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VTNLLRRSELALPACNDHMFDKGVTCGADLVFLDLEDATPVGLKVESRAKAIHALTQLDWGRTARAVRIN GLDTEWCHDDIIEILTHAGDHLDTIVIPKAKTARDVWWVDVLLTQLEAKLGLDKTIRLEVLIEEVEGLAN AEDIVRASPRLDAVIFGVGDFSLSQGARVDTNFDPLGEYPGDFWVYARNKIMVAARIAGIDAIDSPYPDY RNLEGYERDARRSSLMGYTGKWAIHPDQVPIANEVYAPTTDEIARAERNVAAYREAEAKGRGAVGVEGVL VDAAHVKMAEETLARAALISGGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6644 | - | - | 100% (303) | malyl-CoA lyase |
| M. smegmatis MC2 155 | MSMEG_5064 | - | 9e-51 | 40.83% (289) | malyl-CoA lyase |
| M. smegmatis MC2 155 | MSMEG_6298 | - | 2e-25 | 30.54% (298) | malyl-CoA lyase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2526c | citE | 4e-20 | 30.80% (289) | citrate (Pro-3S)-lyase beta subunit |
| M. gilvum PYR-GCK | Mflv_2209 | - | 2e-47 | 37.72% (289) | Citryl-CoA lyase |
| M. tuberculosis H37Rv | Rv2498c | citE | 4e-20 | 30.80% (289) | citrate (Pro-3S)-lyase beta subunit |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1369 | - | 3e-53 | 39.93% (288) | citrate lyase beta chain |
| M. marinum M | MMAR_4158 | citE_1 | 1e-23 | 32.30% (291) | citrate (pro-3s)-lyase (beta subunit) CitE_1 |
| M. avium 104 | MAV_0343 | - | 1e-142 | 81.06% (301) | malyl-CoA lyase |
| M. thermoresistible (build 8) | TH_3034 | - | 6e-49 | 39.22% (283) | PUTATIVE Citrate (pro-3S)-lyase |
| M. ulcerans Agy99 | MUL_4021 | citE_1 | 1e-23 | 32.30% (291) | citrate (pro-3s)-lyase (beta subunit) CitE_1 |
| M. vanbaalenii PYR-1 | Mvan_4487 | - | 1e-49 | 39.79% (289) | citrate (pro-3S)-lyase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6644|M.smegmatis_MC2_155 ---MTNLLRRSELALPACNDHMFDKGVTCGADLVFLDLEDATPVGLKVES
MAV_0343|M.avium_104 ---MTQLLRRSELAVPASNDNMFDKAAGCGADLVFLDLEDAVPPAFKEES
Mflv_2209|M.gilvum_PYR-GCK -MENRYRPRRTCLSVPGSSEKMIQKAKALPADEVFLDLEDAVAAEAKDEA
Mvan_4487|M.vanbaalenii_PYR-1 -MENRYRPRRTCLSVPGSSAKMIQKAKTLPADEVFLDLEDAVAPGAKEQA
TH_3034|M.thermoresistible__bu --------------VPGSSAKMIAKAKTLPADQVFLDLEDAVAPDAKAEA
MAB_1369|M.abscessus_ATCC_1997 MTAPAYRPRRTTLAVPGSSQKMIDKAKTLPADEVFLDLEDAVAAPAKVEA
Mb2526c|M.bovis_AF2122/97 --MNLRAAGPGWLFCPADRPERFAKAAAA-ADVVILDLEDGVAEAQKPAA
Rv2498c|M.tuberculosis_H37Rv --MNLRAAGPGWLFCPADRPERFAKAAAA-ADVVILDLEDGVAEAQKPAA
MMAR_4158|M.marinum_M ----MKPIPRSLLFTPATKTQHYLTAAAVHAEALILDLEDSVAPRDKAQA
