For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VKAEALSISLLLEMAVSEDPDRVALVDGANRLTLGELSSLADGGAGVIAASGAQHVAYVGSGVTMAPLLI FASARAGNAYTPINYRLSAGGIQELIVRLPDPLVIVDSRYRDMVGDVGKLVMDSDEFLAAARAADPVAEF ADPEDVAIVLFTSGTTSKPKAVELTHGNLTSYITGTVEFGSAEPEDAALICVPPYHIAGVNAAISNLYAG RKMVYLANFDAREWVRLVAAERVTTATVVPTMLDRIVAALERDPVELPSLRNLAYGGSKVGLPLVRKALD LLPHVGFVNAYGLTETSSTIAVLTPDDHREAYGNPDEAVAKRLGSVGRPVPGVEVQIRDESGRVLGPGEP GELYVRGEQVSGKYTGIGSVLDDEGWFPTRDIATLDEAGYLFITGRADDTIIRGGENIAPAELEDVLIEH PHVHEVAVVGVDDPQWGQAIVAVIVPVPGVTPDPDELRDYAHKYLRGSRTPDRVVFRDELPTNATGKLLR REIVDSLSATMAEK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1843 | - | - | 100% (504) | AMP-dependent synthetase and ligase |
| M. avium 104 | MAV_4950 | - | 0.0 | 74.21% (504) | AMP-dependent synthetase and ligase |
| M. avium 104 | MAV_2574 | - | 0.0 | 73.48% (494) | feruloyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0276 | fadD2 | 8e-52 | 29.98% (497) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_2385 | - | 0.0 | 73.23% (493) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv0270 | fadD2 | 8e-52 | 29.98% (497) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 5e-51 | 29.55% (511) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4559 | - | 2e-48 | 26.52% (509) | putative long-chain-fatty-acid CoA ligase |
| M. marinum M | MMAR_0466 | - | 0.0 | 74.34% (495) | long-chain-fatty-acid-CoA ligase |
| M. smegmatis MC2 155 | MSMEG_4883 | - | 0.0 | 73.78% (492) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_2995 | - | 0.0 | 72.31% (484) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_1115 | - | 0.0 | 73.74% (495) | long-chain-fatty-acid-CoA ligase |
| M. vanbaalenii PYR-1 | Mvan_4263 | - | 0.0 | 73.43% (493) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0466|M.marinum_M --------------------------------------------------
MUL_1115|M.ulcerans_Agy99 --------------------------------------------------
MAV_1843|M.avium_104 --------------------------------------------------
Mflv_2385|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4263|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4883|M.smegmatis_MC2_155 --------------------------------------------------
TH_2995|M.thermoresistible__bu --------------------------------------------------
Mb0276|M.bovis_AF2122/97 MPNLTDLPGQAVSKLQKSIGQYVARGTAELHYLRKIIESGAIGLEPPLNY
Rv0270|M.tuberculosis_H37Rv MPNLTDLPGQAVSKLQKSIGQYVARGTAELHYLRKIIESGAIGLEPPLNY
