For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VAEFAAWLAAFLPNDYYENYRRYRWDLTLRRDYQRAAFEAGWIQPTWPREHGGRSLGLRDAMEVRLEAAL RSAPKLPNIAGPNVAAPGIRQFGTPAQIERLLVPLLRGDEWWALGMSEPEAGSDFAGLRTRAVRDGDVFR VNGHKIWTTQAHESRWCTLYARTDPEAPKHRGISCLILDLHSPGVRIEPIRMASISDETFCEVFLDDVEV PTENLLGPLHGGWDVALSSLHHERQMIWIMNWVEINRGLDAVRTANGAGPGHDIHTELGSLLADAEALRA TGYRALANELAGRPSPEADTMKLLGSLTLQRVWELAAAAAGPDSATDPDLLFERQDALAATIYGGTSEVQ RNIIAERLLGLPKG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1630 | - | - | 100% (365) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1268 | - | 5e-63 | 39.26% (377) | acyl-CoA dehydrogenase domain-containing protein |
| M. avium 104 | MAV_0898 | - | 1e-62 | 42.04% (383) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1969c | fadE17 | 3e-49 | 35.54% (363) | acyl-CoA dehydrogenase FADE17 |
| M. gilvum PYR-GCK | Mflv_2492 | - | 3e-62 | 40.93% (386) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1934c | fadE17 | 3e-49 | 35.54% (363) | acyl-CoA dehydrogenase FADE17 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 5e-21 | 28.40% (324) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3122 | - | 1e-47 | 34.65% (355) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_3980 | - | 0.0 | 83.56% (365) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4805 | - | 6e-66 | 41.41% (384) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4023 | - | 5e-58 | 38.86% (386) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_0322 | - | 1e-50 | 39.87% (306) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4162 | - | 3e-58 | 38.97% (390) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1630|M.avium_104 --------------MVAEFAAWLAAFLP--NDYYENYRRYR-WDLTLRRD
MMAR_3980|M.marinum_M ------MTPAPAVPVAEEFASWLADFLP--RDYYQRYPRYR-WDIALRRD
Mflv_2492|M.gilvum_PYR-GCK ---MQLAFDSDVEEFRAEFSAFLDEHTPSAAETLERPRSVS-HMPQWARD
Mvan_4162|M.vanbaalenii_PYR-1 ---MQLTFEPDVEEFRAEFSAFLDEHTPSAAETLERPRSVS-HMPQWARE
MSMEG_4805|M.smegmatis_MC2_155 ---MQLTFDSDVEKFRAEFVAFLDANLPSEAATLERPRSVS-HMPQWARD
TH_4023|M.thermoresistible__bu ---MQLTFDADVEEFRAEFIAFLEANLPDEAQTLERPRSVS-HMPQWARD
MUL_0322|M.ulcerans_Agy99 ---MQLTFDADVEAFRDEFISFLDRNLPDQAAGMERPRSCS-HVPEWARR
Mb1969c|M.bovis_AF2122/97 ---MDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGALPPHE--REEFARH
Rv1934c|M.tuberculosis_H37Rv ---MDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGALPPHE--REEFARH
MAB_3122|M.abscessus_ATCC_1997 ---MPVTSSEPSSAGSNALHTSGSSQRDRVAAAAHEVLAKHPPATTPVTD
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
MAV_1630|M.avium_104 YQRAAFEAGWIQPTWPREHGGRSLGLRDAMEVRLEAALRSAPK--LPNIA
MMAR_3980|M.marinum_M YQRAAFEAGWIQPTWPRRHGGRSLGLAEAMEIRIEAALRSAPK--LPNIA
Mflv_2492|M.gilvum_PYR-GCK WQRLLFDNGWLLPAQPPEFGGRNASVLQTFVHAEELCRRRIYH--SFNPQ
Mvan_4162|M.vanbaalenii_PYR-1 WQRLLFDNGWLLPAQPPEFGGRNASVLQTFVHAEELCRRRIYH--SFNPQ
MSMEG_4805|M.smegmatis_MC2_155 WQRLLFDNGWLLPAQPPEFGGRNANVVQQFVHLDELCRRRIYH--SFNPQ
TH_4023|M.thermoresistible__bu WQRLLFDNGWLLPAQPPEFGGRNATVLQQYVHLEELCKRRIYH--SFNPQ
MUL_0322|M.ulcerans_Agy99 WQRLLFDNGWLIPGNPPEFGGRNASLLQQYVHLQELARRRLYR--SFNPQ
Mb1969c|M.bovis_AF2122/97 WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAGAPERAENDLL
Rv1934c|M.tuberculosis_H37Rv WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAGAPERAENDLL
MAB_3122|M.abscessus_ATCC_1997 LLGAVYDAGLAWVHFPVGLGGLDAPPALQAVSDTILRAAGVPDPLFVNVI
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
* * ** .
