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MSDLRAVMQAQRACRRFDPDGKVLDSDIEQMLQLAAHAPSAENTQPWSFVVVRAEENRKLLADWWTETWN AGGGDFVRQNLEDKALVADLEFGFNKGGFAAAPVVVVVCADTDRVAEIYAPSSIYPAVQNLLLAAADLGY GSCLTTGLTTFGVDRVRELLELPPNLIPMAAVYVGRPVKKLSPPRRRPVSEVTYREKFGTAW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1962 | - | - | 100% (202) | NADPH nitroreductase |
| M. avium 104 | MAV_2661 | - | 2e-95 | 80.20% (202) | nitroreductase |
| M. avium 104 | MAV_0933 | - | 3e-15 | 31.79% (195) | nitroreductase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3290 | fbiB | 6e-08 | 30.73% (179) | F420-0--gamma-glutamyl ligase |
| M. gilvum PYR-GCK | Mflv_3382 | - | 1e-22 | 34.30% (207) | nitroreductase |
| M. tuberculosis H37Rv | Rv3262 | fbiB | 6e-08 | 30.73% (179) | F420-0--gamma-glutamyl ligase |
| M. leprae Br4923 | MLBr_00758 | - | 7e-07 | 28.41% (176) | F420-0--gamma-glutamyl ligase |
| M. abscessus ATCC 19977 | MAB_3693c | - | 2e-12 | 29.24% (171) | oxidoreductase |
| M. marinum M | MMAR_2938 | - | 7e-21 | 35.29% (204) | nitroreductase |
| M. smegmatis MC2 155 | MSMEG_6627 | - | 3e-15 | 29.05% (210) | nitroreductase family protein |
| M. thermoresistible (build 8) | TH_2448 | - | 1e-22 | 34.74% (213) | PUTATIVE nitroreductase |
| M. ulcerans Agy99 | MUL_2198 | - | 3e-21 | 35.29% (204) | nitroreductase |
| M. vanbaalenii PYR-1 | Mvan_3115 | - | 1e-19 | 32.38% (210) | nitroreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6627|M.smegmatis_MC2_155 --------------------------------------------------
TH_2448|M.thermoresistible__bu --------------------------------------------------
Mvan_3115|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3382|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_2938|M.marinum_M --------------------------------------------------
MUL_2198|M.ulcerans_Agy99 --------------------------------------------------
MAV_1962|M.avium_104 --------------------------------------------------
Mb3290|M.bovis_AF2122/97 MTG---------PEHGSASTIEILPVIGLPEFRPGDDLSAAVAAAAPWLR
Rv3262|M.tuberculosis_H37Rv MTG---------PEHGSASTIEILPVIGLPEFRPGDDLSAAVAAAAPWLR
MLBr_00758|M.leprae_Br4923 MTSSDSHRSAPSPEHGTASTIEILPVAGLPEFRPGDDLSAALAAAAPWLR
MAB_3693c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6627|M.smegmatis_MC2_155 --------------------------------------------------
TH_2448|M.thermoresistible__bu --------------------------------------------------