MLBr_02546|M.leprae_Br4923 -----------MTKLR----HYLERGAAEVHYLRSIFESGALGFEPPLTY
MAB_4559|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0466|M.marinum_M ----------MSVSLLLEMAASASPDRIAVVSGDLRLTTQQLSDLADGGA
MUL_1115|M.ulcerans_Agy99 ----------MSVSLLLEMAASASPDRIAVVSGDLRLKTQQLSDLADGGA
MAV_1843|M.avium_104 -----MKAEALSISLLLEMAVSEDPDRVALVDGANRLTLGELSSLADGGA
Mflv_2385|M.gilvum_PYR-GCK ----------MSISLLLEMATDAGPDRTAVVSDDTRLTTAELSALADGGA
Mvan_4263|M.vanbaalenii_PYR-1 ----------MSISLLLEMAQDAGPDRTAVVSDDLRLTTAELSALADGGA
MSMEG_4883|M.smegmatis_MC2_155 ----------MSISLLLEMASSGDPDRTAVVSDDTRLTAGELSTLADGAA
TH_2995|M.thermoresistible__bu ------------------MAVSGDPDRVAVIDRDVRLTTTELARLAGGGA
Mb0276|M.bovis_AF2122/97 AALAADIRKWGEVGMLPSHNARRAPNRAAVIDEEGTLTFSELDEAAHAVA
Rv0270|M.tuberculosis_H37Rv AALAADIRKWGEVGMLPSHNARRAPNRAAVIDEEGTLTFSELDEAAHAVA
MLBr_02546|M.leprae_Br4923 AAMAVAMRKWGDLAMLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALA
MAB_4559|M.abscessus_ATCC_1997 ----------MQFTQWLHRALQQYPDRLITIDQGREHTVEQFADRVARLS
*.* :. . :: . :
MMAR_0466|M.marinum_M GAIAASDAQ---HVVYVGTGGAMLPLLIFASARAGLPFTSINYRLSADGI
MUL_1115|M.ulcerans_Agy99 GAIAASDAQ---HVVYVGTGGAMLPLLIFASARAGLPFTSINYRLSADGI
MAV_1843|M.avium_104 GVIAASGAQ---HVAYVGSGVTMAPLLIFASARAGNAYTPINYRLSAGGI
Mflv_2385|M.gilvum_PYR-GCK GVIAASGAR---HVAYVGTGGALLPLLLFASARAAVPVTPLNYRLSAEGL
Mvan_4263|M.vanbaalenii_PYR-1 GVIAASGAR---HVAYVGAGGAMLPLLLFASARAAVPVTPLNYRLSADGL
MSMEG_4883|M.smegmatis_MC2_155 GVIAGSGAA---HVAYVGTGGALLPLLLFASARAAIPFTPLNYRLSAEGL
TH_2995|M.thermoresistible__bu QVIAGSGVQ---HVAYVGLGGAMLPLLIFASTHATVPFTPLNYRLSAEGL
Mb0276|M.bovis_AF2122/97 NGLLAKGVRAGDGVAILARNHRWFVIANYGAARVGARIILLNSEFSGPQI
Rv0270|M.tuberculosis_H37Rv NGLLAKGVRAGDGVAILARNHRWFVIANYGAARVGARIILLNSEFSGPQI
MLBr_02546|M.leprae_Br4923 NGLIAKGVRGGDGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQI
MAB_4559|M.abscessus_ATCC_1997 AGLRANGVRPGDRVGMLSLNSDRYIEYLTAVPWLGAALNAVNIRWSLAEI
: .... : :. . . . :* . * :
MMAR_0466|M.marinum_M AALIRRLPRPLVVVDERYRDTI--AADQSLSSQQFLELAGRAEP------
MUL_1115|M.ulcerans_Agy99 AALIRRLPRPLVVVDERYRETI--AADQSLSSQQFLELAGRAEP------
MAV_1843|M.avium_104 QELIVRLPDPLVIVDSRYRDMVGDVGKLVMDSDEFLAAARAADP------
Mflv_2385|M.gilvum_PYR-GCK RALLDRLPDPLVVVDDEYRDAVGDSYR-TMGSREFFEASRTAEP------
Mvan_4263|M.vanbaalenii_PYR-1 RALLDRLPDPLVVVDDEYRDAVGDGYR-TIGSAEFLDAARTAEP------
MSMEG_4883|M.smegmatis_MC2_155 RELVDRLPTPLVIADGEYAGMLAGAGRPVLTSEEFLSQARTADP------
TH_2995|M.thermoresistible__bu HQLIERLPSPLVIADDEYVDAVAGTGKQVMRSSEFVEAARAAEP------
