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SAPRDERDIPHFVYAELPMATDRGRGWATLRDAGPVVIGDGFYYLTRRDDVLDALRHPEVFSSKRAFDIL GSPLPLVPLAFDPPEHTRFRKVLQPFFSPHALAAMLPSLQAQAIEIIDAIAAGSQCEVITELAIPYPSQV FLTLFGLSLADRDRLIRWKDAIIALGLLASLDDADLTPALELTSYLVDAIAAHRRHPGTDILSQVLLGDD PLDDSEALGLSYVFVLAGLDTVTSAIGAALLELARRPQLRQLLRENHGQIAVFVDEIVRLEPPAPVVPRV TTREVNIAGAKIPAGSRVWLCLGAINRDGSDATSVNDVVMDGKVHKHWGFGGGTHRCLGSHLARMELSLV ISEWLRRIPQFELACGYTPEIDWPSATLGLSTLTLQFTS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2631 | cyp143A3 | - | 100% (390) | cytochrome P450 143A3 Cyp143A3 |
| M. marinum M | MMAR_2666 | cyp143A4 | e-126 | 58.05% (379) | cytochrome P450 143A4 Cyp143A4 |
| M. marinum M | MMAR_0274 | cyp271A1 | 1e-40 | 31.31% (329) | cytochrome P450 271A1 Cyp271A1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1813c | cyp143 | 1e-135 | 60.26% (380) | cytochrome P450 143 |
| M. gilvum PYR-GCK | Mflv_1764 | - | 1e-146 | 66.67% (378) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1785c | cyp143 | 1e-135 | 60.26% (380) | cytochrome P450 143 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-33 | 27.86% (384) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1406c | - | 1e-38 | 31.06% (367) | cytochrome P450 |
| M. avium 104 | MAV_2548 | - | 1e-146 | 65.52% (377) | putative cytochrome P450 143 |
| M. smegmatis MC2 155 | MSMEG_3551 | - | 6e-42 | 31.88% (367) | linalool 8-monooxygenase |
| M. thermoresistible (build 8) | TH_3609 | - | 2e-42 | 33.99% (356) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3106 | cyp143A3 | 0.0 | 98.97% (390) | cytochrome P450 143A3 Cyp143A3 |
| M. vanbaalenii PYR-1 | Mvan_4983 | - | 1e-145 | 66.58% (380) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1813c|M.bovis_AF2122/97 ---MTTPGEDHAGSFYLPRLEYSTLPMAVD----RGVGWKTLRDAGPVVF
Rv1785c|M.tuberculosis_H37Rv ---MTTPGEDHAGSFYLPRLEYSTLPMAVD----RGVGWKTLRDAGPVVF
MMAR_2631|M.marinum_M ---MSAPRDERD----IPHFVYAELPMATD----RGRGWATLRDAGPVVI
MUL_3106|M.ulcerans_Agy99 ---MSAPRDERD----IPHFVYAELPMATD----RGRGWATLRDAGPVVI
Mflv_1764|M.gilvum_PYR-GCK ---MTATAAPLG----LPQVLYGDLPMSRD----RGHGWATLRDLGPVLY
Mvan_4983|M.vanbaalenii_PYR-1 ---MSA----------LPHVLYGDLPMAAD----RGAGWATLREFGPVAY
MAV_2548|M.avium_104 ---MET----LG----APELSFASLPMAAD----RGVGWKVLRDAGRVVS
MAB_1406c|M.abscessus_ATCC_199 -------MSVDVSHTVAPRYVPGTADNWTN----PWPMYAALRDHDPVHH
TH_3609|M.thermoresistible__bu -----------VSQTPV-RFTLSTAATWSD----PWPMYAALRDHDPVHH
MSMEG_3551|M.smegmatis_MC2_155 MGIAPRVNGAAPPDVPLSEINLGSWDFWALDDDIRDGAFATLRREAPISF
MLBr_02088|M.leprae_Br4923 ---MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTR
. **
Mb1813c|M.bovis_AF2122/97 MN-------------------GWYYLTRREDVLAALRNPKVFSSRKALQP
Rv1785c|M.tuberculosis_H37Rv MN-------------------GWYYLTRREDVLAALRNPKVFSSRKALQP
MMAR_2631|M.marinum_M GD-------------------GFYYLTRRDDVLDALRHPEVFSSKRAFDI
MUL_3106|M.ulcerans_Agy99 GD-------------------GFYYLTRRDDVLDALRHPEVFSSKRAFDI
Mflv_1764|M.gilvum_PYR-GCK GD-------------------GWFYLTRREDVLAALRNPEVFSSRIAYDD
Mvan_4983|M.vanbaalenii_PYR-1 GD-------------------GWYYLTRRDDVLAALRNPEVFSSRIAYDD
MAV_2548|M.avium_104 VD-------------------GIFYLTHREDVLAALRDPELFSSKKAFDV
MAB_1406c|M.abscessus_ATCC_199 VVPEYTPD------------QDYYVLTRHADVYEAARDWETFSSARGLTV
TH_3609|M.thermoresistible__bu VVPEHRPE------------HDYYVLSRHADVWRAARDHETFSSARGLTV
MSMEG_3551|M.smegmatis_MC2_155 HPAFDTEEGFPQG-------AGHWALTRHDDVFYASRHPELFSSASGIVI
MLBr_02088|M.leprae_Br4923 ADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATL
:: * * *. *.
Mb1813c|M.bovis_AF2122/97 PGNPLPVVPLA----------FDPPEHTRYRRILQPYFSPAALSKALPSL
Rv1785c|M.tuberculosis_H37Rv PGNPLPVVPLA----------FDPPEHTRYRRILQPYFSPAALSKALPSL
MMAR_2631|M.marinum_M LGSPLPLVPLA----------FDPPEHTRFRKVLQPFFSPHALAAMLPSL
MUL_3106|M.ulcerans_Agy99 LGSPLPLVPLA----------FDPPEHTRFRKVLQPFFSPHALAAMLPSL
Mflv_1764|M.gilvum_PYR-GCK MISPVPLVPLG----------FDPPEHTRYRHILHPFFSPQTLAALLPSL
Mvan_4983|M.vanbaalenii_PYR-1 MISPVPLVPLG----------FDPPEHTRYRRILHPFFSPQALGVLLPSL
MAV_2548|M.avium_104 LGSPLPLVPIS----------FDPPEHTRFRKILQPFFSPHTLKEMLPSL
MAB_1406c|M.abscessus_ATCC_199 TYGDLEKTGMGD---NPPMVMQDPPTHTEFRKLVSRGFTPRQVTAVEPKV
TH_3609|M.thermoresistible__bu NYDELELIGLAD---NPPFVMQDPPVHTEFRKLVSRGFTPRQVTAVEPAV
MSMEG_3551|M.smegmatis_MC2_155 GDQTPELAEYFG-----SMIAMDDPRHTRLRNIVRSAFTPRVLAVIEDSV
MLBr_02088|M.leprae_Br4923 AQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDI
* * **. *.:: *:* : :
Mb1813c|M.bovis_AF2122/97 RRHTVAMIDAIAGR---GECEAMADLANLFPFQLFLVLYGLPLEDRDRLI
Rv1785c|M.tuberculosis_H37Rv RRHTVAMIDAIAGR---GECEAMADLANLFPFQLFLVLYGLPLEDRDRLI
MMAR_2631|M.marinum_M QAQAIEIIDAIAAG---SQCEVITELAIPYPSQVFLTLFGLSLADRDRLI
MUL_3106|M.ulcerans_Agy99 QAQAIEIIDAIAAG---SQCEVITKLAIPYPSQVFLTLFGLSLADRDRLI
Mflv_1764|M.gilvum_PYR-GCK QAQVADIVEEIARR---DRCEVMAELATPYPSQVFLTLFGLPLQDRERLI
Mvan_4983|M.vanbaalenii_PYR-1 QAQAADIVETIAQR---DACEVMAELATPYPSQVFLTLFGLPLQDRERLI
MAV_2548|M.avium_104 QQQAIEIIERVAAQ---GECEVVADVAIPYPSQVFLTLFGLPLEDRDKLV
MAB_1406c|M.abscessus_ATCC_199 REFVVQRLERLKER---GEGDIVVELFKPLPSMVVAHYLGVPEEDRTQFD
TH_3609|M.thermoresistible__bu RRFVVERIERLRAD---GGGDIVAELFKPLPSMVVAHYLGVPESDRAQFD
MSMEG_3551|M.smegmatis_MC2_155 RDRARRLVAGMVDRNPDGHAELVTELAGPLPLQIICDMMGIPESDHQQIF
MLBr_02088|M.leprae_Br4923 AALVDSLLDKGAAA---GQFDVIADLAFPLAVAVICRLLGVPYEDAPEFG
. : . : :..: . :. *:. * .:
Mb1813c|M.bovis_AF2122/97 GWKDAVIAMSDR--------PHPTEADVAAARELLEYLTAMVAERRRNPG
Rv1785c|M.tuberculosis_H37Rv GWKDAVIAMSDR--------PHPTEADVAAARELLEYLTAMVAERRRNPG
MMAR_2631|M.marinum_M RWKDAIIALGLL--------ASLDDADLTPALELTSYLVDAIAAHRRHPG
MUL_3106|M.ulcerans_Agy99 RWKDAIIALGLL--------ASLDDADLTPALELTSYLVDAIAAHRRHPG
Mflv_1764|M.gilvum_PYR-GCK AWKDAIIAFSLT--------TDPSSVDLKPAVELYTYLSEAVAAQRDDPR
Mvan_4983|M.vanbaalenii_PYR-1 AWKDAIIAFSLT--------NDPTSVDLTPAVELYGYLTEAVARQREKPR
MAV_2548|M.avium_104 AWKTSVIAISEA--------PSLEDADLTPALELVAYLTEAINARRADPG
MAB_1406c|M.abscessus_ATCC_199 AWTDGIVAAASGGA---IDIEAMQGEVAQTIGELMMYFTGLIERRRAEPE
TH_3609|M.thermoresistible__bu RWTDAIVAANTG-------ADGVMG-AGAAVGEMMAYFTELIEYRRREPA
MSMEG_3551|M.smegmatis_MC2_155 HWTNVILGFGDP------DLTTDFDEFVTVAMDIGAYATALADQRRSAPA
MLBr_02088|M.leprae_Br4923 RVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPG
. :: : * :* *
Mb1813c|M.bovis_AF2122/97 PDVLSQVQIGEDPLS-----EIEVLGLSHLLILAGLDTVTAAVGFSLLEL
Rv1785c|M.tuberculosis_H37Rv PDVLSQVQIGEDPLS-----EIEVLGLSHLLILAGLDTVTAAVGFSLLEL
MMAR_2631|M.marinum_M TDILSQVLLGDDPLD-----DSEALGLSYVFVLAGLDTVTSAIGAALLEL
MUL_3106|M.ulcerans_Agy99 TDILSQVLLGDDPLD-----DSEALGLSYVFVLAGLDTVTSAIGAALLEL
Mflv_1764|M.gilvum_PYR-GCK EGVLSHLLHGDDPLT-----DNEAVGLSLVFVLAGLDTVTSAIGATMLEL
Mvan_4983|M.vanbaalenii_PYR-1 EGILSHLLHGDEQLT-----DNEAVGLSLVFVLAGLDTVTSTIGATMLEL
MAV_2548|M.avium_104 PDILSQLLNGEEPLD-----DAEIMGLSFLFVLAGLDTVTAAMSSALLEL
MAB_1406c|M.abscessus_ATCC_199 DDTVSHLVAAGVGADGDISGTLQILGFAFTMVTGGNDTTTGMLGGAIQLL
TH_3609|M.thermoresistible__bu DDTISHLVAAGVDP-------LPVLAFTFTMVTGGNDTTTGMLGGTMQLL
MSMEG_3551|M.smegmatis_MC2_155 DDLTTSLVQAEVDGER--LTSAEVASFFILLVVAGNETTRNAISHGVLAL
MLBr_02088|M.leprae_Br4923 EDLISRLIELDESGDQ--LTEEEIIATCGLLLVAGHETTVNLIANAVLAM
. : : . :: .* :*. :. : :
Mb1813c|M.bovis_AF2122/97 ARRPQLRAMLRDNPKQIR-VFIEEIVRLEPSAPVAPRVTTEPVTVGGMTL
Rv1785c|M.tuberculosis_H37Rv ARRPQLRAMLRDNPKQIR-VFIEEIVRLEPSAPVAPRVTTEPVTVGGMTL
MMAR_2631|M.marinum_M ARRPQLRQLLRENHGQIA-VFVDEIVRLEPPAPVVPRVTTREVNIAGAKI
MUL_3106|M.ulcerans_Agy99 ARRPQLRQLLRENHGQIA-VFVDEIVRLEPPAPVVPRVTTREVNIAGAKI
Mflv_1764|M.gilvum_PYR-GCK ARRPELRGALREDPEGIA-VFVEEMIRLEPAAPIVGRVTTRPVTVAGVTL
Mvan_4983|M.vanbaalenii_PYR-1 ARRPELRAALLGDPDGIA-GFVEEMIRLEPAAPVVGRVTTREVTVAGVTL
MAV_2548|M.avium_104 ARNPELRATLHDDPDQID-VFVEEIVRLEPPAPMLPRVTTTEVTIGDVTL
MAB_1406c|M.abscessus_ATCC_199 HQNPAQRQKLIDDPSLIP-GAVEEFLRLTSPVQGLARTATRDVIIGDTTI
TH_3609|M.thermoresistible__bu HRRPDQRRLLVERPELIA-DAVDEFLRLTSPVQGLARTSTRDVTIGDTTI
MSMEG_3551|M.smegmatis_MC2_155 TRYPEQRRLWWSRFDELAPTAVEEIVRWASPVSYMRRTVTRDTELAGTAL
MLBr_02088|M.leprae_Br4923 LRNPSQWKALSSNPQRAP-LVVEETLRYDPAIHLIGRVAAKDMTIGQTTL
: * ::* :* .. *. : :. :
Mb1813c|M.bovis_AF2122/97 PAGSPVRLCMAAVNRDGSDA-MSTDELVMDGKVHRHWGFGGG-PHRCLGS
Rv1785c|M.tuberculosis_H37Rv PAGSPVRLCMAAVNRDGSDA-MSTDELVMDGKVHRHWGFGGG-PHRCLGS
MMAR_2631|M.marinum_M PAGSRVWLCLGAINRDGSDA-TSVNDVVMDGKVHKHWGFGGG-THRCLGS
MUL_3106|M.ulcerans_Agy99 PAGSRVWLCLGAINRDGSDA-TSVNDVVMDGKVHKHWDFGGG-THRCLGS
Mflv_1764|M.gilvum_PYR-GCK PAGSEVRLCLGAINRDGTDE-HSGDDLVLDGKLHKHWGFGGG-PHRCLGS
Mvan_4983|M.vanbaalenii_PYR-1 PKGAEVRLCLGAINRDGADE-HSGDDFVLDGKLHKHWGFGGG-PHRCLGS
MAV_2548|M.avium_104 PADTMVRLCVAAINRDDSDE-ISTNDVVMDGKVHRHWGFGGG-PHRCLGS
MAB_1406c|M.abscessus_ATCC_199 PAGRRALLLYGSANRDEREYGNDAAELDVLRKPRNILTFSHG-NHHCLGA
TH_3609|M.thermoresistible__bu PAGRKVLLLYASANRDEREFGPDAAELDVTRRPRNILTFSHG-AHFCLGA
MSMEG_3551|M.smegmatis_MC2_155 PAGSKVTLWYGSANRDETKF-DNPWMFDVQRHPNPHVGFGGGGAHFCLGA
MLBr_02088|M.leprae_Br4923 TEGDTMVLLLAAANRDPAVY-SRPDEFDPDRPSSRHLAFAVG-SHFCLGA
. . * .: *** . *. * * ***:
Mb1813c|M.bovis_AF2122/97 HLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS--
Rv1785c|M.tuberculosis_H37Rv HLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS--
MMAR_2631|M.marinum_M HLARMELSLVISEWLRRIPQFELACGYTPEIDWPSATLGLSTLTLQFTS-
MUL_3106|M.ulcerans_Agy99 HLARMELSLVISEWLCRIPQFELACGYTPEIDWPSATLGLSTLPLQFTS-
Mflv_1764|M.gilvum_PYR-GCK HLARMELKLVVSEWLSRIPDFDLEPGYVPEITWPSATCTLTGLPLRILR-
Mvan_4983|M.vanbaalenii_PYR-1 HLARMELRLVVTEWLSRIPDFELAPGYVPEITWPSATCTLPTLPLILTRK
MAV_2548|M.avium_104 HLARLELKLIVGEWLRRIPEFSVKVGEEPQIVFPASTFSLERVPLKLG--
MAB_1406c|M.abscessus_ATCC_199 AAARMQSRIALEELLTRIPDFEVDLD---GVTWADGSYVRRPLTVPIRVR
TH_3609|M.thermoresistible__bu AAARMQSRVALTELLVRCPEFSVDED---GITWADGGYVRRPLTLPVRIP
MSMEG_3551|M.smegmatis_MC2_155 NLARREITVLFSELHRHLPDIVATEE--PDRLQSAFIHGIKRLPVAWR--
MLBr_02088|M.leprae_Br4923 ALARLEATVTLSAISARFPQVQLAGELVYKPNVAMR--GMSALPVQV---
** : : . : *:. . :.:
Mb1813c|M.bovis_AF2122/97 ------
Rv1785c|M.tuberculosis_H37Rv ------
MMAR_2631|M.marinum_M ------
MUL_3106|M.ulcerans_Agy99 ------
Mflv_1764|M.gilvum_PYR-GCK ------
Mvan_4983|M.vanbaalenii_PYR-1 TP----
MAV_2548|M.avium_104 ------
MAB_1406c|M.abscessus_ATCC_199 ------
TH_3609|M.thermoresistible__bu GQAPRR
MSMEG_3551|M.smegmatis_MC2_155 ------
MLBr_02088|M.leprae_Br4923 ------