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APTLRPRRSALYLPGNKPRALEKGKSLPADVLIFDLEDAVGPDAKAESRAAVCEAISSPDYRPREIVVRI NGLDTEWHDDDLAAVAGSAADGVLVPKVETAQQVQALDRALDTLGASASLQLWVMMETPRAFLRAEEVAS ASDRLAGLVVGTNDLVNELHGRHVAGRGPVVPALGLALLGARAAGKVVLDGVFNDITDDAGFRAEAAQGR EMGFDGKTLIHPSQIAPANEVFGPSQHELADARKVVSAYQQAQAAGTSVITVDGRMIESLHVRDAQRILA LADLISERDAAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2730 | - | - | 100% (293) | citrate lyase beta chain (Citrase beta chain) (citrate(pro-3S)-lyase beta chain) |
| M. avium 104 | MAV_0343 | - | 5e-40 | 35.25% (295) | malyl-CoA lyase |
| M. avium 104 | MAV_5074 | - | 1e-34 | 37.32% (284) | citrate lyase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2526c | citE | 6e-27 | 33.57% (277) | citrate (Pro-3S)-lyase beta subunit |
| M. gilvum PYR-GCK | Mflv_2209 | - | 2e-35 | 35.74% (263) | Citryl-CoA lyase |
| M. tuberculosis H37Rv | Rv2498c | citE | 6e-27 | 33.57% (277) | citrate (Pro-3S)-lyase beta subunit |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1369 | - | 5e-40 | 36.84% (266) | citrate lyase beta chain |
| M. marinum M | MMAR_3845 | citE | 3e-29 | 33.94% (277) | citrate (pro-3s)-lyase (beta subunit) CitE |
| M. smegmatis MC2 155 | MSMEG_6644 | - | 6e-41 | 34.58% (295) | malyl-CoA lyase |
| M. thermoresistible (build 8) | TH_3034 | - | 2e-33 | 33.68% (288) | PUTATIVE Citrate (pro-3S)-lyase |
| M. ulcerans Agy99 | MUL_3776 | citE | 8e-29 | 33.57% (277) | citrate (pro-3s)-lyase (beta subunit) CitE |
| M. vanbaalenii PYR-1 | Mvan_4487 | - | 3e-36 | 35.02% (297) | citrate (pro-3S)-lyase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2209|M.gilvum_PYR-GCK -MENRYRPRRTCLSVPGSSEKMIQKAKALPADEVFLDLEDAVAAEAKDEA
Mvan_4487|M.vanbaalenii_PYR-1 -MENRYRPRRTCLSVPGSSAKMIQKAKTLPADEVFLDLEDAVAPGAKEQA
TH_3034|M.thermoresistible__bu --------------VPGSSAKMIAKAKTLPADQVFLDLEDAVAPDAKAEA
MAB_1369|M.abscessus_ATCC_1997 MTAPAYRPRRTTLAVPGSSQKMIDKAKTLPADEVFLDLEDAVAAPAKVEA
MSMEG_6644|M.smegmatis_MC2_155 -MTNLLR--RSELALPACNDHMFDKGVTCGADLVFLDLEDATPVGLKVES
Mb2526c|M.bovis_AF2122/97 --MNLRAAGPGWLFCPADRPERFAK-AAAAADVVILDLEDGVAEAQKPAA
Rv2498c|M.tuberculosis_H37Rv --MNLRAAGPGWLFCPADRPERFAK-AAAAADVVILDLEDGVAEAQKPAA
MMAR_3845|M.marinum_M --MKLRTAGPAWLFCPADRPERFAK-AAAAADVVILDLEDGVAEAQKPAA
MUL_3776|M.ulcerans_Agy99 --MKLRTASPAWLFCPADRPERFAK-AAAAADVVILDLEDGVAEAQKPAA
MAV_2730|M.avium_104 -MAPTLRPRRSALYLPGNKPRALEKGKSLPADVLIFDLEDAVGPDAKAES
*. . : * : ** :::****.. * :
Mflv_2209|M.gilvum_PYR-GCK RQRVAQALAEPGWGDQLRGVRVNDWTTPWTHADIIEVMARAGASLDIVVL
Mvan_4487|M.vanbaalenii_PYR-1 RGQVAAALAEPGWAGQLRGVRVNDWTTPWTHSDIIEVVARAGASLDIVVL
TH_3034|M.thermoresistible__bu RTRVAAALAEDGWGDQMRGVRVNDWSTPWTHSDVIEVVSAAGAHLDIIVL
MAB_1369|M.abscessus_ATCC_1997 RRRIAEALNAPGWSGQLLSVRVNDWTTEWTYADLVEIVSRAGANIDNILL
MSMEG_6644|M.smegmatis_MC2_155 RAKAIHALTQLDWGRTARAVRINGLDTEWCHDDIIEILTHAGDHLDTIVI
Mb2526c|M.bovis_AF2122/97 RNALRDTPLDPER----TVVRINAGGTADQAR---DLEALAGTAYTTVML
Rv2498c|M.tuberculosis_H37Rv RNALRDTPLDPER----TVVRINAGGTADQAR---DLEALAGTAYTTVML
MMAR_3845|M.marinum_M RQALLDTPLDPER----TIVRINAGDTDEQAR---DLAALAGTAYTTVML
MUL_3776|M.ulcerans_Agy99 RQALLDTPLDPER----TIVRINAGDTDEQAR---DLAALAGTAYTTVML
MAV_2730|M.avium_104 RAAVCEAISSPDYRPREIVVRINGLDTEWHDD---DLAAVAGSAADGVLV
* : **:* * :: : ** :::
Mflv_2209|M.gilvum_PYR-GCK PKVTDVSHVHALDLLLSQLEATHDLPPGRIGIEAQIEDARGLTHIDAIAS
Mvan_4487|M.vanbaalenii_PYR-1 PKVTDASHVHALDLLLSQLEATHGLPLGRIGIEAQIEDAKGLTNVDAIAS
TH_3034|M.thermoresistible__bu PKVTDVSHIHALDLLLSQLEVQHGLPVGRIGIEAQIENAQGLTNIDAIAA
MAB_1369|M.abscessus_ATCC_1997 PKVTAASHVTALDLLLTQLERSHGLQVGAIGIQAQIENAEGLTNIDAIAS
MSMEG_6644|M.smegmatis_MC2_155 PKAKTARDVWWVDVLLTQLEAKLGLD-KTIRLEVLIEEVEGLANAEDIVR
Mb2526c|M.bovis_AF2122/97 PKAESAAQVIEL---------------APRDVIALVETARGAVCAAEIAA
Rv2498c|M.tuberculosis_H37Rv PKAESAAQVIEL---------------APRDVIALVETARGAVCAAEIAA
MMAR_3845|M.marinum_M PKAESAAQLALL---------------APRDVIALVETARGALFAAEIAA
MUL_3776|M.ulcerans_Agy99 PKAESVAQLALL---------------APRDVIALVETARGALFAAEIAA
MAV_2730|M.avium_104 PKVETAQQVQALDRALDTLGAS-----ASLQLWVMMETPRAFLRAEEVAS
**. . .: : : . :* .. :.
Mflv_2209|M.gilvum_PYR-GCK A-PRVQALVLGPADLMASLNMRTLVVGEQPEGYDVGDAYHHVLMRILIAA
Mvan_4487|M.vanbaalenii_PYR-1 A-PRVQALVLGPADLMASLNMRTLEVGEQPEGYTEGDAYHHVLMRILVAA
TH_3034|M.thermoresistible__bu A-PRVQALVLGPADLMASLNMRTLVVGEQPEGYDVGDAYHHVLMRILIAA
MAB_1369|M.abscessus_ATCC_1997 ASPRMRSLVFGPADFMASLGMRTLVVGEQPPGYD-GEAYHHVLMTILVAA
MSMEG_6644|M.smegmatis_MC2_155 ASPRLDAVIFGVGDFSLSQGAR-VDTNFDPLGEYPGDFWVYARNKIMVAA
Mb2526c|M.bovis_AF2122/97 ADP-TVGMMWGAEDLIATLGGSSSRRADGA----YRDVARHVRSTILLAA
Rv2498c|M.tuberculosis_H37Rv ADP-TVGMMWGAEDLIATLGGSSSRRADGA----YRDVARHVRSTILLAA
MMAR_3845|M.marinum_M ADN-TVGMMWGAEDLIATLGGSSSRRGDGS----YRDVARHVRSTTLLAA
MUL_3776|M.ulcerans_Agy99 ADN-TVGMMWGAEDLIATLGGSSSRRGDGT----YRDVARHVRSTILLAA
MAV_2730|M.avium_104 ASDRLAGLVVGTNDLVNELHG---RHVAG------RGPVVPALGLALLGA
* .:: * *: . ::.*
Mflv_2209|M.gilvum_PYR-GCK RANGIAAIDGPFLKVRDVEAFRRVAGRSAALGYDGKWVLHPDQIEAGNEI
Mvan_4487|M.vanbaalenii_PYR-1 RANGIAAIDGPYLKVRDVASFRRVAGRSAALGYDGKWVLHPDQIEAGNEI
TH_3034|M.thermoresistible__bu RTHGIAAIDGPFLQIRDVEAFRRVAARSAALGYDGKWVLHPDQIAAGNEV
MAB_1369|M.abscessus_ATCC_1997 RAHGIDAIDGPYLKVRDVDAFRTAAARSAALGFDGKWVLHPAQIEAGNEI
MSMEG_6644|M.smegmatis_MC2_155 RIAGIDAIDSPYPDYRNLEGYERDARRSSLMGYTGKWAIHPDQVPIANEV
Mb2526c|M.bovis_AF2122/97 SAFGRLALDAVHLDILDVEGLQEEARDAAAVGFDVTVCIHPSQIPVVRKA
Rv2498c|M.tuberculosis_H37Rv SAFGRLALDAVHLDILDVEGLQEEARDAAAVGFDVTVCIHPSQIPVVRKA
MMAR_3845|M.marinum_M SAFGRLALDAVHLDIGDIDGLHAEAIDAATVGFDVTVCIHPSQVEVVRKA
MUL_3776|M.ulcerans_Agy99 SAFGRLALDAVHLDIGDVDGLHAEAMDAATVGFDVTVCIHPSQVEVVRKA
MAV_2730|M.avium_104 RAAGKVVLDGVFNDITDDAGFRAEAAQGREMGFDGKTLIHPSQIAPANEV
* .:*. . . : . . * . :*: . :** *: .:
Mflv_2209|M.gilvum_PYR-GCK FSPRQQDYDHAELLLEAYEWHTSRAGGARGAVMLGDEMIDEASRKMALVI
Mvan_4487|M.vanbaalenii_PYR-1 FSPRQQAYDHAELILEAYEWHTSQAGGARGAVMLGDEMIDEASRKMALVI
TH_3034|M.thermoresistible__bu FSPRQEDYNHAELILEAYEWYTSQAGGARGAAMLGDEMIDEASRKMALVI
MAB_1369|M.abscessus_ATCC_1997 FSPRQDDYDRAELILDAYEWHTSVAGGARGAVMLGDEMIDEASRKMALVI
MSMEG_6644|M.smegmatis_MC2_155 YAPTTDEIARAERNVAAYREAEAKG---RGAVGVEGVLVDAAHVKMAEET
Mb2526c|M.bovis_AF2122/97 YRPSHEKLAWARRVLAASRSERG-------AFAFEGQMVDSPVLTHAETM
Rv2498c|M.tuberculosis_H37Rv YRPSHEKLAWARRVLAASRSERG-------AFAFEGQMVDSPVLTHAETM
MMAR_3845|M.marinum_M YRPDEEKLAWARRVLVAARTERG-------VFAFEGQMVDSPVLRHAEML
MUL_3776|M.ulcerans_Agy99 YRPDEEKLAWARRVLVAARTERG-------VFAFEGQMVDSPVLRHAEML
MAV_2730|M.avium_104 FGPSQHELADARKVVSAYQQAQAAG---TSVITVDGRMIESLHVRDAQRI
: * . *. : * . . . . . ::: *
Mflv_2209|M.gilvum_PYR-GCK AGKGRAAGMTRTGERFVPPG-
Mvan_4487|M.vanbaalenii_PYR-1 AGKGRAAGMQRTGEGFRPPS-
TH_3034|M.thermoresistible__bu AAKGRAAGMTRTGGRFQPPS-
MAB_1369|M.abscessus_ATCC_1997 AGKGRAAGMARQAAPYEPPTG
MSMEG_6644|M.smegmatis_MC2_155 LAR---AALISGGR-------
Mb2526c|M.bovis_AF2122/97 LRRAGEATSE-----------
Rv2498c|M.tuberculosis_H37Rv LRRAGEATSE-----------
MMAR_3845|M.marinum_M LRRAGESVPA-----------
MUL_3776|M.ulcerans_Agy99 LRRAGESVPA-----------
MAV_2730|M.avium_104 LALADLISERDAAS-------