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MSISLLLEMAQDAGPDRTAVVSDDLRLTTAELSALADGGAGVIAASGARHVAYVGAGGAMLPLLLFASAR AAVPVTPLNYRLSADGLRALLDRLPDPLVVVDDEYRDAVGDGYRTIGSAEFLDAARTAEPAAEFADPDAV GVVLFTSGTTSKPKAVELSHANLTSYIMGTVEFASAEPDDAALICVPPYHIAGVSAALSNLYAGRKMVYL TQFDAGRWVDLVTGEGVTSATVVPTMLDRIVSVLETRGTTLPTLRTLAYGGSKVPLPLVRKALSLLPAVG FVNAYGLTETSSTIAVLTPDDHRAALAASDEAAIRRLGSVGQPVPGIEVEIRADDGTVLGAGETGELFVR GEQVSGKYTDIGSVLDEQGWFPTKDVAFLDEEGYLFIGGRSDDTIIRGGENIAPAEIEDVLVEHPHVRDC AVVGADDPEWGQIIVAVVVAQPGTEPDVEDLRSHVRSQLRGSRTPDRVVFRDELPTNATGKVLRRELVDE LNQDPSPAQPAV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4263 | - | - | 100% (502) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_0970 | - | 6e-59 | 32.27% (471) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 2e-58 | 30.16% (494) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3116 | fadD13 | 5e-52 | 29.41% (510) | chain-fatty-acid-CoA ligase |
| M. gilvum PYR-GCK | Mflv_2385 | - | 0.0 | 91.04% (502) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv3089 | fadD13 | 5e-52 | 29.41% (510) | chain-fatty-acid-CoA ligase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 5e-51 | 28.24% (510) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4559 | - | 7e-52 | 33.33% (354) | putative long-chain-fatty-acid CoA ligase |
| M. marinum M | MMAR_0466 | - | 0.0 | 73.32% (491) | long-chain-fatty-acid-CoA ligase |
| M. avium 104 | MAV_1843 | - | 0.0 | 73.43% (493) | AMP-dependent synthetase and ligase |
| M. smegmatis MC2 155 | MSMEG_4883 | - | 0.0 | 80.08% (492) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_2995 | - | 0.0 | 72.91% (491) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_1115 | - | 0.0 | 72.51% (491) | long-chain-fatty-acid-CoA ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4263|M.vanbaalenii_PYR-1 ---------------------------------------------MSISL
Mflv_2385|M.gilvum_PYR-GCK ---------------------------------------------MSISL
MSMEG_4883|M.smegmatis_MC2_155 ---------------------------------------------MSISL
TH_2995|M.thermoresistible__bu --------------------------------------------------
MMAR_0466|M.marinum_M ---------------------------------------------MSVSL
MUL_1115|M.ulcerans_Agy99 ---------------------------------------------MSVSL
MAV_1843|M.avium_104 ----------------------------------------MKAEALSISL
Mb3116|M.bovis_AF2122/97 ---------------------------------------------MKNIG
Rv3089|M.tuberculosis_H37Rv ---------------------------------------------MKNIG
MAB_4559|M.abscessus_ATCC_1997 ---------------------------------------------MQFTQ
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
Mvan_4263|M.vanbaalenii_PYR-1 LLEMAQDAGPDRTAVVSD---DLRLTTAELSALADGGAGVIAASGAR---
Mflv_2385|M.gilvum_PYR-GCK LLEMATDAGPDRTAVVSD---DTRLTTAELSALADGGAGVIAASGAR---
MSMEG_4883|M.smegmatis_MC2_155 LLEMASSGDPDRTAVVSD---DTRLTAGELSTLADGAAGVIAGSGAA---
TH_2995|M.thermoresistible__bu ---MAVSGDPDRVAVIDR---DVRLTTTELARLAGGGAQVIAGSGVQ---
MMAR_0466|M.marinum_M LLEMAASASPDRIAVVSG---DLRLTTQQLSDLADGGAGAIAASDAQ---
MUL_1115|M.ulcerans_Agy99 LLEMAASASPDRIAVVSG---DLRLKTQQLSDLADGGAGAIAASDAQ---
MAV_1843|M.avium_104 LLEMAVSEDPDRVALVDG---ANRLTLGELSSLADGGAGVIAASGAQ---
Mb3116|M.bovis_AF2122/97 WMLRQRATVSPRLQAYVEPSTDVRMTYAQMNALANRCADVLTALGIAKGD
Rv3089|M.tuberculosis_H37Rv WMLRQRATVSPRLQAYVEPSTDVRMTYAQMNALANRCADVLTALGIAKGD
MAB_4559|M.abscessus_ATCC_1997 WLHRALQQYPDRLITIDQ---GREHTVEQFADRVARLSAGLRANGVRPGD
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDE---EGTLTYKELDRAAHALANGLIAKGVRGGD
. * . :: . : : . .
