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MKPIPRSLLFTPATKTQHYLTAAAVHAEALILDLEDSVAPRDKAQARRDALNFLCTTTPAKTMAAIRVNA PDTLDGWRDLTALLDSAADPDFLMLPKVQSAAEIGLVKRLLRQSQKTTRLIATAETAVVAANPDCALDPR LVDAVIFGSADMAADLGAEPSAAVVRHARSTILSHAAAAKIPVIDAPFFDIDDIPGLRQAVREAVAEGFA GKAAIHPDHVALINSGFLPGQSEINWAREVLKSAQAGPGSVGGRMVDEAMARRARGILARAQGVNEEEPC MS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4021 | citE_1 | - | 100% (282) | citrate (pro-3s)-lyase (beta subunit) CitE_1 |
| M. ulcerans Agy99 | MUL_3776 | citE | 3e-29 | 34.56% (272) | citrate (pro-3s)-lyase (beta subunit) CitE |
| M. ulcerans Agy99 | MUL_3451 | citE_2 | 2e-18 | 27.72% (285) | citrate lyase beta subunit, CitE_2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2526c | citE | 1e-30 | 34.89% (278) | citrate (Pro-3S)-lyase beta subunit |
| M. gilvum PYR-GCK | Mflv_2556 | - | 7e-30 | 36.00% (275) | HpcH/HpaI aldolase |
| M. tuberculosis H37Rv | Rv2498c | citE | 1e-30 | 34.89% (278) | citrate (Pro-3S)-lyase beta subunit |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4378c | - | 6e-22 | 34.07% (270) | putative citrate lyase beta subunit |
| M. marinum M | MMAR_4158 | citE_1 | 1e-156 | 99.29% (282) | citrate (pro-3s)-lyase (beta subunit) CitE_1 |
| M. avium 104 | MAV_5074 | - | 3e-31 | 36.86% (274) | citrate lyase |
| M. smegmatis MC2 155 | MSMEG_6298 | - | 3e-30 | 34.60% (289) | malyl-CoA lyase |
| M. thermoresistible (build 8) | TH_0719 | - | 4e-27 | 34.93% (272) | HpcH/HpaI aldolase/citrate lyase family protein |
| M. vanbaalenii PYR-1 | Mvan_4087 | - | 3e-28 | 37.13% (272) | HpcH/HpaI aldolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2556|M.gilvum_PYR-GCK -----MTL-APGTAWLFCPADRPERFEKAAA-AADIVILDLEDGVAAKDR
Mvan_4087|M.vanbaalenii_PYR-1 -----MTL-AAGPAWLFCPADRPERFEKAAA-AADVVILDLEDGVAAKDR
TH_0719|M.thermoresistible__bu -----MDLSAVGPAWLFCPADRPERFEKAAA-AADVVILDLEDGVAAKDR
MAB_4378c|M.abscessus_ATCC_199 -----MTVATAGPGWLFCPADRPERFEKAAV-AADVVILDLEDGVAAADR
Mb2526c|M.bovis_AF2122/97 -----MNLRAAGPGWLFCPADRPERFAKAAA-AADVVILDLEDGVAEAQK
Rv2498c|M.tuberculosis_H37Rv -----MNLRAAGPGWLFCPADRPERFAKAAA-AADVVILDLEDGVAEAQK
MAV_5074|M.avium_104 ----MHDDLASARSLLFVPGDRPDRFTKAASSDADGIIIDLEDAVAPEAK
MSMEG_6298|M.smegmatis_MC2_155 MGGRPTRALPLLRTLLFVPGDRPDRIAKAAASAAAGVAVDLEDAVAVSRK
