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ADPTPSTSEALARLDMSLIDVMMTQRAVRRVYPDPVDDEIVMKCLEVALHAPTGANGQNWEFIVVKDYET KKKLAKRYRQAWNLYYQTVIRRVSKRDPSMAKTARAVQWQVDHFTEVPVLIVACLKLGPKDGRIPFVPMP HAALSGFYGSIYPSVQNLLLAARAMGLGASLITLPLWSVTSTRKTLGLPVSVTPCCVVPLGWPRGRYGPT TRRPVAEVMHLNTYGNRPWMGTG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3382 | - | - | 100% (234) | nitroreductase |
| M. gilvum PYR-GCK | Mflv_4892 | - | 3e-24 | 32.57% (218) | nitroreductase |
| M. gilvum PYR-GCK | Mflv_1262 | - | 2e-21 | 32.86% (210) | nitroreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3403c | - | 1e-19 | 30.00% (220) | oxidoreductase |
| M. tuberculosis H37Rv | Rv3368c | - | 2e-19 | 30.00% (220) | oxidoreductase |
| M. leprae Br4923 | MLBr_00418 | - | 2e-18 | 29.44% (214) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3693c | - | 7e-26 | 31.39% (223) | oxidoreductase |
| M. marinum M | MMAR_2938 | - | 2e-65 | 57.28% (213) | nitroreductase |
| M. avium 104 | MAV_0933 | - | 1e-23 | 34.78% (207) | nitroreductase family protein |
| M. smegmatis MC2 155 | MSMEG_1635 | - | 1e-22 | 30.73% (218) | nitroreductase family protein |
| M. thermoresistible (build 8) | TH_2448 | - | 2e-99 | 74.45% (227) | PUTATIVE nitroreductase |
| M. ulcerans Agy99 | MUL_2198 | - | 1e-65 | 57.28% (213) | nitroreductase |
| M. vanbaalenii PYR-1 | Mvan_3115 | - | 1e-101 | 69.83% (232) | nitroreductase |
CLUSTAL 2.0.9 multiple sequence alignment
TH_2448|M.thermoresistible__bu MPDTPKPIPSVAEALARLDMPLAEAMMTQRAVRR--VLPDPVDDELVLKC
Mvan_3115|M.vanbaalenii_PYR-1 ---MPEPIPSAAEALARLDMPLVEAMMTQRAIRR--VLPDPVDDEIVLKC
Mflv_3382|M.gilvum_PYR-GCK ---MADPTPSTSEALARLDMSLIDVMMTQRAVRR--VYPDPVDDEIVMKC
MMAR_2938|M.marinum_M -------------------MPLEDAMRTQRSIRR--LKSDPVDDSLVLHL
MUL_2198|M.ulcerans_Agy99 -------------------MPLEDAMRTQRSIRR--LKSDPVDDSLVLHL
MAV_0933|M.avium_104 ------------------------MMSTARTIRR--FTDEPVDDATLARC
Mb3403c|M.bovis_AF2122/97 ---------------MTLNLSVDEVLTTTRSVRKRLDFDKPVPRDVLMEC
Rv3368c|M.tuberculosis_H37Rv ---------------MTLNLSVDEVLTTTRSVRKRLDFDKPVPRDVLMEC
MLBr_00418|M.leprae_Br4923 -------------------MSVDEVLTTTRSVRKRLDFDKPVPRDVLMEC
MSMEG_1635|M.smegmatis_MC2_155 ---------------MTLNLSVDELLTTTRSVRKRLDFEKPVSREVILEC
MAB_3693c|M.abscessus_ATCC_199 --------------MTSLNLSADEVLTTTRSVRKRLDFDKPVERAVVEEC
: * *::*: .** : .