Mvan_4263|M.vanbaalenii_PYR-1 HVAYVGAGGAMLPLLLFASARAAVPVTPLNYRLSADGLRALLDRLPDPLV
Mflv_2385|M.gilvum_PYR-GCK HVAYVGTGGALLPLLLFASARAAVPVTPLNYRLSAEGLRALLDRLPDPLV
MSMEG_4883|M.smegmatis_MC2_155 HVAYVGTGGALLPLLLFASARAAIPFTPLNYRLSAEGLRELVDRLPTPLV
TH_2995|M.thermoresistible__bu HVAYVGLGGAMLPLLIFASTHATVPFTPLNYRLSAEGLHQLIERLPSPLV
MMAR_0466|M.marinum_M HVVYVGTGGAMLPLLIFASARAGLPFTSINYRLSADGIAALIRRLPRPLV
MUL_1115|M.ulcerans_Agy99 HVVYVGTGGAMLPLLIFASARAGLPFTSINYRLSADGIAALIRRLPRPLV
MAV_1843|M.avium_104 HVAYVGSGVTMAPLLIFASARAGNAYTPINYRLSAGGIQELIVRLPDPLV
Mb3116|M.bovis_AF2122/97 RVALLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVV
Rv3089|M.tuberculosis_H37Rv RVALLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVV
MAB_4559|M.abscessus_ATCC_1997 RVGMLSLNSDRYIEYLTAVPWLGAALNAVNIRWSLAEIGYSLRESGTRVL
MLBr_02546|M.leprae_Br4923 GIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVI
: : . . . :* . : : ::
Mvan_4263|M.vanbaalenii_PYR-1 VVDDEYRDAVGDGYR-TIGSAEFLDAARTAEP-----------------A
Mflv_2385|M.gilvum_PYR-GCK VVDDEYRDAVGDSYR-TMGSREFFEASRTAEP-----------------A
MSMEG_4883|M.smegmatis_MC2_155 IADGEYAGMLAGAGRPVLTSEEFLSQARTADP-----------------A
TH_2995|M.thermoresistible__bu IADDEYVDAVAGTGKQVMRSSEFVEAARAAEP-----------------L
MMAR_0466|M.marinum_M VVDERYRDTI--AADQSLSSQQFLELAGRAEP-----------------V
MUL_1115|M.ulcerans_Agy99 VVDERYRETI--AADQSLSSQQFLELAGRAEP-----------------V
MAV_1843|M.avium_104 IVDSRYRDMVGDVGKLVMDSDEFLAAARAADP-----------------V
Mb3116|M.bovis_AF2122/97 IYGAPSAPVIDAIRAQADPPGTVTDWIGADS------LAERLRSAAADEP
Rv3089|M.tuberculosis_H37Rv IYGAPSAPVIDAIRAQADPPGTVTDWIGADS------LAERLRSAAADEP
MAB_4559|M.abscessus_ATCC_1997 LVDDTFKAAAAPLRAACACLETVIYCGAGPAPQ-DMIGYEDLLASHEPID
MLBr_02546|M.leprae_Br4923 IYDDEYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIARSSSA
: . .
Mvan_4263|M.vanbaalenii_PYR-1 AEFADPDAVGVVLFTSGTTSKPKAVELSHANLTSYIMGTVEFASAEPD-D
Mflv_2385|M.gilvum_PYR-GCK AEFADPDSVGVVLFTSGTTSKPKAVELTHTNLTSYIMGTVEFASAEPD-D
MSMEG_4883|M.smegmatis_MC2_155 AEFADPDAVAVVLFTSGTTSRPKAVELTHNNLTSYITGTVEFGSAAPE-D
TH_2995|M.thermoresistible__bu EGFADPDSVGIVLFTSGTTSRPKAVELTHNNLTSYVTGTVEFADADAE-D
MMAR_0466|M.marinum_M AEFPDPDSVAIVLFTSGTTSQPKAVELTHSNLTSYVTTTVEFGCAAPS-D
MUL_1115|M.ulcerans_Agy99 AEFPDPDSVAIVLFTSGTTSQPKAVELTHSNLTSYVTTTVEFGCAAPS-D
MAV_1843|M.avium_104 AEFADPEDVAIVLFTSGTTSKPKAVELTHGNLTSYITGTVEFGSAEPE-D
Mb3116|M.bovis_AF2122/97 AVECGGDDNLFIMYTSGTTGHPKGVVHTHESVHSAASSWASTIDVRYR-D
Rv3089|M.tuberculosis_H37Rv AVECGGDDNLFIMYTSGTTGHPKGVVHTHESVHSAASSWASTIDVRYR-D
MAB_4559|M.abscessus_ATCC_1997 DTRTGGDSLLGVFYTGGTTGNPKGVMLSHNNVLASAMGSLSTGNFLTRGG
MLBr_02546|M.leprae_Br4923 PAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKVPFRAH-E
. :: *.***. **.. . : .
Mvan_4263|M.vanbaalenii_PYR-1 AALICVPPYHIAGVSAALSNLYAGRKMVYLTQFDAGRWVDLVTGEGVTSA
Mflv_2385|M.gilvum_PYR-GCK AALICVPPYHIAGVSAALSNLYAGRKMVYLRHFDAEKWVRLVADEGVTSA
MSMEG_4883|M.smegmatis_MC2_155 AALICVPPYHIAGVSAAMSNLYAGRKMVYLRNFDAHRWVELVRTEGVTSA
TH_2995|M.thermoresistible__bu AALVCVPPYHIAGVGAALSNLYAGRKIVCLSRFDPAEWVRLVADEKVTTA
MMAR_0466|M.marinum_M AALICVPPYHIAGVSAVLSNLYAGRKMVYLTNFDAHEWVRLTNAEQVTTA
MUL_1115|M.ulcerans_Agy99 AALICVPPYHIAGVSAVLSNLYAGRKMVYLNNFDAHEWVRLTNAEQVTTA
MAV_1843|M.avium_104 AALICVPPYHIAGVNAAISNLYAGRKMVYLANFDAREWVRLVAAERVTTA
Mb3116|M.bovis_AF2122/97 RLLLPLPMFHVAALTTVIFSAMRGVTLISMPQFDATKVWSLIVEERVCIG
Rv3089|M.tuberculosis_H37Rv RLLLPLPMFHVAALTTVIFSAMRGVTLISMPQFDATKVWSLIVEERVCIG
MAB_4559|M.abscessus_ATCC_1997 RLLHSAPMFHMADFSAVLAGNLSGSTHVIVPSFSPQGVLDAIVAHDVQDM
MLBr_02546|M.leprae_Br4923 VTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKPATVLEDIEKHQATAM
* * :* . * . : *.. . .
Mvan_4263|M.vanbaalenii_PYR-1 TVVPTMLDRIVSVLE--TRGTTLPTLRTLAYGGSKVPLPLVRKALSLLPA
Mflv_2385|M.gilvum_PYR-GCK TVVPTMLDRIVTVLE--TTDTALPTLRTLAYGGSKVPLPLVRKALSLLPD
MSMEG_4883|M.smegmatis_MC2_155 TVVPTMLDRIVTALE--TTRAELPTLRNLAYGGSKVALPLVRKALELMPN
TH_2995|M.thermoresistible__bu TVVPTMLDRIVTELE--ARPRELPSLRNLAYGGSKVGLPLVRKALELLPD
MMAR_0466|M.marinum_M TVVPTMLDRIVAVLE--TGEHKLPSLRNLAYGGSKVGLPLVRRALELLPD
MUL_1115|M.ulcerans_Agy99 TVVPTMLDRIVAVLE--TGEHKLPSLRNLAYGCSKVGLPLVRRALELLPD