MAV_1630|M.avium_104 GPNVAAPGIRQFGTPAQIERLLVPLLRGDEWWALGMSEPEAGSDFAGLRT
MMAR_3980|M.marinum_M GPNVVAPGLRQFGTPSQIDRLMVPLLRGDQWWALGMSEPEAGSDFAGLRT
Mflv_2492|M.gilvum_PYR-GCK GVNIIAASLLTFGTDEQKHRWAVPVLRGERTASLGMSEPSAGSDLASLRT
Mvan_4162|M.vanbaalenii_PYR-1 GVNIIAASLLTFGTDEQKHQWAVPVLRGERTASLGMSEPSAGSDLASLRT
MSMEG_4805|M.smegmatis_MC2_155 GVNIIAASLLTFGTEEQKHRWAVPVLRGEKTASLGMSEPSAGSDLASLRT
TH_4023|M.thermoresistible__bu GVNIIAASLLSFGSDEQKHRWAVPVLKAEMTASLGMSEPSAGSDLASLRT
MUL_0322|M.ulcerans_Agy99 GVGIIAESLLSFGTPEQKRRWAVPILRAEMTASLGMSEPGAGSDLASLKT
Mb1969c|M.bovis_AF2122/97 GIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPEAGSDLASVRT
Rv1934c|M.tuberculosis_H37Rv GIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPEAGSDLASVRT
MAB_3122|M.abscessus_ATCC_1997 GYGMAAPTVLAHGQPELIRRILRPLFTGEELWCQLFSEPGAGSDLAGLAT
MLBr_00737|M.leprae_Br4923 KLGTMG--LILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRT
. . : * : : . :** **** *.: *
MAV_1630|M.avium_104 RAVR----DGDVFRVNGHKIWTTQAHESRWCTLYARTDPEAPKHRGISCL
MMAR_3980|M.marinum_M RAEL----DGALFRVNGHKIWTTQAHESRWCTLYARTDPDAPKHRGISCL
Mflv_2492|M.gilvum_PYR-GCK KAVRD----GDEFVVNGQKVWTSGAHDADFLLTFVRTDPDAPKHKGISVL
Mvan_4162|M.vanbaalenii_PYR-1 KAVLVSESGGSYFVVNGQKVWTSGAHDADFLLTFVRTDPDAPKHKGISVL
MSMEG_4805|M.smegmatis_MC2_155 RAVR----DGDEFVVNGQKVWTSGAHDADWLLTFVRTDPDAPKHKGISVL
TH_4023|M.thermoresistible__bu RAEFVSGDDGDHFVVNGQKVWTSGAHDADFLLTFVRTDPDAPKHKGISVL
MUL_0322|M.ulcerans_Agy99 RAVRYRDGEGDRFVVNGQKVWTSGAHDADVLLTFVRTYPDAPKHKGISAL
Mb1969c|M.bovis_AF2122/97 RGVL----DGDEWVINGHKIWTSAGTTANWIFLLARTDPSAAKHRGLSFL
Rv1934c|M.tuberculosis_H37Rv RGVL----DGDEWVINGHKIWTSAGTTANWIFLLARTDPSAAKHRGLSFL
MAB_3122|M.abscessus_ATCC_1997 RAVR----DGDEWVINGQKVWTSGAHQARWALLVARSNPDVAKHRGLTYF
MLBr_00737|M.leprae_Br4923 RAKA----DGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGAN-GISAF
:. * : :** * * : . : . : *. : *:: :
MAV_1630|M.avium_104 ILDLHSPGVRIEPIR-MASISDETFCEVFLDDVEVPTENLLGPLHGGWDV
MMAR_3980|M.marinum_M ILDLQSPGVRVEPIR-MASVSDEIFCEVFLDDVEVPFDNLLGPLHGGWDV
