For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TAPIWMASPPEVHSALLSSGPGPGPLLVSAEGWHSLSIAYAETADELAALLAAVQAGTWDGPTAAVYVAA HTPYLAWLVQASANSAAMATRQETAATAYGTALAAMPTLAELGANHALHGVLMATNFFGINTIPIALNES DYARMWIQAATTMASYQAVSTAAVAAAPQTTPAPQIVKANAPTAASDEPNQVQEWLQWLQKIGYTDFYNN VIQPFINWLTNLPFLQAMFSGFDPWLPSLGNPLTFLSPANIAFALGYPMDIGSYVAFLSQTFAFIGADLA AAFASGNPATIAFTLMFTTVEAIGTIITDTIALVKTLLEQTLALLPAALPLLAAPLAPLTLAPASAAGGF AGLSGLAGLVGIPPSAPPVIPPVAAIAPSIPTPTPTPAPAPAPTAVTAPTPPPGPPPPPVTAPPPVTGAG IQSFGYLVGDLNSAAQARKAVGTGVRKKTPEPDSAEAPAAAAAPEEQVQPQRRRRPKIKQLGRGYEYLDL DPETGHDPTGSPQGAGTLGFAGTTHKASPGQVAGLITLPNDAFGGSPRTPMMPGTWDTDSATRVE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0256c | PPE2 | - | 100% (556) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv0280 | PPE3 | e-104 | 42.38% (571) | PPE family protein |
| M. tuberculosis H37Rv | Rv0453 | PPE11 | 3e-96 | 40.77% (569) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0262c | PPE2 | 0.0 | 100.00% (556) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-85 | 38.92% (573) | PPE protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 0.0 | 63.48% (564) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 1e-82 | 38.41% (578) | PPE family protein |
| M. marinum M | MMAR_2944 | - | 0.0 | 62.54% (574) | PPE family protein |
| M. avium 104 | MAV_1329 | - | 0.0 | 60.43% (561) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-88 | 40.92% (567) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 1e-71 | 37.23% (564) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1202 | - | 1e-106 | 44.58% (563) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-89 | 40.73% (572) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0256c|M.tuberculosis_H37Rv ----------MTAPIWMASPPEVHSALLSSGPGPGPLLVSAEGWHSLSIA
Mb0262c|M.bovis_AF2122/97 ----------MTAPIWMASPPEVHSALLSSGPGPGPLLVSAEGWHSLSIA
MLBr_01828|M.leprae_Br4923 ----------MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSV
MMAR_2944|M.marinum_M ----------MTAPIWMAAPPEVHSALLSSGPGPGSLLVAAGEWTSLSIT
MAV_1329|M.avium_104 -------MRSMTAPIWMASPPEVHSSLLSAGPGPGPLLAAAAAWSSLSVQ
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
MUL_1202|M.ulcerans_Agy99 --------------MWFTSPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
:: ******::* ***...: .. * **
Rv0256c|M.tuberculosis_H37Rv YAETADELAALLAAVQAGTWDGPTAAVYVAAHTPYLAWLVQASANSAAMA
Mb0262c|M.bovis_AF2122/97 YAETADELAALLAAVQAGTWDGPTAAVYVAAHTPYLAWLVQASANSAAMA
MLBr_01828|M.leprae_Br4923 YAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMA
MMAR_2944|M.marinum_M YAEAAEELAALLAAVQAGAWDGPTAEIYVAAHVPYLMWLIQASANSAAMA
MAV_1329|M.avium_104 YAESADELVTLLGAVRAGDWDGPTAGAYLAAHAPYLAWLVRASTDSAAVA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
MUL_1202|M.ulcerans_Agy99 YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
* * ** : . *:* : * *: *** ** :. .* .
