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QLTFDADVEAFRDEFISFLDRNLPDQAAGMERPRSCSHVPEWARRWQRLLFDNGWLIPGNPPEFGGRNAS LLQQYVHLQELARRRLYRSFNPQGVGIIAESLLSFGTPEQKRRWAVPILRAEMTASLGMSEPGAGSDLAS LKTRAVRYRDGEGDRFVVNGQKVWTSGAHDADVLLTFVRTYPDAPKHKGISALLIPTDTPGVVRRPFASV CDHDDVDFNEVFFTDAAAPAENLVGELNGGWRVATGSLGHERTMLWLGYANLLGELATDFTPAGVLQRDH YATLVMDTQAMRLLGSATLASAARGQEDVPAQSVLKLLGSEALQRACEDALDSAGGDGLVHPSITAPIAA LNLDNHYGS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0322 | - | - | 100% (360) | acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2892 | fadE17 | 1e-43 | 38.83% (309) | acyl-CoA dehydrogenase FadE17 |
| M. ulcerans Agy99 | MUL_3681 | fadE17_1 | 1e-42 | 36.29% (350) | acyl-CoA dehydrogenase FadE17_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1969c | fadE17 | 2e-42 | 35.31% (354) | acyl-CoA dehydrogenase FADE17 |
| M. gilvum PYR-GCK | Mflv_2492 | - | 1e-137 | 66.11% (360) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1934c | fadE17 | 2e-42 | 35.31% (354) | acyl-CoA dehydrogenase FADE17 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-18 | 27.03% (296) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2495 | - | 9e-43 | 33.80% (361) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4751 | - | 0.0 | 99.17% (360) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_0898 | - | 1e-169 | 80.56% (360) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4805 | - | 1e-147 | 69.17% (360) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4023 | - | 1e-150 | 70.28% (360) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. vanbaalenii PYR-1 | Mvan_4162 | - | 1e-137 | 65.83% (360) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1969c|M.bovis_AF2122/97 -MDVSYPPEAEAFR--DRIREFVAEHLPPGWPGPGALP--PHEREEFARH
Rv1934c|M.tuberculosis_H37Rv -MDVSYPPEAEAFR--DRIREFVAEHLPPGWPGPGALP--PHEREEFARH
MUL_0322|M.ulcerans_Agy99 -MQLTFDADVEAFR--DEFISFLDRNLPDQAAGMERPR-SCSHVPEWARR
MMAR_4751|M.marinum_M -MQLTFDADVEAFR--DEFISFLDRNLPDQAAGMERPR-SCSHVPEWARR
MAV_0898|M.avium_104 -MQLTFDADVEAFR--AEFVAFLDAHLPAEAEALERPR-SSSHVPEWARR
MSMEG_4805|M.smegmatis_MC2_155 -MQLTFDSDVEKFR--AEFVAFLDANLPSEAATLERPR-SVSHMPQWARD
TH_4023|M.thermoresistible__bu -MQLTFDADVEEFR--AEFIAFLEANLPDEAQTLERPR-SVSHMPQWARD
Mflv_2492|M.gilvum_PYR-GCK -MQLAFDSDVEEFR--AEFSAFLDEHTPSAAETLERPR-SVSHMPQWARD
Mvan_4162|M.vanbaalenii_PYR-1 -MQLTFEPDVEEFR--AEFSAFLDEHTPSAAETLERPR-SVSHMPQWARE
MAB_2495|M.abscessus_ATCC_1997 -MDLAFSAEEEQFR--TEVREFLDANLTAELRAAGRLQTSVYSDHEASMR
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
: : . : *: . : . . .
Mb1969c|M.bovis_AF2122/97 WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAGAPERAENDLL
Rv1934c|M.tuberculosis_H37Rv WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAGAPERAENDLL
MUL_0322|M.ulcerans_Agy99 WQRLLFDNGWLIPGNPPEFGGRNASLLQQYVHLQELARRRLYR--SFNPQ
MMAR_4751|M.marinum_M WQRLLFDNGWLIPGNPPEFGGRNASLLQQYVHLQELARRRLYR--SFNPQ
MAV_0898|M.avium_104 WQRLLFDSGWLLPGNPPEFGGRNATLLQQYVYFEELGRRRIYQ--SFNPQ
MSMEG_4805|M.smegmatis_MC2_155 WQRLLFDNGWLLPAQPPEFGGRNANVVQQFVHLDELCRRRIYH--SFNPQ
TH_4023|M.thermoresistible__bu WQRLLFDNGWLLPAQPPEFGGRNATVLQQYVHLEELCKRRIYH--SFNPQ
Mflv_2492|M.gilvum_PYR-GCK WQRLLFDNGWLLPAQPPEFGGRNASVLQTFVHAEELCRRRIYH--SFNPQ
Mvan_4162|M.vanbaalenii_PYR-1 WQRLLFDNGWLLPAQPPEFGGRNASVLQTFVHAEELCRRRIYH--SFNPQ
MAB_2495|M.abscessus_ATCC_1997 WQAILHRKGWAAPAWPVKYGGQPWSLAQHYIFSVESMVAGAP---SLSPM
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASA--SLIPA
* * * ::** : * .
Mb1969c|M.bovis_AF2122/97 GIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPEAGSDLASVRT
Rv1934c|M.tuberculosis_H37Rv GIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPEAGSDLASVRT
MUL_0322|M.ulcerans_Agy99 GVGIIAESLLSFGTPEQKRRWAVPILRAEMTASLGMSEPGAGSDLASLKT
MMAR_4751|M.marinum_M GVGIIAESLLSFGTPEQKRRWAVPILRAEMTASLGMSEPGAGSDLASLKT
MAV_0898|M.avium_104 GVGIIAASLLSFGTPEQKQRWAVPILRAEMTASLGMSEPGAGSDLASLKT
MSMEG_4805|M.smegmatis_MC2_155 GVNIIAASLLTFGTEEQKHRWAVPVLRGEKTASLGMSEPSAGSDLASLRT
TH_4023|M.thermoresistible__bu GVNIIAASLLSFGSDEQKHRWAVPVLKAEMTASLGMSEPSAGSDLASLRT
Mflv_2492|M.gilvum_PYR-GCK GVNIIAASLLTFGTDEQKHRWAVPVLRGERTASLGMSEPSAGSDLASLRT
Mvan_4162|M.vanbaalenii_PYR-1 GVNIIAASLLTFGTDEQKHQWAVPVLRGERTASLGMSEPSAGSDLASLRT
MAB_2495|M.abscessus_ATCC_1997 GIRMVAHAIIKFGSPEQKEFFLPRILTGEVFFCQGYSEPESGSDLASLQM
MLBr_00737|M.leprae_Br4923 VNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRT
: :: *: *. : . . ** :*** **::
Mb1969c|M.bovis_AF2122/97 RGVLD----GDEWVINGHKIWTSAGTTANWIFLLARTDPSAAKHRGLSFL
Rv1934c|M.tuberculosis_H37Rv RGVLD----GDEWVINGHKIWTSAGTTANWIFLLARTDPSAAKHRGLSFL
MUL_0322|M.ulcerans_Agy99 RAVRYRDGEGDRFVVNGQKVWTSGAHDADVLLTFVRTYPDAPKHKGISAL
MMAR_4751|M.marinum_M RAVRYRDGEGDRFVVNGQKVWTSGAHDADVLLTFVRTDPDAPKHKGISAL
MAV_0898|M.avium_104 RAVL----DGDHFVVNGQKVWTSGAHDADVLLTFVRTDPNAPKHKGISVL
MSMEG_4805|M.smegmatis_MC2_155 RAVR----DGDEFVVNGQKVWTSGAHDADWLLTFVRTDPDAPKHKGISVL
TH_4023|M.thermoresistible__bu RAEFVSGDDGDHFVVNGQKVWTSGAHDADFLLTFVRTDPDAPKHKGISVL
Mflv_2492|M.gilvum_PYR-GCK KAVRD----GDEFVVNGQKVWTSGAHDADFLLTFVRTDPDAPKHKGISVL
Mvan_4162|M.vanbaalenii_PYR-1 KAVLVSESGGSYFVVNGQKVWTSGAHDADFLLTFVRTDPDAPKHKGISVL
MAB_2495|M.abscessus_ATCC_1997 SAVAD----GDDFVLNGSKIWTTHAREANWMFALVRTTKGPKKQLGITFI
MLBr_00737|M.leprae_Br4923 RAKAD----GDDWILNGFKCWITNGGKSTWYTVMAVTDPD-KGANGISAF
. *. :::** * * : . : :. * . *:: :
Mb1969c|M.bovis_AF2122/97 LVPMDQPGVVVRPIVNAAGHS--SFSEVFLTDARTSAGNVVGRVGDGWST
Rv1934c|M.tuberculosis_H37Rv LVPMDQPGVVVRPIVNAAGHS--SFSEVFLTDARTSAGNVVGRVGDGWST
MUL_0322|M.ulcerans_Agy99 LIPTDTPGVVRRPFASVCDHDDVDFNEVFFTDAAAPAENLVGELNGGWRV
MMAR_4751|M.marinum_M LIPTDTPGVVRRPFASVCDHDDVDFNEVFFTDAAVPAENLVGELNGGWRV
MAV_0898|M.avium_104 LIPTDTPGVVRRPFASMCDIDEIDFNEVFFTDARVPAENLVGELNEGWRV
MSMEG_4805|M.smegmatis_MC2_155 IVPTDTPGVVCRPFADMTGQENLDFNEVFFTDARVPAENLVGPLNQGWKV
TH_4023|M.thermoresistible__bu IIPTDLPGVVCRPFADICGPENKDFNEVFFTDVRVPAENLVGPLNGGWKV
Mflv_2492|M.gilvum_PYR-GCK LIPTDLDGVVCRPFADMTGIENLDFNEVFFTDVRVPAENLVGPLNGGWGV
Mvan_4162|M.vanbaalenii_PYR-1 LIPTDLEGVVCRPFADMTGIDNLDFNEVFFTDVRVPVENLVGPLNGGWGV
MAB_2495|M.abscessus_ATCC_1997 LIDFTSPGIDVKPLVMSSGEE--VQNVVFFDNVRVPRANVLGEVDQGWTV
MLBr_00737|M.leprae_Br4923 IVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKT
:: *. * . . . ::: . . .::* . *: .
Mb1969c|M.bovis_AF2122/97 AMTLLGFERG--SHIATAAIDFERDLQRLCELARDRG-LHTDPR-----V
Rv1934c|M.tuberculosis_H37Rv AMTLLGFERG--SHIATAAIDFERDLQRLCELARDRG-LHTDPR-----V
MUL_0322|M.ulcerans_Agy99 ATGSLGHER------TMLWLGYANLLGELATDFTPAGVLQRD--------
MMAR_4751|M.marinum_M ATGSLGHER------TMLWLGYANLLGELATDFTPAGVLQRD--------
MAV_0898|M.avium_104 ATGSLGHER------VMLWMGYVDLLHELSADFRPADALQRD--------
MSMEG_4805|M.smegmatis_MC2_155 ANGSLGHER------TMMWLGFADRIDNMLADFNPRTELERD--------
TH_4023|M.thermoresistible__bu ANGSLGHER------TMMWLGFADRIDNIIADFTPRTPLERD--------
Mflv_2492|M.gilvum_PYR-GCK ANGSLGHER------TMMWLGFADRIANCIADFVPRTPLERD--------
Mvan_4162|M.vanbaalenii_PYR-1 ANGSLGHER------TMMWLGFADRIANCIADFKPKNPLERD--------
MAB_2495|M.abscessus_ATCC_1997 AKYLLEFERGGGAVAPMLQVGLDQLSVDARSVPAENGTLADDPV-----F
MLBr_00737|M.leprae_Br4923 ALATLDHTRP---TIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSI
* * . * :. :
Mb1969c|M.bovis_AF2122/97 RDGLAWCYARVQIMRYRGYRDLTLALTGRPPG-AEAAITKVIWSEYFRRY
Rv1934c|M.tuberculosis_H37Rv RDGLAWCYARVQIMRYRGYRDLTLALTGRPPG-AEAAITKVIWSEYFRRY
MUL_0322|M.ulcerans_Agy99 --HYATLVMDTQAMRLLGSATLASAARGQEDV-PAQSVLKLLGSEALQRA
MMAR_4751|M.marinum_M --RYATLVMDTQAMRLLGSATLASAARGQEDV-PAQSVLKLLGSEALQRA
MAV_0898|M.avium_104 --RYATLVMDAHALRLLGSAALAAAARGEEDV-PAQSVLKLLGSEALQRA
MSMEG_4805|M.smegmatis_MC2_155 --QYATTIMDYQALRALGSAALARAARGEQDT-ASVSVLKLLGSEAERNA
TH_4023|M.thermoresistible__bu --QYATAIMDYQALRLIGSVGLAKAARGEMDT-ASVSVAKLLGSEAELRA
Mflv_2492|M.gilvum_PYR-GCK --ALASSIMDYEALRLLGSVGIAKAARGEVDV-ASVSIPKLLGAEAEQRI
Mvan_4162|M.vanbaalenii_PYR-1 --ALATSIMDYQALRLLGSVGIAKAARGEVDV-ASVSIPKLLGAEAEQRI
MAB_2495|M.abscessus_ATCC_1997 CAKLADLAIRVDVLEVLEHRVLAVVAGGGNPG-AASSMLKILGTELSQAL
MLBr_00737|M.leprae_Br4923 QFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEV
* . . : . * : * : ::
Mb1969c|M.bovis_AF2122/97 TDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDE---------
Rv1934c|M.tuberculosis_H37Rv TDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDE---------
MUL_0322|M.ulcerans_Agy99 CEDALDSAGGDG----LVHPSITAPIAALNLDNHYGS-------------
MMAR_4751|M.marinum_M CEDALDSAGGDG----LVHPSITAPIAALNLDNHYGSWFDR---------
MAV_0898|M.avium_104 SEDALEAAGSAG----LVRRAVTAQVAPLNLDSHYRSWFDR---------
MSMEG_4805|M.smegmatis_MC2_155 FENALAAAGPEG----LIHPSTSGPYAHMNLDHYFASWFER---------
TH_4023|M.thermoresistible__bu AEMALTAAGSDG----LIHPSTTGPYAHMNLDHYFASWFER---------
Mflv_2492|M.gilvum_PYR-GCK EGLALEAAGLDG----LVHPATSGPYEHMNLDHYFASWFER---------
Mvan_4162|M.vanbaalenii_PYR-1 EGLALEAAGPDG----LVHPATSGPYEHMNLDHYFASWFER---------
MAB_2495|M.abscessus_ATCC_1997 TTLTLEAAGPRGR---AYQPHVTKPGGPVVEYTPPADGYHSGELWQAVAP
MLBr_00737|M.leprae_Br4923 TTDAVQLFGGAG-----------------YTSDFPVERFMR---------
:: * .
Mb1969c|M.bovis_AF2122/97 --LLYARAATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC
Rv1934c|M.tuberculosis_H37Rv --LLYARAATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC
MUL_0322|M.ulcerans_Agy99 ----------------------------------------
MMAR_4751|M.marinum_M --YARSFAGTIAGGTSEIQRNIIAERILGLPRG-------
MAV_0898|M.avium_104 --YARTFAATIAGGTSEIQRNIIAERVLGLPRN-------
MSMEG_4805|M.smegmatis_MC2_155 --YARSFGGTIAGGTSEIQRNIIATQVLGLPRG-------
TH_4023|M.thermoresistible__bu --FARSFSGTIAGGTSEIQRNIIAQQVLGLPRR-------
Mflv_2492|M.gilvum_PYR-GCK --YCRSFGGTIAGGTSEIQRNIIAQQVLGLPRR-------
Mvan_4162|M.vanbaalenii_PYR-1 --YCRSFGGTIAGGTSEIQRNIIAQQVLGLPRR-------
MAB_2495|M.abscessus_ATCC_1997 LHYFNDRAGSIYAGSNEIQRNILAKAQLGL----------
MLBr_00737|M.leprae_Br4923 ----DAKITQIYEGTNQIQRVVMSRALLR-----------