Mflv_2492|M.gilvum_PYR-GCK LIPTDLDGVVCRPFADMTGIENLDFNEVFFTDVRVPAENLVGPLNGGWGV
Mvan_4162|M.vanbaalenii_PYR-1 LIPTDLEGVVCRPFADMTGIDNLDFNEVFFTDVRVPVENLVGPLNGGWGV
MSMEG_4805|M.smegmatis_MC2_155 IVPTDTPGVVCRPFADMTGQENLDFNEVFFTDARVPAENLVGPLNQGWKV
TH_4023|M.thermoresistible__bu IIPTDLPGVVCRPFADICGPENKDFNEVFFTDVRVPAENLVGPLNGGWKV
MUL_0322|M.ulcerans_Agy99 LIPTDTPGVVRRPFASVCDHDDVDFNEVFFTDAAAPAENLVGELNGGWRV
Mb1969c|M.bovis_AF2122/97 LVPMDQPGVVVRPIVNAAGHS--SFSEVFLTDARTSAGNVVGRVGDGWST
Rv1934c|M.tuberculosis_H37Rv LVPMDQPGVVVRPIVNAAGHS--SFSEVFLTDARTSAGNVVGRVGDGWST
MAB_3122|M.abscessus_ATCC_1997 VVDMTDPGVEVRPLRQMTGDA--EFNEVYLTDVRIPDAHRLGNEGDGWRV
MLBr_00737|M.leprae_Br4923 IVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKT
:: *. * . *::: . . . :* *: .
MAV_1630|M.avium_104 ALSSLHHERQMIWIMNWVEINRG------LDAVRTANGA--GPGHDIHTE
MMAR_3980|M.marinum_M ALSSLHHERQMIWIMNWVEIKRG------LQVARNTH------DDDVYSE
Mflv_2492|M.gilvum_PYR-GCK ANGSLGHERTMMWLG-FADRIAN------CIADFVPR------TPLERDA
Mvan_4162|M.vanbaalenii_PYR-1 ANGSLGHERTMMWLG-FADRIAN------CIADFKPK------NPLERDA
MSMEG_4805|M.smegmatis_MC2_155 ANGSLGHERTMMWLG-FADRIDN------MLADFNPR------TELERDQ
TH_4023|M.thermoresistible__bu ANGSLGHERTMMWLG-FADRIDN------IIADFTPR------TPLERDQ
MUL_0322|M.ulcerans_Agy99 ATGSLGHERTMLWLG-YANLLGE------LATDFTPA------GVLQRDH
Mb1969c|M.bovis_AF2122/97 AMTLLGFERGSHIATAAIDFER---DLQRLCELARDRGL--HTDPRVRDG
Rv1934c|M.tuberculosis_H37Rv AMTLLGFERGSHIATAAIDFER---DLQRLCELARDRGL--HTDPRVRDG
MAB_3122|M.abscessus_ATCC_1997 SMTTLMNERS--ALGGAFDHGRGGGSIGNALNLWKQRPD--LHTPELRAK
MLBr_00737|M.leprae_Br4923 ALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFM
: * *
MAV_1630|M.avium_104 LGSLLADAEALRATGYRALANELAGR-PSPEA-DTMKLLGSLTLQRVWEL
MMAR_3980|M.marinum_M LGSLLADAEALRATGYRALDNELAGR-PSPEA-DILKLLGSVTLQRVWDL
Mflv_2492|M.gilvum_PYR-GCK LASSIMDYEALRLLGSVGIAKAARGEVDVASV-SIPKLLGAEAEQRIEGL
Mvan_4162|M.vanbaalenii_PYR-1 LATSIMDYQALRLLGSVGIAKAARGEVDVASV-SIPKLLGAEAEQRIEGL
MSMEG_4805|M.smegmatis_MC2_155 YATTIMDYQALRALGSAALARAARGEQDTASV-SVLKLLGSEAERNAFEN
TH_4023|M.thermoresistible__bu YATAIMDYQALRLIGSVGLAKAARGEMDTASV-SVAKLLGSEAELRAAEM
