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VNGTANINDLPFAEDRSRAWRELREAGEAVLSGEEIVLTSAEAVEFAAKRPDIFSSAKAFDRLGSPVPLI PIAIDPPDHTRFRRMLDPFFSPKKMAEREPELRKQAGELIDAILAKGHSDVVADLATPFPSQVFLTLFGL PMADRDRLVQWKDSILEFTDPSSTEATPEVLAHAMELFTYLTEHIAARRADTTGSDMLTQLMQNSEEGGM DDNEILGLCFMFVLAGLDTVTSAVGFALAKLAGDPELRRRISNDYSLIPAFIEELLRVDGPVPFAPRVTT QEVEVAGRVVPKDTTVMLSYGSADRDPLRYEDADNVHLDSKAVHFAFGRGPHRCLGSHLARLELRIILEE WHKRIPEYSLADGKDPQMPWPTGTMGLKSVPLTFPT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1953 | - | - | 100% (386) | cytochrome P450 |
| M. avium 104 | MAV_2658 | - | 0.0 | 84.82% (382) | cytochrome P450 |
| M. avium 104 | MAV_2548 | - | e-100 | 50.53% (374) | putative cytochrome P450 143 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1813c | cyp143 | 3e-85 | 44.00% (375) | cytochrome P450 143 |
| M. gilvum PYR-GCK | Mflv_1764 | - | 5e-91 | 44.97% (378) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1785c | cyp143 | 3e-85 | 44.00% (375) | cytochrome P450 143 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-36 | 30.74% (296) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1406c | - | 3e-39 | 31.61% (367) | cytochrome P450 |
| M. marinum M | MMAR_2631 | cyp143A3 | 5e-97 | 47.21% (377) | cytochrome P450 143A3 Cyp143A3 |
| M. smegmatis MC2 155 | MSMEG_3551 | - | 5e-42 | 29.92% (361) | linalool 8-monooxygenase |
| M. thermoresistible (build 8) | TH_2539 | - | 2e-46 | 32.82% (393) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3106 | cyp143A3 | 6e-97 | 47.48% (377) | cytochrome P450 143A3 Cyp143A3 |
| M. vanbaalenii PYR-1 | Mvan_4983 | - | 1e-91 | 45.77% (378) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1813c|M.bovis_AF2122/97 MTTPGEDHAGSFYLPRLEYSTLPMA----------------------VDR
Rv1785c|M.tuberculosis_H37Rv MTTPGEDHAGSFYLPRLEYSTLPMA----------------------VDR
Mflv_1764|M.gilvum_PYR-GCK MTATAAPLG----LPQVLYGDLPMS----------------------RDR
Mvan_4983|M.vanbaalenii_PYR-1 MSA----------LPHVLYGDLPMA----------------------ADR
MMAR_2631|M.marinum_M MSAPRDERD----IPHFVYAELPMA----------------------TDR
MUL_3106|M.ulcerans_Agy99 MSAPRDERD----IPHFVYAELPMA----------------------TDR
MAV_1953|M.avium_104 MNG------------TANINDLPFA----------------------EDR
MSMEG_3551|M.smegmatis_MC2_155 MGIAPRVNG--AAPPDVPLSEINLGSWD-------------FWALDDDIR
MAB_1406c|M.abscessus_ATCC_199 MSVDVSHTVAP--RYVPGTADNWTN------------------------P
TH_2539|M.thermoresistible__bu VSVQVDKPVDGPVQFDPFSEDYFNG------------------------P
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
:
Mb1813c|M.bovis_AF2122/97 GVGWKTLRDAGPVVFM------------NGWYYLTRREDVLAALRNPKVF
