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MTQLLRRSELAVPASNDNMFDKAAGCGADLVFLDLEDAVPPAFKEESRGKAISALNDLDWGRTARAVRIN GLDTPWCHDDLIEVVTAAGRNLDTVIIPKARRARDVWWVDVLLSQLEAKLNLGNKIRLEVLIEEVEGLAN AEEIAVASPRLDALIFGVGDFSLSQGARVDTNFVPLGEYPGDFWQYARNKVIVAARIAGIDAIDAPYPDY RDLAGYERDARRAALMGYTGKWAIHPDQVPVANRVYAPTADEIARAEANLAAYREAESNGRGAVGVNGVL VDAAHVKMAQQTLARAALINGTGGSNDR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0343 | - | - | 100% (308) | malyl-CoA lyase |
| M. avium 104 | MAV_2730 | - | 6e-40 | 35.25% (295) | citrate lyase beta chain (Citrase beta chain) |
| M. avium 104 | MAV_5074 | - | 2e-25 | 33.33% (291) | citrate lyase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3102c | - | 8e-24 | 34.60% (263) | hypothetical protein Mb3102c |
| M. gilvum PYR-GCK | Mflv_2209 | - | 2e-52 | 39.93% (293) | Citryl-CoA lyase |
| M. tuberculosis H37Rv | Rv3075c | - | 9e-24 | 34.60% (263) | hypothetical protein Rv3075c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1369 | - | 2e-54 | 41.10% (292) | citrate lyase beta chain |
| M. marinum M | MMAR_4158 | citE_1 | 2e-26 | 32.54% (295) | citrate (pro-3s)-lyase (beta subunit) CitE_1 |
| M. smegmatis MC2 155 | MSMEG_6644 | - | 1e-142 | 81.06% (301) | malyl-CoA lyase |
| M. thermoresistible (build 8) | TH_3034 | - | 1e-53 | 40.46% (304) | PUTATIVE Citrate (pro-3S)-lyase |
| M. ulcerans Agy99 | MUL_4021 | citE_1 | 3e-26 | 31.29% (294) | citrate (pro-3s)-lyase (beta subunit) CitE_1 |
| M. vanbaalenii PYR-1 | Mvan_4487 | - | 4e-56 | 42.56% (289) | citrate (pro-3S)-lyase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0343|M.avium_104 --------------------MTQLLRRSELAVPASNDNMFDKAAGCGADL
MSMEG_6644|M.smegmatis_MC2_155 --------------------MTNLLRRSELALPACNDHMFDKGVTCGADL
Mflv_2209|M.gilvum_PYR-GCK ------------------MENRYRPRRTCLSVPGSSEKMIQKAKALPADE
Mvan_4487|M.vanbaalenii_PYR-1 ------------------MENRYRPRRTCLSVPGSSAKMIQKAKTLPADE
TH_3034|M.thermoresistible__bu -------------------------------VPGSSAKMIAKAKTLPADQ
MAB_1369|M.abscessus_ATCC_1997 -----------------MTAPAYRPRRTTLAVPGSSQKMIDKAKTLPADE
MMAR_4158|M.marinum_M ---------------------MKPIPRSLLFTPATKTQHYLTAAAVHAEA
MUL_4021|M.ulcerans_Agy99 ---------------------MKPIPRSLLFTPATKTQHYLTAAAVHAEA
Mb3102c|M.bovis_AF2122/97 MTSMYEQVDTNTADPVAGSRIDPVLARSWLLVNGAHGDRFESAAHSRADI
Rv3075c|M.tuberculosis_H37Rv MTSMYEQVDTNTADPVAGSRIDPVLARSWLLVNGAHGDRFESAAHSRADI
. . .. *:
MAV_0343|M.avium_104 VFLDLEDAVPPAFKEESRGKAISALNDLDWGRTARAVRINGLDTPWCHDD
MSMEG_6644|M.smegmatis_MC2_155 VFLDLEDATPVGLKVESRAKAIHALTQLDWGRTARAVRINGLDTEWCHDD
Mflv_2209|M.gilvum_PYR-GCK VFLDLEDAVAAEAKDEARQRVAQALAEPGWGDQLRGVRVNDWTTPWTHAD
Mvan_4487|M.vanbaalenii_PYR-1 VFLDLEDAVAPGAKEQARGQVAAALAEPGWAGQLRGVRVNDWTTPWTHSD
TH_3034|M.thermoresistible__bu VFLDLEDAVAPDAKAEARTRVAAALAEDGWGDQMRGVRVNDWSTPWTHSD
MAB_1369|M.abscessus_ATCC_1997 VFLDLEDAVAAPAKVEARRRIAEALNAPGWSGQLLSVRVNDWTTEWTYAD
MMAR_4158|M.marinum_M LILDLEDSVAPRDKAQARRDALNFLCTTTPAKTMAAIRVNAPDTLDGWRD
MUL_4021|M.ulcerans_Agy99 LILDLEDSVAPRDKAQARRDALNFLCTTTPAKTMAAIRVNAPDTLDGWRD
Mb3102c|M.bovis_AF2122/97 VVLDIEDAVAPKDKHAARDNAVRWFGD----GNADWVRINGFGTPWWADD
Rv3075c|M.tuberculosis_H37Rv VVLDIEDAVAPKDKHAARDNAVRWFGD----GNADWVRINGFGTPWWADD
:.**:**:.. * :* : :*:* * *
MAV_0343|M.avium_104 LIEVVTAAGRNLDTVIIPKARRARDVWWVDVLLSQLEAKLNLG-NKIRLE
MSMEG_6644|M.smegmatis_MC2_155 IIEILTHAGDHLDTIVIPKAKTARDVWWVDVLLTQLEAKLGLD-KTIRLE
Mflv_2209|M.gilvum_PYR-GCK IIEVMARAGASLDIVVLPKVTDVSHVHALDLLLSQLEATHDLPPGRIGIE
Mvan_4487|M.vanbaalenii_PYR-1 IIEVVARAGASLDIVVLPKVTDASHVHALDLLLSQLEATHGLPLGRIGIE
TH_3034|M.thermoresistible__bu VIEVVSAAGAHLDIIVLPKVTDVSHIHALDLLLSQLEVQHGLPVGRIGIE
MAB_1369|M.abscessus_ATCC_1997 LVEIVSRAGANIDNILLPKVTAASHVTALDLLLTQLERSHGLQVGAIGIQ
MMAR_4158|M.marinum_M LTALLDSA-ADPDFLMLPKVQSAAEIGLVKRLLRQSQK-------TTRLI
MUL_4021|M.ulcerans_Agy99 LTALLDSA-ADPDFLMLPKVQSAAEIGLVKRLLRQSQK-------TTRLI
Mb3102c|M.bovis_AF2122/97 LAMLADSP---VGGVMLAMVESVDHVTETAKRLP-----------NVPIV
Rv3075c|M.tuberculosis_H37Rv LAMLADSP---VGGVMLAMVESVDHVTETAKRLP-----------NVPIV
: : . . :::. . . .: * :
MAV_0343|M.avium_104 VLIEEVEGLANAEEIAVASPRLDALIFGVGDFSLSQGAR-VDTNFVPLGE
MSMEG_6644|M.smegmatis_MC2_155 VLIEEVEGLANAEDIVRASPRLDAVIFGVGDFSLSQGAR-VDTNFDPLGE
Mflv_2209|M.gilvum_PYR-GCK AQIEDARGLTHIDAIASA-PRVQALVLGPADLMASLNMRTLVVGEQPEGY
Mvan_4487|M.vanbaalenii_PYR-1 AQIEDAKGLTNVDAIASA-PRVQALVLGPADLMASLNMRTLEVGEQPEGY
TH_3034|M.thermoresistible__bu AQIENAQGLTNIDAIAAA-PRVQALVLGPADLMASLNMRTLVVGEQPEGY
MAB_1369|M.abscessus_ATCC_1997 AQIENAEGLTNIDAIASASPRMRSLVFGPADFMASLGMRTLVVGEQPPGY
MMAR_4158|M.marinum_M ATAESAVVAANPDCALDP-RLVDAVIFGSADMAADLGAEPSAAVVR----
MUL_4021|M.ulcerans_Agy99 ATAETAVVAANPDCALDP-RLVDAVIFGSADMAADLGAEPSAAVVR----
Mb3102c|M.bovis_AF2122/97 ALVETARGLERINEIAAAKGTFR-LAFGIGDFRRDTGFGEDPATLA----
Rv3075c|M.tuberculosis_H37Rv ALVETARGLERINEIAAAKGTFR-LAFGIGDFRRDTGFGEDPATLA----
. * . . : . . : :* .*: . . .
MAV_0343|M.avium_104 YPGDFWQYARNKVIVAARIAGID-AIDAPYPDYRDLAGYERDARRAALMG
MSMEG_6644|M.smegmatis_MC2_155 YPGDFWVYARNKIMVAARIAGID-AIDSPYPDYRNLEGYERDARRSSLMG
Mflv_2209|M.gilvum_PYR-GCK DVGDAYHHVLMRILIAARANGIA-AIDGPFLKVRDVEAFRRVAGRSAALG
Mvan_4487|M.vanbaalenii_PYR-1 TEGDAYHHVLMRILVAARANGIA-AIDGPYLKVRDVASFRRVAGRSAALG
TH_3034|M.thermoresistible__bu DVGDAYHHVLMRILIAARTHGIA-AIDGPFLQIRDVEAFRRVAARSAALG
MAB_1369|M.abscessus_ATCC_1997 D-GEAYHHVLMTILVAARAHGID-AIDGPYLKVRDVDAFRTAAARSAALG
MMAR_4158|M.marinum_M -------HARSTILSHAAAAKIP-VIDAPFFDIDDIPGLRQAVREAVAEG
MUL_4021|M.ulcerans_Agy99 -------HARSTILSHAAAAKIP-VIDAPFFDIDDIPGLRQAVREAVAEG
Mb3102c|M.bovis_AF2122/97 -------YARSRFTIAARAAGLPSAIDGPTIGSNALKLIEATAVS-AEFG
Rv3075c|M.tuberculosis_H37Rv -------YARSRFTIAARAAGLPSAIDGPTIGSNALKLIEATAVS-AEFG
:. . * : .**.* : . . *
MAV_0343|M.avium_104 YTGKWAIHPDQVPVANRVYAPTADEIARAEANLAAYREAESNG---RGAV
MSMEG_6644|M.smegmatis_MC2_155 YTGKWAIHPDQVPIANEVYAPTTDEIARAERNVAAYREAEAKG---RGAV
Mflv_2209|M.gilvum_PYR-GCK YDGKWVLHPDQIEAGNEIFSPRQQDYDHAELLLEAYEWHTSRAGGARGAV
Mvan_4487|M.vanbaalenii_PYR-1 YDGKWVLHPDQIEAGNEIFSPRQQAYDHAELILEAYEWHTSQAGGARGAV
TH_3034|M.thermoresistible__bu YDGKWVLHPDQIAAGNEVFSPRQEDYNHAELILEAYEWYTSQAGGARGAA
MAB_1369|M.abscessus_ATCC_1997 FDGKWVLHPAQIEAGNEIFSPRQDDYDRAELILDAYEWHTSVAGGARGAV
MMAR_4158|M.marinum_M FAGKAAIHPDHVALINSGFLPGQSEINWAREVLKSAQAG---------AG
MUL_4021|M.ulcerans_Agy99 FAGKAAIHPDHVALINSGFLPGQSEINWAREVLKSAQAG---------PG
Mb3102c|M.bovis_AF2122/97 MTGKICLSPDQCPVVNEGLSPSQDEIVWAKEFFAEFARDGGEIRNGSDLP
Rv3075c|M.tuberculosis_H37Rv MTGKICLSPDQCPVVNEGLSPSQDEIVWAKEFFAEFARDGGEIRNGSDLP
** : * : * * . *. .
MAV_0343|M.avium_104 GVN--GVLVDAAHVKMAQQTLAR--AALINGTGGSNDR---
MSMEG_6644|M.smegmatis_MC2_155 GVE--GVLVDAAHVKMAEETLAR--AALIS--GGR------
Mflv_2209|M.gilvum_PYR-GCK MLG--DEMIDEASRKMALVIAGKGRAAGMTRTGERFVPPG-
Mvan_4487|M.vanbaalenii_PYR-1 MLG--DEMIDEASRKMALVIAGKGRAAGMQRTGEGFRPPS-
TH_3034|M.thermoresistible__bu MLG--DEMIDEASRKMALVIAAKGRAAGMTRTGGRFQPPS-
MAB_1369|M.abscessus_ATCC_1997 MLG--DEMIDEASRKMALVIAGKGRAAGMARQAAPYEPPTG
MMAR_4158|M.marinum_M SVG--GRMVDEAMARRARGILARAQGVNEEEPCMS------
MUL_4021|M.ulcerans_Agy99 SVG--GRMVDEAMARRARGILARAQGVNEEEPCMS------
Mb3102c|M.bovis_AF2122/97 RIARATKILDLARAYGIEVSDFEDEPVHMPAPTDTYHY---
Rv3075c|M.tuberculosis_H37Rv RIARATKILDLARAYGIEVSDFEDEPVHMPAPTDTYHY---
: ::* * . .