MUL_0322|M.ulcerans_Agy99 YATLVMDTQAMRLLGSATLASAARGQEDVPAQ-SVLKLLGSEALQRACED
Mb1969c|M.bovis_AF2122/97 LAWCYARVQIMRYRGYRDLTLALTGRPPGAEA-AITKVIWSEYFRRYTDL
Rv1934c|M.tuberculosis_H37Rv LAWCYARVQIMRYRGYRDLTLALTGRPPGAEA-AITKVIWSEYFRRYTDL
MAB_3122|M.abscessus_ATCC_1997 LTNLFVRSEGNRY-GTQMRIAAQGDAPMGPEG-SIGKLMGAELNQQIYDF
MLBr_00737|M.leprae_Br4923 LADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTD
: * . * : : .
MAV_1630|M.avium_104 AAAAAGPD-------SATDPDLLFE----RQDA---------LAATIYGG
MMAR_3980|M.marinum_M AAVAAGPS-------WAGDADLLLE----RQDA---------LAATIYGG
Mflv_2492|M.gilvum_PYR-GCK ALEAAGLDGLVHPATSGPYEHMNLD----HYFASWFERYCRSFGGTIAGG
Mvan_4162|M.vanbaalenii_PYR-1 ALEAAGPDGLVHPATSGPYEHMNLD----HYFASWFERYCRSFGGTIAGG
MSMEG_4805|M.smegmatis_MC2_155 ALAAAGPEGLIHPSTSGPYAHMNLD----HYFASWFERYARSFGGTIAGG
TH_4023|M.thermoresistible__bu ALTAAGSDGLIHPSTTGPYAHMNLD----HYFASWFERFARSFSGTIAGG
MUL_0322|M.ulcerans_Agy99 ALDSAGGDGLVHPSITAPIAALNLD----NHYGS----------------
Mb1969c|M.bovis_AF2122/97 AVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDELLYARAATIYAG
Rv1934c|M.tuberculosis_H37Rv AVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDELLYARAATIYAG
MAB_3122|M.abscessus_ATCC_1997 CVELLGIEAT--LYASYDMRRVVEDDRRADT----MWAFLRSKANTIEGG
MLBr_00737|M.leprae_Br4923 AVQLFGGAG---YTSDFPVERFMRD----------------AKITQIYEG
. * . :
MAV_1630|M.avium_104 TSEVQRNIIAERLLGLPKG---------------
MMAR_3980|M.marinum_M TSEIQRNIIAERLLGLPKG---------------
Mflv_2492|M.gilvum_PYR-GCK TSEIQRNIIAQQVLGLPRR---------------
Mvan_4162|M.vanbaalenii_PYR-1 TSEIQRNIIAQQVLGLPRR---------------
MSMEG_4805|M.smegmatis_MC2_155 TSEIQRNIIATQVLGLPRG---------------
TH_4023|M.thermoresistible__bu TSEIQRNIIAQQVLGLPRR---------------
MUL_0322|M.ulcerans_Agy99 ----------------------------------
Mb1969c|M.bovis_AF2122/97 SSQIQRNVIGERLLGLPKEPRPEVLC--------
Rv1934c|M.tuberculosis_H37Rv SSQIQRNVIGERLLGLPKEPRPEVLC--------
MAB_3122|M.abscessus_ATCC_1997 TSDVMRNIIGERVLGLPGDIRVDTDKAWKDVPRG
MLBr_00737|M.leprae_Br4923 TNQIQRVVMSRALLR-------------------