Rv1785c|M.tuberculosis_H37Rv GVGWKTLRDAGPVVFM------------NGWYYLTRREDVLAALRNPKVF
Mflv_1764|M.gilvum_PYR-GCK GHGWATLRDLGPVLYG------------DGWFYLTRREDVLAALRNPEVF
Mvan_4983|M.vanbaalenii_PYR-1 GAGWATLREFGPVAYG------------DGWYYLTRRDDVLAALRNPEVF
MMAR_2631|M.marinum_M GRGWATLRDAGPVVIG------------DGFYYLTRRDDVLDALRHPEVF
MUL_3106|M.ulcerans_Agy99 GRGWATLRDAGPVVIG------------DGFYYLTRRDDVLDALRHPEVF
MAV_1953|M.avium_104 SRAWRELREAGEAVLS------------GEEIVLTSAEAVEFAAKRPDIF
MSMEG_3551|M.smegmatis_MC2_155 DGAFATLRREAPISFHPAFDTEEGFPQGAGHWALTRHDDVFYASRHPELF
MAB_1406c|M.abscessus_ATCC_199 WPMYAALRDHDPVHHVVP-----EYTPDQDYYVLTRHADVYEAARDWETF
TH_2539|M.thermoresistible__bu WQTYRRLRDEAPVY----------YNAEWDFWALSRFDDVAAATKDHETF
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-----------MPLTVFSSFSDCDEALRHPLSA
: * :: * :
Mb1813c|M.bovis_AF2122/97 SSRKALQPPGNPLPVVP----------LAFDPPEHTRYRRILQPYFSPAA
Rv1785c|M.tuberculosis_H37Rv SSRKALQPPGNPLPVVP----------LAFDPPEHTRYRRILQPYFSPAA
Mflv_1764|M.gilvum_PYR-GCK SSRIAYDDMISPVPLVP----------LGFDPPEHTRYRHILHPFFSPQT
Mvan_4983|M.vanbaalenii_PYR-1 SSRIAYDDMISPVPLVP----------LGFDPPEHTRYRRILHPFFSPQA
MMAR_2631|M.marinum_M SSKRAFDILGSPLPLVP----------LAFDPPEHTRFRKVLQPFFSPHA
MUL_3106|M.ulcerans_Agy99 SSKRAFDILGSPLPLVP----------LAFDPPEHTRFRKVLQPFFSPHA
MAV_1953|M.avium_104 SSAKAFDRLGSPVPLIP----------IAIDPPDHTRFRRMLDPFFSPKK
MSMEG_3551|M.smegmatis_MC2_155 SSASGIVIGDQTPELAEYFG---S--MIAMDDPRHTRLRNIVRSAFTPRV
MAB_1406c|M.abscessus_ATCC_199 SSARGLTVTYGDLEKTGMGD---NPPMVMQDPPTHTEFRKLVSRGFTPRQ
TH_2539|M.thermoresistible__bu SSAKGATLDMVKAPEQSIPV---PKVIISMDPPEHNRMRKLVSSVFTPRA
MLBr_02088|M.leprae_Br4923 SDRLKATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKV
*. : * * *.. *.:: *:*
Mb1813c|M.bovis_AF2122/97 LSKALPSLRRHTVAMIDAIAGR---GECEAMADLANLFPFQLFLVLYGLP
Rv1785c|M.tuberculosis_H37Rv LSKALPSLRRHTVAMIDAIAGR---GECEAMADLANLFPFQLFLVLYGLP
Mflv_1764|M.gilvum_PYR-GCK LAALLPSLQAQVADIVEEIARR---DRCEVMAELATPYPSQVFLTLFGLP
Mvan_4983|M.vanbaalenii_PYR-1 LGVLLPSLQAQAADIVETIAQR---DACEVMAELATPYPSQVFLTLFGLP
MMAR_2631|M.marinum_M LAAMLPSLQAQAIEIIDAIAAG---SQCEVITELAIPYPSQVFLTLFGLS
MUL_3106|M.ulcerans_Agy99 LAAMLPSLQAQAIEIIDAIAAG---SQCEVITKLAIPYPSQVFLTLFGLS
MAV_1953|M.avium_104 MAEREPELRKQAGELIDAILAK---GHSDVVADLATPFPSQVFLTLFGLP
MSMEG_3551|M.smegmatis_MC2_155 LAVIEDSVRDRARRLVAGMVDRNPDGHAELVTELAGPLPLQIICDMMGIP
MAB_1406c|M.abscessus_ATCC_199 VTAVEPKVREFVVQRLERLKER---GEGDIVVELFKPLPSMVVAHYLGVP
TH_2539|M.thermoresistible__bu VAALEDMVREKIYRLIERLDPA---AGFDAVADFSAIFPNQVITTMLGVP
MLBr_02088|M.leprae_Br4923 VQALEGDIAALVDSLLDKGAAA---GQFDVIADLAFPLAVAVICRLLGVP
: : : : :..: . :. *:.
Mb1813c|M.bovis_AF2122/97 LEDRDRLIGWKDAVIAMSD--------RPHPTEADVAAARELLEYLTAMV
Rv1785c|M.tuberculosis_H37Rv LEDRDRLIGWKDAVIAMSD--------RPHPTEADVAAARELLEYLTAMV
Mflv_1764|M.gilvum_PYR-GCK LQDRERLIAWKDAIIAFSL--------TTDPSSVDLKPAVELYTYLSEAV
Mvan_4983|M.vanbaalenii_PYR-1 LQDRERLIAWKDAIIAFSL--------TNDPTSVDLTPAVELYGYLTEAV
MMAR_2631|M.marinum_M LADRDRLIRWKDAIIALGL--------LASLDDADLTPALELTSYLVDAI
MUL_3106|M.ulcerans_Agy99 LADRDRLIRWKDAIIALGL--------LASLDDADLTPALELTSYLVDAI
MAV_1953|M.avium_104 MADRDRLVQWKDSILEFTDP------SSTEATPEVLAHAMELFTYLTEHI
MSMEG_3551|M.smegmatis_MC2_155 ESDHQQIFHWTNVILGFGDP------DLTTDFDEFVTVAMDIGAYATALA
MAB_1406c|M.abscessus_ATCC_199 EEDRTQFDAWTDGIVAAASGGA---IDIEAMQGEVAQTIGELMMYFTGLI
TH_2539|M.thermoresistible__bu EEDREQIRRWLDLLIERKPG-Q---IHITDEGYEASVATG---MYYYGLV
MLBr_02088|M.leprae_Br4923 YEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLV
* .: :: *
Mb1813c|M.bovis_AF2122/97 AERRRNP-GPDVLSQVQIGEDP------LSEIEVLGLSHLLILAGLDTVT
Rv1785c|M.tuberculosis_H37Rv AERRRNP-GPDVLSQVQIGEDP------LSEIEVLGLSHLLILAGLDTVT
Mflv_1764|M.gilvum_PYR-GCK AAQRDDP-REGVLSHLLHGDDP------LTDNEAVGLSLVFVLAGLDTVT
Mvan_4983|M.vanbaalenii_PYR-1 ARQREKP-REGILSHLLHGDEQ------LTDNEAVGLSLVFVLAGLDTVT
MMAR_2631|M.marinum_M AAHRRHP-GTDILSQVLLGDDP------LDDSEALGLSYVFVLAGLDTVT
MUL_3106|M.ulcerans_Agy99 AAHRRHP-GTDILSQVLLGDDP------LDDSEALGLSYVFVLAGLDTVT
MAV_1953|M.avium_104 AARRADTTGSDMLTQLMQNSEEG----GMDDNEILGLCFMFVLAGLDTVT
MSMEG_3551|M.smegmatis_MC2_155 DQRRSAPADDLTTSLVQAEVDGE----RLTSAEVASFFILLVVAGNETTR
MAB_1406c|M.abscessus_ATCC_199 ERRRAEPEDDTVSHLVAAGVGADGDIS--GTLQILGFAFTMVTGGNDTTT
TH_2539|M.thermoresistible__bu QKRRAAPQDDMISRLIETEIERDGRIEKLTDVDITGFATMLGGAGAETVT
MLBr_02088|M.leprae_Br4923 KCRRGTPGEDLISRLIELDESGD----QLTEEEIIATCGLLLVAGHETTV
:* . : : . : .* :*.
Mb1813c|M.bovis_AF2122/97 AAVGFSLLELARRPQLRAMLRDNPKQIR-VFIEEIVRLEPSAPVAPRVTT
Rv1785c|M.tuberculosis_H37Rv AAVGFSLLELARRPQLRAMLRDNPKQIR-VFIEEIVRLEPSAPVAPRVTT
Mflv_1764|M.gilvum_PYR-GCK SAIGATMLELARRPELRGALREDPEGIA-VFVEEMIRLEPAAPIVGRVTT
Mvan_4983|M.vanbaalenii_PYR-1 STIGATMLELARRPELRAALLGDPDGIA-GFVEEMIRLEPAAPVVGRVTT
MMAR_2631|M.marinum_M SAIGAALLELARRPQLRQLLRENHGQIA-VFVDEIVRLEPPAPVVPRVTT
MUL_3106|M.ulcerans_Agy99 SAIGAALLELARRPQLRQLLRENHGQIA-VFVDEIVRLEPPAPVVPRVTT
MAV_1953|M.avium_104 SAVGFALAKLAGDPELRRRISNDYSLIP-AFIEELLRVDGPVPFAPRVTT
MSMEG_3551|M.smegmatis_MC2_155 NAISHGVLALTRYPEQRRLWWSRFDELAPTAVEEIVRWASPVSYMRRTVT
MAB_1406c|M.abscessus_ATCC_199 GMLGGAIQLLHQNPAQRQKLIDDPSLIP-GAVEEFLRLTSPVQGLARTAT