Mb0276|M.bovis_AF2122/97 KEVSDREGAKVIIYDDEYTKAVSLAQPPLGKLRALGVNPDDDKPSGSSDE
Rv0270|M.tuberculosis_H37Rv KEVSDREGAKVIIYDDEYTKAVSLAQPPLGKLRALGVNPDDDKPSGSSDE
MLBr_02546|M.leprae_Br4923 KEVSEREGAKVIIYDDEYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDE
MAB_4559|M.abscessus_ATCC_1997 GYSLRESGTRVLLVDDTFKAAAAPLRAACACLETVIYCGAGPAPQDMIG-
. ::: * : . *
MMAR_0466|M.marinum_M -VAEFPDPDS----------VAIVLFTSGTTSQPKAVELTHSNLTSYVTT
MUL_1115|M.ulcerans_Agy99 -VAEFPDPDS----------VAIVLFTSGTTSQPKAVELTHSNLTSYVTT
MAV_1843|M.avium_104 -VAEFADPED----------VAIVLFTSGTTSKPKAVELTHGNLTSYITG
Mflv_2385|M.gilvum_PYR-GCK -AAEFADPDS----------VGVVLFTSGTTSKPKAVELTHTNLTSYIMG
Mvan_4263|M.vanbaalenii_PYR-1 -AAEFADPDA----------VGVVLFTSGTTSKPKAVELSHANLTSYIMG
MSMEG_4883|M.smegmatis_MC2_155 -AAEFADPDA----------VAVVLFTSGTTSRPKAVELTHNNLTSYITG
TH_2995|M.thermoresistible__bu -LEGFADPDS----------VGIVLFTSGTTSRPKAVELTHNNLTSYVTG
Mb0276|M.bovis_AF2122/97 TLAELIAHSSTAPAPKASRRASIIILTSGTTGTPKGANRNTPPTLAPIGG
Rv0270|M.tuberculosis_H37Rv TLAELIAHSSTAPAPKASRRASIIILTSGTTGTPKGANRNTPPTLAPIGG
MLBr_02546|M.leprae_Br4923 TLAELIARSSSAPAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGG
MAB_4559|M.abscessus_ATCC_1997 YEDLLASHEPIDDTRTGGDSLLGVFYTGGTTGNPKGVMLSHNNVLASAMG
: . :: *.***. **.. . :
MMAR_0466|M.marinum_M TVEFGCAAP-SDAALICVPPYHIAGVSAVLSNLYAGRKMVYLTNFDAHEW
MUL_1115|M.ulcerans_Agy99 TVEFGCAAP-SDAALICVPPYHIAGVSAVLSNLYAGRKMVYLNNFDAHEW
MAV_1843|M.avium_104 TVEFGSAEP-EDAALICVPPYHIAGVNAAISNLYAGRKMVYLANFDAREW
Mflv_2385|M.gilvum_PYR-GCK TVEFASAEP-DDAALICVPPYHIAGVSAALSNLYAGRKMVYLRHFDAEKW
Mvan_4263|M.vanbaalenii_PYR-1 TVEFASAEP-DDAALICVPPYHIAGVSAALSNLYAGRKMVYLTQFDAGRW
MSMEG_4883|M.smegmatis_MC2_155 TVEFGSAAP-EDAALICVPPYHIAGVSAAMSNLYAGRKMVYLRNFDAHRW
TH_2995|M.thermoresistible__bu TVEFADADA-EDAALVCVPPYHIAGVGAALSNLYAGRKIVCLSRFDPAEW
Mb0276|M.bovis_AF2122/97 ILSHVPFKA-GEVTLLPSPMFHALGYMHAALAMFLGSTLVLRRRFKPALV
Rv0270|M.tuberculosis_H37Rv ILSHVPFKA-GEVTLLPSPMFHALGYMHAALAMFLGSTLVLRRRFKPALV
MLBr_02546|M.leprae_Br4923 ILSKVPFRA-HEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKPATV
MAB_4559|M.abscessus_ATCC_1997 SLSTGNFLTRGGRLLHSAPMFHMADFSAVLAGNLSGSTHVIVPSFSPQGV
:. . * * :* . . * . * *..
MMAR_0466|M.marinum_M VRLTNAEQVTTATVVPTMLDRIVAVLETGEHK--LPSLRNLAYGGSKVGL
MUL_1115|M.ulcerans_Agy99 VRLTNAEQVTTATVVPTMLDRIVAVLETGEHK--LPSLRNLAYGCSKVGL
MAV_1843|M.avium_104 VRLVAAERVTTATVVPTMLDRIVAALERDPVE--LPSLRNLAYGGSKVGL
Mflv_2385|M.gilvum_PYR-GCK VRLVADEGVTSATVVPTMLDRIVTVLETTDTA--LPTLRTLAYGGSKVPL
Mvan_4263|M.vanbaalenii_PYR-1 VDLVTGEGVTSATVVPTMLDRIVSVLETRGTT--LPTLRTLAYGGSKVPL
MSMEG_4883|M.smegmatis_MC2_155 VELVRTEGVTSATVVPTMLDRIVTALETTRAE--LPTLRNLAYGGSKVAL
TH_2995|M.thermoresistible__bu VRLVADEKVTTATVVPTMLDRIVTELEARPRE--LPSLRNLAYGGSKVGL
Mb0276|M.bovis_AF2122/97 LEDIEKHKATSMVVVPVMLSRILDQLEKTEPKPDLSSLKIVFVSGSQLGA
Rv0270|M.tuberculosis_H37Rv LEDIEKHKATSMVVVPVMLSRILDQLEKTEPKPDLSSLKIVFVSGSQLGA
MLBr_02546|M.leprae_Br4923 LEDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGA
MAB_4559|M.abscessus_ATCC_1997 LDAIVAHDVQDMLLVPTMIQMLVDHPGAAQLD--LSGIRSITYGASVISE
: . . :**.*:. :: *. :: : . * :
MMAR_0466|M.marinum_M PLVRRALELLPDVGFVNAYGLTETSSTIAVLTPDDHRAAQSAAAAGLARR
MUL_1115|M.ulcerans_Agy99 PLVRRALELLPDVGFVNAYRLTETSSTIAVLTPDDHRAAQSAAAAGLARR
MAV_1843|M.avium_104 PLVRKALDLLPHVGFVNAYGLTETSSTIAVLTPDDHREAYGNPDEAVAKR
Mflv_2385|M.gilvum_PYR-GCK PLVRKALSLLPDVGFVNAYGLTETSSTIAVLTPDDHRAALAAADDAALRR
Mvan_4263|M.vanbaalenii_PYR-1 PLVRKALSLLPAVGFVNAYGLTETSSTIAVLTPDDHRAALAASDEAAIRR
MSMEG_4883|M.smegmatis_MC2_155 PLVRKALELMPNVGFVNAYGLTETSSTIAVLGPDDHRAALASDDPGVTRR
TH_2995|M.thermoresistible__bu PLVRKALELLPDVGFVNAYGLTETSSTIAVLGPEDHRIALASDDEKVVRR
Mb0276|M.bovis_AF2122/97 ELATRALGDLGPVIYN-MYGSTEVAFATIAGPKD------------LQFN
Rv0270|M.tuberculosis_H37Rv ELATRALGDLGPVIYN-MYGSTEVAFATIAGPKD------------LQFN
MLBr_02546|M.leprae_Br4923 ELATRALEELGPVIYN-MYGSTEIAFATIAGPKD------------LQIN
MAB_4559|M.abscessus_ATCC_1997 AVLQRATRVFPNARFTQAYGMTEVSPVATLLLPDDHDDP---------AL
: :* : . : * ** : . :
MMAR_0466|M.marinum_M LGSVGRPVPGVELQIRGQDGRVLGPGETGELFVRGGQVSGRYTGI---GS
MUL_1115|M.ulcerans_Agy99 LGSVGRPVPGVELQIRGQDGRVLGPGETGELFVRGEQVSGRYTGI---GS
MAV_1843|M.avium_104 LGSVGRPVPGVEVQIRDESGRVLGPGEPGELYVRGEQVSGKYTGI---GS
Mflv_2385|M.gilvum_PYR-GCK LGSVGQPVPGIEVEVRAEDGTVLGPGETGELFVRGEQVSGKYTDI---GS
Mvan_4263|M.vanbaalenii_PYR-1 LGSVGQPVPGIEVEIRADDGTVLGAGETGELFVRGEQVSGKYTDI---GS
MSMEG_4883|M.smegmatis_MC2_155 LGSVGQVVPGIEVQIRGEDGTVLGPGETGELFVRGEQVSGRYTEI---GS
TH_2995|M.thermoresistible__bu LGSVGQPVPGIEIQIRSKNGEVLGPGETGELFVRGPQVSGRYTGI---GS
Mb0276|M.bovis_AF2122/97 PSTVGPVVKGVTVKILDENGNEVPQGAVGRIFVGNAFPFEGYTGG---GG
Rv0270|M.tuberculosis_H37Rv PSTVGPVVKGVTVKILDENGNEVPQGAVGRIFVGNAFPFEGYTGG---GG
MLBr_02546|M.leprae_Br4923 SATVGPVVKGVKVKILDDSGKEVPRGQVGRIFVGNAFPFEGYTGG---GG
MAB_4559|M.abscessus_ATCC_1997 LRSAGRAAPHCEVRIVDPDDNEVPRGEIGEVIVKGDNVMLGYWELPEESA
:.* . :.: .. : * *.: * . * ..
MMAR_0466|M.marinum_M VLDGHGWFGTKDIAMLDEDGYLFIGGRSDDTIIRGGENIAPAELEEVLIE
MUL_1115|M.ulcerans_Agy99 VLDGHGWFGTKDIAMLDEDGYLFIGGRSDDTIIRGGENIAPAELEEVLIE
MAV_1843|M.avium_104 VLDDEGWFPTRDIATLDEAGYLFITGRADDTIIRGGENIAPAELEDVLIE
Mflv_2385|M.gilvum_PYR-GCK VLDENGWFPTKDVAYLDSEGYLFIGGRSDDTIIRGGENIAPAEIEDVLVE
Mvan_4263|M.vanbaalenii_PYR-1 VLDEQGWFPTKDVAFLDEEGYLFIGGRSDDTIIRGGENIAPAEIEDVLVE
MSMEG_4883|M.smegmatis_MC2_155 VLDEDGWFPTKDVAMLDQDGYLFIGGRSDDTIIRGGENIAPAEIEDVLVE
TH_2995|M.thermoresistible__bu VLDDDGWFPTKDVAMVDEDGYLFIGGRSDDTIIRGGENIAPAEIENVLVE
Mb0276|M.bovis_AF2122/97 KQIIDGLLSSGDVGYFDERGLLYVSGRDDEMIVSGGENVFPAEVEDLISG
Rv0270|M.tuberculosis_H37Rv KQIIDGLLSSGDVGYFDERGLLYVSGRDDEMIVSGGENVFPAEVEDLISG
MLBr_02546|M.leprae_Br4923 KQIIDGLLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISG
MAB_4559|M.abscessus_ATCC_1997 AAIRDGWMHTGDAGRMDDRGYVYIVDRIKDMVVTGGENVYSAEVENALAK
.* : : * . .*. . ::: .* .: :: ****: .**:*: :
MMAR_0466|M.marinum_M HPQVRDVAVVGVEDAQWGQEIVAVVVPVAGVDPDPEELREFVRRSLRGSR
MUL_1115|M.ulcerans_Agy99 HPQVRDVAVVGVEDAQWGQEIVAVVVPVAGVDPDPEELREFVRRSLRGSR
MAV_1843|M.avium_104 HPHVHEVAVVGVDDPQWGQAIVAVIVPVPGVTPDPDELRDYAHKYLRGSR
Mflv_2385|M.gilvum_PYR-GCK HPHVRDCAVVGADDPQWGQIIVAVVVPHQDTAPDPEDLRAHVRSQLRGSR
Mvan_4263|M.vanbaalenii_PYR-1 HPHVRDCAVVGADDPEWGQIIVAVVVAQPGTEPDVEDLRSHVRSQLRGSR
MSMEG_4883|M.smegmatis_MC2_155 HPDVRDVAVVGPEDPQWGQIIVAVVVPADGAEPDADVLREHVRKHLRGSR
TH_2995|M.thermoresistible__bu HPQVREAVVVGPEDPQWGQILVAVVVPAEGETPDPEELRAHVRKHLRGSR
Mb0276|M.bovis_AF2122/97 HPDVVEAAAIGVDDKEFGARLRAFVVKKPGADLDEDTIKQYVRDHLARYK
Rv0270|M.tuberculosis_H37Rv HPDVVEAAAIGVDDKEFGARLRAFVVKKPGADLDEDTIKQYVRDHLARYK
MLBr_02546|M.leprae_Br4923 HPEVVEATAIGVDDKEWGARLRAFVVKKQDATIDEDAIKAYVRDHLARYK
MAB_4559|M.abscessus_ATCC_1997 HPAVAACAVIGIPDEQWGERVHAVVVKQAQSECCDGDLQEHCREHIANYK
** * ..:* * ::* : *.:* :: . : : :
MMAR_0466|M.marinum_M TPDRVVFRHELPTTATGKILRREIIEELAG----TKS--
MUL_1115|M.ulcerans_Agy99 TPDRVVFRRELPTTATGKILRREIIEELAG----TKS--
MAV_1843|M.avium_104 TPDRVVFRDELPTNATGKLLRREIVDSLSA----TMAEK
Mflv_2385|M.gilvum_PYR-GCK TPDRVVFRDELPTNATGKVLRRELVSELNQDRSPAQPAV
Mvan_4263|M.vanbaalenii_PYR-1 TPDRVVFRDELPTNATGKVLRRELVDELNQDPSPAQPAV
MSMEG_4883|M.smegmatis_MC2_155 TPDRVVFRAELPTNATGKVLRRQLVDEL-------QPIS
TH_2995|M.thermoresistible__bu TPDKVVFRTELPVNALGKVLRRQLVDELQT----KEPA-
Mb0276|M.bovis_AF2122/97 VPREVIFLDELPRNPTGKVLKRELRKL------------
Rv0270|M.tuberculosis_H37Rv VPREVIFLDELPRNPTGKVLKRELRKL------------
MLBr_02546|M.leprae_Br4923 VPREVIFLEELPRNPTGKVLKRELRDFEVH---------
MAB_4559|M.abscessus_ATCC_1997 VPRSFEFVDELPLSGAGKILKRVLRQKYWESRDAGVS--
.* . * *** . **:*:* : .