Rv0256c|M.tuberculosis_H37Rv TRQETAATAYGTALAAMPTLAELGANHALHGVLMATNFFGINTIPIALNE
Mb0262c|M.bovis_AF2122/97 TRQETAATAYGTALAAMPTLAELGANHALHGVLMATNFFGINTIPIALNE
MLBr_01828|M.leprae_Br4923 AHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNE
MMAR_2944|M.marinum_M GQQQTAAAAYTAALAAMPTLAELGANHTIHTGLVVTNFFGINTIPIAVNE
MAV_1329|M.avium_104 AQQEVAAAAYTAALAAMPTLPELAANHAAHAVLTATNFFGVNTIPIAVNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
MUL_1202|M.ulcerans_Agy99 AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
: :. *:*: :** ***: ** *:. * * ***:*:****** .*
Rv0256c|M.tuberculosis_H37Rv SDYARMWIQAATTMASYQAVSTAAVAAAPQTTPAPQIVKANAPTAASDEP
Mb0262c|M.bovis_AF2122/97 SDYARMWIQAATTMASYQAVSTAAVAAAPQTTPAPQIVKANAPTAASDEP
MLBr_01828|M.leprae_Br4923 IDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASSDQP
MMAR_2944|M.marinum_M ADYVRMWIQAAAVMGGYQDVSATAVAAAPQPAPAPPIMNAAAPAAAAAQA
MAV_1329|M.avium_104 ADYARMWVQAATVMGTYQDVAAAALAATPHTEPAPRVMAAAAPAATAAQS
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVG-------
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVG-------
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVG-------
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSG-------
MUL_1202|M.ulcerans_Agy99 ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAAPAAAHD----
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
** ***::** .*. *: *: : ::* . ..* :: .
Rv0256c|M.tuberculosis_H37Rv N--------QVQEWLQWLQKIGYTDFYNNVIQPFINWLTNLPFLQAMFSG
Mb0262c|M.bovis_AF2122/97 N--------QVQEWLQWLQKIGYTDFYNNVIQPFINWLTNLPFLQAMFSG
MLBr_01828|M.leprae_Br4923 SPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGMFSG
MMAR_2944|M.marinum_M AELPPD---RQSQFLQWLKDIGYVDLYNKLIKPFVDWLANIPFLQALFSG
MAV_1329|M.avium_104 SSYPPD---TQDQWLDWLEKTGFVDFYNRYIQPLIDQLMNNPFFQSLFSG
Mflv_0325|M.gilvum_PYR-GCK ---------------------------------------------EAGRA
Mvan_0415|M.vanbaalenii_PYR-1 ---------------------------------------------EAGRA
MSMEG_0619|M.smegmatis_MC2_155 ---------------------------------------------EAGSA
MAB_4783|M.abscessus_ATCC_1997 ---------------------------------------------AAART
MUL_1202|M.ulcerans_Agy99 ------------------------------------------HDHDHGGD
TH_3113|M.thermoresistible__bu TG----------------------------------------AHVTAELR
Rv0256c|M.tuberculosis_H37Rv FDPWLPSLGNPLTFLSPANIAFALGYPMDIGSYVAFLSQTFAFIGADLAA
Mb0262c|M.bovis_AF2122/97 FDPWLPSLGNPLTFLSPANIAFALGYPMDIGSYVAFLSQTFAFIGADLAA
MLBr_01828|M.leprae_Br4923 FDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGADLAA
MMAR_2944|M.marinum_M FDPYLLTLGNPLTYLSPLNIAFALGYPMDFATYVTLLSQTFAFIGADLAA
MAV_1329|M.avium_104 FDPWLPSLGNPLSFLNPFNIAFALGYPMDFGSYFGYLAQMFSFVAADLAA
Mflv_0325|M.gilvum_PYR-GCK AADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRD
Mvan_0415|M.vanbaalenii_PYR-1 AADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRD
MSMEG_0619|M.smegmatis_MC2_155 SASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKD
MAB_4783|M.abscessus_ATCC_1997 -------AAQDATKPPPIVPDPNDPIEMLLKNS-QHFLGMYRALKGLITD
MUL_1202|M.ulcerans_Agy99 PTPIDYFVAEVLRIISGGRIIWDPAEGTVNGIPYDDYVNAAQPIWWLVRA
TH_3113|M.thermoresistible__bu AAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLLAPLLPGATGD
: :
Rv0256c|M.tuberculosis_H37Rv AFASGNPATIAFTLMFTTVEAIGTIITDTIALVKTLLEQTLALLPAALPL
Mb0262c|M.bovis_AF2122/97 AFASGNPATIAFTLMFTTVEAIGTIITDTIALVKTLLEQTLALLPAALPL
MLBr_01828|M.leprae_Br4923 AFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMILPL
MMAR_2944|M.marinum_M AFASGNPMTIGLTILFTSVEAIGTIITDTIALLKTLLEQTAVLLAALAPM
MAV_1329|M.avium_104 AFASGNPATIAWTLLFTTIEVIGTVITDTIALIKTLLEQMIVLIPAILPL
Mflv_0325|M.gilvum_PYR-GCK PIG--NTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILY
Mvan_0415|M.vanbaalenii_PYR-1 PLG--NTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILY
MSMEG_0619|M.smegmatis_MC2_155 PLG--NLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIF
MAB_4783|M.abscessus_ATCC_1997 PVG--TIVRIIIDFSTNPAAAIVTWTPLFYVFAYAA-----TFAVMGTPI
MUL_1202|M.ulcerans_Agy99 LEFGQDFQTFIKELFTNPIGAIEFMVELVLFDWPTH----IAQIIQALAQ
TH_3113|M.thermoresistible__bu GPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAVSGMLAQLVPL
: .. :
Rv0256c|M.tuberculosis_H37Rv LAAPLAPLTLAPASAAGGFAGLSGLAGLVGIPPSAPPVIPPVAAIAPSIP
Mb0262c|M.bovis_AF2122/97 LAAPLAPLTLAPASAAGGFAGLSGLAGLVGIPPSAPPVIPPVAAIAPSIP
MLBr_01828|M.leprae_Br4923 LTAPLA---VATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVP
MMAR_2944|M.marinum_M LAAPLVP---LAAGAVLVPLGAKGLAALVAVPPPALPVAAPAAPPVALTP
MAV_1329|M.avium_104 LTVSVVP--LVVPTLVGGLAGLTGLAGLHAIPVPPFVPAPTLVPVALAPS
Mflv_0325|M.gilvum_PYR-GCK PSLFLLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSR
Mvan_0415|M.vanbaalenii_PYR-1 PSLLLLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTR
MSMEG_0619|M.smegmatis_MC2_155 ASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----R
MAB_4783|M.abscessus_ATCC_1997 YAAIMGPAAGISIPLAITLAS---LSQMPEAPPVDAPAETVPARIDQPHA
MUL_1202|M.ulcerans_Agy99 SPQLLAVALGGVVANLGAISGLAGLSGLAGLHSAALPAAIAPIAPPMPPG
TH_3113|M.thermoresistible__bu MPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGGASAAPVPAGG
. : *
Rv0256c|M.tuberculosis_H37Rv ------TPTPTPAPAPAPTAVTAPTPPPGPPPPPVTAPPPVTGA----GI
Mb0262c|M.bovis_AF2122/97 ------TPTPTPAPAPAPTAVTAPTPPPGPPPPPVTAPPPVTGA----GI
MLBr_01828|M.leprae_Br4923 PSMPTLASIPTPTPMPAPAASTAPVVTP-PGPPPVTAPPSVTGA----GV
MMAR_2944|M.marinum_M -------NVPPTPPAPAPVDASTLTLTQAPPPPPSTAPPPVSGAGLGVGM
MAV_1329|M.avium_104 -------PPPAPAPAPSPAPAPAPTSAAAPAAAAPGAPPPTPSGPPVATL
Mflv_0325|M.gilvum_PYR-GCK PDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATF------
Mvan_0415|M.vanbaalenii_PYR-1 ADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASF------
MSMEG_0619|M.smegmatis_MC2_155 TDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATF------
MAB_4783|M.abscessus_ATCC_1997 VAMGGAPAPTASTAAP--TPTTTSPATPGSAPAP-TPPPAGAEG------
MUL_1202|M.ulcerans_Agy99 VALAPTVAASVAAPTPPSAPPSAASTVANAAPPPPPAPAAAGFG------
TH_3113|M.thermoresistible__bu PSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPPAPHSAPPVGT
.. . . . .. . ..
Rv0256c|M.tuberculosis_H37Rv QSFGYLVGDLNSAAQARKAVGTGVRKK-TPEPDSAEAPAAAAAPEEQVQP
Mb0262c|M.bovis_AF2122/97 QSFGYLVGDLNSAAQARKAVGTGVRKK-TPEPDSAEAPAAAAAPEEQVQP
MLBr_01828|M.leprae_Br4923 ESFGYLVGRLPSTARG--VVGTSVRQQ-SSAPDRIEAPDAAATPQEQARS
MMAR_2944|M.marinum_M ENFGYMVGGLGADAKS--AARASARKK-APRPDGAEVPVVAPAPSEPARS
MAV_1329|M.avium_104 HSLAYLVGGLTADARR--AANAGVRRREAAAPENVEAPAVAQ-PEEESTQ
Mflv_0325|M.gilvum_PYR-GCK --VPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKR
Mvan_0415|M.vanbaalenii_PYR-1 --VPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKR
MSMEG_0619|M.smegmatis_MC2_155 --VPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKR
MAB_4783|M.abscessus_ATCC_1997 --LGYAVRGDGPGFGFGPTIGASTGATAHAPSSAVSAAAALACNPATGKS
MUL_1202|M.ulcerans_Agy99 --FPFVVGG-GPGIGYGEGMSASAAASARRKAPEPDSAALAAAAAVREEA
TH_3113|M.thermoresistible__bu SGPPYLIAAQPAPGVARRSAGAR---RAASIVEPAGSAAAAAAARESAPI
: : . .
