFVRGGLEYEGYTPDKATRPTAKEIVDGHV
Mb3116|M.bovis_AF2122/97 TDVAVRGDDGVIREHGEGEVVIKSDILLKEYWNRPEATR---DAFDNGWF
Rv3089|M.tuberculosis_H37Rv TDVAVRGDDGVIREHGEGEVVIKSDILLKEYWNRPEATR---DAFDNGWF
.: : .. *: :: . :. . .* .
Mflv_2385|M.gilvum_PYR-GCK PTKDVAYLDSEGYLFIGGRSDDTIIRGGENIAPAEIEDVLVEHPHVRDCA
Mvan_4263|M.vanbaalenii_PYR-1 PTKDVAFLDEEGYLFIGGRSDDTIIRGGENIAPAEIEDVLVEHPHVRDCA
MSMEG_4883|M.smegmatis_MC2_155 PTKDVAMLDQDGYLFIGGRSDDTIIRGGENIAPAEIEDVLVEHPDVRDVA
TH_2995|M.thermoresistible__bu PTKDVAMVDEDGYLFIGGRSDDTIIRGGENIAPAEIENVLVEHPQVREAV
MAV_2574|M.avium_104 ATRDVAMLDEDGYLFIGGRSDDTIIRGGENIAPSEVEDVLIEHPDVREVV
MMAR_0466|M.marinum_M GTKDIAMLDEDGYLFIGGRSDDTIIRGGENIAPAELEEVLIEHPQVRDVA
MUL_1115|M.ulcerans_Agy99 GTKDIAMLDEDGYLFIGGRSDDTIIRGGENIAPAELEEVLIEHPQVRDVA
MLBr_02546|M.leprae_Br4923 SSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEAT
MAB_2539c|M.abscessus_ATCC_199 NTGDMGHFDADGRLYIDGRSDDMIVSGGENVFPGEVEDRLTTYPGITDAV
Mb3116|M.bovis_AF2122/97 RTGDIGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVA
Rv3089|M.tuberculosis_H37Rv RTGDIGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVA
: *:. .* .. *:* .* .: *: ****: *.*:*. : * : : .
Mflv_2385|M.gilvum_PYR-GCK VVGADDPQWGQIIVAVVVPHQDTAPD-PEDLRAHVRSQLRGSRTPDRVVF
Mvan_4263|M.vanbaalenii_PYR-1 VVGADDPEWGQIIVAVVVAQPGTEPD-VEDLRSHVRSQLRGSRTPDRVVF
MSMEG_4883|M.smegmatis_MC2_155 VVGPEDPQWGQIIVAVVVPADGAEPD-ADVLREHVRKHLRGSRTPDRVVF
TH_2995|M.thermoresistible__bu VVGPEDPQWGQILVAVVVPAEGETPD-PEELRAHVRKHLRGSRTPDKVVF
MAV_2574|M.avium_104 VVGLDDAEWGQAIVAVIVPESGTAPA-PERLREFARSKLRGSRTPDRIVF
MMAR_0466|M.marinum_M VVGVEDAQWGQEIVAVVVPVAGVDPD-PEELREFVRRSLRGSRTPDRVVF
MUL_1115|M.ulcerans_Agy99 VVGVEDAQWGQEIVAVVVPVAGVDPD-PEELREFVRRSLRGSRTPDRVVF
MLBr_02546|M.leprae_Br4923 AIGVDDKEWGARLRAFVVKKQDATID-EDAIKAYVRDHLARYKVPREVIF
MAB_2539c|M.abscessus_ATCC_199 VIGVPDDDFGQVLHAFVVAADGAPAPSEEVLKTHVRQGLERYKVPKRFIV
Mb3116|M.bovis_AF2122/97 VIGLPDEKWGEIAAAIVVADQNEVSE--QQIVEYCGTRLARYKLPKKVIF
Rv3089|M.tuberculosis_H37Rv VIGLPDEKWGEIAAAIVVADQNEVSE--QQIVEYCGTRLARYKLPKKVIF
.:* * .:* *.:* . : : . * : * ..:.
Mflv_2385|M.gilvum_PYR-GCK RDELPTNATGKVLRRELVSELNQDRSPAQPAV
Mvan_4263|M.vanbaalenii_PYR-1 RDELPTNATGKVLRRELVDELNQDPSPAQPAV
MSMEG_4883|M.smegmatis_MC2_155 RAELPTNATGKVLRRQLVDEL-------QPIS
TH_2995|M.thermoresistible__bu RTELPVNALGKVLRRQLVDELQT----KEPA-
MAV_2574|M.avium_104 RDELPTTPTGKVLRREILEDLKP----AAAEH
MMAR_0466|M.marinum_M RHELPTTATGKILRREIIEELAG----TKS--
MUL_1115|M.ulcerans_Agy99 RRELPTTATGKILRREIIEELAG----TKS--
MLBr_02546|M.leprae_Br4923 LEELPRNPTGKVLKRELRDFEVH---------
MAB_2539c|M.abscessus_ATCC_199 LDEIPRNASGKVLRAKLNSPGAC---------
Mb3116|M.bovis_AF2122/97 AEAIPRNPTGKILKTVLREQYSATVPK-----
Rv3089|M.tuberculosis_H37Rv AEAIPRNPTGKILKTVLREQYSATVPK-----
:* .. **:*: : .