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TAPIWMAFPPEIHSALLSSGPGPGPLLASAGAWSSLSTEYAAAASELTALLDEVQAGAWEGPSAAQYAAA HAPYVAWLTQASADSAAMAARQETAATAYTTALAAMPTLGELAANHALHAALVSTNFFGVNTIPIALNEA DYSRMWVQAATTMSTYQAVSTTAVASAPQATAAPKIMNAGMSGGSGMSGGNPYIMGTALPQNLQEWLEAL FPFNPFSPQGWSMHPSLSMFLSRVETLIPMYAHNPAQLLETIVMLALQFVIHRTLYLIWLILYNPAGLLS FFLSNPVYTLALTTPLLIVPAGAAGGLAGLTGLAAVPAPTLTPPVSPSTIPVTDAPPPPTVGAAPIMGTA SSPGAAPMPALPEAAATPGAPPTPPPTIVGPETSFTAQAFVSPYLVGVLGAATESSVSGKNCRPAADATA AAAAAPAPTAADRQTLRRRRNAPSRVDRGYRYEFLDPEADTEPDERAAADIAPQPNSSLTSERGAGRLGI TTVTGRRASGLARLAGDAFGGAPTVPMMPGSWRPATG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2514 | - | - | 100% (528) | PPE family protein |
| M. avium 104 | MAV_4872 | - | e-108 | 44.26% (549) | PPE family protein |
| M. avium 104 | MAV_4879 | - | e-107 | 46.94% (556) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0262c | PPE2 | 1e-107 | 43.63% (589) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 9e-91 | 41.24% (548) | PPE protein |
| M. tuberculosis H37Rv | Rv0256c | PPE2 | 1e-107 | 43.63% (589) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 9e-80 | 37.88% (586) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-88 | 40.75% (535) | PPE family protein |
| M. marinum M | MMAR_1418 | - | 1e-102 | 45.34% (547) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-96 | 42.78% (547) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 2e-75 | 40.12% (501) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1202 | - | 3e-91 | 41.73% (544) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 5e-92 | 41.29% (557) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1418|M.marinum_M ----------MTAPIWMASPPEVHSALLSSGPGPGPLLSAAAAWSQLSNE
MUL_1202|M.ulcerans_Agy99 --------------MWFTSPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
Mb0262c|M.bovis_AF2122/97 ----------MTAPIWMASPPEVHSALLSSGPGPGPLLVSAEGWHSLSIA
Rv0256c|M.tuberculosis_H37Rv ----------MTAPIWMASPPEVHSALLSSGPGPGPLLVSAEGWHSLSIA
MLBr_01828|M.leprae_Br4923 ----------MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSV
MAV_2514|M.avium_104 ----------MTAPIWMAFPPEIHSALLSSGPGPGPLLASAGAWSSLSTE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
:: ***:**::* ***...: .. * **
MMAR_1418|M.marinum_M YASAANELTAMLGAVQAGPWEGSSAEQYVAAHLPYVAWLMQASVDTTQAA
MUL_1202|M.ulcerans_Agy99 YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
Mb0262c|M.bovis_AF2122/97 YAETADELAALLAAVQAGTWDGPTAAVYVAAHTPYLAWLVQASANSAAMA
Rv0256c|M.tuberculosis_H37Rv YAETADELAALLAAVQAGTWDGPTAAVYVAAHTPYLAWLVQASANSAAMA
MLBr_01828|M.leprae_Br4923 YAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMA
MAV_2514|M.avium_104 YAAAASELTALLDEVQAGAWEGPSAAQYAAAHAPYVAWLTQASADSAAMA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
* * ** : . *:* : * *: **: ** :. : .
MMAR_1418|M.marinum_M AQLETAAAAYTTALAAMPTLPELATNHTIHAALTATNFFGINTIPITLNE
MUL_1202|M.ulcerans_Agy99 AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
Mb0262c|M.bovis_AF2122/97 TRQETAATAYGTALAAMPTLAELGANHALHGVLMATNFFGINTIPIALNE
Rv0256c|M.tuberculosis_H37Rv TRQETAATAYGTALAAMPTLAELGANHALHGVLMATNFFGINTIPIALNE
MLBr_01828|M.leprae_Br4923 AHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNE
MAV_2514|M.avium_104 ARQETAATAYTTALAAMPTLGELAANHALHAALVSTNFFGVNTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
.: :: *:*: :** ***: ** *:. * .* ***:*:*****: .*
MMAR_1418|M.marinum_M ADYVRMWIQAATTMSTYQAVSGTALASTPQTAPAPYILKSNAQTEDS---
MUL_1202|M.ulcerans_Agy99 ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAAPAAAHDH---
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVG-------
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVG-------
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVG-------
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSG-------
Mb0262c|M.bovis_AF2122/97 SDYARMWIQAATTMASYQAVSTAAVAAAPQTTPAPQIVKANAPTAASDEP
Rv0256c|M.tuberculosis_H37Rv SDYARMWIQAATTMASYQAVSTAAVAAAPQTTPAPQIVKANAPTAASDEP
MLBr_01828|M.leprae_Br4923 IDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASSDQP
MAV_2514|M.avium_104 ADYSRMWVQAATTMSTYQAVSTTAVASAPQATAAPKIMNAGMSGG-----
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESAT---
** ***::** .*.:*: *: : ::* : ..* :: .
MMAR_1418|M.marinum_M -------------------------------------------QPPVEGS
MUL_1202|M.ulcerans_Agy99 -------------------------------------------DHDHGGD
Mflv_0325|M.gilvum_PYR-GCK ---------------------------------------------EAGRA
Mvan_0415|M.vanbaalenii_PYR-1 ---------------------------------------------EAGRA
MSMEG_0619|M.smegmatis_MC2_155 ---------------------------------------------EAGSA
MAB_4783|M.abscessus_ATCC_1997 ---------------------------------------------AAART
Mb0262c|M.bovis_AF2122/97 N--------QVQEWLQWLQKIGYTDFYNNVIQPFINWLTNLPFLQAMFSG
Rv0256c|M.tuberculosis_H37Rv N--------QVQEWLQWLQKIGYTDFYNNVIQPFINWLTNLPFLQAMFSG
MLBr_01828|M.leprae_Br4923 SPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGMFSG
MAV_2514|M.avium_104 ---------------------------------------------SGMSG
TH_3113|M.thermoresistible__bu --------------------------------------------AAITGA
MMAR_1418|M.marinum_M -DPLDSLVADILRAITDGRVNWDPVSRTVN---GIEYEEYTDAGDPVWWV
MUL_1202|M.ulcerans_Agy99 PTPIDYFVAEVLRIISGGRIIWDPAEGTVN---GIPYDDYVNAAQPIWWL
Mflv_0325|M.gilvum_PYR-GCK AADMSAFAAQPMAAQAGAAFDVSNIIADII---RLYGEVLRFLFEPIFNF
Mvan_0415|M.vanbaalenii_PYR-1 AADVTAFAAQAQAAEAGSALDLSNIIADLI---RAYGELLRFLFEPIFDF
MSMEG_0619|M.smegmatis_MC2_155 SASVQQMSAQATAAESGSSLDLSSIISDLL---NQYLQGVPGG-QAILDF
MAB_4783|M.abscessus_ATCC_1997 -------AAQDATKPPPIVPDPNDPIEMLL---KNS-QHFLGMYRALKGL
Mb0262c|M.bovis_AF2122/97 FDPWLPSLGNPLTFLSPANIAFALGYPMDI---GSYVAFLSQTFAFIGAD
Rv0256c|M.tuberculosis_H37Rv FDPWLPSLGNPLTFLSPANIAFALGYPMDI---GSYVAFLSQTFAFIGAD
MLBr_01828|M.leprae_Br4923 FDPWLPSLGNPLSFLSPFNIAFALGTPMDI---GSYVGYLSQTFAFIGAD
MAV_2514|M.avium_104 GNPYIMGTALPQNLQEWLEALFPFNPFSPQ---GWSMHPSLSMFLSRVET
TH_3113|M.thermoresistible__bu HVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLLAPL
.
MMAR_1418|M.marinum_M VRALEFSQDFRTFARLLPTDPQAALQFYGELFLFDYPVHIPQLLTWLSQS
MUL_1202|M.ulcerans_Agy99 VRALEFGQDFQTFIKELFTNPIGAIEFMVELVLFDWPTHIAQIIQALAQS
Mflv_0325|M.gilvum_PYR-GCK LRDPIG--NTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGAS
Mvan_0415|M.vanbaalenii_PYR-1 LRDPLG--NTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGAS
MSMEG_0619|M.smegmatis_MC2_155 LKDPLG--NLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWG
MAB_4783|M.abscessus_ATCC_1997 ITDPVG--TIVRIIIDFSTNPAAAIVTWTPLFYVFAYAA-----TFAVMG
Mb0262c|M.bovis_AF2122/97 LAAAFASGNPATIAFTLMFTTVEAIGTIITDTIALVKTLLEQTLALLPAA
Rv0256c|M.tuberculosis_H37Rv LAAAFASGNPATIAFTLMFTTVEAIGTIITDTIALVKTLLEQTLALLPAA
MLBr_01828|M.leprae_Br4923 LAAAFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMI
MAV_2514|M.avium_104 LIPMYAH-NPAQLLETIVMLALQFVIHRTLYLIWLILYNPAGLLSFFLSN
TH_3113|M.thermoresistible__bu LPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAVSGM
: :
MMAR_1418|M.marinum_M PQLLAVALGQ--AVSGLG---------AVTGFAGLAGLAAQPIGTVASAL
MUL_1202|M.ulcerans_Agy99 PQLLAVALGG--VVANLG---------AISGLAGLSGLAGLHSAALPAAI
Mflv_0325|M.gilvum_PYR-GCK ILYPSLFLLP--LLATT---------LAIVAGVGQHLLSLLNTPPAEEAA
Mvan_0415|M.vanbaalenii_PYR-1 ILYPSLLLLP--LVATT---------LAIVLGVGAYLLENLPAPAEDAPA
MSMEG_0619|M.smegmatis_MC2_155 MIFASPFLIP--ALAALGI-------TGLVLLIDHVLNNPVDVPAEDEAP
MAB_4783|M.abscessus_ATCC_1997 TPIYAAIMGP--AAGISIP-------LAITLAS---LSQMPEAPPVDAPA
Mb0262c|M.bovis_AF2122/97 LPLLAAPLAPLTLAPASAA-------GGFAGLSGLAGLVGIPPSAPPVIP
Rv0256c|M.tuberculosis_H37Rv LPLLAAPLAPLTLAPASAA-------GGFAGLSGLAGLVGIPPSAPPVIP
MLBr_01828|M.leprae_Br4923 LPLLTAPLA---VATAGAA-------GSFAGLSELAGLVGVAPPGLPSAP
MAV_2514|M.avium_104 PVYTLALTTPLLIVPAGAA-------GGLAGLTGLAAVPAPTLTPPVSPS
TH_3113|M.thermoresistible__bu LAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGGASA
..
MMAR_1418|M.marinum_M GPVAAPADMLPVTSMAPTVTTPVAAPVSATAPAPATALTAGGPPPVPPAA
MUL_1202|M.ulcerans_Agy99 APIAPP--MPPGVALAPTVAASVAAPTPPSAPPSAASTVANAAPPPPPAP
Mflv_0325|M.gilvum_PYR-GCK EEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPA
Mvan_0415|M.vanbaalenii_PYR-1 EEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPA
MSMEG_0619|M.smegmatis_MC2_155 QEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPA
MAB_4783|M.abscessus_ATCC_1997 ETVPARIDQPHAVAMGGAPAPTASTAAP--TPTTTSPATPGSAPAP-TPP
Mb0262c|M.bovis_AF2122/97 PVAAIAPSIP------TPTPTPAPAPAPTAVTAPTPPPGPPPPPVTAPPP
Rv0256c|M.tuberculosis_H37Rv PVAAIAPSIP------TPTPTPAPAPAPTAVTAPTPPPGPPPPPVTAPPP
MLBr_01828|M.leprae_Br4923 PVAAVAPVVPPSMPTLASIPTPTPMPAPAASTAPVVTP-PGPPPVTAPPS
MAV_2514|M.avium_104 TIPVTDAPPPPTVGAAPIMGTASSPGAAPMPALPEAAATPGAPPTPPPTI
TH_3113|M.thermoresistible__bu APVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPPAPH
. . . . . . ..
MMAR_1418|M.marinum_M GGAG---FSYPYLIGG-GPSIGFGSGMSTSASASAKKKTPEPD---TAAA
MUL_1202|M.ulcerans_Agy99 AAAG---FGFPFVVGG-GPGIGYGEGMSASAAASARRKAPEPDSAALAAA
Mflv_0325|M.gilvum_PYR-GCK AAAA---TFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAAS
Mvan_0415|M.vanbaalenii_PYR-1 AATA---SFVPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASGVAAS
MSMEG_0619|M.smegmatis_MC2_155 PAAA---TFVPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAAASGVAAS
MAB_4783|M.abscessus_ATCC_1997 PAGA---EGLGYAVRGDGPGFGFGPTIGASTGATAHAPSSAVSAAAALAC
Mb0262c|M.bovis_AF2122/97 VTGAG-IQSFGYLVGDLNSAAQARKAVGTGVRKKTPEPD-SAEAPAAAAA
Rv0256c|M.tuberculosis_H37Rv VTGAG-IQSFGYLVGDLNSAAQARKAVGTGVRKKTPEPD-SAEAPAAAAA
MLBr_01828|M.leprae_Br4923 VTGAG-VESFGYLVGRLPSTARG--VVGTSVRQQSSAPD-RIEAPDAAAT
MAV_2514|M.avium_104 VGPETSFTAQAFVSPYLVGVLGAATESSVSGKNCRPAADATAAAAAAPAP
TH_3113|M.thermoresistible__bu SAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAAARE
:
MMAR_1418|M.marinum_M AAARERARARRRRRAT--LRGYGDEFMDIEVDPDWGAPPGEGPGA---ST
MUL_1202|M.ulcerans_Agy99 AAVREEARRRRRKRKT--ERGYGEEFMDVEVDPDWGGPLDDEP-------
Mflv_0325|M.gilvum_PYR-GCK AAERRKRRRRQKEEIK--GRGYADAYADYEELPDDGPPEQPAPR-----V
Mvan_0415|M.vanbaalenii_PYR-1 AAERRKRRRRQKDEIA--GRAYADAYADYEPEPDDEPPVRQEPR-----I
MSMEG_0619|M.smegmatis_MC2_155 LASRRKRRRKKGAQIE--ERGYADAYMDYEE-PDEDPAPQPEPR-----V
MAB_4783|M.abscessus_ATCC_1997 NPATGKSRRRRRRTID--DRGYRHEYATMDDHTPTGP--QDPVT-----A
Mb0262c|M.bovis_AF2122/97 PEEQVQPQRRRRPKIK--QLGRGYEYLDLDPETGHDP-------------
Rv0256c|M.tuberculosis_H37Rv PEEQVQPQRRRRPKIK--QLGRGYEYLDLDPETGHDP-------------
MLBr_01828|M.leprae_Br4923 PQEQARSRWRRRAKVT--PFDS-----SGSPNPKAAP-------------
MAV_2514|M.avium_104 TAADRQTLRRRRNAPSRVDRGYRYEFLDPEADTEPDERAAADIAPQPNSS
TH_3113|M.thermoresistible__bu SAPIRRRRGQKDGLHG-----HRHEHQQPASMSAATAP------------
. :: .
MMAR_1418|M.marinum_M VASDHGAGPVGIAGTVHTGSVTPAAGLTTLGGDDFDGEPRMPMLPGTWDP
MUL_1202|M.ulcerans_Agy99 VASTQGAGRLGFAGTVHSESAATAAGLTTLVADEFGGGPKMPMLPGTWDT
Mflv_0325|M.gilvum_PYR-GCK TASTRGAGPMGFAGTVSRG-DEQAGGLTTLAGDSFGGGPREPMLPGTWDP
Mvan_0415|M.vanbaalenii_PYR-1 AATERGAGPMGFAGTVSRD-AAQAGGLTTLPGDPFGGGPKAPMLPGTWDP
MSMEG_0619|M.smegmatis_MC2_155 RASERGSDAMGFTGTVTRH-DVTAAGLTTLTGDTFDDRPVTPMLPGTWDG
MAB_4783|M.abscessus_ATCC_1997 VASGTGAGRLGFAGVHTATTAVEATGLSTLDGDAEN--RTIPMLPGTWDV
Mb0262c|M.bovis_AF2122/97 TGSPQGAGTLGFAGTTHKASPGQVAGLITLPNDAFGGSPRTPMMPGTWDT
Rv0256c|M.tuberculosis_H37Rv TGSPQGAGTLGFAGTTHKASPGQVAGLITLPNDAFGGSPRTPMMPGTWDT
MLBr_01828|M.leprae_Br4923 TASDQGAGTLGLAGTARQASSGPATGLVTLSNGTFSDSPRAPMLPRTWGA
MAV_2514|M.avium_104 LTSERGAGRLGITTVTGRR----ASGLARLAGDAFGGAPTVPMMPGSWRP
TH_3113|M.thermoresistible__bu --SAAGIRVLGGAGRISRTRGSVPHAEITP------GDPTEPSSPTDRAH
: * :* : . * *
MMAR_1418|M.marinum_M DGARDAGKGS-------------
MUL_1202|M.ulcerans_Agy99 DSDAPSD----------------
Mflv_0325|M.gilvum_PYR-GCK DATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 DTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 DENPAP------SPDDPEGGPRR
MAB_4783|M.abscessus_ATCC_1997 TDDDR------------------
Mb0262c|M.bovis_AF2122/97 DSATRVE----------------
Rv0256c|M.tuberculosis_H37Rv DSATRVE----------------
MLBr_01828|M.leprae_Br4923 DPTFCYNAADIGPAGGWDDE---
MAV_2514|M.avium_104 ATG--------------------
TH_3113|M.thermoresistible__bu RPAEPN-----------------