MUL_4021|M.ulcerans_Agy99 ----MKPIPRSLLFTPATKTQHYLTAAAVHAEALILDLEDSVAPRDKAQA
*. . .. *: ::*****... * :
MSMEG_6644|M.smegmatis_MC2_155 RAKAIHALTQLDWGRTARAVRINGLDTEWCHDDIIEILTHAGDHLDTIVI
MAV_0343|M.avium_104 RGKAISALNDLDWGRTARAVRINGLDTPWCHDDLIEVVTAAGRNLDTVII
Mflv_2209|M.gilvum_PYR-GCK RQRVAQALAEPGWGDQLRGVRVNDWTTPWTHADIIEVMARAGASLDIVVL
Mvan_4487|M.vanbaalenii_PYR-1 RGQVAAALAEPGWAGQLRGVRVNDWTTPWTHSDIIEVVARAGASLDIVVL
TH_3034|M.thermoresistible__bu RTRVAAALAEDGWGDQMRGVRVNDWSTPWTHSDVIEVVSAAGAHLDIIVL
MAB_1369|M.abscessus_ATCC_1997 RRRIAEALNAPGWSGQLLSVRVNDWTTEWTYADLVEIVSRAGANIDNILL
Mb2526c|M.bovis_AF2122/97 R----NALRDTPLDPERTVVRINAGGTADQARDLEALAG-TAYT--TVML
Rv2498c|M.tuberculosis_H37Rv R----NALRDTPLDPERTVVRINAGGTADQARDLEALAG-TAYT--TVML
MMAR_4158|M.marinum_M RRDALNFLCTTTPAKTMAAIRVNAPDTLDGWRDLTALLD-SAADPDFLML
MUL_4021|M.ulcerans_Agy99 RRDALNFLCTTTPAKTMAAIRVNAPDTLDGWRDLTALLD-SAADPDFLML
* * :*:* * *: : :. :::
MSMEG_6644|M.smegmatis_MC2_155 PKAKTARDVWWVDVLLTQLEAKLGLD-KTIRLEVLIEEVEGLANAEDIVR
MAV_0343|M.avium_104 PKARRARDVWWVDVLLSQLEAKLNLG-NKIRLEVLIEEVEGLANAEEIAV
Mflv_2209|M.gilvum_PYR-GCK PKVTDVSHVHALDLLLSQLEATHDLPPGRIGIEAQIEDARGLTHIDAIAS
Mvan_4487|M.vanbaalenii_PYR-1 PKVTDASHVHALDLLLSQLEATHGLPLGRIGIEAQIEDAKGLTNVDAIAS
TH_3034|M.thermoresistible__bu PKVTDVSHIHALDLLLSQLEVQHGLPVGRIGIEAQIENAQGLTNIDAIAA
MAB_1369|M.abscessus_ATCC_1997 PKVTAASHVTALDLLLTQLERSHGLQVGAIGIQAQIENAEGLTNIDAIAS
Mb2526c|M.bovis_AF2122/97 PKAESAAQV-----IELAPRD-------VIALVETARGAVCAAEIAAADP
Rv2498c|M.tuberculosis_H37Rv PKAESAAQV-----IELAPRD-------VIALVETARGAVCAAEIAAADP
MMAR_4158|M.marinum_M PKVQSAAEIGLVKRLLRQSQK-------TTRLIATAESAVVAANPDCALD
MUL_4021|M.ulcerans_Agy99 PKVQSAAEIGLVKRLLRQSQK-------TTRLIATAETAVVAANPDCALD
**. . .: : . : . . :.
MSMEG_6644|M.smegmatis_MC2_155 ASPRLDAVIFGVGDFSLSQGAR-VDTNFDPLGEYPGDFWVYARNKIMVAA
MAV_0343|M.avium_104 ASPRLDALIFGVGDFSLSQGAR-VDTNFVPLGEYPGDFWQYARNKVIVAA
Mflv_2209|M.gilvum_PYR-GCK A-PRVQALVLGPADLMASLNMRTLVVGEQPEGYDVGDAYHHVLMRILIAA
Mvan_4487|M.vanbaalenii_PYR-1 A-PRVQALVLGPADLMASLNMRTLEVGEQPEGYTEGDAYHHVLMRILVAA
TH_3034|M.thermoresistible__bu A-PRVQALVLGPADLMASLNMRTLVVGEQPEGYDVGDAYHHVLMRILIAA
MAB_1369|M.abscessus_ATCC_1997 ASPRMRSLVFGPADFMASLGMRTLVVGEQPPGYD-GEAYHHVLMTILVAA
Mb2526c|M.bovis_AF2122/97 ----TVGMMWGAEDLIATLGGSSSRRADGA----YRDVARHVRSTILLAA
Rv2498c|M.tuberculosis_H37Rv ----TVGMMWGAEDLIATLGGSSSRRADGA----YRDVARHVRSTILLAA
MMAR_4158|M.marinum_M P-RLVDAVIFGSADMAADLGAEPS-----------AAVVRHARSTILSHA
MUL_4021|M.ulcerans_Agy99 P-RLVDAVIFGSADMAADLGAEPS-----------AAVVRHARSTILSHA
.:: * *: . :. :: *
MSMEG_6644|M.smegmatis_MC2_155 RIAGIDAIDSPYPDYRNLEGYERDARRSSLMGYTGKWAIHPDQVPIANEV
MAV_0343|M.avium_104 RIAGIDAIDAPYPDYRDLAGYERDARRAALMGYTGKWAIHPDQVPVANRV
Mflv_2209|M.gilvum_PYR-GCK RANGIAAIDGPFLKVRDVEAFRRVAGRSAALGYDGKWVLHPDQIEAGNEI
Mvan_4487|M.vanbaalenii_PYR-1 RANGIAAIDGPYLKVRDVASFRRVAGRSAALGYDGKWVLHPDQIEAGNEI
TH_3034|M.thermoresistible__bu RTHGIAAIDGPFLQIRDVEAFRRVAARSAALGYDGKWVLHPDQIAAGNEV
MAB_1369|M.abscessus_ATCC_1997 RAHGIDAIDGPYLKVRDVDAFRTAAARSAALGFDGKWVLHPAQIEAGNEI
Mb2526c|M.bovis_AF2122/97 SAFGRLALDAVHLDILDVEGLQEEARDAAAVGFDVTVCIHPSQIPVVRKA
Rv2498c|M.tuberculosis_H37Rv SAFGRLALDAVHLDILDVEGLQEEARDAAAVGFDVTVCIHPSQIPVVRKA
MMAR_4158|M.marinum_M AAAKIPVIDAPFFDIDDIPGLRQAVREAVAEGFAGKAAIHPDHVALINSG
MUL_4021|M.ulcerans_Agy99 AAAKIPVIDAPFFDIDDIPGLRQAVREAVAEGFAGKAAIHPDHVALINSG
.:*. . . :: . . . : *: . :** :: .
MSMEG_6644|M.smegmatis_MC2_155 YAPTTDEIARAERNVAAYREAEAKG---RGAVGVEGVLVDAAHVKMAEET
MAV_0343|M.avium_104 YAPTADEIARAEANLAAYREAESNG---RGAVGVNGVLVDAAHVKMAQQT
Mflv_2209|M.gilvum_PYR-GCK FSPRQQDYDHAELLLEAYEWHTSRAGGARGAVMLGDEMIDEASRKMALVI
Mvan_4487|M.vanbaalenii_PYR-1 FSPRQQAYDHAELILEAYEWHTSQAGGARGAVMLGDEMIDEASRKMALVI
TH_3034|M.thermoresistible__bu FSPRQEDYNHAELILEAYEWYTSQAGGARGAAMLGDEMIDEASRKMALVI
MAB_1369|M.abscessus_ATCC_1997 FSPRQDDYDRAELILDAYEWHTSVAGGARGAVMLGDEMIDEASRKMALVI
Mb2526c|M.bovis_AF2122/97 YRPSHEKLAWARRVLAASRSE-------RGAFAFEGQMVDSPVLTHAETM
Rv2498c|M.tuberculosis_H37Rv YRPSHEKLAWARRVLAASRSE-------RGAFAFEGQMVDSPVLTHAETM
MMAR_4158|M.marinum_M FLPGQSEINWAREVLKSAQAG-------AGSVG--GRMVDEAMARRARGI
MUL_4021|M.ulcerans_Agy99 FLPGQSEINWAREVLKSAQAG-------PGSVG--GRMVDEAMARRARGI
: * . *. : : . *: . ::* . *
MSMEG_6644|M.smegmatis_MC2_155 LAR--AALIS--GGR------
MAV_0343|M.avium_104 LAR--AALINGTGGSNDR---
Mflv_2209|M.gilvum_PYR-GCK AGKGRAAGMTRTGERFVPPG-
Mvan_4487|M.vanbaalenii_PYR-1 AGKGRAAGMQRTGEGFRPPS-
TH_3034|M.thermoresistible__bu AAKGRAAGMTRTGGRFQPPS-
MAB_1369|M.abscessus_ATCC_1997 AGKGRAAGMARQAAPYEPPTG
Mb2526c|M.bovis_AF2122/97 LRRAGEATSE-----------
Rv2498c|M.tuberculosis_H37Rv LRRAGEATSE-----------
MMAR_4158|M.marinum_M LARAQGVNEEEPCMS------
MUL_4021|M.ulcerans_Agy99 LARAQGVNEEEPCMS------
: .