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MTTPGEDHAGSFYLPRLEYSTLPMAVDRGVGWKTLRDAGPVVFMNGWYYLTRREDVLAALRNPKVFSSRK ALQPPGNPLPVVPLAFDPPEHTRYRRILQPYFSPAALSKALPSLRRHTVAMIDAIAGRGECEAMADLANL FPFQLFLVLYGLPLEDRDRLIGWKDAVIAMSDRPHPTEADVAAARELLEYLTAMVAERRRNPGPDVLSQV QIGEDPLSEIEVLGLSHLLILAGLDTVTAAVGFSLLELARRPQLRAMLRDNPKQIRVFIEEIVRLEPSAP VAPRVTTEPVTVGGMTLPAGSPVRLCMAAVNRDGSDAMSTDELVMDGKVHRHWGFGGGPHRCLGSHLARL ELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1813c | cyp143 | - | 100% (393) | cytochrome P450 143 |
| M. bovis AF2122 / 97 | Mb0801 | cyp126 | 1e-32 | 30.65% (336) | cytochrome P450 126 |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 7e-32 | 26.08% (418) | cytochrome P450 124 CYP124 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1764 | - | 1e-135 | 60.05% (378) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1785c | cyp143 | 0.0 | 100.00% (393) | cytochrome P450 143 |
| M. leprae Br4923 | MLBr_02088 | - | 1e-35 | 31.03% (348) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1406c | - | 3e-36 | 29.35% (368) | cytochrome P450 |
| M. marinum M | MMAR_2666 | cyp143A4 | 1e-176 | 75.89% (394) | cytochrome P450 143A4 Cyp143A4 |
| M. avium 104 | MAV_2931 | - | 1e-167 | 73.39% (387) | P450 heme-thiolate protein |
| M. smegmatis MC2 155 | MSMEG_0762 | - | 4e-38 | 31.23% (365) | cytochrome P450 FAS1 |
| M. thermoresistible (build 8) | TH_2897 | - | 9e-50 | 36.16% (365) | PUTATIVE putative cytochrome P450 superfamily protein |
| M. ulcerans Agy99 | MUL_3091 | cyp143A4 | 1e-176 | 75.63% (394) | cytochrome P450 143A4 Cyp143A4 |
| M. vanbaalenii PYR-1 | Mvan_4983 | - | 1e-131 | 59.42% (377) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1813c|M.bovis_AF2122/97 ----------------------MTTPGEDHAGSFYLPRLEYSTLPMAVDR
Rv1785c|M.tuberculosis_H37Rv ----------------------MTTPGEDHAGSFYLPRLEYSTLPMAVDR
MMAR_2666|M.marinum_M ----------------------MSTPGEGSASSFYLPRLEYSTLPLAADR
MUL_3091|M.ulcerans_Agy99 ----------------------MSTPGEGSASSFYLPRLEYSTLPLSADR
MAV_2931|M.avium_104 ----------------------MS---EGQYGTFHLPRLDFATLPMSVDR
Mflv_1764|M.gilvum_PYR-GCK ----------------------MTAT----AAPLGLPQVLYGDLPMSRDR
Mvan_4983|M.vanbaalenii_PYR-1 ----------------------MSA----------LPHVLYGDLPMAADR
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MSMEG_0762|M.smegmatis_MC2_155 ------------------------------MTQAQALPPLHIRR-DAFDP
MAB_1406c|M.abscessus_ATCC_199 --------------------------MSVDVSHTVAPRYVPGTADNWTNP
TH_2897|M.thermoresistible__bu --------------------------MTASDVTVSPADYDPADQEGLQDP
:
Mb1813c|M.bovis_AF2122/97 GVGWKTLRDAGPVVFMNG-------WYYLTRREDVLAALRNPKVFSSRKA
Rv1785c|M.tuberculosis_H37Rv GVGWKTLRDAGPVVFMNG-------WYYLTRREDVLAALRNPKVFSSRKA
MMAR_2666|M.marinum_M AVGWNTLRDAGPVVFMNG-------HYYLTRREDVLAALRNPKIFSSR-I
MUL_3091|M.ulcerans_Agy99 AVGWNTLRDAGPVVFMNG-------HYYLTRREDVLAALRNPKIFSSR-I
MAV_2931|M.avium_104 GLGWKTLRDAGPVVFMNG-------HYYLTRREDVLAALRNPKVFSST-V
Mflv_1764|M.gilvum_PYR-GCK GHGWATLRDLGPVLYGDG-------WFYLTRREDVLAALRNPEVFSSRIA
Mvan_4983|M.vanbaalenii_PYR-1 GAGWATLREFGPVAYGDG-------WYYLTRRDDVLAALRNPEVFSSRIA
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLT--VFSSFSDCDEALRHPLSASDRLKATLA
MSMEG_0762|M.smegmatis_MC2_155 TPELGEIRAGEGVHVTVNPFG--MQVYLVTRHEDVKTVLSDHERFSNSRP
MAB_1406c|M.abscessus_ATCC_199 WPMYAALRDHDPVHHVVPEYTPDQDYYVLTRHADVYEAARDWETFSSARG
TH_2897|M.thermoresistible__bu QPMYRALRAARVAYSEKQEGG----FYALARYEDVHGAARDWQTFSSADG
: : . :.
Mb1813c|M.bovis_AF2122/97 LQPPGNPLP------------VVPLAFDPPEHTRYRRILQPYFSPAALSK
Rv1785c|M.tuberculosis_H37Rv LQPPGNPLP------------VVPLAFDPPEHTRYRRILQPYFSPAALSK
MMAR_2666|M.marinum_M LQPPGNPLP------------VVPLAFDPPEHTRYRKALQPYFSPHALGK
MUL_3091|M.ulcerans_Agy99 LQPPGNPLP------------VVPLAFDPPEHTRYRKALQPYFSPHALGK
MAV_2931|M.avium_104 LQPPGHPLP------------VLPLAFDPPQHTRYRKILQPYFSPHALGK
Mflv_1764|M.gilvum_PYR-GCK YDDMISPVP------------LVPLGFDPPEHTRYRHILHPFFSPQTLAA
Mvan_4983|M.vanbaalenii_PYR-1 YDDMISPVP------------LVPLGFDPPEHTRYRRILHPFFSPQALGV
MLBr_02088|M.leprae_Br4923 QQAIAAGA------EPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQA
MSMEG_0762|M.smegmatis_MC2_155 PGFVLPGAPQISAEEQASNRAGNLLGLDPPEHQRLRRMLTPEFTIRRIKR
MAB_1406c|M.abscessus_ATCC_199 LTVTYGDLEKTG-----MGDNPPMVMQDPPTHTEFRKLVSRGFTPRQVTA
TH_2897|M.thermoresistible__bu ITLPAVGNP----------EPFIPIEVDPPRLQEYRRILAPLFTPAKTKE
: *** . *: : *:
Mb1813c|M.bovis_AF2122/97 ALPSLRRHTVAMIDAIAGRG-ECEAMADLANLFPFQLFLV--LYGLPLE-
Rv1785c|M.tuberculosis_H37Rv ALPSLRRHTVAMIDAIAGRG-ECEAMADLANLFPFQLFLV--LYGLPLE-
MMAR_2666|M.marinum_M SRPVLERHAAEMIAGFAGRG-ECDAMAEFARLYPFQVFLD--LYGLPLQ-
MUL_3091|M.ulcerans_Agy99 SRPVLERHAAEMIAGFAGRG-ECDAMAEFARLYPFQVFLD--LYGLPLQ-
MAV_2931|M.avium_104 SRPVLERHAAEMIAALADRG-ECEVMADFAHLYPFQVFMD--LYGLPLQ-
Mflv_1764|M.gilvum_PYR-GCK LLPSLQAQVADIVEEIARRD-RCEVMAELATPYPSQVFLT--LFGLPLQ-
Mvan_4983|M.vanbaalenii_PYR-1 LLPSLQAQAADIVETIAQRD-ACEVMAELATPYPSQVFLT--LFGLPLQ-
MLBr_02088|M.leprae_Br4923 LEGDIAALVDSLLDKGAAAG-QFDVIADLAFPLAVAVICR--LLGVPYE-
MSMEG_0762|M.smegmatis_MC2_155 LEPRIVEIVDAHLDAMESAGPPADIVADFALPIPSLVICE--LLGVPYE-
MAB_1406c|M.abscessus_ATCC_199 VEPKVREFVVQRLERLKERG-EGDIVVELFKPLPSMVVAH--YLGVPEE-
TH_2897|M.thermoresistible__bu MVPELRRIAREIIDDIAKRN-SCEFVDEFAYMYPTVAMYRSPWMGEPLEG
: . : . : : :: . . * * :
Mb1813c|M.bovis_AF2122/97 ---DRDRLIGWKDAVIAMSDRPHP-------TEADVAA-ARELLEYLTAM
Rv1785c|M.tuberculosis_H37Rv ---DRDRLIGWKDAVIAMSDRPHP-------TEADVAA-ARELLEYLTAM
MMAR_2666|M.marinum_M ---DRDRVIAWKDAIIG--DKLYL-------TREELEVGQLELLEYLNNA
MUL_3091|M.ulcerans_Agy99 ---DRDRVIAWKDAIIG--DKLYL-------TREELEVGQLELLEYLNNA
MAV_2931|M.avium_104 ---DRDRLLDWKNAVVG--EKPFV-------TESDVEK-SEQLLAYLADA
Mflv_1764|M.gilvum_PYR-GCK ---DRERLIAWKDAIIAFSLTTDP-------SSVDLKP-AVELYTYLSEA
Mvan_4983|M.vanbaalenii_PYR-1 ---DRERLIAWKDAIIAFSLTNDP-------TSVDLTP-AVELYGYLTEA
MLBr_02088|M.leprae_Br4923 ---DAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQL
MSMEG_0762|M.smegmatis_MC2_155 ---DRTDFQQRSARQLDLSAPMP-----------ERLELQRQGRAYMRGL
MAB_1406c|M.abscessus_ATCC_199 ---DRTQFDAWTDGIVAAASGGAID---IEAMQGEVAQTIGELMMYFTGL
TH_2897|M.thermoresistible__bu EKLDPEGSDDWAQNLRDSVRTFIHG------FGEPSARIAGLIIEYSKKL
* *
Mb1813c|M.bovis_AF2122/97 VAERRRNPGPDVLS---QVQIGED--PLSEIEVLGLSHLLILAGLDTVTA
Rv1785c|M.tuberculosis_H37Rv VAERRRNPGPDVLS---QVQIGED--PLSEIEVLGLSHLLILAGLDTVTA
MMAR_2666|M.marinum_M IQQRRQNPGSDMLS---QVMTGPG--EFTDLELLGMSHLLILAGLDTVTA
MUL_3091|M.ulcerans_Agy99 IQQRRQNPGSDMLS---QVMTGPG--EFTDLELLGMSHLLILAGLDTVTA
MAV_2931|M.avium_104 IAQRRQHPGTDMLS---QVMTGEG--NFTDIELLGMSHLLILAGLDTVTA
Mflv_1764|M.gilvum_PYR-GCK VAAQRDDPREGVLS---HLLHGDD--PLTDNEAVGLSLVFVLAGLDTVTS
Mvan_4983|M.vanbaalenii_PYR-1 VARQREKPREGILS---HLLHGDE--QLTDNEAVGLSLVFVLAGLDTVTS
MLBr_02088|M.leprae_Br4923 VKCRRGTPGEDLISRLIELDESGD--QLTEEEIIATCGLLLVAGHETTVN
MSMEG_0762|M.smegmatis_MC2_155 VERSRTRPGDDILG--MLVREHGT--ELTDDELIGIAGLLLLAGHETTSN
MAB_1406c|M.abscessus_ATCC_199 IERRRAEPEDDTVSHLVAAGVGADGDISGTLQILGFAFTMVTGGNDTTTG
TH_2897|M.thermoresistible__bu LEHRRANPADDIPTYLLKAEINGR--KLTEAEMLNTLLLQFNAGPPTTGA
: * * . : : . .* *.
Mb1813c|M.bovis_AF2122/97 AVGFSLLELARRPQLRAMLRDNPKQIRVFIEEIVRLEPSAPVAP-RVTTE
Rv1785c|M.tuberculosis_H37Rv AVGFSLLELARRPQLRAMLRDNPKQIRVFIEEIVRLEPSAPVAP-RVTTE
MMAR_2666|M.marinum_M AIGFSLLELARRPQLRTQLRDNPKEIRVFIEEIVRLEPSAPVAP-RITTD
MUL_3091|M.ulcerans_Agy99 AIGFSLLELARRPQLRTQLRDNPKEIRVFIEEIVRLEPSAPVAP-RITTD
MAV_2931|M.avium_104 AIGFSLFELARRPQLRKELRDNPKQTRVFIEEIVRLEPSAPVAP-RITTE
Mflv_1764|M.gilvum_PYR-GCK AIGATMLELARRPELRGALREDPEGIAVFVEEMIRLEPAAPIVG-RVTTR
Mvan_4983|M.vanbaalenii_PYR-1 TIGATMLELARRPELRAALLGDPDGIAGFVEEMIRLEPAAPVVG-RVTTR
MLBr_02088|M.leprae_Br4923 LIANAVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIG-RVAAK
MSMEG_0762|M.smegmatis_MC2_155 MLGLGVLALLRHPDQLACVRDDPDAVGPAIEELLRWLSIVSTALPRITTT
MAB_1406c|M.abscessus_ATCC_199 MLGGAIQLLHQNPAQRQKLIDDPSLIPGAVEEFLRLTSPVQGLA-RTATR
TH_2897|M.thermoresistible__bu FLSGAFWFLAQRPDLQEVLAGDPTKIPLAMEELLRYLGPTQVSK-RTTTR
:. . : :.* : :* :** :* * ::
Mb1813c|M.bovis_AF2122/97 PVTVGGMTLPAGSPVRLCMAAVNRDGSDA-MSTDELVMDGKVHRHWGFGG
Rv1785c|M.tuberculosis_H37Rv PVTVGGMTLPAGSPVRLCMAAVNRDGSDA-MSTDELVMDGKVHRHWGFGG
MMAR_2666|M.marinum_M FVNVGGMTLPPGSQVRLCMAAVNRDGSDA-MSTNELVMDGKVHRHWGFGG
MUL_3091|M.ulcerans_Agy99 FVNVGGMTLPPGSQVRLCMAAVNRDGSDA-MSTNELVMDGKVHRHWGFGG
MAV_2931|M.avium_104 YVEVGGMTLPPGTSVRLCMAAVNRDDSDS-MSTNELNMDGKVHRHWGFGG
Mflv_1764|M.gilvum_PYR-GCK PVTVAGVTLPAGSEVRLCLGAINRDGTDE-HSGDDLVLDGKLHKHWGFGG
Mvan_4983|M.vanbaalenii_PYR-1 EVTVAGVTLPKGAEVRLCLGAINRDGADE-HSGDDFVLDGKLHKHWGFGG
MLBr_02088|M.leprae_Br4923 DMTIGQTTLTEGDTMVLLLAAANRDPAVY-SRPDEFDPDRPSSRHLAFAV
MSMEG_0762|M.smegmatis_MC2_155 DVELAGVTIPAGHLVFASLPAGNRDPEFI-DDPDTLDIRRGAPGHLAFGH
MAB_1406c|M.abscessus_ATCC_199 DVIIGDTTIPAGRRALLLYGSANRDEREYGNDAAELDVLRKPRNILTFSH
TH_2897|M.thermoresistible__bu PVTVGGTEIPAKCPVGLVWAAANRDEAEF-PNAEEFVLDRFPNRHIAFGM
: :. :. : *** : *.
Mb1813c|M.bovis_AF2122/97 GPHRCLGSHLARLELTLLVGEWLNQIPDFELAPDYAPEIRFP-SKSFALK
Rv1785c|M.tuberculosis_H37Rv GPHRCLGSHLARLELTLLVGEWLNQIPDFELAPDYAPEIRFP-SKSFALK
MMAR_2666|M.marinum_M GPHRCLGSHLARIELTVIVAEWLKQLPDFELAPDYSPEIAFP-SKTFALK
MUL_3091|M.ulcerans_Agy99 GPHRCLGSHLARIELTVIVAEWLKQLPDFELAPDYSPEIAFP-SKTFALK
MAV_2931|M.avium_104 GPHRCLGSHLARIELTVVVAEWLTQIPDFELPDGYEPVINYP-SKSFALK
Mflv_1764|M.gilvum_PYR-GCK GPHRCLGSHLARMELKLVVSEWLSRIPDFDLEPGYVPEITWP-SATCTLT
Mvan_4983|M.vanbaalenii_PYR-1 GPHRCLGSHLARMELRLVVTEWLSRIPDFELAPGYVPEITWP-SATCTLP
MLBr_02088|M.leprae_Br4923 GSHFCLGAALARLEATVTLSAISARFPQVQLAG---ELVYKPNVAMRGMS
MSMEG_0762|M.smegmatis_MC2_155 GVHHCLGAPLARMEMRIALPALLRRFPTLALAEPFEDVRWRPFHFIYGLQ
MAB_1406c|M.abscessus_ATCC_199 GNHHCLGAAAARMQSRIALEELLTRIPDFEVDLDGVTWADGS--YVRRPL
TH_2897|M.thermoresistible__bu GVHRCIGSNVARALIQISLEEWFRQIPKFSIRPGSPTPWDVG--ISRNLQ
* * *:*: ** : : ::* . :
Mb1813c|M.bovis_AF2122/97 NLPLRWS----
Rv1785c|M.tuberculosis_H37Rv NLPLRWS----
MMAR_2666|M.marinum_M SLPLRWA----
MUL_3091|M.ulcerans_Agy99 SLPLRWA----
MAV_2931|M.avium_104 ELPLHWG----
Mflv_1764|M.gilvum_PYR-GCK GLPLRILR---
Mvan_4983|M.vanbaalenii_PYR-1 TLPLILTRKTP
MLBr_02088|M.leprae_Br4923 ALPVQV-----
MSMEG_0762|M.smegmatis_MC2_155 SLAVAW-----
MAB_1406c|M.abscessus_ATCC_199 TVPIRVR----
TH_2897|M.thermoresistible__bu NLELVW-----
: :