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EGNERFVPRLAPLTLAVKSLANPQFIYNAKAQGVRAERTEAGVVTLYRRDDLMRISRHPAVLGPGGRGGN FGNDNPLIPLEIDGEEHKKWRRLLDPLFAPKQMARLEAAVRNRAAQLVDGFASQTSAELYQAYCAPLPCF TFLELLGAPLEDIEFFTAFKNGVLHPQGETREEIQANQAAAGAMLLEYFTRLVARQRAEGAQGEEVLAVL LRSRIDGQPLTDAELFNIIHLLIFAGLDTVTASMSCILAWLGQHPHERRRLVEDTARIPAAIEELMRYES PAPSGIRYATADIDLGDGLTIRAGEAIHVSWAAANVDPTAHPDPLHVDFDRARFHHLAFGSGIHRCLGSH LARLELRVALEEFLARIPDYAVDTAGLVYDNVSVRTVQQLRITFNANTPSPVDPSQRHAFMAPLTGQRDS VLERNGHEHR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0274 | cyp271A1 | - | 100% (431) | cytochrome P450 271A1 Cyp271A1 |
| M. marinum M | MMAR_2666 | cyp143A4 | 8e-43 | 32.93% (331) | cytochrome P450 143A4 Cyp143A4 |
| M. marinum M | MMAR_4833 | cyp123B1 | 4e-41 | 34.65% (303) | cytochrome P450 123B1 Cyp123B1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1813c | cyp143 | 8e-45 | 35.08% (325) | cytochrome P450 143 |
| M. gilvum PYR-GCK | Mflv_1764 | - | 1e-41 | 32.62% (328) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1785c | cyp143 | 8e-45 | 35.08% (325) | cytochrome P450 143 |
| M. leprae Br4923 | MLBr_02088 | - | 1e-29 | 32.40% (321) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1406c | - | 8e-36 | 30.97% (310) | cytochrome P450 |
| M. avium 104 | MAV_2213 | - | 1e-77 | 40.63% (379) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2240 | - | 4e-37 | 34.02% (291) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_3303 | - | 3e-47 | 31.53% (333) | PUTATIVE putative cytochrome P450 superfamily protein |
| M. ulcerans Agy99 | MUL_3091 | cyp143A4 | 6e-43 | 32.93% (331) | cytochrome P450 143A4 Cyp143A4 |
| M. vanbaalenii PYR-1 | Mvan_0317 | - | 9e-42 | 34.29% (312) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_1406c|M.abscessus_ATCC_199 ----MSVDVSHTVAPRYVPGTADNWTNPWPMYAALRDHDPVHH-------
Mvan_0317|M.vanbaalenii_PYR-1 ---------MVSVQIRYDPFDASILNDPYPTYRLLRDVAPVYR-------
MMAR_0274|M.marinum_M ----------MEGNERFVPRLAPLTLAVKSLANPQFIYNAKAQ-------
MAV_2213|M.avium_104 ----------MTEAGGFVD------QTVTGVAEPQPMYKALRE-------
Mb1813c|M.bovis_AF2122/97 -------MTTPGEDHAGSFYLPRLEYSTLPMAVDRGVGWKTLR-------
Rv1785c|M.tuberculosis_H37Rv -------MTTPGEDHAGSFYLPRLEYSTLPMAVDRGVGWKTLR-------
MUL_3091|M.ulcerans_Agy99 -------MSTPGEGSASSFYLPRLEYSTLPLSADRAVGWNTLR-------
Mflv_1764|M.gilvum_PYR-GCK -------MTAT----AAPLGLPQVLYGDLPMSRDRGHGWATLR-------
TH_3303|M.thermoresistible__bu -------MTTFDTRPTVDFDHHSPEYAQNSAAINAELRAKCP--------
MSMEG_2240|M.smegmatis_MC2_155 --------MDSRIRDDPAVDTAALLRDPYPIFARYRAQAGVFRG------
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAB_1406c|M.abscessus_ATCC_199 ---------VVPEYTPDQDYYVLTRHADVYEAARDWETFSSARGLTVTYG
Mvan_0317|M.vanbaalenii_PYR-1 ---------AEESHT-----WVLSRHADVQAAALDHSTYSSVDGIFPTPP
MMAR_0274|M.marinum_M ---------GVRAERTEAGVVTLYRRDDLMRISRHPAVLGPGGRGGNFG-
MAV_2213|M.avium_104 ---------SNPVFRSPQ-AVVLSRLADIEMALKHTELFSSNMDAVDLG-
Mb1813c|M.bovis_AF2122/97 ---------DAGPVVFMNGWYYLTRREDVLAALRNPKVFSSRKALQPPG-
Rv1785c|M.tuberculosis_H37Rv ---------DAGPVVFMNGWYYLTRREDVLAALRNPKVFSSRKALQPPG-
MUL_3091|M.ulcerans_Agy99 ---------DAGPVVFMNGHYYLTRREDVLAALRNPKIFSSR-ILQPPG-
Mflv_1764|M.gilvum_PYR-GCK ---------DLGPVLYGDGWFYLTRREDVLAALRNPEVFSSRIAYDDMI-
TH_3303|M.thermoresistible__bu ----------VAHTDAHGGFWVISRYDDVVAAAKNDEVFASGYTVNGVSP
MSMEG_2240|M.smegmatis_MC2_155 ---SVMDWSKTPKELMPEHQYAAMSFDAVNTVFRDGKTFNSKIYDSTIG-
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
.
MAB_1406c|M.abscessus_ATCC_199 -DLE--KTGMGDNPPMVMQDPPTHTEFRKLVSRGFTPRQVTAVEPKVREF
Mvan_0317|M.vanbaalenii_PYR-1 -GSD--FIGS-FLPMMIVMDPPRHDQLRALVSRAFTPRRVAGLQGTITQM
MMAR_0274|M.marinum_M ---------NDNPLIPLEIDGEEHKKWRRLLDPLFAPKQMARLEAAVRNR
MAV_2213|M.avium_104 ---------NVRPLIPLQIDPPEHAKYRRILDPLFTPREMARREPLVTEL
Mb1813c|M.bovis_AF2122/97 ---------NPLPVVPLAFDPPEHTRYRRILQPYFSPAALSKALPSLRRH
Rv1785c|M.tuberculosis_H37Rv ---------NPLPVVPLAFDPPEHTRYRRILQPYFSPAALSKALPSLRRH
MUL_3091|M.ulcerans_Agy99 ---------NPLPVVPLAFDPPEHTRYRKALQPYFSPHALGKSRPVLERH
Mflv_1764|M.gilvum_PYR-GCK ---------SPVPLVPLGFDPPEHTRYRHILHPFFSPQTLAALLPSLQAQ
TH_3303|M.thermoresistible__bu LGVT--IPPSPVPMCPIEMDPPEYLPYRKLLNPFFSPGESKKWEPRIAHW
MSMEG_2240|M.smegmatis_MC2_155 ---------LFIGPSILAMEGKTHRDHRNLVSAAFKSKSLARWEPEIARP
MLBr_02088|M.leprae_Br4923 AIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAAL
: : : * : * . :
MAB_1406c|M.abscessus_ATCC_199 VVQRLERLKE-RGEGDIVVELFKPLPSMVVAHYLGVPEEDRTQFDAWTDG
Mvan_0317|M.vanbaalenii_PYR-1 AAELFERLDEGSGSADFVTDFAAILPAAVIADLLGVPATDRDQFRLWSSQ
MMAR_0274|M.marinum_M AAQLVDGFAS-QTSAELYQAYCAPLPCFTFLELLGAPLEDIEFFTAFKNG
MAV_2213|M.avium_104 VNEMIDRFAA-RGECDFHAEFAVPLPCTVFLQLLGLPLEDLDRFLLWKDG
Mb1813c|M.bovis_AF2122/97 TVAMIDAIAG-RGECEAMADLANLFPFQLFLVLYGLPLEDRDRLIGWKDA
Rv1785c|M.tuberculosis_H37Rv TVAMIDAIAG-RGECEAMADLANLFPFQLFLVLYGLPLEDRDRLIGWKDA
MUL_3091|M.ulcerans_Agy99 AAEMIAGFAG-RGECDAMAEFARLYPFQVFLDLYGLPLQDRDRVIAWKDA
Mflv_1764|M.gilvum_PYR-GCK VADIVEEIAR-RDRCEVMAELATPYPSQVFLTLFGLPLQDRERLIAWKDA
TH_3303|M.thermoresistible__bu VDVCLDQVIE-KGSFDLVDDLANPVPSLFTCEFLGLPIEKWNDFASVQHE
MSMEG_2240|M.smegmatis_MC2_155 ICEALVDEFVDTGSADLVRDYTFEFPTRVISKLLGLPEEDLPWFRRRAVE
MLBr_02088|M.leprae_Br4923 VDSLLDKGAA-AGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVSAL
. : . * * . .
