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TTDALPKVCTDDLPMPEARDDAWHQLDKHPLVEVEDGYAVTRRDVVELVLKNPSLFSSKRAFDVLASPVP LVPIAFDPPEQTRYRRILQPFFSPRMIKPLEPDLRRQVVDLIEPIARRGQCDFIAEVAAVFPIQVFLTLF GLPLDMRDQFIEWKDAVLNLSAAAGQTSVDEAAQEGMQKALELFMYLTDLIQKRRGAPGDDVLSQVLSIE PPDALSDEEAVGLCFLFVLAGLDTVMDALGFGMQRLAENPDKRQEIVNDPSLIPAAMEELLRLDPPAPFV PRVSTQEVTVAGHTLPEGTRITNYLAVANRDERQFPNPYDIDFHRTENRHVSFGMGVHRCLGSHLARLEM AVLYEEWHKRIPNYHITPGTTPRVHWPRGTVGLDSLHLTIEAGDRA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1950 | - | - | 100% (397) | putative cytochrome P450 126 |
| M. avium 104 | MAV_2658 | - | 1e-97 | 47.29% (387) | cytochrome P450 |
| M. avium 104 | MAV_1953 | - | 1e-97 | 47.24% (381) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1813c | cyp143 | 2e-86 | 44.68% (385) | cytochrome P450 143 |
| M. gilvum PYR-GCK | Mflv_1764 | - | 5e-91 | 45.74% (387) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1785c | cyp143 | 2e-86 | 44.68% (385) | cytochrome P450 143 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-42 | 30.31% (320) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1406c | - | 8e-48 | 33.43% (347) | cytochrome P450 |
| M. marinum M | MMAR_2631 | cyp143A3 | 2e-92 | 46.23% (385) | cytochrome P450 143A3 Cyp143A3 |
| M. smegmatis MC2 155 | MSMEG_4818 | - | 7e-47 | 33.96% (371) | putative cytochrome P450 123 |
| M. thermoresistible (build 8) | TH_2539 | - | 1e-51 | 35.13% (353) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3106 | cyp143A3 | 1e-91 | 45.97% (385) | cytochrome P450 143A3 Cyp143A3 |
| M. vanbaalenii PYR-1 | Mvan_4983 | - | 1e-91 | 46.13% (388) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2631|M.marinum_M --MSAPRDERD----IPHFVYAELPMAT----------------------
MUL_3106|M.ulcerans_Agy99 --MSAPRDERD----IPHFVYAELPMAT----------------------
Mflv_1764|M.gilvum_PYR-GCK --MTATAAPLG----LPQVLYGDLPMSR----------------------
Mvan_4983|M.vanbaalenii_PYR-1 --MSA----------LPHVLYGDLPMAA----------------------
Mb1813c|M.bovis_AF2122/97 --MTTPGEDHAGSFYLPRLEYSTLPMAV----------------------
Rv1785c|M.tuberculosis_H37Rv --MTTPGEDHAGSFYLPRLEYSTLPMAV----------------------
MAV_1950|M.avium_104 --MTTDA--------LPKVCTDDLPMPE----------------------
MSMEG_4818|M.smegmatis_MC2_155 -------MTTP----QMIFDPFSEQYFE----------------------
TH_2539|M.thermoresistible__bu VSVQVDKPVDG----PVQFDPFSEDYFN----------------------
MAB_1406c|M.abscessus_ATCC_199 --MSVDVSHTV----APRYVPGTADNWT----------------------
MLBr_02088|M.leprae_Br4923 --MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRA
MMAR_2631|M.marinum_M DRGRGWATLRDAGPVV-------IGDGFYYLTRRDDVLDALRHPEVFSSK
MUL_3106|M.ulcerans_Agy99 DRGRGWATLRDAGPVV-------IGDGFYYLTRRDDVLDALRHPEVFSSK
Mflv_1764|M.gilvum_PYR-GCK DRGHGWATLRDLGPVL-------YGDGWFYLTRREDVLAALRNPEVFSSR
Mvan_4983|M.vanbaalenii_PYR-1 DRGAGWATLREFGPVA-------YGDGWYYLTRRDDVLAALRNPEVFSSR
Mb1813c|M.bovis_AF2122/97 DRGVGWKTLRDAGPVV-------FMNGWYYLTRREDVLAALRNPKVFSSR
Rv1785c|M.tuberculosis_H37Rv DRGVGWKTLRDAGPVV-------FMNGWYYLTRREDVLAALRNPKVFSSR
MAV_1950|M.avium_104 ARDDAWHQLDKHPLVE-------VEDG-YAVTRRDVVELVLKNPSLFSSK
MSMEG_4818|M.smegmatis_MC2_155 NPFDIYRQMRDDAPLY-----YDSEQDFYALSRHEDVAAALKDHEAFSSS
TH_2539|M.thermoresistible__bu GPWQTYRRLRDEAPVY-----YNAEWDFWALSRFDDVAAATKDHETFSSA
MAB_1406c|M.abscessus_ATCC_199 NPWPMYAALRDHDPVHHVVPEYTPDQDYYVLTRHADVYEAARDWETFSSA
MLBr_02088|M.leprae_Br4923 DPFPVYRALIDYGPMQ------LPGMPLTVFSSFSDCDEALRHPLSASDR
: : . : .: . :. *.
MMAR_2631|M.marinum_M RAFDILGS-------PLPLVP---LAFDPPEHTRFRKVLQPFFSPHALAA
MUL_3106|M.ulcerans_Agy99 RAFDILGS-------PLPLVP---LAFDPPEHTRFRKVLQPFFSPHALAA
Mflv_1764|M.gilvum_PYR-GCK IAYDDMIS-------PVPLVP---LGFDPPEHTRYRHILHPFFSPQTLAA
Mvan_4983|M.vanbaalenii_PYR-1 IAYDDMIS-------PVPLVP---LGFDPPEHTRYRRILHPFFSPQALGV
Mb1813c|M.bovis_AF2122/97 KALQPPGN-------PLPVVP---LAFDPPEHTRYRRILQPYFSPAALSK
Rv1785c|M.tuberculosis_H37Rv KALQPPGN-------PLPVVP---LAFDPPEHTRYRRILQPYFSPAALSK
MAV_1950|M.avium_104 RAFDVLAS-------PVPLVP---IAFDPPEQTRYRRILQPFFSPRMIKP
MSMEG_4818|M.smegmatis_MC2_155 RGCDLAMVKGDE---PPQKSI---IFMDPPEHRHMRSLLNKAFTPRAVQA
TH_2539|M.thermoresistible__bu KGATLDMVKAPEQSIPVPKVI---ISMDPPEHNRMRKLVSSVFTPRAVAA
MAB_1406c|M.abscessus_ATCC_199 RGLTVTYGDLEKTGMGDNPPM---VMQDPPTHTEFRKLVSRGFTPRQVTA
MLBr_02088|M.leprae_Br4923 LKATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQA
: *** : . * :: *:* :
MMAR_2631|M.marinum_M MLPSLQAQAIEIIDAIAAGSQCEVITELAIPYPSQVFLTLFGLSLADRDR
MUL_3106|M.ulcerans_Agy99 MLPSLQAQAIEIIDAIAAGSQCEVITKLAIPYPSQVFLTLFGLSLADRDR
Mflv_1764|M.gilvum_PYR-GCK LLPSLQAQVADIVEEIARRDRCEVMAELATPYPSQVFLTLFGLPLQDRER
Mvan_4983|M.vanbaalenii_PYR-1 LLPSLQAQAADIVETIAQRDACEVMAELATPYPSQVFLTLFGLPLQDRER
Mb1813c|M.bovis_AF2122/97 ALPSLRRHTVAMIDAIAGRGECEAMADLANLFPFQLFLVLYGLPLEDRDR
Rv1785c|M.tuberculosis_H37Rv ALPSLRRHTVAMIDAIAGRGECEAMADLANLFPFQLFLVLYGLPLEDRDR
MAV_1950|M.avium_104 LEPDLRRQVVDLIEPIARRGQCDFIAEVAAVFPIQVFLTLFGLPLDMRDQ
MSMEG_4818|M.smegmatis_MC2_155 QRDTVVEQVEHYLGQIDSDE-FDVVQDFSGPFPVEVITRMAGVEPEYRQQ
TH_2539|M.thermoresistible__bu LEDMVREKIYRLIERLDPAAGFDAVADFSAIFPNQVITTMLGVPEEDREQ
MAB_1406c|M.abscessus_ATCC_199 VEPKVREFVVQRLERLKERGEGDIVVELFKPLPSMVVAHYLGVPEEDRTQ
MLBr_02088|M.leprae_Br4923 LEGDIAALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPE
: : : : .. . :. *: .
MMAR_2631|M.marinum_M LIRWKDAIIALGLL----ASLDDADLTP------ALELTSYLVDAIAAHR
MUL_3106|M.ulcerans_Agy99 LIRWKDAIIALGLL----ASLDDADLTP------ALELTSYLVDAIAAHR
Mflv_1764|M.gilvum_PYR-GCK LIAWKDAIIAFSLT----TDPSSVDLKP------AVELYTYLSEAVAAQR
Mvan_4983|M.vanbaalenii_PYR-1 LIAWKDAIIAFSLT----NDPTSVDLTP------AVELYGYLTEAVARQR
Mb1813c|M.bovis_AF2122/97 LIGWKDAVIAMSDR----PHPTEADVAA------ARELLEYLTAMVAERR
Rv1785c|M.tuberculosis_H37Rv LIGWKDAVIAMSDR----PHPTEADVAA------ARELLEYLTAMVAERR
MAV_1950|M.avium_104 FIEWKDAVLNLSAA----AGQTSVDEAAQEGMQKALELFMYLTDLIQKRR
MSMEG_4818|M.smegmatis_MC2_155 VRHWIDTSLSREPG---QVAYSEAGMKAN-----IDTAMYYYS-LVQKRR
TH_2539|M.thermoresistible__bu IRRWLDLLIERKPG---QIHITDEGYEAS-----VATGMYYYG-LVQKRR
MAB_1406c|M.abscessus_ATCC_199 FDAWTDGIVAAASGGAIDIEAMQGEVAQT-----IGELMMYFTGLIERRR
MLBr_02088|M.leprae_Br4923 FGRVSALLVQSVDPFITITGEPPEATEER--LRAGVWLRDYLEQLVKCRR
. : * : :*
MMAR_2631|M.marinum_M RHPGTDILSQVLLGD--------DPLDDSEALGLSYVFVLAGLDTVTSAI
MUL_3106|M.ulcerans_Agy99 RHPGTDILSQVLLGD--------DPLDDSEALGLSYVFVLAGLDTVTSAI
Mflv_1764|M.gilvum_PYR-GCK DDPREGVLSHLLHGD--------DPLTDNEAVGLSLVFVLAGLDTVTSAI
Mvan_4983|M.vanbaalenii_PYR-1 EKPREGILSHLLHGD--------EQLTDNEAVGLSLVFVLAGLDTVTSTI
Mb1813c|M.bovis_AF2122/97 RNPGPDVLSQVQIGE--------DPLSEIEVLGLSHLLILAGLDTVTAAV
Rv1785c|M.tuberculosis_H37Rv RNPGPDVLSQVQIGE--------DPLSEIEVLGLSHLLILAGLDTVTAAV
MAV_1950|M.avium_104 GAPGDDVLSQVLSIEPP------DALSDEEAVGLCFLFVLAGLDTVMDAL
MSMEG_4818|M.smegmatis_MC2_155 ENPQDDMISRLIAAEIPGENGEMRRLDDVEITGFATLLGGAGAETVTKLI
TH_2539|M.thermoresistible__bu AAPQDDMISRLIETEIE-RDGRIEKLTDVDITGFATMLGGAGAETVTKLI
MAB_1406c|M.abscessus_ATCC_199 AEPEDDTVSHLVAAGVG-ADGDIS--GTLQILGFAFTMVTGGNDTTTGML
MLBr_02088|M.leprae_Br4923 GTPGEDLISRLIELDES-----GDQLTEEEIIATCGLLLVAGHETTVNLI
* . :*:: : . . : .* :*. :
MMAR_2631|M.marinum_M GAALLELARRPQLRQLLRENHGQIAVFVDEIVRLEPPAPVVPRVTTREVN
MUL_3106|M.ulcerans_Agy99 GAALLELARRPQLRQLLRENHGQIAVFVDEIVRLEPPAPVVPRVTTREVN
Mflv_1764|M.gilvum_PYR-GCK GATMLELARRPELRGALREDPEGIAVFVEEMIRLEPAAPIVGRVTTRPVT
Mvan_4983|M.vanbaalenii_PYR-1 GATMLELARRPELRAALLGDPDGIAGFVEEMIRLEPAAPVVGRVTTREVT
Mb1813c|M.bovis_AF2122/97 GFSLLELARRPQLRAMLRDNPKQIRVFIEEIVRLEPSAPVAPRVTTEPVT
Rv1785c|M.tuberculosis_H37Rv GFSLLELARRPQLRAMLRDNPKQIRVFIEEIVRLEPSAPVAPRVTTEPVT
MAV_1950|M.avium_104 GFGMQRLAENPDKRQEIVNDPSLIPAAMEELLRLDPPAPFVPRVSTQEVT
MSMEG_4818|M.smegmatis_MC2_155 GTAMVTFAKFPDQWQKLLDDRSKVPAAVEELLRYEGPVQYNVRYTLKEAR
TH_2539|M.thermoresistible__bu GNAVVAFADFPDEWQKLRADRSKIPAAIEELLRFEAPSQYQVRVNTRDVT
MAB_1406c|M.abscessus_ATCC_199 GGAIQLLHQNPAQRQKLIDDPSLIPGAVEEFLRLTSPVQGLARTATRDVI
MLBr_02088|M.leprae_Br4923 ANAVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMT
. : : * : : ::* :* . * .
MMAR_2631|M.marinum_M IAGAKIPAGSRVWLCLGAINRDGSDATSVNDVVMDG--KVHKHWGFGGGT
MUL_3106|M.ulcerans_Agy99 IAGAKIPAGSRVWLCLGAINRDGSDATSVNDVVMDG--KVHKHWDFGGGT
Mflv_1764|M.gilvum_PYR-GCK VAGVTLPAGSEVRLCLGAINRDGTDEHSGDDLVLDG--KLHKHWGFGGGP
Mvan_4983|M.vanbaalenii_PYR-1 VAGVTLPKGAEVRLCLGAINRDGADEHSGDDFVLDG--KLHKHWGFGGGP
Mb1813c|M.bovis_AF2122/97 VGGMTLPAGSPVRLCMAAVNRDGSDAMSTDELVMDG--KVHRHWGFGGGP
Rv1785c|M.tuberculosis_H37Rv VGGMTLPAGSPVRLCMAAVNRDGSDAMSTDELVMDG--KVHRHWGFGGGP
MAV_1950|M.avium_104 VAGHTLPEGTRITNYLAVANRDERQFPNPYDIDFHR--TENRHVSFGMGV
MSMEG_4818|M.smegmatis_MC2_155 VPSGTIPAGKPVFLLKASANRDERAWTDPDVFDIDRDRTEAQNLGLGYGI
TH_2539|M.thermoresistible__bu LHGTTIPEGSAVLLLTGSALRDERVFRDPDRLDIDRDRVMGFNLAFGYGI
MAB_1406c|M.abscessus_ATCC_199 IGDTTIPAGRRALLLYGSANRDEREYGN-DAAELDVLRKPRNILTFSHGN
MLBr_02088|M.leprae_Br4923 IGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDR--PSSRHLAFAVGS
: .:. * . ** . :. *
MMAR_2631|M.marinum_M HRCLGSHLARMELSLVISEWLRRIPQFELACGYTPEIDWPSATLGLSTLT
MUL_3106|M.ulcerans_Agy99 HRCLGSHLARMELSLVISEWLCRIPQFELACGYTPEIDWPSATLGLSTLP
Mflv_1764|M.gilvum_PYR-GCK HRCLGSHLARMELKLVVSEWLSRIPDFDLEPGYVPEITWPSATCTLTGLP
Mvan_4983|M.vanbaalenii_PYR-1 HRCLGSHLARMELRLVVTEWLSRIPDFELAPGYVPEITWPSATCTLPTLP
Mb1813c|M.bovis_AF2122/97 HRCLGSHLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLP
Rv1785c|M.tuberculosis_H37Rv HRCLGSHLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLP
MAV_1950|M.avium_104 HRCLGSHLARLEMAVLYEEWHKRIPNYHITPGTTPRVHWPRGTVGLDSLH
MSMEG_4818|M.smegmatis_MC2_155 HSCLGAALARLESTIALERLLDFMPRYEVKWDGLQRVHMQN-VAGYSHVP
TH_2539|M.thermoresistible__bu HSCLGAALARMESRIALEALLDLIPEYEVDRAGLRRVQMSN-VSGFKNVP
MAB_1406c|M.abscessus_ATCC_199 HHCLGAAAARMQSRIALEELLTRIPDFEVDLDGVTWADGSY-VRRPLTVP
MLBr_02088|M.leprae_Br4923 HFCLGAALARLEATVTLSAISARFPQVQLAGELVYKP--NVAMRGMSALP
* ***: **:: : :* .: :
MMAR_2631|M.marinum_M LQFTS----
MUL_3106|M.ulcerans_Agy99 LQFTS----
Mflv_1764|M.gilvum_PYR-GCK LRILR----
Mvan_4983|M.vanbaalenii_PYR-1 LILTRKTP-
Mb1813c|M.bovis_AF2122/97 LRWS-----
Rv1785c|M.tuberculosis_H37Rv LRWS-----
MAV_1950|M.avium_104 LTIEAGDRA
MSMEG_4818|M.smegmatis_MC2_155 VKVLR----
TH_2539|M.thermoresistible__bu VRAGR----
MAB_1406c|M.abscessus_ATCC_199 IRVR-----
MLBr_02088|M.leprae_Br4923 VQV------
: