For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VTLDPDSFGHYRILELLGRGGMGRVYRAYDATTDRVVALKVLPPHLAEDQDFQQRFRREARIAAGLNDPH VVPIHGYGEIDGQLYVDMRLIEGRDLAHYITENGGRLSPQRAVAVIEQVAAALDSAHRAGLIHRDVKPMN VLVTTARDFVYLIDFGLARAQADTALTQTGATMGTVAYMAPERFTGTTDHRADVYSLACVLHECLTGKRP FAGDSLEEQLNAHLNTAPPRPSATAPEVPAAFDAVIARGMAKDPERRYQSVTELAEAARAALAPGAVEKP SAPTPQPRAARRVRAAVVGASALTLAVVAAVVVAMVTHGHGSHGATPKTPGSPAPGRTAPPLPAFVAPPD LGVNCQYRAVPDPSSRPVSPPPSGRVPTTPGQIGAVIATNLGDIGISLANSESPCAVNSFISLARQRFFD NTQCARLVDSPDGGSLLCGGPDVDGSGGPGYEFADEYPANQYRPDDPALRATLLYPRGTVVMATEGPNTN GSQFALIFHDSEMDPQSTVLGTIDPAGLATLDKIARAGIAGNRPSGPPANPVTITSVRIG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. avium 104 | MAV_3463 | - | - | 100% (550) | protein kinase/peptidyl-prolyl cis-trans isomerase, cyclophilin-type |
M. avium 104 | MAV_1417 | - | 7e-82 | 44.47% (407) | serine/threonine-protein kinase PknE |
M. avium 104 | MAV_4238 | - | 5e-75 | 44.09% (372) | serine/threonine-protein kinase PknD |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1772 | pknE | 2e-84 | 44.21% (423) | transmembrane serine/threonine-protein kinase E |
M. gilvum PYR-GCK | Mflv_5237 | - | 3e-95 | 57.57% (304) | protein kinase |
M. tuberculosis H37Rv | Rv1743 | pknE | 3e-83 | 43.97% (423) | transmembrane serine/threonine-protein kinase E |
M. leprae Br4923 | MLBr_00492 | ppiB | 2e-73 | 51.72% (261) | putative peptidyl-prolyl cis-trans isomerase |
M. abscessus ATCC 19977 | MAB_4435 | - | 5e-62 | 41.99% (362) | serine/threonine-protein kinase PknJ |
M. marinum M | MMAR_3398 | - | 8e-89 | 49.32% (365) | transmembrane serine/threonine-protein kinase D |
M. smegmatis MC2 155 | MSMEG_1200 | - | 7e-96 | 55.73% (323) | serine/threonine-protein kinase PknD |
M. thermoresistible (build 8) | TH_2333 | ppiB | 1e-63 | 45.96% (272) | PROBABLE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B PPIB |
M. ulcerans Agy99 | MUL_3180 | pknE | 7e-83 | 46.48% (383) | transmembrane serine/threonine-protein kinase E PknE |
M. vanbaalenii PYR-1 | Mvan_1033 | - | 2e-95 | 52.20% (364) | protein kinase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_5237|M.gilvum_PYR-GCK -------------------MNATPFGHYRLQKLIGQGGMGEVYQAYDTKT Mvan_1033|M.vanbaalenii_PYR-1 -------------------MNATPFGHYRLQKLIGRGGMGEVYQAYDTKT MSMEG_1200|M.smegmatis_MC2_155 -------------------MDATPFGHYQLQKLIGRGGMGEVYQAYDTKT MMAR_3398|M.marinum_M -------------------MEGTSFGKYRLLELLGRGGMGEVWRAYDPVT Mb1772|M.bovis_AF2122/97 ------------MDGTAESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVR Rv1743|M.tuberculosis_H37Rv ------------MDGTAESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVR MUL_3180|M.ulcerans_Agy99 -----------MSDATADSREGSQFGPYRLRRIVGRGAMGDVYEAEDTVR MAB_4435|M.abscessus_ATCC_1997 MTSSDRSSPGPGGQQPGDLPPGTVVSGYQIERVLGRGGMGTVYLAANPNL MLBr_00492|M.leprae_Br4923 -------------------------------------------------- TH_2333|M.thermoresistible__bu -------------------------------------------------- MAV_3463|M.avium_104 -----------------MTLDPDSFGHYRILELLGRGGMGRVYRAYDATT Mflv_5237|M.gilvum_PYR-GCK DRVVALKVLPHHMAQDETFQARFRRESQAAAGINDPHVVPIHGFG-EIDG Mvan_1033|M.vanbaalenii_PYR-1 DRVVALKVLPHSMAQDETFQARFRRESQAAAGINDPHVVPIHGYG-EIDG MSMEG_1200|M.smegmatis_MC2_155 QRIVALKVLPPHLAQDASFQDRFRRESHAAAGVNDPHVVPIHGFG-EIDG MMAR_3398|M.marinum_M DRVVAVKILPAEISDDEVFQQRFRREAHVAARLTSPHLIPIHTYG-EIDG Mb1772|M.bovis_AF2122/97 ERIVALKLMSETLSSDPDFRTRMQREARTAGRLQEPHVVPIHDFG-EIDG Rv1743|M.tuberculosis_H37Rv ERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVVPIHDFG-EIDG MUL_3180|M.ulcerans_Agy99 ERVVALKLMSQTLSNDPVFRTRMQREARTAGRLQEPHVVPIHDYG-EIDG MAB_4435|M.abscessus_ATCC_1997 QRSEALKILSAQSSRDPEFRARFMREASLAASLDHPNIVTVHNRGETPEG MLBr_00492|M.leprae_Br4923 -------------------------------------------------- TH_2333|M.thermoresistible__bu -------------------------------------------------- MAV_3463|M.avium_104 DRVVALKVLPPHLAEDQDFQQRFRREARIAAGLNDPHVVPIHGYG-EIDG Mflv_5237|M.gilvum_PYR-GCK RLYLDMRLIEGRNLGTMLQETDKPLGAAFAVMIVDQVANGLDAAHRLGLI Mvan_1033|M.vanbaalenii_PYR-1 RLYLDMRLIEGRNLGTMLQETEKPLGAAFAVTVVEQVANGLDAAHKLDLI MSMEG_1200|M.smegmatis_MC2_155 RLYLDMRLIEGRNLGTMLTRADKPLDPTFVVDMIEQVAMALDAAHQAGLI MMAR_3398|M.marinum_M RLFVDMRLIEGHDLQSVLSR--GPLPPARAVHIIEQVAKALHAAHRDGLL Mb1772|M.bovis_AF2122/97 QLYVDMRLINGVDLAAMLRR-QGPLAPPRAVAIVRQIGSALDAAHAAGAT Rv1743|M.tuberculosis_H37Rv QLYVDMRLINGVDLAAMLRR-QGPLAPPRAVAIVRQIGSALDAAHAAGAT MUL_3180|M.ulcerans_Agy99 QLYVDMRLIDGKDLAAMLKR-YGPLPPPRAVAITRQIGSALDAAHAAGVT MAB_4435|M.abscessus_ATCC_1997 DLWIAMQYVQGSDAHSESAS--GRMSLTRAVHIISEVAKALDYLHARGLV MLBr_00492|M.leprae_Br4923 -------------------------------------------------- TH_2333|M.thermoresistible__bu -------------------------------------------------- MAV_3463|M.avium_104 QLYVDMRLIEGRDLAHYITENGGRLSPQRAVAVIEQVAAALDSAHRAGLI Mflv_5237|M.gilvum_PYR-GCK HRDIKPSNILITDKD-FVYLIDFGLVRTAGEQG-LTTAGSTLGTLAYMAP Mvan_1033|M.vanbaalenii_PYR-1 HRDIKPSNILITGRD-FVYLIDFGLARTAGEKG-LTTAGSTLGTLAYMAP MSMEG_1200|M.smegmatis_MC2_155 HRDVKPSNILITDND-FVYLIDFGLARSAGESG-MTTAGSTLGTLAYMAP MMAR_3398|M.marinum_M HRDVKPSNILLDDDD-FAYLIDFGIARAPGELG-LTAAGDVIGTCHYIAP Mb1772|M.bovis_AF2122/97 HRDVKPENILVSADD-FAYLVDFGIASATTDEK-LTQLGNTVGTLYYMAP Rv1743|M.tuberculosis_H37Rv HRDVKPENILVSADD-FAYLVDFGIASATTDEK-LTQLGNTVGTLYYMAP MUL_3180|M.ulcerans_Agy99 HRDVKPENILVSHDD-FAYLVDFGIASATSDEK-LTQLGSTVGTLYYMAP MAB_4435|M.abscessus_ATCC_1997 HRDVKPANILLSAGDRRIMLGDFGLTRALDDSNSVTSAGNVTATIAYAAP MLBr_00492|M.leprae_Br4923 -------------------------------------------------- TH_2333|M.thermoresistible__bu -------------------------------------------------- MAV_3463|M.avium_104 HRDVKPMNVLVTTARDFVYLIDFGLARAQADTA-LTQTGATMGTVAYMAP Mflv_5237|M.gilvum_PYR-GCK ERFEGGEVDARSDIYALTCVLYECLTGARPYP-AESLEQQIAGHMVSPIP Mvan_1033|M.vanbaalenii_PYR-1 ERFEGGEVDARSDIYALTCVLYECLTGSRPYP-ADSLEQQIAGHMVSEIP MSMEG_1200|M.smegmatis_MC2_155 ERFDAGKVDPRSDIYALACVLYECLTGARPYP-ADSLEQQIAGHMVSPPP MMAR_3398|M.marinum_M ERFNLAQIDARADIYSLACVLYECLTAQHPFP-GNTVDQQISGHLEAPPP Mb1772|M.bovis_AF2122/97 ERFSESHATYRADIYALTCVLYECLTGSPPYQ-GDQLS-VMGAHINQAIP Rv1743|M.tuberculosis_H37Rv ERFSESHATYRADIYALTCVLYECLTGSPPYQ-GDQLS-VMGAHINQAIP MUL_3180|M.ulcerans_Agy99 ERFSSGDVTYRADIYALACVLYECLTGSPPYR-GDQLS-VIGAHLSQPIP MAB_4435|M.abscessus_ATCC_1997 EILSGTAVDGRADVYALGCTLFRMLTGQPPFGSGNSLPAIINAHLSAPPP MLBr_00492|M.leprae_Br4923 -------------------------------------------------- TH_2333|M.thermoresistible__bu -------------------------------------------------- MAV_3463|M.avium_104 ERFTG-TTDHRADVYSLACVLHECLTGKRPFA-GDSLEEQLNAHLNTAPP Mflv_5237|M.gilvum_PYR-GCK RPSDVDPRLAA-FDEVIAKGMAKKPAKRYQSAGELAEAAKRALSAPVRR- Mvan_1033|M.vanbaalenii_PYR-1 RPSDTDPRLAA-FDEVIAKGMAKKPDKRYQSAGELAQAAKRALNAPVRRP MSMEG_1200|M.smegmatis_MC2_155 RPSDKDPRLAA-FDDVIAKGMAKKPAKRYQTAGQLAAAAREALTTPVLRT MMAR_3398|M.marinum_M RPSRIKPGLPAGLDTVIAKGMAKNPADRYETAVALARAAREALTAPLSGP Mb1772|M.bovis_AF2122/97 RPSTVRPGIPVAFDAVIARGMAKNPEDRYVTCGDLSAAAHAALATADQDR Rv1743|M.tuberculosis_H37Rv RPSTVRPGIPVAFDAVIARGMAKNPEDRYVTCGDLSAAAHAALATADQDR MUL_3180|M.ulcerans_Agy99 RPSAARPGIPAGFDNVIARGMAKDPADRYATCGDLSAAAYSALATPDQDR MAB_4435|M.abscessus_ATCC_1997 RISQLAP-VPESWDALIAKAMAKTPADRYQSAGELAMAAQQILTDPAQHR MLBr_00492|M.leprae_Br4923 -----MP-TNEQRRATAKRKLKRQLERR----AKQARWRRVLLISGGV-- TH_2333|M.thermoresistible__bu -----VPTTNAERREAAKRKLEEQLARR----EARARRNRLLAVIGSV-- MAV_3463|M.avium_104 RPSATAPEVPAAFDAVIARGMAKDPERRYQSVTELAEAARAALAPGAVEK * : : . * : Mflv_5237|M.gilvum_PYR-GCK --GSSRH-AARPA---------AKRPRKGLIAATVGALVLVAAGLGLWAW Mvan_1033|M.vanbaalenii_PYR-1 -GRTSRHAAARPD---------RKKPHKGLLAAGAAVLVAALVGIGLWVW MSMEG_1200|M.smegmatis_MC2_155 SGRSGRHSAQRVHRLTTAQRTRARVPRRVAVIAGATVLVAALLSVGMWQL MMAR_3398|M.marinum_M PMRPRTPNAGVAD----GRPDGVAGPGQPDTSTATTVPRRLRHPSPRREP Mb1772|M.bovis_AF2122/97 ATDILRRSQ-------------VAKLPV--PSTHP--------------V Rv1743|M.tuberculosis_H37Rv ATDILRRSQ-------------VAKLPV--PSTHP--------------V MUL_3180|M.ulcerans_Agy99 ATDILQRSQ-------------VAQLPAGFASTSPGGFAPSSPAVPVPGS MAB_4435|M.abscessus_ATCC_1997 --------------------QTVTQPVPATTPAPIAAPEPVHAMAPLAMA MLBr_00492|M.leprae_Br4923 ----------------------VVAVAVIITVVATVVISKLGHKHDT-AS TH_2333|M.thermoresistible__bu ----------------------VAVIALVGAAVYVFVLDRDDAESDTTAQ MAV_3463|M.avium_104 PSAPTPQPRAARR---------VRAAVVGASALTLAVVAAVVVAMVTHGH Mflv_5237|M.gilvum_PYR-GCK APWDDGDDD-------------ALPAGAVAEIAATVPADVRAAG------ Mvan_1033|M.vanbaalenii_PYR-1 APWRHDAGA-------------PLPDGAVEAIAATVPADIRGTG------ MSMEG_1200|M.smegmatis_MC2_155 RDGNSAGREPALADTASTTGPVEAPTGAVPEIAATVPAHIRETG------ MMAR_3398|M.marinum_M TAGRPAEQPRSPSRPWWRRKAVAISAAALLVVAATVAAVITVTTLHSGEQ Mb1772|M.bovis_AF2122/97 SPGTRWPQP--------------TPWAG------------GAPPWG---- Rv1743|M.tuberculosis_H37Rv SPGTRWPQP--------------TPWAG------------GAPPWG---- MUL_3180|M.ulcerans_Agy99 APSTGWPAPSVPGAPVAPSAPVPTPWAGVPGWGVGHTGTTGAPPWG---- MAB_4435|M.abscessus_ATCC_1997 DTGQSMLKH--------------KRIAAIIGVMVLVVASSVVAVLIWP-- MLBr_00492|M.leprae_Br4923 STASNSLTAT---------------------------------------- TH_2333|M.thermoresistible__bu SETPDTQLAG---------------------------------------- MAV_3463|M.avium_104 GSHGATPKTP---------------------------------------- Mflv_5237|M.gilvum_PYR-GCK ---RLVIGVNVPYAPMEFKNADGQLVGFDVELMDAVSRVLGLVPDYRDTA Mvan_1033|M.vanbaalenii_PYR-1 ---RLVIGVNVPYAPMEFKNADGQLVGFDVELMDAVTRVLGLVPDYRNTT MSMEG_1200|M.smegmatis_MC2_155 ---RLVIGVNVPYAPNEFKNSDGEIVGFDVDLMKAVTRTLGLVPDIRETG MMAR_3398|M.marinum_M RFHQVTLPFTGLRDPQGLSVDYGGTVYVGDTLHNRILALSAGSTTPAVLP Mb1772|M.bovis_AF2122/97 -PPSSPLPRSARQPWLWVGVAVAVVVALAGGLGIALAHPWRSSGPRTSAP Rv1743|M.tuberculosis_H37Rv -PPSSPLPRSARQPWLWVGVAVAVVVALAGGLGIALAHPWRSSGPRTSAP MUL_3180|M.ulcerans_Agy99 -QPP-PEPTVAAKTWPWIAAAVAVVVVIAGVLGVVIAHPWRSPGPPTASA MAB_4435|M.abscessus_ATCC_1997 ---RADEGTDPRTKASPSAAQVAPGASLAGQPNTVLDTLLPGQFDYPEGW MLBr_00492|M.leprae_Br4923 -KTPAVTPSVLPLPSFQPSTNLGVNCQYPPSADKAAKPVKPPRAGKVPTD TH_2333|M.thermoresistible__bu -PTPLPAGGPGQLPAFNPPPDLGADCQYPAAATPASKEVNPPRTGKVPTD MAV_3463|M.avium_104 -GSPAPGRTAPPLPAFVAPPDLGVNCQYRAVPDPSSRPVSPPPSGRVPTT . Mflv_5237|M.gilvum_PYR-GCK FDTILPGVVDGTYDVGMSSVTDTKEREELVDFVTYLQAGTQWARRPGTAL Mvan_1033|M.vanbaalenii_PYR-1 FDAILPSVVDGTFDVGMSSVTDTREREELVDFVTYLEAGTQWARRPGTAL MSMEG_1200|M.smegmatis_MC2_155 FEGILPSVRDGSFNVGMSSITDTAEREELVDFVTYFQAGTLWAQRTGSSV MMAR_3398|M.marinum_M FEGLSYPTGVTADNSGTVYVNDAGNRRVLVLRAGTSTQITLPFTDLGNPT Mb1772|M.bovis_AF2122/97 PPPPPADAVELRVLNDGVFVGSSVAPTTIDIFNEPICPPCGSFIRSYASD Rv1743|M.tuberculosis_H37Rv PPPPPADAVELRVLNDGVFVGSSVAPTTIDIFNEPICPPCGSFIRSYASD MUL_3180|M.ulcerans_Agy99 PPPPPPDAVQLRVLNDGVFIGSSAATTTIDIFNEPICPPCGAFIRSYASD MAB_4435|M.abscessus_ATCC_1997 EKNPSPTFRSGEFNPAVPPGSATNIGG--TPVGCNTIDPAWALRAKGRET MLBr_00492|M.leprae_Br4923 PATVSASMATNQGNIG-LLLNNAESPCTVNSFASLTGQGFFNNTKCHRLT TH_2333|M.thermoresistible__bu PEWVSVSMSTNQGNLG-LWLDNGKAPCTVNSFVSLAQQGYFDDTTCHRLT MAV_3463|M.avium_104 PGQIGAVIATNLGDIG-ISLANSESPCAVNSFISLARQRFFDNTQCARLV Mflv_5237|M.gilvum_PYR-GCK GPASACGLKVGVAEGTLQATEELPAKS---DQCAAAGMPPIEMVVFKSQD Mvan_1033|M.vanbaalenii_PYR-1 GPASACGLKVGVAEATLQATEELPAKS---DQCTAAGMEPIEMVVFKNQD MSMEG_1200|M.smegmatis_MC2_155 DPDAACGLRVGVAYSTIQETEEIPAKS---DACVAAGLPPIEKVVRTHQD MMAR_3398|M.marinum_M GLTVDSSRTVYVTDTAKNRVVALPAGSNMQTQLPFTGLNSPTGLVVNGSG Mb1772|M.bovis_AF2122/97 IDTAVADKQLAVRYHLLNFLDDQSHSKNYSTRAVAASYCVAGQNDPKLYA Rv1743|M.tuberculosis_H37Rv IDTAVADKQLAVRYHLLNFLDDQSHSKNYSTRAVAASYCVAGQNDPKLYA MUL_3180|M.ulcerans_Agy99 IDAAVANKKLAVRYHLLNFLDEQSHTKTYSTRAVAASYCVAAQDDPKVYT MAB_4435|M.abscessus_ATCC_1997 STLYLRDRKKPEREILIRVVPAADALS---TDGASDALKRCDAVAYIIPG MLBr_00492|M.leprae_Br4923 TSLMLGVLQCGDPKVDGTGGPGYKFANEYPTDQYPPNDPKLKQPVLYPRG TH_2333|M.thermoresistible__bu ATPALSVLQCGDPTGTGAGGPGYQFGNEYPTNQYPQGDPALQEPVTYPRG MAV_3463|M.avium_104 DSPDGGSLLCGGPDVDGSGGPGYEFADEYPANQYRPDDPALRATLLYPRG . Mflv_5237|M.gilvum_PYR-GCK EVTSALVKGEVDAMSADSPVTGFAIKLSRGDLVPAGDVFDSAPYGWPVAK Mvan_1033|M.vanbaalenii_PYR-1 EVTTALIKGEVDAMSADSPVTGFAIKLSRGELVPAGDVFDSAPYGWPVAK MSMEG_1200|M.smegmatis_MC2_155 EVTAALIAGEVDAMTADSPVTGFAIKLSGGALAPAGEVFDSAPYGWPVAK MMAR_3398|M.marinum_M TVYVADGGNNRVLALPAGSKRQIALPFT-GLNQPGGVTLDNEGAVYVTDS Mb1772|M.bovis_AF2122/97 SFYSALFGSDFQPQENAASDRTDAELAHLAQTVGAEPTAIS-----CIKS Rv1743|M.tuberculosis_H37Rv SFYSALFGSDFQPQENAASDRTDAELAHLAQTVGAEPTAIS-----CIKS MUL_3180|M.ulcerans_Agy99 DFYAALFASDFQPQEAAASDRTDAELAHLAQTVGANGTATS-----CIKA MAB_4435|M.abscessus_ATCC_1997 SSTTWRCSFEFDEPNPVQNGQKELTTTESCYMFPSGANSIRQHVSFNVVR MLBr_00492|M.leprae_Br4923 TLAMANS-------GPNTNGSQFFLVYHDSQLPPEYTVFGTIQADGLATL TH_2333|M.thermoresistible__bu ALAMAHSA------GQHNNGSQFFLVYQDSQLPPDYTVFGVIDETGLETL MAV_3463|M.avium_104 TVVMATE-------GPNTNGSQFALIFHDSEMDPQSTVLGTIDPAGLATL Mflv_5237|M.gilvum_PYR-GCK ESGMTEPLQRALEHLMETGEYRAIATMWGVERGMIDKPVVNGAGR----- Mvan_1033|M.vanbaalenii_PYR-1 GSGLTESLRLALEHLIESGDYRAIATMWGVERGMIDKPAVNGATR----- MSMEG_1200|M.smegmatis_MC2_155 DSGLAEPLRLALEHLMDTGEYRTIATMWGVEKGMITQPVINGAF------ MMAR_3398|M.marinum_M GNNRTLKLPAGSTTQIELP-FTGLDFPWGLAVDNMGTVYVGSRSSQIVAL Mb1772|M.bovis_AF2122/97 GADLGTAQTKATNASETLAGFNASGTPFVWDGSMVVNYQDPSWLARLIG- Rv1743|M.tuberculosis_H37Rv GADLGTAQTKATNASETLAGFNASGTPFVWDGSMVVNYQDPSWLARLIG- MUL_3180|M.ulcerans_Agy99 GNDMGTARTKAAAADATLSELNAG-------------------LRRC--- MAB_4435|M.abscessus_ATCC_1997 GLLVYILASGASNRNDAAGSLSATALSFATTMKILRYGR----------- MLBr_00492|M.leprae_Br4923 DKIAKGGIASGGDDGPPATEVTIESLRLD--------------------- TH_2333|M.thermoresistible__bu DKIAAAGIAGNAMDGAPAEEVRVTSILMD--------------------- MAV_3463|M.avium_104 DKIARAGIAGNRPSGPPANPVTITSVRIG--------------------- Mflv_5237|M.gilvum_PYR-GCK --- Mvan_1033|M.vanbaalenii_PYR-1 --- MSMEG_1200|M.smegmatis_MC2_155 --- MMAR_3398|M.marinum_M RQK Mb1772|M.bovis_AF2122/97 --- Rv1743|M.tuberculosis_H37Rv --- MUL_3180|M.ulcerans_Agy99 --- MAB_4435|M.abscessus_ATCC_1997 --- MLBr_00492|M.leprae_Br4923 --- TH_2333|M.thermoresistible__bu --- MAV_3463|M.avium_104 ---