MUL_4021|M.ulcerans_Agy99 -------MKPIPRSLLFTPATKTQHYLTAAAVHAEALILDLEDSVAPRDK
MMAR_4158|M.marinum_M -------MKPIPRSLLFTPATKTQHYLTAAAVHAEALILDLEDSVAPRDK
. ** *. :.:: .** * : :****.** :
Mflv_2556|M.gilvum_PYR-GCK QAAREALVN-----TPLDPARTVVRVNPTGTADHGPDLEAVARTAYT--T
Mvan_4087|M.vanbaalenii_PYR-1 EAARKALVD-----TPLDPSRTVVRVNPAGTPDHKLDLEALSRTSYT--T
TH_0719|M.thermoresistible__bu PAAREALLS-----TPLDPARTVVRVNPAGTADHRLDLDALTRTPYR--T
MAB_4378c|M.abscessus_ATCC_199 PAARDALIS-----TPLDPGRTVVRLNPAATADHALDLEALAQTEYT--T
Mb2526c|M.bovis_AF2122/97 PAARNALRD-----TPLDPERTVVRINAGGTADQARDLEALAGTAYT--T
Rv2498c|M.tuberculosis_H37Rv PAARNALRD-----TPLDPERTVVRINAGGTADQARDLEALAGTAYT--T
MAV_5074|M.avium_104 ARAREAVDR---WLATGGVG--TVRINGTETPWHQEDL---EMAARHGCP
MSMEG_6298|M.smegmatis_MC2_155 DAARDAAVTALSALPTAGVPVLCVRINAVDSGFAEDDLTALEPVLHRLDL
MUL_4021|M.ulcerans_Agy99 AQARRDALN-FLCTTTPAKTMAAIRVNAPDTLDGWRDLTALLDSAADPDF
MMAR_4158|M.marinum_M AQARRDALN-FLCTTTPAKTMAAIRVNAPDTLDGWRDLTALLDSAADPDF
** .. :*:* : **
Mflv_2556|M.gilvum_PYR-GCK VMLAKTEAPEQVRALAPLD---------------VIVLIETPLGALNVVD
Mvan_4087|M.vanbaalenii_PYR-1 VMLAKTESPQQVAALAPLD---------------VVVLIETPLGALAVVE
TH_0719|M.thermoresistible__bu VMLAKTDAAEQVRALAPLQ---------------VVVLIETPLGALNVVE
MAB_4378c|M.abscessus_ATCC_199 VILAKSEHADQVLGLAPLN---------------VVVLVETPMGALNVAE
Mb2526c|M.bovis_AF2122/97 VMLPKAESAAQVIELAPRD---------------VIALVETARGAVCAAE
Rv2498c|M.tuberculosis_H37Rv VMLPKAESAAQVIELAPRD---------------VIALVETARGAVCAAE
MAV_5074|M.avium_104 VMVPKARSASHLAQISRRLPTGT----------ALIALIETAAGVLAAAD
MSMEG_6298|M.smegmatis_MC2_155 VMVPMSAEPDRIRRVSELLTRAERSAGADDGRIGIIPLVETAAGILNAPS
MUL_4021|M.ulcerans_Agy99 LMLPKVQSAAEIGLVKRLLRQSQ----------KTTRLIATAETAVVAAN
MMAR_4158|M.marinum_M LMLPKVQSAAEIGLVKRLLRQSQ----------KTTRLIATAESAVVAAN
:::. . .: : *: *. : . .
Mflv_2556|M.gilvum_PYR-GCK LARVDN---AYALMWGAEDLFAELGGTANRYPDGSYREVARHVRSQTLLA
Mvan_4087|M.vanbaalenii_PYR-1 LARVDN---ALALMWGAEDLFAVLGGTANRYPDGSYREVARHVRSQTLLA
TH_0719|M.thermoresistible__bu SARADN---AVAVMWGAEDLFAVTGGTDNRNPDGSYRDVARHVRSQSLLA
MAB_4378c|M.abscessus_ATCC_199 LVRPGN---VVAAMWGAEDLFAATWGTNNRWPDGSYRDVAQHVRSQTLLA
Mb2526c|M.bovis_AF2122/97 IAAADP---TVGMMWGAEDLIATLGGSSSRRADGAYRDVARHVRSTILLA
Rv2498c|M.tuberculosis_H37Rv IAAADP---TVGMMWGAEDLIATLGGSSSRRADGAYRDVARHVRSTILLA
MAV_5074|M.avium_104 ICAVEG---VVRAAFGSVDLGAELG----IDPE-DHESLRYARSAVVLGS