TH_2448|M.thermoresistible__bu IELALRAPTGSNGQNWEFIVVKDPAVKAKLADRYRQAWAVYGG--IGRR-
Mvan_3115|M.vanbaalenii_PYR-1 LELALRAPTGANGQNWEFVVVKDPKIKRKLQRRYRLAWRVFHR--TSIRD
Mflv_3382|M.gilvum_PYR-GCK LEVALHAPTGANGQNWEFIVVKDYETKKKLAKRYRQAWNLYYQ--TVIRR
MMAR_2938|M.marinum_M LELAMKAPTGSNAQNWEFIVVKDREVVAKLGRLNRRAMQLFGP--IYRRS
MUL_2198|M.ulcerans_Agy99 LELAMKAPTGSNAQNWEFIVVKDREVVAKLGRLNRRAMQLFGP--IYRRS
MAV_0933|M.avium_104 LGAARWAPSGANAQGWRFVVLRSPEQRAVVAKAAAQALEVIEP--VYGMS
Mb3403c|M.bovis_AF2122/97 LELALQAPTGSNSQGWQWVFVEDAAKKKAIADVYLANARGYLSGPAPEYP
Rv3368c|M.tuberculosis_H37Rv LELALQAPTGSNSQGWQWVFVEDAAKKKAIADVYLANARGYLSGPAPEYP
MLBr_00418|M.leprae_Br4923 LQLALQAPTGSNSQGWHWVFVEDAEKRKAIGDIYLVNARCYLSQPAPEYP
MSMEG_1635|M.smegmatis_MC2_155 LDLALQAPTGSNAQGWQWVFVEDEAKKKALADIYRSNAIPYLEQEAAER-
MAB_3693c|M.abscessus_ATCC_199 LNIAMQAPTGSNHQGWHWVIVEDAEKKKAIADIYREGWNKYAKGAGATYA
: * **:*:* *.*.::.:.. :
TH_2448|M.thermoresistible__bu VTAG-DESMAKILRAVQWQVDHFTEIPVLVVACLRAGPREGRLPFMPAPP
Mvan_3115|M.vanbaalenii_PYR-1 IASY-DEEMAKSVRAIEWQLEHFHEIPVLVIACLRLSAREGKVPYVPMPH
Mflv_3382|M.gilvum_PYR-GCK VSKR-DPSMAKTARAVQWQVDHFTEVPVLIVACLKLGPKDGRIPFVPMPH
MMAR_2938|M.marinum_M IARRGDEKMLRLQKAVQWQADHFEEIPVVVVACLRG-------VIAPWPR
MUL_2198|M.ulcerans_Agy99 IARRGDEKMLRLQKAVQWQADHFEEIPVVVVACLRG-------VIAPWPR
MAV_0933|M.avium_104 RPAPDDHSRRARTYRATYELHDRAGEFTSVLFAQAH-----------YPT
Mb3403c|M.bovis_AF2122/97 DGDTRGERMGRVRDSATYLAEHMHRAPVLLIPCLKG-------REDESAV
Rv3368c|M.tuberculosis_H37Rv DGDTRGERMGRVRDSATYLAEHMHRAPVLLIPCLKG-------REDESAV
MLBr_00418|M.leprae_Br4923 EGDTRGERMRLVRDSATYLAEHMHEVPVLLIPCLLG-------RAEESPL
MSMEG_1635|M.smegmatis_MC2_155 -GDIRDQQQPKVRDSARHLTDNFEKAPVLLIPCLEG-------RPDGAPA
MAB_3693c|M.abscessus_ATCC_199 EGDTRAERKAKVVDSAGYLAENFERSPLFLIPCIEG-------RLDNLPV
.. :: . .
