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M. gilvum PYR-GCK Mflv_2492 (-)

annotation: acyl-CoA dehydrogenase domain-containing protein
coordinates: 2591734 - 2592909
length: 391

MQLAFDSDVEEFRAEFSAFLDEHTPSAAETLERPRSVSHMPQWARDWQRLLFDNGWLLPAQPPEFGGRNA
SVLQTFVHAEELCRRRIYHSFNPQGVNIIAASLLTFGTDEQKHRWAVPVLRGERTASLGMSEPSAGSDLA
SLRTKAVRDGDEFVVNGQKVWTSGAHDADFLLTFVRTDPDAPKHKGISVLLIPTDLDGVVCRPFADMTGI
ENLDFNEVFFTDVRVPAENLVGPLNGGWGVANGSLGHERTMMWLGFADRIANCIADFVPRTPLERDALAS
SIMDYEALRLLGSVGIAKAARGEVDVASVSIPKLLGAEAEQRIEGLALEAAGLDGLVHPATSGPYEHMNL
DHYFASWFERYCRSFGGTIAGGTSEIQRNIIAQQVLGLPRR

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. gilvum PYR-GCK Mflv_2492 - - 100% (391) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_1794 - 9e-55 37.53% (389) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_1481 - 4e-51 35.35% (396) acyl-CoA dehydrogenase domain-containing protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1969c fadE17 1e-53 33.09% (417) acyl-CoA dehydrogenase FADE17
M. tuberculosis H37Rv Rv1934c fadE17 1e-53 33.09% (417) acyl-CoA dehydrogenase FADE17
M. leprae Br4923 MLBr_00737 fadE25 2e-23 25.77% (392) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_0597 - 4e-49 35.51% (352) acyl-CoA dehydrogenase FadE
M. marinum M MMAR_4718 - 1e-176 76.67% (390) acyl-CoA dehydrogenase
M. avium 104 MAV_0935 - 1e-180 78.72% (390) putative acyl-CoA dehydrogenase
M. smegmatis MC2 155 MSMEG_4805 - 0.0 84.87% (390) acyl-CoA dehydrogenase
M. thermoresistible (build 8) TH_4023 - 0.0 83.80% (395) PUTATIVE acyl-CoA dehydrogenase domain protein
M. ulcerans Agy99 MUL_0322 - 1e-137 66.11% (360) acyl-CoA dehydrogenase
M. vanbaalenii PYR-1 Mvan_4162 - 0.0 94.43% (395) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb1969c|M.bovis_AF2122/97           ---MDVSYPPEAEAF--------RDRIREFVAEHLPPGWPGPGAL--PPH
Rv1934c|M.tuberculosis_H37Rv        ---MDVSYPPEAEAF--------RDRIREFVAEHLPPGWPGPGAL--PPH
MAB_0597|M.abscessus_ATCC_1997      MVESQVSPAPAGEPMSEMSDDQVRTEIREWLAENLVGEFAELKGLGGPGS
Mflv_2492|M.gilvum_PYR-GCK          ---MQLAFDSDVEEF--------RAEFSAFLDEHTP---SAAETLERPRS
Mvan_4162|M.vanbaalenii_PYR-1       ---MQLTFEPDVEEF--------RAEFSAFLDEHTP---SAAETLERPRS
MSMEG_4805|M.smegmatis_MC2_155      ---MQLTFDSDVEKF--------RAEFVAFLDANLP---SEAATLERPRS
TH_4023|M.thermoresistible__bu      ---MQLTFDADVEEF--------RAEFIAFLEANLP---DEAQTLERPRS
MMAR_4718|M.marinum_M               ---MQLTFDPDVEAF--------RTEFATFLDEHLP---PASETVERPRS
MAV_0935|M.avium_104                ---MQLTFDPDVEAF--------RAEFAAFLDENLP---PASETLERPRS
MUL_0322|M.ulcerans_Agy99           ---MQLTFDADVEAF--------RDEFISFLDRNLP---DQAAGMERPRS
MLBr_00737|M.leprae_Br4923          --MVGWSGNPLFDLFK-------LPEEHNELRATIR-ALAEKEIAPHAAD
                                          :  .  : :          .    :                .  

Mb1969c|M.bovis_AF2122/97           EREEFAR--HWRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAG
Rv1934c|M.tuberculosis_H37Rv        EREEFAR--HWRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAG
MAB_0597|M.abscessus_ATCC_1997      EHEAFEERLAWNRHLAAAGWTCLGWPVEHGGRGATVSQRVIFYEEYARAE
Mflv_2492|M.gilvum_PYR-GCK          VSHMPQWARDWQRLLFDNGWLLPAQPPEFGGRNASVLQTFVHAEELCRRR
Mvan_4162|M.vanbaalenii_PYR-1       VSHMPQWAREWQRLLFDNGWLLPAQPPEFGGRNASVLQTFVHAEELCRRR
MSMEG_4805|M.smegmatis_MC2_155      VSHMPQWARDWQRLLFDNGWLLPAQPPEFGGRNANVVQQFVHLDELCRRR
TH_4023|M.thermoresistible__bu      VSHMPQWARDWQRLLFDNGWLLPAQPPEFGGRNATVLQQYVHLEELCKRR
MMAR_4718|M.marinum_M               VSHLPQWARRWQRLLFDNGWLLPGQPPEFGGRNATVVQQFVHLEELCRRR
MAV_0935|M.avium_104                VSHMPQWARRWQRLLFDNGWLLPSQPPEYGGRNATVLQQFVYLEELSRRR
MUL_0322|M.ulcerans_Agy99           CSHVPEWARRWQRLLFDNGWLIPGNPPEFGGRNASLLQQYVHLQELARRR
MLBr_00737|M.leprae_Br4923          VDQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVD
                                      .           *   *      * *.** .       :  :* .:  

Mb1969c|M.bovis_AF2122/97           APERAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPE
Rv1934c|M.tuberculosis_H37Rv        APERAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPE
MAB_0597|M.abscessus_ATCC_1997      APHKVN--HLGEELLGPTLIAYGTPEQQQRFLPAIRDVTELWCQGYSEPG
Mflv_2492|M.gilvum_PYR-GCK          IYHSFN--PQGVNIIAASLLTFGTDEQKHRWAVPVLRGERTASLGMSEPS
Mvan_4162|M.vanbaalenii_PYR-1       IYHSFN--PQGVNIIAASLLTFGTDEQKHQWAVPVLRGERTASLGMSEPS
MSMEG_4805|M.smegmatis_MC2_155      IYHSFN--PQGVNIIAASLLTFGTEEQKHRWAVPVLRGEKTASLGMSEPS
TH_4023|M.thermoresistible__bu      IYHSFN--PQGVNIIAASLLSFGSDEQKHRWAVPVLKAEMTASLGMSEPS
MMAR_4718|M.marinum_M               IYHSLN--PQGVNIVAASILSFGTDEQKLRWAVPILRAQITASLGMSEPS
MAV_0935|M.avium_104                IYHSFN--PQGVNIVAASLLSFGSDEQKQRWAVPILRAEITASLGMSEPS
MUL_0322|M.ulcerans_Agy99           LYRSFN--PQGVGIIAESLLSFGTPEQKRRWAVPILRAEMTASLGMSEPG
MLBr_00737|M.leprae_Br4923          ASASLI--PAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSERE
                                                 :    ::  *:   : :    :       . . **  

Mb1969c|M.bovis_AF2122/97           AGSDLASVRTRGVLD----GDEWVINGHKIWTSAGTTANWIFLLARTDPS
Rv1934c|M.tuberculosis_H37Rv        AGSDLASVRTRGVLD----GDEWVINGHKIWTSAGTTANWIFLLARTDPS
MAB_0597|M.abscessus_ATCC_1997      AGSDLANVSTSAVLD----GGDWVINGQKVWTSLALQSQWCFVVARTEPG
Mflv_2492|M.gilvum_PYR-GCK          AGSDLASLRTKAVRD----GDEFVVNGQKVWTSGAHDADFLLTFVRTDPD
Mvan_4162|M.vanbaalenii_PYR-1       AGSDLASLRTKAVLVSESGGSYFVVNGQKVWTSGAHDADFLLTFVRTDPD
MSMEG_4805|M.smegmatis_MC2_155      AGSDLASLRTRAVRD----GDEFVVNGQKVWTSGAHDADWLLTFVRTDPD
TH_4023|M.thermoresistible__bu      AGSDLASLRTRAEFVSGDDGDHFVVNGQKVWTSGAHDADFLLTFVRTDPD
MMAR_4718|M.marinum_M               AGSDLASLRTRAVLD----GDHFVVNGQKVWTSGAHDADVLLTFVRTDPD
MAV_0935|M.avium_104                AGSDLASLRTRAVLD----GDHFVVNGQKVWTSGAHDADVLLTFVRTDPD
MUL_0322|M.ulcerans_Agy99           AGSDLASLKTRAVRYRDGEGDRFVVNGQKVWTSGAHDADVLLTFVRTYPD
MLBr_00737|M.leprae_Br4923          AGSDAASMRTRAKAD----GDDWILNGFKCWITNGGKSTWYTVMAVTDPD
                                    **** *.: * .       *. :::** * * : .  :     .. * *.

