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M. gilvum PYR-GCK Mflv_4379 (-)

annotation: acyl-CoA dehydrogenase domain-containing protein
coordinates: 4658796 - 4660028
length: 410

MDLGWSATDLEFRDEVRAFLEEKLAPELRQAGRLMTSVYADHDASMAWQAILHERGWAAPAWPVAHGGCD
WSLTQHYIFSRESTLAGAPSLSPMGIRMVAHAIIKFGTDEQKDFFLPRILTGEVFFCQGYSEPEAGSDLA
ALSMAARDDGDHLVCTGSKIWTTHAQEANWMFALVRTTRTDKKQRGITFVLIDMATPGIEIRPLVMTSGE
EVQNQVFFDEVRVPKSNVIGQIDDGWTVAKYLLEFERGGGAVAPGLQVMAENIATVAADQPGPGGGRLLD
DPAFARKLADVRIRTEVLEILEYQVLAVVAGGGNPGAKSSMLKVLGTELSQAITELAMEAAGPRGRVYQP
HATYPGGPIAEFEPPEGDYVSGEPWQAVAPLRYFNDRAGSIYAGSNEIQRNILAKAALGL

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. gilvum PYR-GCK Mflv_4379 - - 100% (410) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_2287 - 2e-73 39.90% (411) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_1481 - 5e-52 33.83% (405) acyl-CoA dehydrogenase domain-containing protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1969c fadE17 2e-60 34.76% (420) acyl-CoA dehydrogenase FADE17
M. tuberculosis H37Rv Rv1934c fadE17 2e-60 34.76% (420) acyl-CoA dehydrogenase FADE17
M. leprae Br4923 MLBr_00737 fadE25 1e-21 24.41% (426) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_2495 - 1e-175 73.17% (410) acyl-CoA dehydrogenase
M. marinum M MMAR_3737 fadE17_1 8e-75 40.88% (411) acyl-CoA dehydrogenase FadE17_1
M. avium 104 MAV_1766 - 2e-74 39.17% (411) acyl-CoA dehydrogenase domain-containing protein
M. smegmatis MC2 155 MSMEG_2191 - 0.0 85.85% (410) acyl-CoA dehydrogenase family protein
M. thermoresistible (build 8) TH_4368 - 0.0 82.68% (410) PUTATIVE acyl-CoA dehydrogenase family protein
M. ulcerans Agy99 MUL_3681 fadE17_1 5e-75 40.88% (411) acyl-CoA dehydrogenase FadE17_1
M. vanbaalenii PYR-1 Mvan_1965 - 0.0 91.95% (410) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb1969c|M.bovis_AF2122/97           -MDVSYPPEAEAFR--DRIREFVAEHLPPGWPGPGALPPHERE--EFARH
Rv1934c|M.tuberculosis_H37Rv        -MDVSYPPEAEAFR--DRIREFVAEHLPPGWPGPGALPPHERE--EFARH
Mflv_4379|M.gilvum_PYR-GCK          -MDLGWSATDLEFR--DEVRAFLEEKLAPELRQAGRLMTSVYADHDASMA
Mvan_1965|M.vanbaalenii_PYR-1       -MDLEWSATDLAFR--DEVRAFLDDRLTPELRRAGRLMTSVYADHDASMA
MSMEG_2191|M.smegmatis_MC2_155      -MDLKWSKTDQEFR--DEVRGFLAEKLTPDLREAGRLQTSVYSEHEASME
TH_4368|M.thermoresistible__bu      -MDLQWSPADLAFR--DEVRAFLDEKLTPGLRRAGRLQTSVYSDHEASME
MAB_2495|M.abscessus_ATCC_1997      -MDLAFSAEEEQFR--TEVREFLDANLTAELRAAGRLQTSVYSDHEASMR
MMAR_3737|M.marinum_M               -MKLALTPDEAAFR--DELRTFYTTRIPEDLRELVR-QGQSPS-RDEIVT
MUL_3681|M.ulcerans_Agy99           -MKLALTPDEAAFR--DELRTFYTTRIPEDLRELVR-QGQSPS-RDEIVT
MAV_1766|M.avium_104                -MQLALTPEEAAFR--DELRTIYTTKIPEELRERVR-RGSAEVNRDDIVT
MLBr_00737|M.leprae_Br4923          MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
                                     :          *:   . . :     .                      

Mb1969c|M.bovis_AF2122/97           WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAGAPERAENDLL
Rv1934c|M.tuberculosis_H37Rv        WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAGAPERAENDLL
Mflv_4379|M.gilvum_PYR-GCK          WQAILHERGWAAPAWPVAHGGCDWSLTQHYIFSRESTLAGAPSLSP---M
Mvan_1965|M.vanbaalenii_PYR-1       WQQILHERGWAAPAWPVAHGGCDWSLTQHYIFSRESTLAGAPSLSP---M
MSMEG_2191|M.smegmatis_MC2_155      WQRILHERGWAAPAWPVEHGGCDWSLTQHYIFSRESTLAGAPALSP---M
TH_4368|M.thermoresistible__bu      WQRILHERGWAAPAWPVEYGGCDWTLTQHYIFERETTLAGAPSLSP---M
MAB_2495|M.abscessus_ATCC_1997      WQAILHRKGWAAPAWPVKYGGQPWSLAQHYIFSVESMVAGAPSLSP---M
MMAR_3737|M.marinum_M               CHKILNDHGLAVPNWPVEWGGKDWTPTQHQIWADEMQLASVPEPLN---F
MUL_3681|M.ulcerans_Agy99           CHKILNDHGLAVPNWPVEWGGKDWTPTQHQIWADEMQLASVPEPLN---F
MAV_1766|M.avium_104                SHKILHEHGLAVPNWPVEWGGKDWTPTQHQIWADEMQLACVPEPLN---F
MLBr_00737|M.leprae_Br4923          ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIP--A
                                        *   *  .   *   **         :   *   . ..        

Mb1969c|M.bovis_AF2122/97           GIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPEAGSDLASVRT
Rv1934c|M.tuberculosis_H37Rv        GIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPEAGSDLASVRT
Mflv_4379|M.gilvum_PYR-GCK          GIRMVAHAIIKFGTDEQKDFFLPRILTGEVFFCQGYSEPEAGSDLAALSM
Mvan_1965|M.vanbaalenii_PYR-1       GIRMVAHAIIRFGSDEQKNYFLPRILTGEVFFCQGYSEPEAGSDLAALSM
MSMEG_2191|M.smegmatis_MC2_155      GIRMVAHAIIKFGTEEQKSYFLPRILTGEVFFCQGYSEPEAGSDLAALSM
TH_4368|M.thermoresistible__bu      GIKMVAHAIIAYGTQEQKDYFLPRILTGEVFFCQGYSEPEAGSDLAALSM
MAB_2495|M.abscessus_ATCC_1997      GIRMVAHAIIKFGSPEQKEFFLPRILTGEVFFCQGYSEPESGSDLASLQM
MMAR_3737|M.marinum_M               NTKMVGPVIAEFGSQEIKQRFLPPTASLDIWWCQGFSEPEAGSDLASLRT
MUL_3681|M.ulcerans_Agy99           NTKMVGPVIAEFGSQEIKQRFLPPTASLDIWWCQGFSEPEAGSDLASLRT
MAV_1766|M.avium_104                NTKMVGPVIAEFGSEEVKQRFLPPTASLDIWWCQGFSEPDAGSDLASLRT
MLBr_00737|M.leprae_Br4923          VNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRT
                                       :    :   *:   *  .**   :     . . ** ::*** *::  

Mb1969c|M.bovis_AF2122/97           RGVLDGDEWVINGHKIWTSAGTTANWIFLLARTD-PSAAKHRGLSFLLVP
Rv1934c|M.tuberculosis_H37Rv        RGVLDGDEWVINGHKIWTSAGTTANWIFLLARTD-PSAAKHRGLSFLLVP
Mflv_4379|M.gilvum_PYR-GCK          AARDDGDHLVCTGSKIWTTHAQEANWMFALVRTT-RTDKKQRGITFVLID
Mvan_1965|M.vanbaalenii_PYR-1       AARDDGDHLVCTGSKIWTTHAREANWMFALVRTT-RSEKKQRGITFVLID
MSMEG_2191|M.smegmatis_MC2_155      SAVSDGDDLVCTGSKIWTTHAQEANWMFALVRTT-RGAKKQQGITFVLID
TH_4368|M.thermoresistible__bu      AAVDDGDDLICSGSKIWTTHAVEANWMFALVRTS-RSDKKQKGITFLLID
MAB_2495|M.abscessus_ATCC_1997      SAVADGDDFVLNGSKIWTTHAREANWMFALVRTT-KGPKKQLGITFILID
MMAR_3737|M.marinum_M               TAVRDGDSYVVNGQKTWTTLGQYADWIFCLVRTDPQAPKRQAGISFLLID
MUL_3681|M.ulcerans_Agy99           TAVRDGDSYVVNGQKTWTTLGQYADWIFCLVRTDPQAPKRQAGISFLLID
MAV_1766|M.avium_104                TAVRDGDHYIVNGQKTWTTLGQYADWIFCLVRTDPQAPKRQAGISFLLFD
MLBr_00737|M.leprae_Br4923          RAKADGDDWILNGFKCWITNGGKSTWYTVMAVTD--PDKGANGISAFIVH
                                     .  ***  : .* * * : .  : *   :. *         *:: .:. 

Mb1969c|M.bovis_AF2122/97           MDQPGVVVRPIVNAAGH--SSFSEVFLTDARTSAGNVVGRVGDGWSTAMT
Rv1934c|M.tuberculosis_H37Rv        MDQPGVVVRPIVNAAGH--SSFSEVFLTDARTSAGNVVGRVGDGWSTAMT
Mflv_4379|M.gilvum_PYR-GCK          MATPGIEIRPLVMTSGE--EVQNQVFFDEVRVPKSNVIGQIDDGWTVAKY
Mvan_1965|M.vanbaalenii_PYR-1       MSTPGIEIRPLVMTSGE--EVQNQVFFDDVRVPKANVIGEIDDGWTVAKY
MSMEG_2191|M.smegmatis_MC2_155      MTSPGIQIRPLVMTSGE--EVQNQVFFDEVRVPKKNVIGAIDDGWTVAKY
TH_4368|M.thermoresistible__bu      MTSPGIEIRPLVMTSGE--VVQNQVFFDEVRVPKRNVVGKIDEGWTVAKY
MAB_2495|M.abscessus_ATCC_1997      FTSPGIDVKPLVMSSGE--EVQNVVFFDNVRVPRANVLGEVDQGWTVAKY
MMAR_3737|M.marinum_M               MATPGITLRPIKTIDGG--HEVNEVFFSDVRVPADQLVGQENQGWTYAKF
MUL_3681|M.ulcerans_Agy99           MATPGITLRPIKTIDGG--HEVNEVFFSDVRVPADQLVGQENQGWTYAKF
MAV_1766|M.avium_104                MKSPGITLRPIKTIDGG--HEINEVFFEDVRVPADQLVGEENQGWTYAKF
MLBr_00737|M.leprae_Br4923          KDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALA
                                        *. : *     *      . ::: . * .  .::*  . *:. *  

Mb1969c|M.bovis_AF2122/97           LLGFERGSH-IATAAIDFERDLQRLCELARDR----GLHTDPRVRDGLAW
Rv1934c|M.tuberculosis_H37Rv        LLGFERGSH-IATAAIDFERDLQRLCELARDR----GLHTDPRVRDGLAW
Mflv_4379|M.gilvum_PYR-GCK          LLEFERGGG-AVAPGLQVMAENIATVAADQPGPGGGRLLDDPAFARKLAD
Mvan_1965|M.vanbaalenii_PYR-1       LLEFERGGG-ASAPALQVMVEEITTAAAGQPGPSGGRLLDDPAFARKLAD
MSMEG_2191|M.smegmatis_MC2_155      LLEFERGGG-ASSPALQVLGEEIATVAARQPGPSGGRLIDDPAFSRKLAD
TH_4368|M.thermoresistible__bu      LLEFERGGS-ATSPGLQVMADQIATAAAEQPGPGGTRLIDDPGFSRRLAD
MAB_2495|M.abscessus_ATCC_1997      LLEFERGGG-AVAPMLQVGLDQLSVDARSVPAENG-TLADDPVFCAKLAD
MMAR_3737|M.marinum_M               LLGNERTGI-AGVGRTKVRLAEVKKHAANNG------LLDDPLFAARLAE
MUL_3681|M.ulcerans_Agy99           LLGNERTGI-AGVGRTKVRLAEVKKHAANNG------LLDDPLFAARLAE
MAV_1766|M.avium_104                LLGNERTGI-AGVGRTKVRLAEVKKHAAATG------VLDDPLFAARLAE
MLBr_00737|M.leprae_Br4923          TLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLAD
                                     *   *                               :     .   ** 

Mb1969c|M.bovis_AF2122/97           CYARVQIMRYRGYRDLTLALTGR-PPGAEAAITKVIWSEYFRRYTDLAVE
Rv1934c|M.tuberculosis_H37Rv        CYARVQIMRYRGYRDLTLALTGR-PPGAEAAITKVIWSEYFRRYTDLAVE
Mflv_4379|M.gilvum_PYR-GCK          VRIRTEVLEILEYQVLAVVAGGG-NPGAKSSMLKVLGTELSQAITELAME
Mvan_1965|M.vanbaalenii_PYR-1       VRIRTEVLEILEYQVLAAVAEGG-NPGAKSSMLKVLSTELSQAITELAME
MSMEG_2191|M.smegmatis_MC2_155      ARIRTDVLEILEYQVLAAVAEGR-NPGTASSMLKVLSTELSQILTELSME
TH_4368|M.thermoresistible__bu      ARIRTEVLEILEYQVLATVAAGK-NPGSASSMLKVLSTELSQTLTELAME
MAB_2495|M.abscessus_ATCC_1997      LAIRVDVLEVLEHRVLAVVAGGG-NPGAASSMLKILGTELSQALTTLTLE
MMAR_3737|M.marinum_M               AENELLALELTQARVVTDSADG--KPNPASSVLKLRGSQLQQVATELLVE
MUL_3681|M.ulcerans_Agy99           AENELLALELTQARVVTDSADG--KPNPASSVLKLRGSQLQQVATELLVE
MAV_1766|M.avium_104                AENELLALELTQSRVTTDSANG--QPNPASSVLKLRGSQLQQVATELLVE
MLBr_00737|M.leprae_Br4923          MAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTDAVQ
                                       .    .       :    *    .  ::  *   ::     *   ::

Mb1969c|M.bovis_AF2122/97           ILG--LEALGPRGPGNGGARLVP------EAGTPNSPACWMDELLYARAA
Rv1934c|M.tuberculosis_H37Rv        ILG--LEALGPRGPGNGGARLVP------EAGTPNSPACWMDELLYARAA
Mflv_4379|M.gilvum_PYR-GCK          AAGPRGRVYQPHATYPGGPIAEFEPPEGDYVSGEPWQAVAPLRYFNDRAG
Mvan_1965|M.vanbaalenii_PYR-1       AAGPRGRVYQPHATCPGGPIAEFEPPADDYVSGEPWQAVAPLRYFNDRAG
MSMEG_2191|M.smegmatis_MC2_155      AAGPRGRAYQPHATRPGGPVAEFEPPADGYVSGEPWQAVAPLRYFNDRAG
TH_4368|M.thermoresistible__bu      AAGPQGRAYQPHATCPGGPVSDFVPPADGYVTGEPWQAVAPLRYFNDRAG
MAB_2495|M.abscessus_ATCC_1997      AAGPRGRAYQPHVTKPGGPVVEYTPPADGYHSGELWQAVAPLHYFNDRAG
MMAR_3737|M.marinum_M               VAG-------PDALPVGGAQAAG-------IASPQWAQSSAPRYLNYRKT
MUL_3681|M.ulcerans_Agy99           VAG-------PDALPVGGAQAAG-------IASPQWAQSSAPRYLNYRKT
MAV_1766|M.avium_104                VAG-------PDALP---AKADD-------IASPSWAQSSAPHYLNYRKT
MLBr_00737|M.leprae_Br4923          LFG---------------------------GAGYTSDFPVERFMRDAKIT
                                      *                                            :  

Mb1969c|M.bovis_AF2122/97           TIYAGSSQIQRNVIGERLLGLPKEPRPEVLC
Rv1934c|M.tuberculosis_H37Rv        TIYAGSSQIQRNVIGERLLGLPKEPRPEVLC
Mflv_4379|M.gilvum_PYR-GCK          SIYAGSNEIQRNILAKAALGL----------
Mvan_1965|M.vanbaalenii_PYR-1       SIYAGSNEIQRNILAKAALGL----------
MSMEG_2191|M.smegmatis_MC2_155      SIYAGSNEIQRNILAKAALGL----------
TH_4368|M.thermoresistible__bu      SIYAGSNEIQRNILAKAALGL----------
MAB_2495|M.abscessus_ATCC_1997      SIYAGSNEIQRNILAKAQLGL----------
MMAR_3737|M.marinum_M               SIYGGSNEVQRNIIASTILGL----------
MUL_3681|M.ulcerans_Agy99           SIYGGSNEVQRNIIASTILGL----------
MAV_1766|M.avium_104                SIYGGSSEVQRNIIASTILGL----------
MLBr_00737|M.leprae_Br4923          QIYEGTNQIQRVVMSRALLR-----------
                                     ** *:.::** ::.   *

species	id	gene	e-value	identity (len)	annotation
M. gilvum PYR-GCK	Mflv_4379	-	-	100% (410)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_2287	-	2e-73	39.90% (411)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_1481	-	5e-52	33.83% (405)	acyl-CoA dehydrogenase domain-containing protein