MAB_1406c|M.abscessus_ATCC_199 IVAAASGGAIDIEAMQGEVAQTI---GELMMYFTGLIERRRAEPEDDTVS
Mvan_0317|M.vanbaalenii_PYR-1 LVQVDVNHGQTTDALAAAAA--------IYAYFTDFLADRRKNPREDLMS
MMAR_0274|M.marinum_M VLHPQGET-REEIQANQAAAGA-----MLLEYFTRLVARQRAEGAQGEEV
MAV_2213|M.avium_104 VIRPAGDSGFDRRHESSAGVAQ-----QIYEYFDKAIDEHIAVPR--DDV
Mb1813c|M.bovis_AF2122/97 VIAMSDRPHPTEADVAAAR--------ELLEYLTAMVAERRRNPGP----
Rv1785c|M.tuberculosis_H37Rv VIAMSDRPHPTEADVAAAR--------ELLEYLTAMVAERRRNPGP----
MUL_3091|M.ulcerans_Agy99 IIG--DKLYLTREELEVGQL-------ELLEYLNNAIQQRRQNPGS----
Mflv_1764|M.gilvum_PYR-GCK IIAFSLTTDPSSVDLKPAV--------ELYTYLSEAVAAQRDDPRE----
TH_3303|M.thermoresistible__bu IIYT-----PPEEQEDILRRYM-----ELCGEVFQLITERRQNPTG-EGL
MSMEG_2240|M.smegmatis_MC2_155 LISYSVKYKRAFEASAALK-----------DYFLDQIERRRSRPTED--I
MLBr_02088|M.leprae_Br4923 LVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGE--DL
:: . : :
MAB_1406c|M.abscessus_ATCC_199 HLVAAGVGADGDISGTLQILGFAFTMVTGGNDTTTGMLGGAIQLLHQNPA
Mvan_0317|M.vanbaalenii_PYR-1 ALANATVDGIG--LTDEEVLGFCALLLVAGYETTTNLLGNSAVVLAQHRQ
MMAR_0274|M.marinum_M LAVLLRSRIDGQPLTDAELFNIIHLLIFAGLDTVTASMSCILAWLGQHPH
MAV_2213|M.avium_104 LSAMIAADVGGQPLSREELLDICFLFLIAGLDTVTDSLDCFFVYLARHPQ
Mb1813c|M.bovis_AF2122/97 -DVLSQVQIGEDPLSEIEVLGLSHLLILAGLDTVTAAVGFSLLELARRPQ
Rv1785c|M.tuberculosis_H37Rv -DVLSQVQIGEDPLSEIEVLGLSHLLILAGLDTVTAAVGFSLLELARRPQ
MUL_3091|M.ulcerans_Agy99 -DMLSQVMTGPGEFTDLELLGMSHLLILAGLDTVTAAIGFSLLELARRPQ
Mflv_1764|M.gilvum_PYR-GCK -GVLSHLLHGDDPLTDNEAVGLSLVFVLAGLDTVTSAIGATMLELARRPE
TH_3303|M.thermoresistible__bu IDFLVTAEIDGEPIPDDKVFSMVNLVIAGGFDTTTAVTVSSLVYLAEHPE
MSMEG_2240|M.smegmatis_MC2_155 IGDLVTAEIDGEKLTDEAIYSFLRLLLPAGLETTYRSSGNLLYLLLTHPD
MLBr_02088|M.leprae_Br4923 ISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLRNPS
.: .* :*. : .
MAB_1406c|M.abscessus_ATCC_199 QRQKLIDDPSLIPGAVEEFLRLTSPVQGLARTATRDVIIG-DTTIPAGRR
Mvan_0317|M.vanbaalenii_PYR-1 TRRRLAADRTLLGPAVEELLRYDSPAQGLSRTLTRDVTLH-DTTMRQGEK
MMAR_0274|M.marinum_M ERRRLVEDTARIPAAIEELMRYESPAPSGIRYATADIDLGDGLTIRAGEA
MAV_2213|M.avium_104 HRRQLVERPDVLPGAVEELLRWETPVPGVARVATQDVEVG-GCPISKGER
Mb1813c|M.bovis_AF2122/97 LRAMLRDNPKQIRVFIEEIVRLEPSAPVAPRVTTEPVTVG-GMTLPAGSP
Rv1785c|M.tuberculosis_H37Rv LRAMLRDNPKQIRVFIEEIVRLEPSAPVAPRVTTEPVTVG-GMTLPAGSP
MUL_3091|M.ulcerans_Agy99 LRTQLRDNPKEIRVFIEEIVRLEPSAPVAPRITTDFVNVG-GMTLPPGSQ
Mflv_1764|M.gilvum_PYR-GCK LRGALREDPEGIAVFVEEMIRLEPAAPIVGRVTTRPVTVA-GVTLPAGSE
TH_3303|M.thermoresistible__bu DRQRLIDNPDLLPRAIEEFLRAFTPQQALARTVTKPVTVA-GVELQPGER
MSMEG_2240|M.smegmatis_MC2_155 QFAAVQNDHDLIGAAIEEGLRYETPLTTVQRSATKDTELE-GVQIPAGAV
