For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTPAPAVPVAEEFASWLADFLPRDYYQRYPRYRWDIALRRDYQRAAFEAGWIQPTWPRRHGGRSLGLAEA MEIRIEAALRSAPKLPNIAGPNVVAPGLRQFGTPSQIDRLMVPLLRGDQWWALGMSEPEAGSDFAGLRTR AELDGALFRVNGHKIWTTQAHESRWCTLYARTDPDAPKHRGISCLILDLQSPGVRVEPIRMASVSDEIFC EVFLDDVEVPFDNLLGPLHGGWDVALSSLHHERQMIWIMNWVEIKRGLQVARNTHDDDVYSELGSLLADA EALRATGYRALDNELAGRPSPEADILKLLGSVTLQRVWDLAAVAAGPSWAGDADLLLERQDALAATIYGG TSEIQRNIIAERLLGLPKG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3980 | - | - | 100% (369) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4751 | - | 6e-58 | 40.91% (352) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4718 | - | 8e-57 | 39.68% (378) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1969c | fadE17 | 7e-50 | 37.05% (359) | acyl-CoA dehydrogenase FADE17 |
| M. gilvum PYR-GCK | Mflv_2492 | - | 8e-59 | 41.26% (349) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1934c | fadE17 | 7e-50 | 37.05% (359) | acyl-CoA dehydrogenase FADE17 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-20 | 25.98% (331) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0597 | - | 8e-47 | 34.39% (346) | acyl-CoA dehydrogenase FadE |
| M. avium 104 | MAV_1630 | - | 0.0 | 83.56% (365) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4805 | - | 1e-61 | 41.38% (348) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4023 | - | 9e-57 | 40.23% (353) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_0322 | - | 1e-47 | 38.91% (293) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4162 | - | 9e-56 | 39.38% (353) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1969c|M.bovis_AF2122/97 ---MDVSYPPEAEAF--------RDRIREFVAEHLPPGWPGPGAL--PPH
Rv1934c|M.tuberculosis_H37Rv ---MDVSYPPEAEAF--------RDRIREFVAEHLPPGWPGPGAL--PPH
MAB_0597|M.abscessus_ATCC_1997 MVESQVSPAPAGEPMSEMSDDQVRTEIREWLAENLVGEFAELKGLGGPGS
MMAR_3980|M.marinum_M ------MTPAPAVPV--------AEEFASWLADFLP--RDYYQRY---PR
MAV_1630|M.avium_104 --------------M--------VAEFAAWLAAFLP--NDYYENY---RR
MSMEG_4805|M.smegmatis_MC2_155 ---MQLTFDSDVEKF--------RAEFVAFLDANLPSEAATLERP---RS
TH_4023|M.thermoresistible__bu ---MQLTFDADVEEF--------RAEFIAFLEANLPDEAQTLERP---RS
Mflv_2492|M.gilvum_PYR-GCK ---MQLAFDSDVEEF--------RAEFSAFLDEHTPSAAETLERP---RS
Mvan_4162|M.vanbaalenii_PYR-1 ---MQLTFEPDVEEF--------RAEFSAFLDEHTPSAAETLERP---RS
MUL_0322|M.ulcerans_Agy99 ---MQLTFDADVEAF--------RDEFISFLDRNLPDQAAGMERP---RS
MLBr_00737|M.leprae_Br4923 --MVGWSGNPLFDLFK------LPEEHNELRATIRALAEKEIAPH--AAD
. .
Mb1969c|M.bovis_AF2122/97 EREEFAR--HWRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAG
Rv1934c|M.tuberculosis_H37Rv EREEFAR--HWRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAG
MAB_0597|M.abscessus_ATCC_1997 EHEAFEERLAWNRHLAAAGWTCLGWPVEHGGRGATVSQRVIFYEEYARAE
MMAR_3980|M.marinum_M YRWDIALRRDYQRAAFEAGWIQPTWPRRHGGRSLGLAEAMEIRIEAALRS
MAV_1630|M.avium_104 YRWDLTLRRDYQRAAFEAGWIQPTWPREHGGRSLGLRDAMEVRLEAALRS
MSMEG_4805|M.smegmatis_MC2_155 VSHMPQWARDWQRLLFDNGWLLPAQPPEFGGRNANVVQQFVHLDELCRRR
TH_4023|M.thermoresistible__bu VSHMPQWARDWQRLLFDNGWLLPAQPPEFGGRNATVLQQYVHLEELCKRR
Mflv_2492|M.gilvum_PYR-GCK VSHMPQWARDWQRLLFDNGWLLPAQPPEFGGRNASVLQTFVHAEELCRRR
Mvan_4162|M.vanbaalenii_PYR-1 VSHMPQWAREWQRLLFDNGWLLPAQPPEFGGRNASVLQTFVHAEELCRRR
MUL_0322|M.ulcerans_Agy99 CSHVPEWARRWQRLLFDNGWLIPGNPPEFGGRNASLLQQYVHLQELARRR
MLBr_00737|M.leprae_Br4923 VDQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVD
* * ..** . * .
Mb1969c|M.bovis_AF2122/97 APERAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPE
Rv1934c|M.tuberculosis_H37Rv APERAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPE
MAB_0597|M.abscessus_ATCC_1997 APHKVN--HLGEELLGPTLIAYGTPEQQQRFLPAIRDVTELWCQGYSEPG
MMAR_3980|M.marinum_M APKLPN--IAGPNVVAPGLRQFGTPSQIDRLMVPLLRGDQWWALGMSEPE
MAV_1630|M.avium_104 APKLPN--IAGPNVAAPGIRQFGTPAQIERLLVPLLRGDEWWALGMSEPE
MSMEG_4805|M.smegmatis_MC2_155 IYHSFN--PQGVNIIAASLLTFGTEEQKHRWAVPVLRGEKTASLGMSEPS
TH_4023|M.thermoresistible__bu IYHSFN--PQGVNIIAASLLSFGSDEQKHRWAVPVLKAEMTASLGMSEPS
Mflv_2492|M.gilvum_PYR-GCK IYHSFN--PQGVNIIAASLLTFGTDEQKHRWAVPVLRGERTASLGMSEPS
Mvan_4162|M.vanbaalenii_PYR-1 IYHSFN--PQGVNIIAASLLTFGTDEQKHQWAVPVLRGERTASLGMSEPS
MUL_0322|M.ulcerans_Agy99 LYRSFN--PQGVGIIAESLLSFGTPEQKRRWAVPILRAEMTASLGMSEPG
MLBr_00737|M.leprae_Br4923 ASASLIP--AVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSERE
: : *: : : . . **
Mb1969c|M.bovis_AF2122/97 AGSDLASVRTRGVLD----GDEWVINGHKIWTSAGTTANWIFLLARTDPS
Rv1934c|M.tuberculosis_H37Rv AGSDLASVRTRGVLD----GDEWVINGHKIWTSAGTTANWIFLLARTDPS
MAB_0597|M.abscessus_ATCC_1997 AGSDLANVSTSAVLD----GGDWVINGQKVWTSLALQSQWCFVVARTEPG
MMAR_3980|M.marinum_M AGSDFAGLRTRAEL----DGALFRVNGHKIWTTQAHESRWCTLYARTDPD
MAV_1630|M.avium_104 AGSDFAGLRTRAVR----DGDVFRVNGHKIWTTQAHESRWCTLYARTDPE
MSMEG_4805|M.smegmatis_MC2_155 AGSDLASLRTRAVR----DGDEFVVNGQKVWTSGAHDADWLLTFVRTDPD
TH_4023|M.thermoresistible__bu AGSDLASLRTRAEFVSGDDGDHFVVNGQKVWTSGAHDADFLLTFVRTDPD
Mflv_2492|M.gilvum_PYR-GCK AGSDLASLRTKAVRD----GDEFVVNGQKVWTSGAHDADFLLTFVRTDPD
Mvan_4162|M.vanbaalenii_PYR-1 AGSDLASLRTKAVLVSESGGSYFVVNGQKVWTSGAHDADFLLTFVRTDPD
MUL_0322|M.ulcerans_Agy99 AGSDLASLKTRAVRYRDGEGDRFVVNGQKVWTSGAHDADVLLTFVRTYPD
MLBr_00737|M.leprae_Br4923 AGSDAASMRTRAKAD----GDDWILNGFKCWITNGGKSTWYTVMAVTDPD
**** *.: * . * : :** * * : . : . * *
Mb1969c|M.bovis_AF2122/97 AAKHRGLSFLLVPMDQPGVVVRPIVNAAGHS--SFSEVFLTDARTSAGNV
Rv1934c|M.tuberculosis_H37Rv AAKHRGLSFLLVPMDQPGVVVRPIVNAAGHS--SFSEVFLTDARTSAGNV
MAB_0597|M.abscessus_ATCC_1997 SSRHKGLSYLLVPLDQPGVEIRPIIQLTGTS--EFNEVFFDNARTSADLV
MMAR_3980|M.marinum_M APKHRGISCLILDLQSPGVRVEPIR-MASVSDEIFCEVFLDDVEVPFDNL
MAV_1630|M.avium_104 APKHRGISCLILDLHSPGVRIEPIR-MASISDETFCEVFLDDVEVPTENL
MSMEG_4805|M.smegmatis_MC2_155 APKHKGISVLIVPTDTPGVVCRPFADMTGQENLDFNEVFFTDARVPAENL
TH_4023|M.thermoresistible__bu APKHKGISVLIIPTDLPGVVCRPFADICGPENKDFNEVFFTDVRVPAENL
Mflv_2492|M.gilvum_PYR-GCK APKHKGISVLLIPTDLDGVVCRPFADMTGIENLDFNEVFFTDVRVPAENL
Mvan_4162|M.vanbaalenii_PYR-1 APKHKGISVLLIPTDLEGVVCRPFADMTGIDNLDFNEVFFTDVRVPVENL
MUL_0322|M.ulcerans_Agy99 APKHKGISALLIPTDTPGVVRRPFASVCDHDDVDFNEVFFTDAAAPAENL
MLBr_00737|M.leprae_Br4923 KGAN-GISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRI
: *:* ::: . *. * . . *::: . . :
Mb1969c|M.bovis_AF2122/97 VGRVGDGWSTAMTLLGFERGSHIATAAIDFERDLQRLCELARDRGLHTDP
Rv1934c|M.tuberculosis_H37Rv VGRVGDGWSTAMTLLGFERGSHIATAAIDFERDLQRLCELARDRGLHTDP
MAB_0597|M.abscessus_ATCC_1997 VGEPGDGWRVAMGTLTFERGVSTLGNQITYARELSRLAELAKSNGAADDP
MMAR_3980|M.marinum_M LGPLHGGWDVALSSLHHERQMIWIMNWVEIKRGLQVARNTH-------DD
MAV_1630|M.avium_104 LGPLHGGWDVALSSLHHERQMIWIMNWVEINRGLDAVRTANG---AGPGH
MSMEG_4805|M.smegmatis_MC2_155 VGPLNQGWKVANGSLGHERTMMWLG-FADRIDNMLADFNPR-------TE
TH_4023|M.thermoresistible__bu VGPLNGGWKVANGSLGHERTMMWLG-FADRIDNIIADFTPR-------TP
Mflv_2492|M.gilvum_PYR-GCK VGPLNGGWGVANGSLGHERTMMWLG-FADRIANCIADFVPR-------TP
Mvan_4162|M.vanbaalenii_PYR-1 VGPLNGGWGVANGSLGHERTMMWLG-FADRIANCIADFKPK-------NP
MUL_0322|M.ulcerans_Agy99 VGELNGGWRVATGSLGHERTMLWLG-YANLLGELATDFTPA-------GV
MLBr_00737|M.leprae_Br4923 IGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGES
:* *: .* * . *
Mb1969c|M.bovis_AF2122/97 RVRDGLAWCYARVQIMRYRGYRDLTLALTGRPPGAEAAITKVIWSEYFRR
Rv1934c|M.tuberculosis_H37Rv RVRDGLAWCYARVQIMRYRGYRDLTLALTGRPPGAEAAITKVIWSEYFRR
MAB_0597|M.abscessus_ATCC_1997 AIRERLAQAYVGMRTMR-----AYALATMDEERPGQDNVSKLLWANWHRD
MMAR_3980|M.marinum_M DVYSELGSLLADAEALRATGYRALDNELAGR-PSPEADILKLLGSVTLQR
MAV_1630|M.avium_104 DIHTELGSLLADAEALRATGYRALANELAGR-PSPEADTMKLLGSLTLQR
MSMEG_4805|M.smegmatis_MC2_155 LERDQYATTIMDYQALRALGSAALARAARGEQDTASVSVLKLLGSEAERN
TH_4023|M.thermoresistible__bu LERDQYATAIMDYQALRLIGSVGLAKAARGEMDTASVSVAKLLGSEAELR
Mflv_2492|M.gilvum_PYR-GCK LERDALASSIMDYEALRLLGSVGIAKAARGEVDVASVSIPKLLGAEAEQR
Mvan_4162|M.vanbaalenii_PYR-1 LERDALATSIMDYQALRLLGSVGIAKAARGEVDVASVSIPKLLGAEAEQR
MUL_0322|M.ulcerans_Agy99 LQRDHYATLVMDTQAMRLLGSATLASAARGQEDVPAQSVLKLLGSEALQR
MLBr_00737|M.leprae_Br4923 ISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLG-FISAASKCF
:: . .: :
Mb1969c|M.bovis_AF2122/97 YTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDELLYARAAT
Rv1934c|M.tuberculosis_H37Rv YTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDELLYARAAT
MAB_0597|M.abscessus_ATCC_1997 LGELAMEIIG------------TSTLLTNAGEMDE---WQRLFLFSRADT
MMAR_3980|M.marinum_M VWDLAAVAAGPS-------WAGDADLLLER----QDA---------LAAT
MAV_1630|M.avium_104 VWELAAAAAGPD-------SATDPDLLFER----QDA---------LAAT
MSMEG_4805|M.smegmatis_MC2_155 AFENALAAAGPEGLIHPSTSGPYAHMNLDH----YFASWFERYARSFGGT
TH_4023|M.thermoresistible__bu AAEMALTAAGSDGLIHPSTTGPYAHMNLDH----YFASWFERFARSFSGT
Mflv_2492|M.gilvum_PYR-GCK IEGLALEAAGLDGLVHPATSGPYEHMNLDH----YFASWFERYCRSFGGT
Mvan_4162|M.vanbaalenii_PYR-1 IEGLALEAAGPDGLVHPATSGPYEHMNLDH----YFASWFERYCRSFGGT
MUL_0322|M.ulcerans_Agy99 ACEDALDSAGGDGLVHPSITAPIAALNLDN----HYGS------------
MLBr_00737|M.leprae_Br4923 ASDIAMEVTTDAVQLFGG-AGYTSDFPVER-----------FMRDAKITQ
* : :
Mb1969c|M.bovis_AF2122/97 IYAGSSQIQRNVIGERLLGLPKEPRPEVLC
Rv1934c|M.tuberculosis_H37Rv IYAGSSQIQRNVIGERLLGLPKEPRPEVLC
MAB_0597|M.abscessus_ATCC_1997 IYGGSNEIQRNIISERVLGLPREAR-----
MMAR_3980|M.marinum_M IYGGTSEIQRNIIAERLLGLPKG-------
MAV_1630|M.avium_104 IYGGTSEVQRNIIAERLLGLPKG-------
MSMEG_4805|M.smegmatis_MC2_155 IAGGTSEIQRNIIATQVLGLPRG-------
TH_4023|M.thermoresistible__bu IAGGTSEIQRNIIAQQVLGLPRR-------
Mflv_2492|M.gilvum_PYR-GCK IAGGTSEIQRNIIAQQVLGLPRR-------
Mvan_4162|M.vanbaalenii_PYR-1 IAGGTSEIQRNIIAQQVLGLPRR-------
MUL_0322|M.ulcerans_Agy99 ------------------------------
MLBr_00737|M.leprae_Br4923 IYEGTNQIQRVVMSRALLR-----------