MSMEG_6298|M.smegmatis_MC2_155 LASADAR--VHTLSFGPADLSRELG----ITPTSDGDEFLFARSQLVLAA
MUL_4021|M.ulcerans_Agy99 PDCALDPRLVDAVIFGSADMAADLG-------AEPSAAVVRHARSTILSH
MMAR_4158|M.marinum_M PDCALDPRLVDAVIFGSADMAADLG-------AEPSAAVVRHARSTILSH
. :*. *: . *
Mflv_2556|M.gilvum_PYR-GCK AKAYGRVALDSVFLDIKNLDGLRGEVDDAVAVGFDGKVAIHPTQLPVIRD
Mvan_4087|M.vanbaalenii_PYR-1 AKAYGRLALDSVFLDIKNLDGLRAEVDDAVAVGFDVKVAIHPSQVAVIRS
TH_0719|M.thermoresistible__bu AKAHGRLALDSVYLDIKDLDGLRAEVDDAVAVGFDAKVAIHPTQVAVIRE
MAB_4378c|M.abscessus_ATCC_199 AKAFGRIALDAVYLDIKALDGLRAEADDAVAVGFDAKVAIHPTQVNVIRA
Mb2526c|M.bovis_AF2122/97 ASAFGRLALDAVHLDILDVEGLQEEARDAAAVGFDVTVCIHPSQIPVVRK
Rv2498c|M.tuberculosis_H37Rv ASAFGRLALDAVHLDILDVEGLQEEARDAAAVGFDVTVCIHPSQIPVVRK
MAV_5074|M.avium_104 AAAGLAAPLDGVTTAVHDEGAAGADAARAARLGFGGKLCIHPCQVAPVNS
MSMEG_6298|M.smegmatis_MC2_155 AAANCPAPVDGPYLDLDDDDGLIRSARHARKLGFGGKQVIHPSQIASVAG
MUL_4021|M.ulcerans_Agy99 AAAAKIPVIDAPFFDIDDIPGLRQAVREAVAEGFAGKAAIHPDHVALINS
MMAR_4158|M.marinum_M AAAAKIPVIDAPFFDIDDIPGLRQAVREAVAEGFAGKAAIHPDHVALINS
* * :*. : . . * ** . *** :: :
Mflv_2556|M.gilvum_PYR-GCK GYTPTEAQADWARRVLAAAQAERGV-----FQYEGQMVDMPVLRRAERIV
Mvan_4087|M.vanbaalenii_PYR-1 GYAPTDAEVDWARRVLDTARTQRGV-----FAFEGIMVDAPVLRRAERIV
TH_0719|M.thermoresistible__bu GYTPTPDQVRWARHVLAAARDERGV-----FQFEGIMVDAPVLRRAERIV
MAB_4378c|M.abscessus_ATCC_199 AYEPTAKQVYWARGVLELAGRERGV-----FQFEGVMVDAPVLRRAERII
Mb2526c|M.bovis_AF2122/97 AYRPSHEKLAWARRVLAASRSERGA-----FAFEGQMVDSPVLTHAETML
Rv2498c|M.tuberculosis_H37Rv AYRPSHEKLAWARRVLAASRSERGA-----FAFEGQMVDSPVLTHAETML
MAV_5074|M.avium_104 QFSPSIEEQAWARKVMAAGSGNGAR------TVDGCMVDKPVVDRAARIL
MSMEG_6298|M.smegmatis_MC2_155 AFVTSDAEIDWARAVDAAFSAAEAEGVSSIRLADGTFVDYPVAQRARAIL
MUL_4021|M.ulcerans_Agy99 GFLPGQSEINWAREVLKSAQAGPGS-------VGGRMVDEAMARRARGIL
MMAR_4158|M.marinum_M GFLPGQSEINWAREVLKSAQAGAGS-------VGGRMVDEAMARRARGIL
: . : *** * . * :** .: :* ::
Mflv_2556|M.gilvum_PYR-GCK ALAP----------
Mvan_4087|M.vanbaalenii_PYR-1 ELAPHPGA------
TH_0719|M.thermoresistible__bu QLAPDPGR------
MAB_4378c|M.abscessus_ATCC_199 QLSALTGGLCE---
Mb2526c|M.bovis_AF2122/97 RRAGEATSE-----
Rv2498c|M.tuberculosis_H37Rv RRAGEATSE-----
MAV_5074|M.avium_104 ARAQGLTSP-----
MSMEG_6298|M.smegmatis_MC2_155 AGAR----------
MUL_4021|M.ulcerans_Agy99 ARAQGVNEEEPCMS
MMAR_4158|M.marinum_M ARAQGVNEEEPCMS
: