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VENRYRPRRTCLSVPGSSEKMIQKAKALPADEVFLDLEDAVAAEAKDEARQRVAQALAEPGWGDQLRGVR VNDWTTPWTHADIIEVMARAGASLDIVVLPKVTDVSHVHALDLLLSQLEATHDLPPGRIGIEAQIEDARG LTHIDAIASAPRVQALVLGPADLMASLNMRTLVVGEQPEGYDVGDAYHHVLMRILIAARANGIAAIDGPF LKVRDVEAFRRVAGRSAALGYDGKWVLHPDQIEAGNEIFSPRQQDYDHAELLLEAYEWHTSRAGGARGAV MLGDEMIDEASRKMALVIAGKGRAAGMTRTGERFVPPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2209 | - | - | 100% (318) | Citryl-CoA lyase |
| M. gilvum PYR-GCK | Mflv_2556 | - | 2e-17 | 27.66% (282) | HpcH/HpaI aldolase |
| M. gilvum PYR-GCK | Mflv_4009 | - | 4e-14 | 33.21% (262) | HpcH/HpaI aldolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3102c | - | 5e-16 | 33.06% (248) | hypothetical protein Mb3102c |
| M. tuberculosis H37Rv | Rv3075c | - | 5e-16 | 33.06% (248) | hypothetical protein Rv3075c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1369 | - | 1e-134 | 76.11% (314) | citrate lyase beta chain |
| M. marinum M | MMAR_4158 | citE_1 | 9e-20 | 27.80% (295) | citrate (pro-3s)-lyase (beta subunit) CitE_1 |
| M. avium 104 | MAV_0343 | - | 2e-52 | 39.93% (293) | malyl-CoA lyase |
| M. smegmatis MC2 155 | MSMEG_5064 | - | 1e-151 | 82.02% (317) | malyl-CoA lyase |
| M. thermoresistible (build 8) | TH_3034 | - | 1e-150 | 85.53% (304) | PUTATIVE Citrate (pro-3S)-lyase |
| M. ulcerans Agy99 | MUL_4021 | citE_1 | 3e-19 | 27.46% (295) | citrate (pro-3s)-lyase (beta subunit) CitE_1 |
| M. vanbaalenii PYR-1 | Mvan_4487 | - | 1e-162 | 89.91% (317) | citrate (pro-3S)-lyase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2209|M.gilvum_PYR-GCK ------------------MENRYRPRRTCLSVPGSSEKMIQKAKALPADE
Mvan_4487|M.vanbaalenii_PYR-1 ------------------MENRYRPRRTCLSVPGSSAKMIQKAKTLPADE
MSMEG_5064|M.smegmatis_MC2_155 ------------------MENTYRPRRTCLSVPGSSAKMIEKAKTLPADQ
TH_3034|M.thermoresistible__bu -------------------------------VPGSSAKMIAKAKTLPADQ
MAB_1369|M.abscessus_ATCC_1997 -----------------MTAPAYRPRRTTLAVPGSSQKMIDKAKTLPADE
MAV_0343|M.avium_104 --------------------MTQLLRRSELAVPASNDNMFDKAAGCGADL
MMAR_4158|M.marinum_M ---------------------MKPIPRSLLFTPATKTQHYLTAAAVHAEA
MUL_4021|M.ulcerans_Agy99 ---------------------MKPIPRSLLFTPATKTQHYLTAAAVHAEA
Mb3102c|M.bovis_AF2122/97 MTSMYEQVDTNTADPVAGSRIDPVLARSWLLVNGAHGDRFESAAHSRADI
Rv3075c|M.tuberculosis_H37Rv MTSMYEQVDTNTADPVAGSRIDPVLARSWLLVNGAHGDRFESAAHSRADI
. .: . .* *:
Mflv_2209|M.gilvum_PYR-GCK VFLDLEDAVAAEAKDEARQRVAQALAEPGWGDQLRGVRVNDWTTPWTHAD
Mvan_4487|M.vanbaalenii_PYR-1 VFLDLEDAVAPGAKEQARGQVAAALAEPGWAGQLRGVRVNDWTTPWTHSD
MSMEG_5064|M.smegmatis_MC2_155 VFLDLEDAVAADAKAQARTQVAVALAEDGWAGQLRGVRVNDWTTPWTYSD
TH_3034|M.thermoresistible__bu VFLDLEDAVAPDAKAEARTRVAAALAEDGWGDQMRGVRVNDWSTPWTHSD
MAB_1369|M.abscessus_ATCC_1997 VFLDLEDAVAAPAKVEARRRIAEALNAPGWSGQLLSVRVNDWTTEWTYAD
MAV_0343|M.avium_104 VFLDLEDAVPPAFKEESRGKAISALNDLDWGRTARAVRINGLDTPWCHDD
MMAR_4158|M.marinum_M LILDLEDSVAPRDKAQARRDALNFLCTTTPAKTMAAIRVNAPDTLDGWRD
MUL_4021|M.ulcerans_Agy99 LILDLEDSVAPRDKAQARRDALNFLCTTTPAKTMAAIRVNAPDTLDGWRD
Mb3102c|M.bovis_AF2122/97 VVLDIEDAVAPKDKHAARDNAVRWFGD----GNADWVRINGFGTPWWADD
Rv3075c|M.tuberculosis_H37Rv VVLDIEDAVAPKDKHAARDNAVRWFGD----GNADWVRINGFGTPWWADD
:.**:**:*.. * :* : :*:* * *
Mflv_2209|M.gilvum_PYR-GCK IIEVMARAGASLDIVVLPKVTDVSHVHALDLLLSQLEATHDLPPGRIGIE
Mvan_4487|M.vanbaalenii_PYR-1 IIEVVARAGASLDIVVLPKVTDASHVHALDLLLSQLEATHGLPLGRIGIE
MSMEG_5064|M.smegmatis_MC2_155 VIEVVSTAGAHLDLIVLPKVTDVSHVHALDLLLTQLEQTHGLPVGRIGIE
TH_3034|M.thermoresistible__bu VIEVVSAAGAHLDIIVLPKVTDVSHIHALDLLLSQLEVQHGLPVGRIGIE
MAB_1369|M.abscessus_ATCC_1997 LVEIVSRAGANIDNILLPKVTAASHVTALDLLLTQLERSHGLQVGAIGIQ
MAV_0343|M.avium_104 LIEVVTAAGRNLDTVIIPKARRARDVWWVDVLLSQLEAKLNLG-NKIRLE
MMAR_4158|M.marinum_M LTALLDSA-ADPDFLMLPKVQSAAEIGLVKRLLRQSQK-------TTRLI
MUL_4021|M.ulcerans_Agy99 LTALLDSA-ADPDFLMLPKVQSAAEIGLVKRLLRQSQK-------TTRLI
Mb3102c|M.bovis_AF2122/97 LAMLADSP---VGGVMLAMVESVDHVTETAKRLP-----------NVPIV
Rv3075c|M.tuberculosis_H37Rv LAMLADSP---VGGVMLAMVESVDHVTETAKRLP-----------NVPIV
: : . . :::. . . .: * :
Mflv_2209|M.gilvum_PYR-GCK AQIEDARGLTHIDAIASA-PRVQALVLGPADLMASLNMRTLVVGEQPEGY
Mvan_4487|M.vanbaalenii_PYR-1 AQIEDAKGLTNVDAIASA-PRVQALVLGPADLMASLNMRTLEVGEQPEGY
MSMEG_5064|M.smegmatis_MC2_155 PQIEDALGLTNVEAIAAG-PRVQALVLGPGDMAASLRMRTLEVGGQPDGY
TH_3034|M.thermoresistible__bu AQIENAQGLTNIDAIAAA-PRVQALVLGPADLMASLNMRTLVVGEQPEGY
MAB_1369|M.abscessus_ATCC_1997 AQIENAEGLTNIDAIASASPRMRSLVFGPADFMASLGMRTLVVGEQPPGY
MAV_0343|M.avium_104 VLIEEVEGLANAEEIAVASPRLDALIFGVGDFSLSQGAR-VDTNFVPLGE
MMAR_4158|M.marinum_M ATAESAVVAANPDCALDP-RLVDAVIFGSADMAADLGAEPSAAVVR----
MUL_4021|M.ulcerans_Agy99 ATAETAVVAANPDCALDP-RLVDAVIFGSADMAADLGAEPSAAVVR----
Mb3102c|M.bovis_AF2122/97 ALVETARGLERINEIAAA-KGTFRLAFGIGDFRRDTGFGEDPATLA----
Rv3075c|M.tuberculosis_H37Rv ALVETARGLERINEIAAA-KGTFRLAFGIGDFRRDTGFGEDPATLA----
* . . : : :* .*: . .
Mflv_2209|M.gilvum_PYR-GCK DVGDAYHHVLMRILIAARANGIA-AIDGPFLKVRDVEAFRRVAGRSAALG
Mvan_4487|M.vanbaalenii_PYR-1 TEGDAYHHVLMRILVAARANGIA-AIDGPYLKVRDVASFRRVAGRSAALG
MSMEG_5064|M.smegmatis_MC2_155 DIGDAHHHVLMRILIAARAHGIN-AIDGPYVKVRDVEGFRRVAGRSAALG
TH_3034|M.thermoresistible__bu DVGDAYHHVLMRILIAARTHGIA-AIDGPFLQIRDVEAFRRVAARSAALG
MAB_1369|M.abscessus_ATCC_1997 D-GEAYHHVLMTILVAARAHGID-AIDGPYLKVRDVDAFRTAAARSAALG
MAV_0343|M.avium_104 YPGDFWQYARNKVIVAARIAGID-AIDAPYPDYRDLAGYERDARRAALMG
MMAR_4158|M.marinum_M -------HARSTILSHAAAAKIP-VIDAPFFDIDDIPGLRQAVREAVAEG
MUL_4021|M.ulcerans_Agy99 -------HARSTILSHAAAAKIP-VIDAPFFDIDDIPGLRQAVREAVAEG
Mb3102c|M.bovis_AF2122/97 -------YARSRFTIAARAAGLPSAIDGPTIGSNALK-LIEATAVSAEFG
Rv3075c|M.tuberculosis_H37Rv -------YARSRFTIAARAAGLPSAIDGPTIGSNALK-LIEATAVSAEFG
:. . * : .**.* : . :. *
Mflv_2209|M.gilvum_PYR-GCK YDGKWVLHPDQIEAGNEIFSPRQQDYDHAELLLEAYEWHTSRAGGARGAV
Mvan_4487|M.vanbaalenii_PYR-1 YDGKWVLHPDQIEAGNEIFSPRQQAYDHAELILEAYEWHTSQAGGARGAV
MSMEG_5064|M.smegmatis_MC2_155 YDGKWVLHPDQIAAGNEIFAPRQKDYDHAELILEAYEWHTSQAGGARGAV
TH_3034|M.thermoresistible__bu YDGKWVLHPDQIAAGNEVFSPRQEDYNHAELILEAYEWYTSQAGGARGAA
MAB_1369|M.abscessus_ATCC_1997 FDGKWVLHPAQIEAGNEIFSPRQDDYDRAELILDAYEWHTSVAGGARGAV
MAV_0343|M.avium_104 YTGKWAIHPDQVPVANRVYAPTADEIARAEANLAAYREAESNG---RGAV
MMAR_4158|M.marinum_M FAGKAAIHPDHVALINSGFLPGQSEINWAREVLKS---------AQAGAG
MUL_4021|M.ulcerans_Agy99 FAGKAAIHPDHVALINSGFLPGQSEINWAREVLKS---------AQAGPG
Mb3102c|M.bovis_AF2122/97 MTGKICLSPDQCPVVNEGLSPSQDEIVWAKEFFAEFARDGGEIRNGSDLP
Rv3075c|M.tuberculosis_H37Rv MTGKICLSPDQCPVVNEGLSPSQDEIVWAKEFFAEFARDGGEIRNGSDLP
** : * : * * . *. : .
Mflv_2209|M.gilvum_PYR-GCK MLG--DEMIDEASRKMALVIAGKGRAAGMTRTGERFVPPG-
Mvan_4487|M.vanbaalenii_PYR-1 MLG--DEMIDEASRKMALVIAGKGRAAGMQRTGEGFRPPS-
MSMEG_5064|M.smegmatis_MC2_155 MLG--DEMIDEASRKMALVIAAKGRAAGLSRTGERFRPPA-
TH_3034|M.thermoresistible__bu MLG--DEMIDEASRKMALVIAAKGRAAGMTRTGGRFQPPS-
MAB_1369|M.abscessus_ATCC_1997 MLG--DEMIDEASRKMALVIAGKGRAAGMARQAAPYEPPTG
MAV_0343|M.avium_104 GVN--GVLVDAAHVKMAQQTLAR--AALINGTGGSNDR---
MMAR_4158|M.marinum_M SVG--GRMVDEAMARRARGILARAQGVNEEEPCMS------
MUL_4021|M.ulcerans_Agy99 SVG--GRMVDEAMARRARGILARAQGVNEEEPCMS------
Mb3102c|M.bovis_AF2122/97 RIARATKILDLARAYGIEVSDFEDEPVHMPAPTDTYHY---
Rv3075c|M.tuberculosis_H37Rv RIARATKILDLARAYGIEVSDFEDEPVHMPAPTDTYHY---
: ::* * . .