MAV_1843|M.avium_104 TVVPTMLDRIVAALE--RDPVELPSLRNLAYGGSKVGLPLVRKALDLLPH
Mb3116|M.bovis_AF2122/97 GAVPAILNFMRQVPE--FAELDAPDFRYFITGGAPMPEALIK--IYAAKN
Rv3089|M.tuberculosis_H37Rv GAVPAILNFMRQVPE--FAELDAPDFRYFITGGAPMPEALIK--IYAAKN
MAB_4559|M.abscessus_ATCC_1997 LLVPTMIQMLVDHPG--AAQLDLSGIRSITYGASVISEAVLQRATRVFPN
MLBr_02546|M.leprae_Br4923 VVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRALEELGP
**.::. : . :* . . : : :
Mvan_4263|M.vanbaalenii_PYR-1 VGFVNAYGLTETSSTIAVLTPDDHRAALAASDEAAIRRLGSVGQPVPGIE
Mflv_2385|M.gilvum_PYR-GCK VGFVNAYGLTETSSTIAVLTPDDHRAALAAADDAALRRLGSVGQPVPGIE
MSMEG_4883|M.smegmatis_MC2_155 VGFVNAYGLTETSSTIAVLGPDDHRAALASDDPGVTRRLGSVGQVVPGIE
TH_2995|M.thermoresistible__bu VGFVNAYGLTETSSTIAVLGPEDHRIALASDDEKVVRRLGSVGQPVPGIE
MMAR_0466|M.marinum_M VGFVNAYGLTETSSTIAVLTPDDHRAAQSAAAAGLARRLGSVGRPVPGVE
MUL_1115|M.ulcerans_Agy99 VGFVNAYRLTETSSTIAVLTPDDHRAAQSAAAAGLARRLGSVGRPVPGVE
MAV_1843|M.avium_104 VGFVNAYGLTETSSTIAVLTPDDHREAYGNPDEAVAKRLGSVGRPVPGVE
Mb3116|M.bovis_AF2122/97 IEVVQGYALTESCGGGTLLLSEDALR-----------KAGSAGRATMFTD
Rv3089|M.tuberculosis_H37Rv IEVVQGYALTESCGGGTLLLSEDALR-----------KAGSAGRATMFTD
MAB_4559|M.abscessus_ATCC_1997 ARFTQAYGMTEVSPVATLLLPDDHDDPA---------LLRSAGRAAPHCE
MLBr_02546|M.leprae_Br4923 VIYN-MYGSTEIAFATIAGPKDLQIN------------SATVGPVVKGVK
* ** . : :.* . .
Mvan_4263|M.vanbaalenii_PYR-1 VEIRADDGTVLGAGETGELFVRGEQVSGKYTDIG---SVLDEQGWFPTKD
Mflv_2385|M.gilvum_PYR-GCK VEVRAEDGTVLGPGETGELFVRGEQVSGKYTDIG---SVLDENGWFPTKD
MSMEG_4883|M.smegmatis_MC2_155 VQIRGEDGTVLGPGETGELFVRGEQVSGRYTEIG---SVLDEDGWFPTKD
TH_2995|M.thermoresistible__bu IQIRSKNGEVLGPGETGELFVRGPQVSGRYTGIG---SVLDDDGWFPTKD
MMAR_0466|M.marinum_M LQIRGQDGRVLGPGETGELFVRGGQVSGRYTGIG---SVLDGHGWFGTKD
MUL_1115|M.ulcerans_Agy99 LQIRGQDGRVLGPGETGELFVRGEQVSGRYTGIG---SVLDGHGWFGTKD
MAV_1843|M.avium_104 VQIRDESGRVLGPGEPGELYVRGEQVSGKYTGIG---SVLDDEGWFPTRD
Mb3116|M.bovis_AF2122/97 VAVRG-DDGVIREHGEGEVVIKSDILLKEYWNRPEATRDAFDNGWFRTGD
Rv3089|M.tuberculosis_H37Rv VAVRG-DDGVIREHGEGEVVIKSDILLKEYWNRPEATRDAFDNGWFRTGD
MAB_4559|M.abscessus_ATCC_1997 VRIVDPDDNEVPRGEIGEVIVKGDNVMLGYWELPEESAAAIRDGWMHTGD
MLBr_02546|M.leprae_Br4923 VKILDDSGKEVPRGQVGRIFVGNAFPFEGYTGGG---GKQIIDGLLSSGD
: : .. : *.: : . * .* : : *
Mvan_4263|M.vanbaalenii_PYR-1 VAFLDEEGYLFIGGRSDDTIIRGGENIAPAEIEDVLVEHPHVRDCAVVGA
Mflv_2385|M.gilvum_PYR-GCK VAYLDSEGYLFIGGRSDDTIIRGGENIAPAEIEDVLVEHPHVRDCAVVGA
MSMEG_4883|M.smegmatis_MC2_155 VAMLDQDGYLFIGGRSDDTIIRGGENIAPAEIEDVLVEHPDVRDVAVVGP
TH_2995|M.thermoresistible__bu VAMVDEDGYLFIGGRSDDTIIRGGENIAPAEIENVLVEHPQVREAVVVGP
MMAR_0466|M.marinum_M IAMLDEDGYLFIGGRSDDTIIRGGENIAPAELEEVLIEHPQVRDVAVVGV
MUL_1115|M.ulcerans_Agy99 IAMLDEDGYLFIGGRSDDTIIRGGENIAPAELEEVLIEHPQVRDVAVVGV
MAV_1843|M.avium_104 IATLDEAGYLFITGRADDTIIRGGENIAPAELEDVLIEHPHVHEVAVVGV
Mb3116|M.bovis_AF2122/97 IGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIGL
Rv3089|M.tuberculosis_H37Rv IGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIGL
MAB_4559|M.abscessus_ATCC_1997 AGRMDDRGYVYIVDRIKDMVVTGGENVYSAEVENALAKHPAVAACAVIGI
MLBr_02546|M.leprae_Br4923 VGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGV
. .*. . ::* .* .: :: ****: .**:*. : * * ..:*
Mvan_4263|M.vanbaalenii_PYR-1 DDPEWGQIIVAVVVAQPGTEPDVEDLRSHVRSQLRGSRTPDRVVFRDELP
Mflv_2385|M.gilvum_PYR-GCK DDPQWGQIIVAVVVPHQDTAPDPEDLRAHVRSQLRGSRTPDRVVFRDELP
MSMEG_4883|M.smegmatis_MC2_155 EDPQWGQIIVAVVVPADGAEPDADVLREHVRKHLRGSRTPDRVVFRAELP
TH_2995|M.thermoresistible__bu EDPQWGQILVAVVVPAEGETPDPEELRAHVRKHLRGSRTPDKVVFRTELP
MMAR_0466|M.marinum_M EDAQWGQEIVAVVVPVAGVDPDPEELREFVRRSLRGSRTPDRVVFRHELP
MUL_1115|M.ulcerans_Agy99 EDAQWGQEIVAVVVPVAGVDPDPEELREFVRRSLRGSRTPDRVVFRRELP
MAV_1843|M.avium_104 DDPQWGQAIVAVIVPVPGVTPDPDELRDYAHKYLRGSRTPDRVVFRDELP
Mb3116|M.bovis_AF2122/97 PDEKWGEIAAAIVVAD-QNEVSEQQIVEYCGTRLARYKLPKKVIFAEAIP
Rv3089|M.tuberculosis_H37Rv PDEKWGEIAAAIVVAD-QNEVSEQQIVEYCGTRLARYKLPKKVIFAEAIP
MAB_4559|M.abscessus_ATCC_1997 PDEQWGERVHAVVVKQAQSECCDGDLQEHCREHIANYKVPRSFEFVDELP
MLBr_02546|M.leprae_Br4923 DDKEWGARLRAFVVKKQDATIDEDAIKAYVRDHLARYKVPREVIFLEELP
* :** *.:* : . : : * . * :*
Mvan_4263|M.vanbaalenii_PYR-1 TNATGKVLRRELVDELNQDPSPAQPAV--
Mflv_2385|M.gilvum_PYR-GCK TNATGKVLRRELVSELNQDRSPAQPAV--
MSMEG_4883|M.smegmatis_MC2_155 TNATGKVLRRQLVDEL-------QPIS--
TH_2995|M.thermoresistible__bu VNALGKVLRRQLVDELQT----KEPA---
MMAR_0466|M.marinum_M TTATGKILRREIIEELAG----TKS----
MUL_1115|M.ulcerans_Agy99 TTATGKILRREIIEELAG----TKS----
MAV_1843|M.avium_104 TNATGKLLRREIVDSLSA----TMAEK--
Mb3116|M.bovis_AF2122/97 RNPTGKILKTVLREQYSA----TVPK---
Rv3089|M.tuberculosis_H37Rv RNPTGKILKTVLREQYSA----TVPK---
MAB_4559|M.abscessus_ATCC_1997 LSGAGKILKRVLRQKYWE----SRDAGVS
MLBr_02546|M.leprae_Br4923 RNPTGKVLKRELRDFEVH-----------
. **:*: : .