TH_2539|M.thermoresistible__bu KLIGNAVVAFADFPDEWQKLRADRSKIP-AAIEELLRFEAPSQYQVRVNT
MLBr_02088|M.leprae_Br4923 NLIANAVLAMLRNPSQWKALSSNPQRAP-LVVEETLRYDPAIHLIGRVAA
:. : : * ::* :* . *. :
Mb1813c|M.bovis_AF2122/97 EPVTVGGMTLPAGSPVRLCMAAVNRDGSDAMSTDELVMD--GKVHRHWGF
Rv1785c|M.tuberculosis_H37Rv EPVTVGGMTLPAGSPVRLCMAAVNRDGSDAMSTDELVMD--GKVHRHWGF
Mflv_1764|M.gilvum_PYR-GCK RPVTVAGVTLPAGSEVRLCLGAINRDGTDEHSGDDLVLD--GKLHKHWGF
Mvan_4983|M.vanbaalenii_PYR-1 REVTVAGVTLPKGAEVRLCLGAINRDGADEHSGDDFVLD--GKLHKHWGF
MMAR_2631|M.marinum_M REVNIAGAKIPAGSRVWLCLGAINRDGSDATSVNDVVMD--GKVHKHWGF
MUL_3106|M.ulcerans_Agy99 REVNIAGAKIPAGSRVWLCLGAINRDGSDATSVNDVVMD--GKVHKHWDF
MAV_1953|M.avium_104 QEVEVAGRVVPKDTTVMLSYGSADRDPLRYEDADNVHLD--SKA-VHFAF
MSMEG_3551|M.smegmatis_MC2_155 RDTELAGTALPAGSKVTLWYGSANRDETKFDNPWMFDVQ--RHPNPHVGF
MAB_1406c|M.abscessus_ATCC_199 RDVIIGDTTIPAGRRALLLYGSANRDEREYGN-DAAELDVLRKPRNILTF
TH_2539|M.thermoresistible__bu RDVTLHGTTIPEGSAVLLLTGSALRDERVFRDPDRLDIDRDRVMGFNLAF
MLBr_02088|M.leprae_Br4923 KDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPD--RPSSRHLAF
. : :. . * .: ** : *
Mb1813c|M.bovis_AF2122/97 GGG-PHRCLGSHLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFA
Rv1785c|M.tuberculosis_H37Rv GGG-PHRCLGSHLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFA
Mflv_1764|M.gilvum_PYR-GCK GGG-PHRCLGSHLARMELKLVVSEWLSRIPDFDLEPGYVPEITWPSATCT
Mvan_4983|M.vanbaalenii_PYR-1 GGG-PHRCLGSHLARMELRLVVTEWLSRIPDFELAPGYVPEITWPSATCT
MMAR_2631|M.marinum_M GGG-THRCLGSHLARMELSLVISEWLRRIPQFELACGYTPEIDWPSATLG
MUL_3106|M.ulcerans_Agy99 GGG-THRCLGSHLARMELSLVISEWLCRIPQFELACGYTPEIDWPSATLG
MAV_1953|M.avium_104 GRG-PHRCLGSHLARLELRIILEEWHKRIPEYSLADGKDPQMPWPTGTMG
MSMEG_3551|M.smegmatis_MC2_155 GGGGAHFCLGANLARREITVLFSELHRHLPDIVATE--EPDRLQSAFIHG
MAB_1406c|M.abscessus_ATCC_199 SHG-NHHCLGAAAARMQSRIALEELLTRIPDFEVDLDGVTWADGS-YVRR
TH_2539|M.thermoresistible__bu GYG-IHSCLGAALARMESRIALEALLDLIPEYEVDRAGLRRVQMS-NVSG
MLBr_02088|M.leprae_Br4923 AVG-SHFCLGAALARLEATVTLSAISARFPQVQLAG--ELVYKPNVAMRG
. * * ***: ** : : . :*:
Mb1813c|M.bovis_AF2122/97 LKNLPLRWS----
Rv1785c|M.tuberculosis_H37Rv LKNLPLRWS----
Mflv_1764|M.gilvum_PYR-GCK LTGLPLRILR---
Mvan_4983|M.vanbaalenii_PYR-1 LPTLPLILTRKTP
MMAR_2631|M.marinum_M LSTLTLQFTS---
MUL_3106|M.ulcerans_Agy99 LSTLPLQFTS---
MAV_1953|M.avium_104 LKSVPLTFPT---
MSMEG_3551|M.smegmatis_MC2_155 IKRLPVAWR----
MAB_1406c|M.abscessus_ATCC_199 PLTVPIRVR----
TH_2539|M.thermoresistible__bu FKNVPVRAGR---
MLBr_02088|M.leprae_Br4923 MSALPVQV-----
:.: