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VPPGSSDALSAKGRQTRDALAQAARKLFAERGFHGTTLSDITSAAGKSPAAFYRYFSDKEDLLAALAESF LHEVVAPSGLSVPLPESPDDDAFFTAVVTGYWTMFKQNIGIMIAVAQLAATQPRFTLVQNEFRRFGMDIV AASVRRAQEQGYGTELNPEHTAAAIALLFENFTTVFVGASGLGVQMTDQDAIATLSRIWKKTLYGY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4467 | - | - | 100% (206) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0963 | - | 6e-13 | 25.13% (199) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4314 | - | 2e-10 | 24.39% (205) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0279c | - | 1e-18 | 29.65% (199) | transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv0273c | - | 1e-18 | 29.65% (199) | transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_01070 | - | 1e-09 | 24.49% (196) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0314c | - | 4e-22 | 32.07% (184) | TetR family transcriptional regulator |
| M. marinum M | MMAR_1492 | - | 3e-90 | 78.74% (207) | transcriptional regulatory protein |
| M. avium 104 | MAV_4026 | - | 5e-97 | 86.00% (200) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_2071 | - | 8e-87 | 77.72% (202) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_0641 | - | 5e-87 | 78.61% (201) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_2448 | - | 7e-90 | 78.26% (207) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_1893 | - | 1e-103 | 89.81% (206) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0279c|M.bovis_AF2122/97 -----------------MPDFPTQRGRRTQAAIDAAARTVVVRNGILATT
Rv0273c|M.tuberculosis_H37Rv -----------------MPDFPTQRGRRTQAAIDAAARTVVVRNGILATT
MAB_0314c|M.abscessus_ATCC_199 ---------------------------------MDAARVVISRVGYAETR
Mflv_4467|M.gilvum_PYR-GCK ------------MPPGS-SDALSAKGRQTRDALAQAARKLFAERGFHGTT
Mvan_1893|M.vanbaalenii_PYR-1 ------------MPPGP-AESLSAKGRQTRDAIEQAARKLFAERGFHGTT
MAV_4026|M.avium_104 ------------MP----AELLTAKGRQTRQAIEQAARKLFAERGFHGTT
MMAR_1492|M.marinum_M ------------MPARQESRELSSKGRQTRQAIEQAARKLFAERGFHGTT
MUL_2448|M.ulcerans_Agy99 ------------MPARQESRELSSKGRQTRQAIEQVARKLFAERGFHGTT
MSMEG_2071|M.smegmatis_MC2_155 ------------MA----SGELGSKGRQTRTAIELAARKLFAERGFHGTT
TH_0641|M.thermoresistible__bu ------------MA----AETLSSKGRQTRLALEQAARKLFAERGFHGTT
MLBr_01070|M.leprae_Br4923 MIVVGNFTQSNYVPASRGRRSSQLSGDDREQAILAVAERLLAERPLGDFS
.*. :. .
Mb0279c|M.bovis_AF2122/97 VADITAEAGRSAASFYNYYDSKEAMVRQWALRFRDDANQRALSVIRHGLS
Rv0273c|M.tuberculosis_H37Rv VADITAEAGRSAASFYNYYDSKEAMVRQWALRFRDDANQRALSVIRHGLS
MAB_0314c|M.abscessus_ATCC_199 VIDITTEAGKSVGVFYNYFTDKAELLRTMVDEFRDDAYARGDTVATSDRP
Mflv_4467|M.gilvum_PYR-GCK LSDITSAAGKSPAAFYRYFSDKEDLLAALAESFLHEVVAPSGLSVPLPES
Mvan_1893|M.vanbaalenii_PYR-1 LGDITSAAGKSPAVFYRYFADKEDLLAALAESFLHDVVAPSGLSVPLPES
MAV_4026|M.avium_104 LADITSAAGKSPAVFYRYFADKEDLLAALAESFLHEVVTPSGLSVHLPDS
MMAR_1492|M.marinum_M LADITSAAGKSSAVFYRYFTDKEDLLAALAQSFLHDVVTPSGVSLQLPDS
MUL_2448|M.ulcerans_Agy99 LADITSAAGKSSAVFYRYFTDKEDLLAALAQSFLHDVVTPSGVSLQLPDS
MSMEG_2071|M.smegmatis_MC2_155 LADITSAAGKSPAVFYRYFTDKEDLLAALAESFLHDVVEPSGLNLHLPDS
TH_0641|M.thermoresistible__bu LADITSAAGKSPAVFYRYFVDKEDLLAALAESFLREVLAPGWLSVRLPDS
MLBr_01070|M.leprae_Br4923 VDELAKGAGISRPTFYFYFPSKNAVLLSLLDDLNMKSRS-AVEALAEQLP
: ::: ** * ** *: .* :: : . . .
Mb0279c|M.bovis_AF2122/97 DRER--AYEAAAAHWYTYRNRLAEAISVSQLAMVSDDFAQYWSEICQIPI
Rv0273c|M.tuberculosis_H37Rv DRER--AYEAAAAHWYTYRNRLAEAISVSQLAMVSDDFAQYWSEICQIPI
MAB_0314c|M.abscessus_ATCC_199 PHEV--IRDIVTVYWTTYREHAPVLSGVFQAAQVDPTFVDYWRNLRAPAR
Mflv_4467|M.gilvum_PYR-GCK PDDDAFFTAVVTGYWTMFKQNIGIMIAVAQLAATQPRFTLVQNEFRRFGM
Mvan_1893|M.vanbaalenii_PYR-1 PDDDAFFTMVVTGYWTMFKQNIGIMIAVAQLAATQSRFALVQNEFRRFGM
MAV_4026|M.avium_104 PDDDAFFTAVVTGYWNMFKQNIGIMIAVAQLAATQQRFAAVQNEFRRFGI
MMAR_1492|M.marinum_M PDDDTFFTAVVTGYWNIFKQNIGIMIAVDQLAATQQRFAAVQNQFRRFGM
MUL_2448|M.ulcerans_Agy99 PDDDTFFTAVVTGYWNIFKQNIGIMIAVDQLAATQQRFAAVQNQFRRFGM
MSMEG_2071|M.smegmatis_MC2_155 PDDAEFFTSVVTGYWNMFKQNIGIMIAVAQLAATQQRFAEVQNSFRRFGI
TH_0641|M.thermoresistible__bu PDDDEFFTTVVGGYWNMFKQNIGIMIAVDQLAATQQRFADVQNEFRRFGM
MLBr_01070|M.leprae_Br4923 ADPAAVWRSAITAFFEVCGTHRAVAVAGAAAKATSPEVRRLWSTVMQQWI
.: . . .. . .
Mb0279c|M.bovis_AF2122/97 SFITETVKRAQAHGYCVGDDP-QLMAEAIVAMFNQFCYLQLS-GKRSR--
Rv0273c|M.tuberculosis_H37Rv SFITETVKRAQAHGYCVGDDP-QLMAEAIVAMFNQFCYLQLS-GKRSR--
MAB_0314c|M.abscessus_ATCC_199 TMIANNIRHLQARGYCPGMDP-DITASAIGAMLDYFCYVWLVEGGERG--
Mflv_4467|M.gilvum_PYR-GCK DIVAASVRRAQEQGYGTELNP-EHTAAAIALLFENFTTVFVGASG-----
Mvan_1893|M.vanbaalenii_PYR-1 DIVAASVRRAQEQGYGRELNA-EHTAAAIALLFENFTTVFVGASG-----
MAV_4026|M.avium_104 DLVAASVRRAQEQGYGTELHP-QHTAAAIALLFENFTTVFVGPSG-----
MMAR_1492|M.marinum_M DIIAASVRHAQDQGYGTELNP-DHTAVAIALLFENFTSVLVGTSGSSGPG
MUL_2448|M.ulcerans_Agy99 DIIAASVRHAQDQGYGTELNP-DHTAVAIALLFENFTSVLVGTSGSSGPG
MSMEG_2071|M.smegmatis_MC2_155 DIVVASVRRAQEQGHAVGLVP-EHIGAAIALLFENFTTVFVGSSG-----
TH_0641|M.thermoresistible__bu DIVAASVRHAQQQGYGTDLDP-QHIAAAIALMFENFTAVFVGRGG-----
MLBr_01070|M.leprae_Br4923 DYNTAAIQAERKCGVAPDTIPAEDLAVALQLMTERVMAATFSDEK-----
. :: : * . : . *: : : . .
Mb0279c|M.bovis_AF2122/97 --RGQPDDQACIQTLANIYYRAIYSKEDSSN---
Rv0273c|M.tuberculosis_H37Rv --RGQPDDQACIQTLANIYYRAIYSKEDSSN---
MAB_0314c|M.abscessus_ATCC_199 --RSAVTDEEAIDTLARIWFNALWWKSEGAHGAT
Mflv_4467|M.gilvum_PYR-GCK -LGVQMTDQDAIATLSRIWKKTLYGY--------
Mvan_1893|M.vanbaalenii_PYR-1 -LDVDIDDEAAIATLSRIWKKTLYGY--------
MAV_4026|M.avium_104 -LGIEISDEDAIATLSTIWKKTLYGV--------
MMAR_1492|M.marinum_M GLGVTITDEDAITTLSRIWKKTLYGF--------
MUL_2448|M.ulcerans_Agy99 GLGVTITDEDAITTLSRIWKKTLYGF--------
MSMEG_2071|M.smegmatis_MC2_155 -LGVELDDREAITTLATIWKKTLYGF--------
TH_0641|M.thermoresistible__bu -PGLQISDADAVRTLATIWKKTLYGC--------
MLBr_01070|M.leprae_Br4923 ---PLIPDKKVIDTLVHIWLASIYGS--------
* : ** *: :::