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MTTPQMIFDPFSEQYFENPFDIYRQMRDDAPLYYDSEQDFYALSRHEDVAAALKDHEAFSSSRGCDLAMV KGDEPPQKSIIFMDPPEHRHMRSLLNKAFTPRAVQAQRDTVVEQVEHYLGQIDSDEFDVVQDFSGPFPVE VITRMAGVEPEYRQQVRHWIDTSLSREPGQVAYSEAGMKANIDTAMYYYSLVQKRRENPQDDMISRLIAA EIPGENGEMRRLDDVEITGFATLLGGAGAETVTKLIGTAMVTFAKFPDQWQKLLDDRSKVPAAVEELLRY EGPVQYNVRYTLKEARVPSGTIPAGKPVFLLKASANRDERAWTDPDVFDIDRDRTEAQNLGLGYGIHSCL GAALARLESTIALERLLDFMPRYEVKWDGLQRVHMQNVAGYSHVPVKVLR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4818 | - | - | 100% (400) | putative cytochrome P450 123 |
| M. smegmatis MC2 155 | MSMEG_5861 | - | 2e-72 | 37.66% (401) | cytochrome P450 109 |
| M. smegmatis MC2 155 | MSMEG_4887 | - | 8e-67 | 35.34% (399) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 2e-70 | 36.93% (398) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_2479 | - | 0.0 | 76.00% (400) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 2e-70 | 36.93% (398) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-44 | 32.08% (399) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 1e-66 | 35.41% (401) | cytochrome P450 |
| M. marinum M | MMAR_4733 | cyp190A3 | 1e-159 | 66.00% (400) | cytochrome P450 190A3 Cyp190A3 |
| M. avium 104 | MAV_0916 | - | 0.0 | 77.56% (401) | cytochrome P450 monooxygenase |
| M. thermoresistible (build 8) | TH_2585 | - | 0.0 | 85.24% (393) | PUTATIVE putative cytochrome P450 123 |
| M. ulcerans Agy99 | MUL_0475 | cyp123A3 | 2e-67 | 36.82% (402) | cytochrome P450 123A3 Cyp123A3 |
| M. vanbaalenii PYR-1 | Mvan_4175 | - | 0.0 | 76.25% (400) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0789c|M.bovis_AF2122/97 --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
MUL_0475|M.ulcerans_Agy99 --------------------------MSVHVGGPE-LVLDPYDYDFHEDP
MSMEG_4818|M.smegmatis_MC2_155 --------------------------MTTPQ-----MIFDPFSEQYFENP
TH_2585|M.thermoresistible__bu ------------------------------------VKFDPFSEEFFNDP
Mflv_2479|M.gilvum_PYR-GCK --------------------------MTKPK-----LVFDPVAQEYFDNP
Mvan_4175|M.vanbaalenii_PYR-1 --------------------------MTAPE-----LRFDPVSQDYFDNP
MAV_0916|M.avium_104 --------------------------MTKPK-----LVFDPYSEDYFNNP
MMAR_4733|M.marinum_M --------------------------MTTSK-----VVFDPFSEEFFNGP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: : .*
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVSMDK
MUL_0475|M.ulcerans_Agy99 YPYYRRLRNEAPLYHNQELGFWALSRRRDVHQGFRNSTTLSNRDGVSLDP
MSMEG_4818|M.smegmatis_MC2_155 FDIYRQMRDDAPLYYDSEQDFYALSRHEDVAAALKDHEAFSSSRGCDLAM
TH_2585|M.thermoresistible__bu FGIYKRMRDEAPIYYDEDEDFYALSRHADVAAALKDHETFSSSRGCDLAM
Mflv_2479|M.gilvum_PYR-GCK YEIYQRMRDEAPIYYDEEGDFYALTRHADVAAALKDHEAFSSARGCDLAM
Mvan_4175|M.vanbaalenii_PYR-1 YEIYRRMRDEAPIYYDAEEDFYALTRHEDVAAALKDHEAFSSARGCDLGM
MAV_0916|M.avium_104 YEIYRRMREEAPLYYDEKEDFYALTRHVDVAAAFKDYETYSSARGCDLAM
MMAR_4733|M.marinum_M WETYRRMQAEAPVYYSEQYDFYALTRHADVAAGLKNFERYSSAYGIDLSM
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
: *: : .*: : ..: * .::. *. :
Mb0789c|M.bovis_AF2122/97 ----SSRTSEAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
Rv0766c|M.tuberculosis_H37Rv ----SSRTSEAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
MAB_1216c|M.abscessus_ATCC_199 ----ASFGPHAKLVMSFLAMDDPEHLRLRALVSKGFTPRRIRELEGQVVA
MUL_0475|M.ulcerans_Agy99 ----VSRGPHATKTMSFLAIDDPAHLRLRTLVSKGFTPRRIRELEPRVTE
MSMEG_4818|M.smegmatis_MC2_155 ----VKGDEPP--QKSIIFMDPPEHRHMRSLLNKAFTPRAVQAQRDTVVE
TH_2585|M.thermoresistible__bu ----VRSEERP--QKSIIFMDPPEHRHMRSLLNKAFTPRAIQSQRDTVIE
Mflv_2479|M.gilvum_PYR-GCK ----VRSEEGP--VKSIIFMDPPEHRHMRSLLNKAFTPRAIQNQHQTVTE
Mvan_4175|M.vanbaalenii_PYR-1 ----VRSEDGP--VKSIIFMDPPEHRHMRSLLNKAFTPRAIQSQRETVIE
MAV_0916|M.avium_104 ----VRRGISPE-QKSIIFMDPPEHRHMRSLLNKAFTPRAIQSQRETIIE
MMAR_4733|M.marinum_M ----VRSGQKP--PQSIIFMDPPDHRHMRSLLNKVFTPRAIQAQRQTVID
MLBr_02088|M.leprae_Br4923 QAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAA
. *:: :* * * ::* *:.* *:*: :: . :
Mb0789c|M.bovis_AF2122/97 LARIHLDSALQTES----FDFVAEFAGKLPMDVISELIGVPDTDRARIR-
Rv0766c|M.tuberculosis_H37Rv LARIHLDSALQTES----FDFVAEFAGKLPMDVISELIGVPDTDRARIR-
MAB_1216c|M.abscessus_ATCC_199 LARTHLDRALANASD-RSFDFIAEYAGKLPMDVISELMGVPESDRARIR-
MUL_0475|M.ulcerans_Agy99 LAVAHLDTMLDMAGGSQTVDYVAEFAGKLPMDVISELMGVPVADRDQIR-
MSMEG_4818|M.smegmatis_MC2_155 QVEHYLG-QIDSDE----FDVVQDFSGPFPVEVITRMAGVEPEYRQQVR-
TH_2585|M.thermoresistible__bu LVRKYLG-AVKSDE----FDVVQDFSGPFPVEVITRMAGVPEEYRQQVR-
Mflv_2479|M.gilvum_PYR-GCK LVEQYLA-KVDPDN----FDVVQDFSGPFPVEVITRMAGVPEDFRQQVR-
Mvan_4175|M.vanbaalenii_PYR-1 LVEHYLS-KVDPDN----FDVVQDFSGPFPVEVITRMAGVPEEFRQQVR-
MAV_0916|M.avium_104 VVDKYLS-AADPDN----FDVVQDFSGPFPVEVITRMAGVPEEYRQQVR-
MMAR_4733|M.marinum_M KIDKYLG-ALDPEG----FDAVQEFSGPFPVEVITTMLGVPERHAQQVR-
MLBr_02088|M.leprae_Br4923 LVDSLLDKGAAAGQ----FDVIADLAFPLAVAVICRLLGVPYEDAPEFGR
* .* : : : :.: ** : ** ..
Mb0789c|M.bovis_AF2122/97 ------ALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPAN
Rv0766c|M.tuberculosis_H37Rv ------ALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPAN
MAB_1216c|M.abscessus_ATCC_199 ------ELADGVMHREDGLADVPPEAIQASFDLMTYYIEMVRERRRRPTE
MUL_0475|M.ulcerans_Agy99 ------AMADGVMHREDGVTDVPASAIEASINLIVYYQQMIAERRKKPSD
MSMEG_4818|M.smegmatis_MC2_155 ------HWIDTSLSREPGQVAYSEAGMKANIDTAMYYYSLVQKRRENPQD
TH_2585|M.thermoresistible__bu ------HWIDTSLHREPGQIEATEAGMQANIDTAMFYYDLVQKRRQEPQD
Mflv_2479|M.gilvum_PYR-GCK ------HWIDTSLERQPGQIGWSDKNMQANIDSGVYYYGLVQERRQNPQD
Mvan_4175|M.vanbaalenii_PYR-1 ------HWIDKGLERKPGQIEWSDENMQANIDSGVYYYGLVQERRRNPQD
MAV_0916|M.avium_104 ------HWIDTSLHHEPGQIEVSEAGMQANIDTAMYYFGLVQERRQNPQD
MMAR_4733|M.marinum_M ------HWIDESLTREPGQVEVGEQGMQANINTAMLYYDLVKQRRDDPRD
MLBr_02088|M.leprae_Br4923 VSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGE
* : : *.. :: * * :
Mb0789c|M.bovis_AF2122/97 NLTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVY
Rv0766c|M.tuberculosis_H37Rv NLTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVY
MAB_1216c|M.abscessus_ATCC_199 DLTSALLQAEIDGD-----RLTDEEVLAFLFLMVIAGNETTTKLLANAVY
MUL_0475|M.ulcerans_Agy99 DLTSALLAADVDGD-----RLTDEEVLGFMFLMVIAGNETTTKLLANAAF
MSMEG_4818|M.smegmatis_MC2_155 DMISRLIAAEIPGENGEMRRLDDVEITGFATLLGGAGAETVTKLIGTAMV
TH_2585|M.thermoresistible__bu DMISRLIAAEIPDEDGGMRRLDDIEICGFATLLGGAGAETVTKLIGTAVV
Mflv_2479|M.gilvum_PYR-GCK DMISRLIAAEIPDENGQMRRLDDIEITGFTSLLGGAGAETVTKLVGSAVV
Mvan_4175|M.vanbaalenii_PYR-1 DMISRLIAAEIPGENGEMRKLDDIEITGFTSLLGGAGAETVTKLLGSAVV
MAV_0916|M.avium_104 DMISRLIAAEIPGENGQMRKLDDIEITGFATLLGGAGAETVTKLLGNAAV
MMAR_4733|M.marinum_M DLFTKLINAEIEREDGQVTNLDDLEIAGFATLLGGAGAETVTKLVGNAAV
MLBr_02088|M.leprae_Br4923 DLISRLIELDESGD-----QLTEEEIIATCGLLLVAGHETTVNLIANAVL
:: : *: : : .* : *: . *: ** **..:*:..*
Mb0789c|M.bovis_AF2122/97 WAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTT
Rv0766c|M.tuberculosis_H37Rv WAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTT
MAB_1216c|M.abscessus_ATCC_199 WGHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAEDITVYDTK
MUL_0475|M.ulcerans_Agy99 WGHKNTDQLTPIYADLSRVPLWVEETLRYDTSSQILARTVVGELTLYDTT
MSMEG_4818|M.smegmatis_MC2_155 TFAKFPDQWQKLLDDRSKVPAAVEELLRYEGPVQYNVRYTLKEARVPSGT
TH_2585|M.thermoresistible__bu NFARFPDQWQKLLDDRSKIPAAVEELLRYEGPVQYNVRYTLKEAHVPSGT
Mflv_2479|M.gilvum_PYR-GCK EFARHPDQWQLLLDDRSLIPAAVEELLRYVGPVQYNVRYTVKEAHVPSGT
Mvan_4175|M.vanbaalenii_PYR-1 EFARHPEQWQMLLDDRNLIPDAVEELLRYVGPVQYNVRYTVKEAHVPSGT
MAV_0916|M.avium_104 IFARHPDQWQKLQDDRDKIPGAVEELLRYEGPVQYNVRYTLKEAHVSGGV
MMAR_4733|M.marinum_M VFARNPEQWQKLLDDRSKVPAAVEELLRYEAPSQYQVRRAMEDVELHGVT
MLBr_02088|M.leprae_Br4923 AMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTT
: . * : : . * *** *** . : * . : :
Mb0789c|M.bovis_AF2122/97 IPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIG-CKLVSFGSGAHFCLG
Rv0766c|M.tuberculosis_H37Rv IPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIG-CKLVSFGSGAHFCLG
MAB_1216c|M.abscessus_ATCC_199 IPAGDILLLLPGSANRDDRVFDDADQYRIGREIG-AKLVSFGSGAHFCLG
MUL_0475|M.ulcerans_Agy99 IPEGDVVLLLPGSAHRDERAFRDPDEYLIGREIG-SKLLSFGSGAHFCLG
MSMEG_4818|M.smegmatis_MC2_155 IPAGKPVFLLKASANRDERAWTDPDVFDIDRDRTEAQNLGLGYGIHSCLG
TH_2585|M.thermoresistible__bu IPAGKPVFLLKASANRDERAWTDADRFDIDRDRTESPNLALGYGIHSCLG
Mflv_2479|M.gilvum_PYR-GCK IPAHKPVFLMKAAANRDPRAFDNAETFDITRDRTQAQNLGLGYGIHSCLG
Mvan_4175|M.vanbaalenii_PYR-1 IPAHKPVFLMKAAANRDPRAFDNAETFDITRDRTQAQNLGLGYGIHSCLG
MAV_0916|M.avium_104 IPAGKPVFLCGAAANRDPEAFTDADTFDIERDQTEAQHLGLGYGIHSCLG
MMAR_4733|M.marinum_M IPAGKPVFLINGAANRDPHAWTDPDKFDIDRDPHEATNLGFGYGIHSCLG
MLBr_02088|M.leprae_Br4923 LTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS--RHLAFAVGSHFCLG
:. . :.* .:*:** .: .: : * :.:. * * ***
Mb0789c|M.bovis_AF2122/97 AHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR
Rv0766c|M.tuberculosis_H37Rv AHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR
MAB_1216c|M.abscessus_ATCC_199 AHLARMEAKVALTELFTRISGYEIDERNSVRVHSSNVRGFAHLPMTVQLR
MUL_0475|M.ulcerans_Agy99 AHLARMEARVALTELFKRIRGYQVDEGNAVRVHSSNVRGFAHLPITVEVA
MSMEG_4818|M.smegmatis_MC2_155 AALARLESTIALERLLDFMPRYEVKWDGLQRVHMQNVAGYSHVPVKVLR-
TH_2585|M.thermoresistible__bu AALARLESTIALEHLLDFMPRYEVKWDGLRRVTMQNVGGYSHVPVKVLR-
Mflv_2479|M.gilvum_PYR-GCK AALARMETAVALEHLLDFMPRYEVDFDGLQRVSMQNVAGYHHVPVRVLR-
Mvan_4175|M.vanbaalenii_PYR-1 AALARTETAIALEHLLDFMPRFEVDFSGLQRVNMQNVAGYHHVPVKVLR-
MAV_0916|M.avium_104 AALARLESRIALERLLDFMPRYEVDWAGCRRVTMQNVAGWKNVPVKVLR-
MMAR_4733|M.marinum_M AALARMESAIALEKLLDFMPAFEVDWAGCKRVHMQNVAGWQSVPVRVLR-
MLBr_02088|M.leprae_Br4923 AALARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQV---
* *** *: ::* : : :: : * :*: *
Mb0789c|M.bovis_AF2122/97 ---
Rv0766c|M.tuberculosis_H37Rv ---
MAB_1216c|M.abscessus_ATCC_199 EGR
MUL_0475|M.ulcerans_Agy99 ---
MSMEG_4818|M.smegmatis_MC2_155 ---
TH_2585|M.thermoresistible__bu ---
Mflv_2479|M.gilvum_PYR-GCK ---
Mvan_4175|M.vanbaalenii_PYR-1 ---
MAV_0916|M.avium_104 ---
MMAR_4733|M.marinum_M ---
MLBr_02088|M.leprae_Br4923 ---