TH_2448|M.thermoresistible__bu VAASSFFGSIYPSVQNLLLAARAMGLGASLITLPLWS--MTSARRILKLP
Mvan_3115|M.vanbaalenii_PYR-1 AAASAFFGSIYPSVQNLLLAARAMGLGASLITLPLWN--LTSARRVLKLP
Mflv_3382|M.gilvum_PYR-GCK AALSGFYGSIYPSVQNLLLAARAMGLGASLITLPLWS--VTSTRKTLGLP
MMAR_2938|M.marinum_M ISTSSAYGSIYPAVQNLLLAARAAGLGAGLITVPLWS--TVLARRALGLP
MUL_2198|M.ulcerans_Agy99 ISTSSAYGSIYPAVQNLLLAARAAGLGAGLITVPLWS--TVLARRALGLP
MAV_0933|M.avium_104 ASELLLGGSIFPAMQNFLLAARAQGLGACLTSWASYGG-EQLLREAVGVP
Mb3403c|M.bovis_AF2122/97 G-GVSFWASLFPAVWSFCLALRSRGLGSCWTTLHLLDNGEHKVADVLGIP
Rv3368c|M.tuberculosis_H37Rv G-GVSFWASLFPAVWSFCLALRSRGLGSCWTTLHLLDNGEHKVADVLGIP
MLBr_00418|M.leprae_Br4923 G-AVSYWASLFPAVWSFCLALRSRGLGTCWTSLHLLGDGEQRAAEVLGIP
MSMEG_1635|M.smegmatis_MC2_155 GLSASFWGSLLPAVWSFMLALRSRGLGSAWTTLHLLGEGEKQAAEVVGIP
MAB_3693c|M.abscessus_ATCC_199 VGAASSWGSLLPAVWSFMLAARNRGLGSAWTTLHLMDDGEKRTADIVGIP
.*: *:: .: ** * ***: : . : :*
TH_2448|M.thermoresistible__bu -LSVTPCCIVPLGWPRGR-YGPTTRRPVREVVHLDSYGNRAWQSPS----
Mvan_3115|M.vanbaalenii_PYR-1 -TEVTPCCVVPLGWPRGR-YGPTTRRPVDEVVHLDRYGNRAWFGPRGADR
Mflv_3382|M.gilvum_PYR-GCK -VSVTPCCVVPLGWPRGR-YGPTTRRPVAEVMHLNTYGNRPWMGTG----
MMAR_2938|M.marinum_M -WNVTPCAVVPLGWPIGK-YGPTTRRPVAEIVSLDRYGNRAFR-------
MUL_2198|M.ulcerans_Agy99 -RNVTPCAVVPLGWPIGK-YGPTTRRPVAEIVSLDRYGNRAFR-------
MAV_0933|M.avium_104 -EGWMIAGHIVVGWPKGK-HGPLRRRPLAEFVNLDRWDAPADGLLSGL--
Mb3403c|M.bovis_AF2122/97 YDEYSQGGLLPIAYTQGIDFRPAKRLPAESVTHWNGW-------------
Rv3368c|M.tuberculosis_H37Rv YDEYSQGGLLPIAYTQGIDFRPAKRLPAESVTHWNGW-------------
MLBr_00418|M.leprae_Br4923 SDKYSQGGLFPIAYTKGTDFRPANRLPAENVTHWDIW-------------
MSMEG_1635|M.smegmatis_MC2_155 FDKYSQAGLFPIAYTIGTDFKKAKRLPAEQFAHWDTW-------------
MAB_3693c|M.abscessus_ATCC_199 FDKVTQGGLFPIAYTVGTDFRLAKRQPLADVLHWDTW-------------
. :.:. * . * * .. : :
TH_2448|M.thermoresistible__bu -
Mvan_3115|M.vanbaalenii_PYR-1 P
Mflv_3382|M.gilvum_PYR-GCK -
MMAR_2938|M.marinum_M -
MUL_2198|M.ulcerans_Agy99 -
MAV_0933|M.avium_104 -
Mb3403c|M.bovis_AF2122/97 -
Rv3368c|M.tuberculosis_H37Rv -
MLBr_00418|M.leprae_Br4923 -
MSMEG_1635|M.smegmatis_MC2_155 -
MAB_3693c|M.abscessus_ATCC_199 -