Rv0256c|M.tuberculosis_H37Rv QRRRRPKIKQLGRGYEYLDLDPETGHDPTGSPQ----------GAGTLGF
Mb0262c|M.bovis_AF2122/97 QRRRRPKIKQLGRGYEYLDLDPETGHDPTGSPQ----------GAGTLGF
MLBr_01828|M.leprae_Br4923 RWRRRAKVTPFDS-----SGSPNPKAAPTASDQ----------GAGTLGL
MMAR_2944|M.marinum_M QRRRRTKVGQLGRGFEYMDLESETAPDSMTGSERITTASGLAGSAGTFGF
MAV_1329|M.avium_104 RRRHRAAAKQLGRGYEYLDPEPSTTASQL--------------GAPTLGF
Mflv_0325|M.gilvum_PYR-GCK RRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTR--GAGPMGF
Mvan_0415|M.vanbaalenii_PYR-1 RRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATER--GAGPMGF
MSMEG_0619|M.smegmatis_MC2_155 RRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASER--GSDAMGF
MAB_4783|M.abscessus_ATCC_1997 RRRRRRTIDDRGYRHEYATMDDHTPTGP--QDPVTAVASGT--GAGRLGF
MUL_1202|M.ulcerans_Agy99 RRRRRKRKTERGYGEEFMDVEVDPDWGGPLDDEP--VASTQ--GAGRLGF
TH_3113|M.thermoresistible__bu RRRRGQKDGLHGHRHEHQQPASMSAATAPSAAG-----------IRVLGG
: :: . :*
Rv0256c|M.tuberculosis_H37Rv AGTTHKASPGQVAGLITLPNDAFGGSPRTPMMPGTWDTDSATRVE-----
Mb0262c|M.bovis_AF2122/97 AGTTHKASPGQVAGLITLPNDAFGGSPRTPMMPGTWDTDSATRVE-----
MLBr_01828|M.leprae_Br4923 AGTARQASSGPATGLVTLSNGTFSDSPRAPMLPRTWGADPTFCYNAADIG
MMAR_2944|M.marinum_M SGVAGKSGDRTAAGLIKLAGDGYDDGPRTPAMPSTWDGDPAPSPD-----
MAV_1329|M.avium_104 AGTAANRAAAAPAGLSAPVLDEFADAPRAPMMPATWDGSKQ---------
Mflv_0325|M.gilvum_PYR-GCK AGTVSRG-DEQAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRD
Mvan_0415|M.vanbaalenii_PYR-1 AGTVSRD-AAQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------E
MSMEG_0619|M.smegmatis_MC2_155 TGTVTRH-DVTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPAP------
MAB_4783|M.abscessus_ATCC_1997 AGVHTATTAVEATGLSTLDGDAEN--RTIPMLPGTWDVTDDDR-------
MUL_1202|M.ulcerans_Agy99 AGTVHSESAATAAGLTTLVADEFGGGPKMPMLPGTWDTDSDAPSD-----
TH_3113|M.thermoresistible__bu AGRISRTRGSVPHAEITP------GDPTEPSSPTDRAHRPAEPN------
:* . * *
Rv0256c|M.tuberculosis_H37Rv -----------
Mb0262c|M.bovis_AF2122/97 -----------
MLBr_01828|M.leprae_Br4923 PAGGWDDE---
MMAR_2944|M.marinum_M -----------
MAV_1329|M.avium_104 -----------
Mflv_0325|M.gilvum_PYR-GCK GHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 RHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 SPDDPEGGPRR
MAB_4783|M.abscessus_ATCC_1997 -----------
MUL_1202|M.ulcerans_Agy99 -----------
TH_3113|M.thermoresistible__bu -----------