MLBr_02088|M.leprae_Br4923 QWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIG-QTTLTEGDT
: :** :* .. * : : : *
MAB_1406c|M.abscessus_ATCC_199 ALLLYGSANRDEREYGNDAAELDVLRKPRNILTFSHGNHHCLGAAAARMQ
Mvan_0317|M.vanbaalenii_PYR-1 VLLLFGSANRDERAFP-DPDVFDIERTSEHQVAFGRGIHFCLGAALARME
MMAR_0274|M.marinum_M IHVSWAAANVDPTAHP-DPLHVDFDRARFHHLAFGSGIHRCLGSHLARLE
MAV_2213|M.avium_104 VSPLLGAANTDPAEFP-DPETVDFTRSPNRHRAFGGGPHRCLGSHLARME
Mb1813c|M.bovis_AF2122/97 VRLCMAAVNRDGSDAM-STDELVMDGKVHRHWGFGGGPHRCLGSHLARLE
Rv1785c|M.tuberculosis_H37Rv VRLCMAAVNRDGSDAM-STDELVMDGKVHRHWGFGGGPHRCLGSHLARLE
MUL_3091|M.ulcerans_Agy99 VRLCMAAVNRDGSDAM-STNELVMDGKVHRHWGFGGGPHRCLGSHLARIE
Mflv_1764|M.gilvum_PYR-GCK VRLCLGAINRDGTDEH-SGDDLVLDGKLHKHWGFGGGPHRCLGSHLARME
TH_3303|M.thermoresistible__bu VLLSWASANQDETAFE-RPEEIILDRFPNRHTTFGIGIHRCLGSHVARIE
MSMEG_2240|M.smegmatis_MC2_155 IDVCIGSANRDENRWE-RPEEFDIFRKRIPHITFAAGEHTCMGLHLARME
MLBr_02088|M.leprae_Br4923 MVLLLAAANRDPAVYS-RPDEFDPDRPSSRHLAFAVGSHFCLGAALARLE
.: * * . *. * * *:* **::
MAB_1406c|M.abscessus_ATCC_199 SRIALEELLTRIPDFEVDLDGVTWADG-SYVRRPLTVPIRVR--------
Mvan_0317|M.vanbaalenii_PYR-1 ARIALNALLDKVPDWEVDLESARRLRS-GPIRGYTSLPITWTTPV-----
MMAR_0274|M.marinum_M LRVALEEFLARIPDYAVDTAGLVYDNVSVRTVQQLRITFNANTPSPVDPS
MAV_2213|M.avium_104 LRVALREFHRRIPDYEIKPGTQLTYTAALRSVESLPLVFPVR--------
Mb1813c|M.bovis_AF2122/97 LTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS--------
Rv1785c|M.tuberculosis_H37Rv LTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS--------
MUL_3091|M.ulcerans_Agy99 LTVIVAEWLKQLPDFELAPDYSPEIAFPSKTFALKSLPLRWA--------
Mflv_1764|M.gilvum_PYR-GCK LKLVVSEWLSRIPDFDLEPGYVPEITWPSATCTLTGLPLRILR-------
TH_3303|M.thermoresistible__bu LETMIRRVLDRMPDYHVDLAAARRYPSIGIINGWINAPATFTPGQRLRDE
MSMEG_2240|M.smegmatis_MC2_155 TRVAMETLLNRVTDLRLIADDDPHIFG-QPFRSPTAIPVTFRPAG-----
MLBr_02088|M.leprae_Br4923 ATVTLSAISARFP--QVQLAGELVYKPNVAMRGMSALPVQV---------
: :.. :
MAB_1406c|M.abscessus_ATCC_199 -------------------------
Mvan_0317|M.vanbaalenii_PYR-1 -------------------------
MMAR_0274|M.marinum_M QRHAFMAPLTGQRDSVLERNGHEHR
MAV_2213|M.avium_104 -------------------------
Mb1813c|M.bovis_AF2122/97 -------------------------
Rv1785c|M.tuberculosis_H37Rv -------------------------
MUL_3091|M.ulcerans_Agy99 -------------------------
Mflv_1764|M.gilvum_PYR-GCK -------------------------
TH_3303|M.thermoresistible__bu KLPGA--------------------
MSMEG_2240|M.smegmatis_MC2_155 -------------------------
MLBr_02088|M.leprae_Br4923 -------------------------