Mvan_3115|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3382|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_2938|M.marinum_M --------------------------------------------------
MUL_2198|M.ulcerans_Agy99 --------------------------------------------------
MAV_1962|M.avium_104 --------------------------------------------------
Mb3290|M.bovis_AF2122/97 DGDVVVVTSKVVSKCEGRLVPAPEDPEQRDRLRRKLIEDEAVRVLARKDR
Rv3262|M.tuberculosis_H37Rv DGDVVVVTSKVVSKCEGRLVPAPEDPEQRDRLRRKLIEDEAVRVLARKDR
MLBr_00758|M.leprae_Br4923 DGDVVVVTSKVVSKCEGRLVPAPEDTRGRNELRRKLINDETIRVLARKGR
MAB_3693c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6627|M.smegmatis_MC2_155 --------------------------------------------------
TH_2448|M.thermoresistible__bu --------------------------------------------------
Mvan_3115|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3382|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_2938|M.marinum_M --------------------------------------------------
MUL_2198|M.ulcerans_Agy99 --------------------------------------------------
MAV_1962|M.avium_104 --------------------------------------------------
Mb3290|M.bovis_AF2122/97 TLITENRLGLVQAAAGVDGSNVGRSELALLPVDPDASAATLRAGLRERLG
Rv3262|M.tuberculosis_H37Rv TLITENRLGLVQAAAGVDGSNVGRSELALLPVDPDASAATLRAGLRERLG
MLBr_00758|M.leprae_Br4923 TLIIENGLGLVQAAAGVDGSNVGRGELALLPVNPDASAAVLRIGLRAMLG
MAB_3693c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6627|M.smegmatis_MC2_155 --------------------------------------------------
TH_2448|M.thermoresistible__bu --------------------------------------------------
Mvan_3115|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3382|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_2938|M.marinum_M --------------------------------------------------
MUL_2198|M.ulcerans_Agy99 --------------------------------------------------
MAV_1962|M.avium_104 --------------------------------------------------
Mb3290|M.bovis_AF2122/97 VTVAVVITDTMGRAWRNGQTDAAVGAAGLAVLRNYAGVRDPYGNELVVTE
Rv3262|M.tuberculosis_H37Rv VTVAVVITDTMGRAWRNGQTDAAVGAAGLAVLRNYAGVRDPYGNELVVTE
MLBr_00758|M.leprae_Br4923 VNVAVVITDTMGRAWRNGQTDVAIGAAGLAVLHNYSGAVDRYGNELVVTE
MAB_3693c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6627|M.smegmatis_MC2_155 -------------------------------------------MPQPTN-
TH_2448|M.thermoresistible__bu ----------------------------------------MPDTPKPIPS
Mvan_3115|M.vanbaalenii_PYR-1 -------------------------------------------MPEPIPS
Mflv_3382|M.gilvum_PYR-GCK -------------------------------------------MADPTPS
MMAR_2938|M.marinum_M --------------------------------------------------
MUL_2198|M.ulcerans_Agy99 --------------------------------------------------
MAV_1962|M.avium_104 --------------------------------------------------
Mb3290|M.bovis_AF2122/97 VAVADEIAAAADLVKGKLTATPVAVVRGFGVSDDGSTARQLLRPGANDLF
Rv3262|M.tuberculosis_H37Rv VAVADEIAAAADLVKGKLTATPVAVVRGFGVSDDGSTARQLLRPGANDLF
MLBr_00758|M.leprae_Br4923 IAVADEVAAATDLVKGKLTAMPVAVVRGLSPTDDGSTAQHLLRNGPDDLF
MAB_3693c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6627|M.smegmatis_MC2_155 ----------DVWEVLSTARSIR-RFTDE-PVDDATLHRCLQAAAWAPNG
TH_2448|M.thermoresistible__bu VAEALARLDMPLAEAMMTQRAVR-RVLPD-PVDDELVLKCIELALRAPTG
Mvan_3115|M.vanbaalenii_PYR-1 AAEALARLDMPLVEAMMTQRAIR-RVLPD-PVDDEIVLKCLELALRAPTG
Mflv_3382|M.gilvum_PYR-GCK TSEALARLDMSLIDVMMTQRAVR-RVYPD-PVDDEIVMKCLEVALHAPTG
MMAR_2938|M.marinum_M ---------MPLEDAMRTQRSIR-RLKSD-PVDDSLVLHLLELAMKAPTG
MUL_2198|M.ulcerans_Agy99 ---------MPLEDAMRTQRSIR-RLKSD-PVDDSLVLHLLELAMKAPTG
MAV_1962|M.avium_104 --------MSDLRAVMQAQRACR-RFDPDGKVLDSDIEQMLQLAAHAPSA
Mb3290|M.bovis_AF2122/97 WLGTAEALELGRQQAQLLRRSVR-RFSTD-PVPGDLVEAAVAEALTAPAP
Rv3262|M.tuberculosis_H37Rv WLGTAEALELGRQQAQLLRRSVR-RFSTD-PVPGDLVEAAVAEALTAPAP
MLBr_00758|M.leprae_Br4923 WLGTTEALELGRQQAQLLRRSVR-QFSDE-PIAAELIETAVAEALTAPAP
MAB_3693c|M.abscessus_ATCC_199 ----MTSLNLSADEVLTTTRSVRKRLDFDKPVERAVVEECLNIAMQAPTG
. *: * :. : : : : * **
MSMEG_6627|M.smegmatis_MC2_155 ANAQLWRFVVLDAPEQRAAVAGAARSALATIESIYGMSRPADD-DHSRAA
TH_2448|M.thermoresistible__bu SNGQNWEFIVVKDPAVKAKLADRYRQAWAVYGGIGRR-VTAG--DESMAK
Mvan_3115|M.vanbaalenii_PYR-1 ANGQNWEFVVVKDPKIKRKLQRRYRLAWRVFHRTSIRDIASY--DEEMAK
Mflv_3382|M.gilvum_PYR-GCK ANGQNWEFIVVKDYETKKKLAKRYRQAWNLYYQTVIRRVSKR--DPSMAK
MMAR_2938|M.marinum_M SNAQNWEFIVVKDREVVAKLGRLNRRAMQLFGPIYRRSIARRG-DEKMLR
MUL_2198|M.ulcerans_Agy99 SNAQNWEFIVVKDREVVAKLGRLNRRAMQLFGPIYRRSIARRG-DEKMLR
MAV_1962|M.avium_104 ENTQPWSFVVVRAEENRKLLADWWTETWNAGGGDFVRQNLED-----KAL
Mb3290|M.bovis_AF2122/97 HHTRPTRFVWLQTPAIRARLLDRMKDKWRS--DLTSDGLPAD----AIER
Rv3262|M.tuberculosis_H37Rv HHTRPTRFVWLQTPAIRARLLDRMKDKWRS--DLTSDGLPAD----AIER
MLBr_00758|M.leprae_Br4923 HHTRPVRFVWLQTPAVRTRLLDRMADKWRL--DLASDALPAD----AIAQ
MAB_3693c|M.abscessus_ATCC_199 SNHQGWHWVIVEDAEKKKAIADIYREGWNKYAKGAGATYAEGDTRAERKA
: : :: : :
MSMEG_6627|M.smegmatis_MC2_155 RNNRATYELHDRAGELTSVLFVAYKN------------EFASDYLQAGSI
TH_2448|M.thermoresistible__bu -ILRAVQWQVDHFTEIPVLVVACLRAGPREGRLPFMPAPPVAASSFFGSI
Mvan_3115|M.vanbaalenii_PYR-1 -SVRAIEWQLEHFHEIPVLVIACLRLSAREGKVPYVPMPHAAASAFFGSI
Mflv_3382|M.gilvum_PYR-GCK -TARAVQWQVDHFTEVPVLIVACLKLGPKDGRIPFVPMPHAALSGFYGSI
MMAR_2938|M.marinum_M -LQKAVQWQADHFEEIPVVVVACLRG-------VIAPWPRISTSSAYGSI
MUL_2198|M.ulcerans_Agy99 -LQKAVQWQADHFEEIPVVVVACLRG-------VIAPWPRISTSSAYGSI
MAV_1962|M.avium_104 VADLEFGFNKGGFAAAPVVVVVCADT------------DRVAEIYAPSSI
Mb3290|M.bovis_AF2122/97 RVARGQILYDAPEVVIPMLVPDGAHS------YPDAARTDAEHTMFTVAV
Rv3262|M.tuberculosis_H37Rv RVARGQILYDAPEVVIPMLVPDGAHS------YPDAARTDAEHTMFTVAV
MLBr_00758|M.leprae_Br4923 RVARGQILYDAPEVIIPFMVPDGAHA------YPDAARASAEHTMFIVAV
MAB_3693c|M.abscessus_ATCC_199 KVVDSAGYLAENFERSPLFLIPCIEG-------RLDNLPVVGAASSWGSL
. .: ::
MSMEG_6627|M.smegmatis_MC2_155 YPAMQNFYLAARAQGLGACFTSWAAYQG-EQILRDAVGVPAE-WFLAGHV
TH_2448|M.thermoresistible__bu YPSVQNLLLAARAMGLGASLITLPLWS--MTSARRILKLPLS-VTPCCIV
Mvan_3115|M.vanbaalenii_PYR-1 YPSVQNLLLAARAMGLGASLITLPLWN--LTSARRVLKLPTE-VTPCCVV
Mflv_3382|M.gilvum_PYR-GCK YPSVQNLLLAARAMGLGASLITLPLWS--VTSTRKTLGLPVS-VTPCCVV
MMAR_2938|M.marinum_M YPAVQNLLLAARAAGLGAGLITVPLWS--TVLARRALGLPWN-VTPCAVV
MUL_2198|M.ulcerans_Agy99 YPAVQNLLLAARAAGLGAGLITVPLWS--TVLARRALGLPRN-VTPCAVV
MAV_1962|M.avium_104 YPAVQNLLLAAADLGYGSCLTTGLTTFG-VDRVRELLELPPN-LIPMAAV
Mb3290|M.bovis_AF2122/97 GAAVQALLVALAVRGLGSCWIGSTIFA--ADLVRDELDLPVD-WEPLGAI
Rv3262|M.tuberculosis_H37Rv GAAVQALLVALAVRGLGSCWIGSTIFA--ADLVRDELDLPVD-WEPLGAI
MLBr_00758|M.leprae_Br4923 GAAVQALLVALAVRGLGSCWIGSTIFA--DDLVRAELELPAD-WEPLGAI
MAB_3693c|M.abscessus_ATCC_199 LPAVWSFMLAARNRGLGSAWTTLHLMDDGEKRTADIVGIPFDKVTQGGLF
.:: : :* * *: : :* . .
MSMEG_6627|M.smegmatis_MC2_155 VIGRPRG-RHGPVRRRPLDDVVFRNTWDAARADIVYGQGARPSRT
TH_2448|M.thermoresistible__bu PLGWPRG-RYGPTTRRPVREVVHLDSYGNRAWQSPS---------
Mvan_3115|M.vanbaalenii_PYR-1 PLGWPRG-RYGPTTRRPVDEVVHLDRYGNRAWFGPRGADRP----
Mflv_3382|M.gilvum_PYR-GCK PLGWPRG-RYGPTTRRPVAEVMHLNTYGNRPWMGTG---------
MMAR_2938|M.marinum_M PLGWPIG-KYGPTTRRPVAEIVSLDRYGNRAFR------------
MUL_2198|M.ulcerans_Agy99 PLGWPIG-KYGPTTRRPVAEIVSLDRYGNRAFR------------
MAV_1962|M.avium_104 YVGRPVK-KLSPPRRRPVSEVTYREKFGTAW--------------
Mb3290|M.bovis_AF2122/97 AIGYADE-PSGLRDPVPAADLLILK--------------------
Rv3262|M.tuberculosis_H37Rv AIGYADE-PSGLRDPVPAADLLILK--------------------
MLBr_00758|M.leprae_Br4923 AIGYAHE-PTDLREPVRVADLLLRK--------------------
MAB_3693c|M.abscessus_ATCC_199 PIAYTVGTDFRLAKRQPLADVLHWDTW------------------
:. . :: .