Mb1969c|M.bovis_AF2122/97           AAKHRGLSFLLVPMDQPGVVVRPIVNAAG--HSSFSEVFLTDARTSAGNV
Rv1934c|M.tuberculosis_H37Rv        AAKHRGLSFLLVPMDQPGVVVRPIVNAAG--HSSFSEVFLTDARTSAGNV
MAB_0597|M.abscessus_ATCC_1997      SSRHKGLSYLLVPLDQPGVEIRPIIQLTG--TSEFNEVFFDNARTSADLV
Mflv_2492|M.gilvum_PYR-GCK          APKHKGISVLLIPTDLDGVVCRPFADMTGIENLDFNEVFFTDVRVPAENL
Mvan_4162|M.vanbaalenii_PYR-1       APKHKGISVLLIPTDLEGVVCRPFADMTGIDNLDFNEVFFTDVRVPVENL
MSMEG_4805|M.smegmatis_MC2_155      APKHKGISVLIVPTDTPGVVCRPFADMTGQENLDFNEVFFTDARVPAENL
TH_4023|M.thermoresistible__bu      APKHKGISVLIIPTDLPGVVCRPFADICGPENKDFNEVFFTDVRVPAENL
MMAR_4718|M.marinum_M               APKHKGISALLIPTDTAGVVRRPFPSICSADDLDFNEVFFSDVLVPAANL
MAV_0935|M.avium_104                APKHKGISALVIPTDTPGLVRRPFPSICSIDDKDFNEVFFTDVRVPAENL
MUL_0322|M.ulcerans_Agy99           APKHKGISALLIPTDTPGVVRRPFASVCDHDDVDFNEVFFTDAAAPAENL
MLBr_00737|M.leprae_Br4923          KG-ANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRI
                                        .*:* :::  *  *.   *  .  .      .*::: .   .   :

Mb1969c|M.bovis_AF2122/97           VGRVGDGWSTAMTLLGFERGSHIATAAIDFERDLQRLCELARDRGLHTDP
Rv1934c|M.tuberculosis_H37Rv        VGRVGDGWSTAMTLLGFERGSHIATAAIDFERDLQRLCELARDRGLHTDP
MAB_0597|M.abscessus_ATCC_1997      VGEPGDGWRVAMGTLTFERGVSTLGNQITYARELSRLAELAKSNGAADDP
Mflv_2492|M.gilvum_PYR-GCK          VGPLNGGWGVANGSLGHERTMMWLGFADRIANCIADFVPRT--------P
Mvan_4162|M.vanbaalenii_PYR-1       VGPLNGGWGVANGSLGHERTMMWLGFADRIANCIADFKPKN--------P
MSMEG_4805|M.smegmatis_MC2_155      VGPLNQGWKVANGSLGHERTMMWLGFADRIDNMLADFNPRT--------E
TH_4023|M.thermoresistible__bu      VGPLNGGWKVANGSLGHERTMMWLGFADRIDNIIADFTPRT--------P
MMAR_4718|M.marinum_M               VGALNGGWRVANGSLGHERTMMWLGFADRLDNLIADLHPVT--------E
MAV_0935|M.avium_104                VGGLNQGWLVANGSLGHERTMMWLGFADRLENMIADFQPGT--------E
MUL_0322|M.ulcerans_Agy99           VGELNGGWRVATGSLGHERTMLWLGYANLLGELATDFTPAG--------V
MLBr_00737|M.leprae_Br4923          IGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYT---------
                                    :*  . *: .*   * . *                               

Mb1969c|M.bovis_AF2122/97           RVRDGLAWCYARVQIMRYRGYRDLTLALTGRPPGAEAAITKVIWSEYFRR
Rv1934c|M.tuberculosis_H37Rv        RVRDGLAWCYARVQIMRYRGYRDLTLALTGRPPGAEAAITKVIWSEYFRR
MAB_0597|M.abscessus_ATCC_1997      AIRERLAQAYVGMRTMR-----AYALATMDEERPGQDNVSKLLWANWHRD
Mflv_2492|M.gilvum_PYR-GCK          LERDALASSIMDYEALRLLGSVGIAKAARGEVDVASVSIPKLLGAEAEQR
Mvan_4162|M.vanbaalenii_PYR-1       LERDALATSIMDYQALRLLGSVGIAKAARGEVDVASVSIPKLLGAEAEQR
MSMEG_4805|M.smegmatis_MC2_155      LERDQYATTIMDYQALRALGSAALARAARGEQDTASVSVLKLLGSEAERN
TH_4023|M.thermoresistible__bu      LERDQYATAIMDYQALRLIGSVGLAKAARGEMDTASVSVAKLLGSEAELR
MMAR_4718|M.marinum_M               LDHDRYATMVMDKQALRLLGSVALARASRGEDDTSAISVLKLLGSEAELR
MAV_0935|M.avium_104                VERDQYATTIMDRQALRLLGSAALARAARGEDDVAAISVLKLLGSEAELR
MUL_0322|M.ulcerans_Agy99           LQRDHYATLVMDTQAMRLLGSATLASAARGQEDVPAQSVLKLLGSEALQR
MLBr_00737|M.leprae_Br4923          KDRKQFGESISTFQSIQ------FMLADMAMKVEAARLIVYAAAARAERG
                                      :.  .      . ::         *           :     :.    

Mb1969c|M.bovis_AF2122/97           YTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDELLY--ARA
Rv1934c|M.tuberculosis_H37Rv        YTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDELLY--ARA
MAB_0597|M.abscessus_ATCC_1997      LGELAMEIIG------------TSTLLTNAGEMDE---WQRLFLF--SRA
Mflv_2492|M.gilvum_PYR-GCK          IEGLALEAAGLDGLVHP----ATSGPYEHMNLDHYFASWFERYCR--SFG
Mvan_4162|M.vanbaalenii_PYR-1       IEGLALEAAGPDGLVHP----ATSGPYEHMNLDHYFASWFERYCR--SFG
MSMEG_4805|M.smegmatis_MC2_155      AFENALAAAGPEGLIHP----STSGPYAHMNLDHYFASWFERYAR--SFG
TH_4023|M.thermoresistible__bu      AAEMALTAAGSDGLIHP----STTGPYAHMNLDHYFASWFERFAR--SFS
MMAR_4718|M.marinum_M               ASEHALAAAGSDGLIHP----ALTGPYAPMNLDHYFASWFERYAR--SFS
MAV_0935|M.avium_104                AMELALTSAGADGLVHP----GQTGPYAHMNLDHYFASWFERYAR--SFS
MUL_0322|M.ulcerans_Agy99           ACEDALDSAGGDGLVHP----SITAPIAALNLDNHYGS------------
MLBr_00737|M.leprae_Br4923          EPDLGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKI
                                        ..   .             :      .                   

Mb1969c|M.bovis_AF2122/97           ATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC
Rv1934c|M.tuberculosis_H37Rv        ATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC
MAB_0597|M.abscessus_ATCC_1997      DTIYGGSNEIQRNIISERVLGLPREAR-----
Mflv_2492|M.gilvum_PYR-GCK          GTIAGGTSEIQRNIIAQQVLGLPRR-------
Mvan_4162|M.vanbaalenii_PYR-1       GTIAGGTSEIQRNIIAQQVLGLPRR-------
MSMEG_4805|M.smegmatis_MC2_155      GTIAGGTSEIQRNIIATQVLGLPRG-------
TH_4023|M.thermoresistible__bu      GTIAGGTSEIQRNIIAQQVLGLPRR-------
MMAR_4718|M.marinum_M               GTIAGGTSEIQRNIIAQRVLGLPRG-------
MAV_0935|M.avium_104                GTIAGGTLEIQRNIIAQRVLGLPRG-------
MUL_0322|M.ulcerans_Agy99           --------------------------------
MLBr_00737|M.leprae_Br4923          TQIYEGTNQIQRVVMSRALLR-----------

species	id	gene	e-value	identity (len)	annotation
M. gilvum PYR-GCK	Mflv_2492	-	-	100% (391)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_1794	-	9e-55	37.53% (389)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_1481	-	4e-51	35.35% (396)	acyl-CoA dehydrogenase domain-containing protein