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HDDLASARSLLFVPGDRPDRFTKAASSDADGIIIDLEDAVAPEAKARAREAVDRWLATGGVGTVRINGTE TPWHQEDLEMAARHGCPVMVPKARSASHLAQISRRLPTGTALIALIETAAGVLAAADICAVEGVVRAAFG SVDLGAELGIDPEDHESLRYARSAVVLGSAAAGLAAPLDGVTTAVHDEGAAGADAARAARLGFGGKLCIH PCQVAPVNSQFSPSIEEQAWARKVMAAGSGNGARTVDGCMVDKPVVDRAARILARAQGLTSP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5074 | - | - | 100% (273) | citrate lyase |
| M. avium 104 | MAV_3981 | - | 4e-41 | 39.71% (272) | HpcH/HpaI aldolase/citrate lyase family protein, putative |
| M. avium 104 | MAV_1674 | - | 6e-35 | 37.41% (270) | CitE protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3102c | - | 1e-40 | 39.26% (270) | hypothetical protein Mb3102c |
| M. gilvum PYR-GCK | Mflv_4009 | - | 8e-39 | 39.26% (270) | HpcH/HpaI aldolase |
| M. tuberculosis H37Rv | Rv3075c | - | 1e-40 | 39.26% (270) | hypothetical protein Rv3075c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4737 | - | 5e-32 | 35.21% (267) | putative citrate lyase/aldolase |
| M. marinum M | MMAR_1583 | citE_2 | 1e-40 | 38.52% (270) | citrate lyase beta subunit, CitE_2 |
| M. smegmatis MC2 155 | MSMEG_6298 | - | 3e-41 | 40.56% (286) | malyl-CoA lyase |
| M. thermoresistible (build 8) | TH_0719 | - | 4e-28 | 34.09% (264) | HpcH/HpaI aldolase/citrate lyase family protein |
| M. ulcerans Agy99 | MUL_3451 | citE_2 | 2e-40 | 38.15% (270) | citrate lyase beta subunit, CitE_2 |
| M. vanbaalenii PYR-1 | Mvan_2378 | - | 3e-38 | 38.89% (270) | HpcH/HpaI aldolase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1583|M.marinum_M MAAEQAMYEQVNSYVVDPADVGSRIDPVLARSWLLVNGTHADRFQAASHS
MUL_3451|M.ulcerans_Agy99 MAAEQAMYEQVNSYVVDPADVGSRIDPVLARSWLLVNGTHADRFQAASHS
Mb3102c|M.bovis_AF2122/97 ---MTSMYEQVDTNTADPV-AGSRIDPVLARSWLLVNGAHGDRFESAAHS
Rv3075c|M.tuberculosis_H37Rv ---MTSMYEQVDTNTADPV-AGSRIDPVLARSWLLVNGAHGDRFESAAHS
Mflv_4009|M.gilvum_PYR-GCK ------MYDQSFGEAAFGE-QGQRIDPVLARSWLLVNGAHYERFQAAAHS
Mvan_2378|M.vanbaalenii_PYR-1 ------MYEQNFSESAFGE-QGQRIDPVLARSWLLVNGSHYDRFQAAAHS
MAB_4737|M.abscessus_ATCC_1997 ------------------------MNSKVSRSWLLMNPSREASLEAAIAS
MAV_5074|M.avium_104 ----------------------MHDDLASARSLLFVPGDRPDRFTK-AAS
MSMEG_6298|M.smegmatis_MC2_155 ------------------MGGRPTRALPLLRTLLFVPGDRPDRIAK-AAA
TH_0719|M.thermoresistible__bu -----------------------MDLSAVGPAWLFCPADRPERFEK-AAA
: *: : : :
MMAR_1583|M.marinum_M R-ADIVVLDIEDAVAPKDKGSARDNVVH-----WLGDGNADWVRINGFGT
MUL_3451|M.ulcerans_Agy99 R-ADIVVVDIEDAVAPKDKGSARDNVVH-----WLGDGNADWVRINGFGT
Mb3102c|M.bovis_AF2122/97 R-ADIVVLDIEDAVAPKDKHAARDNAVR-----WFGDGNADWVRINGFGT
Rv3075c|M.tuberculosis_H37Rv R-ADIVVLDIEDAVAPKDKHAARDNAVR-----WFGDGNADWVRINGFGT
Mflv_4009|M.gilvum_PYR-GCK R-ADIVVLDIEDAVAPKDKAAARANVVR-----WLGEGHADWVRVNGFGT
Mvan_2378|M.vanbaalenii_PYR-1 R-ADIVVLDIEDAVAPKDKAAARANVTR-----WFGEGHDDWVRINGFGT
MAB_4737|M.abscessus_ATCC_1997 TNADEVILDLEDAVAPNEKEPARGRVLE-----YLNSGGNAWVRVNDASS
MAV_5074|M.avium_104 SDADGIIIDLEDAVAPEAKARAREAVDR---WLATGGVG--TVRINGTET
MSMEG_6298|M.smegmatis_MC2_155 SAAAGVAVDLEDAVAVSRKDAARDAAVTALSALPTAGVPVLCVRINAVDS
TH_0719|M.thermoresistible__bu -AADVVILDLEDGVAAKDRPAAREALLS-----TPLDPARTVVRVNPAGT
* : :*:**.** . : ** **:* :
MMAR_1583|M.marinum_M PWWADDIAILAGSS-VGGVMLAMVESVDHVTETARRLP------------
MUL_3451|M.ulcerans_Agy99 PWWADDIAILAGSS-VGGVMLAMVESVDHVTETARRLP------------
Mb3102c|M.bovis_AF2122/97 PWWADDLAMLADSP-VGGVMLAMVESVDHVTETAKRLP------------
Rv3075c|M.tuberculosis_H37Rv PWWADDLAMLADSP-VGGVMLAMVESVDHVTETAKRLP------------
Mflv_4009|M.gilvum_PYR-GCK EWWAGDLEMLAGTS-VGGVMLAMVESVDHVTETAKRLP------------
Mvan_2378|M.vanbaalenii_PYR-1 EWWAGDLEMLAGTS-VGGVMLAMVESVDHVTETVKRLP------------
MAB_4737|M.abscessus_ATCC_1997 DFWSADCRALADARGLKGVVLAKTEGGNHMWDTSNRLGG-----------
MAV_5074|M.avium_104 PWHQEDL---EMAARHGCPVMVPKARSASHLAQISRRLPTGT--------
MSMEG_6298|M.smegmatis_MC2_155 GFAEDDLTALEPVLHRLDLVMVPMSAEPDRIRRVSELLTRAERSAGADDG
TH_0719|M.thermoresistible__bu ADHRLDLDALTRTPYR--TVMLAKTDAAEQVRALAPLQ------------
* ::
MMAR_1583|M.marinum_M NVPIVALVETARGLERITEIASAKG-TFRLAFGIGDFRRDTG------FG
MUL_3451|M.ulcerans_Agy99 NVPIVALVETARGLERITEIASAKG-TFRLAFGIGDFRRDTG------FG
Mb3102c|M.bovis_AF2122/97 NVPIVALVETARGLERINEIAAAKG-TFRLAFGIGDFRRDTG------FG
Rv3075c|M.tuberculosis_H37Rv NVPIVALVETARGLERINEIAAAKG-TFRLAFGIGDFRRDTG------FG
Mflv_4009|M.gilvum_PYR-GCK GVPIVALVETARGLERITEIAAAKG-TFRLAFGIGDFRRDTG------FG
Mvan_2378|M.vanbaalenii_PYR-1 GVPIVALVETARGLERINEIASAKG-TFRLAFGIGDFRRDTG------FG
MAB_4737|M.abscessus_ATCC_1997 ETPVIALIETARGLSRVHDIAAARP-CFRIAFGVNDYTLDIG------VD
MAV_5074|M.avium_104 --ALIALIETAAGVLAAADICAVEG-VVRAAFGSVDLGAELG----IDPE
MSMEG_6298|M.smegmatis_MC2_155 RIGIIPLVETAAGILNAPSLASADARVHTLSFGPADLSRELG----ITPT
TH_0719|M.thermoresistible__bu ---VVVLIETPLGALNVVESARADN-AVAVMWGAEDLFAVTGGTDNRNPD
:: *:**. * . . . :* * *
MMAR_1583|M.marinum_M EDATTLAYARSRFTIAAKAAGLPSAIDGPTIGS-NPLKLIEASAVSVEFG
MUL_3451|M.ulcerans_Agy99 KDATTLAYARSRFTIAAKAAGLPSAIDGPTIGS-NPLKLIEASAVSVEFG
Mb3102c|M.bovis_AF2122/97 EDPATLAYARSRFTIAARAAGLPSAIDGPTIGS-NALKLIEATAVSAEFG
Rv3075c|M.tuberculosis_H37Rv EDPATLAYARSRFTIAARAAGLPSAIDGPTIGS-NALKLIEATAVSAEFG
Mflv_4009|M.gilvum_PYR-GCK GDALTLAYTRSRFTIAAKAAHLPSAIDGPTVGS-SALKLSEATAVSAEFG
Mvan_2378|M.vanbaalenii_PYR-1 DNPMTLAYARSRFTIAAKAAHLPSAIDGPTVGS-SALRLSEATAVSAEFG
MAB_4737|M.abscessus_ATCC_1997 QDPLALAYSRSQLVVASRAAHIPGPIDGPTR---DPAELPEAVSLTRRMG
MAV_5074|M.avium_104 -DHESLRYARSAVVLGSAAAGLAAPLDGVTTAVHDEGAAGADAARAARLG
MSMEG_6298|M.smegmatis_MC2_155 SDGDEFLFARSQLVLAAAAANCPAPVDGPYLDLDDDDGLIRSARHARKLG
TH_0719|M.thermoresistible__bu GSYRDVARHVRSQSLLAAKAHGRLALDSVYLDIKDLDGLRAEVDDAVAVG
. . : : * .:*. . : .*
MMAR_1583|M.marinum_M MTGKICLSPEQCAVVNEGLSPSQDEIGWAKEFFAEFERDGGEI-------
MUL_3451|M.ulcerans_Agy99 MTGKICLSPEQCAVVNEGLSPSQDEIGWAKEFFAEFERDGGEI-------
Mb3102c|M.bovis_AF2122/97 MTGKICLSPDQCPVVNEGLSPSQDEIVWAKEFFAEFARDGGEI-------
Rv3075c|M.tuberculosis_H37Rv MTGKICLSPDQCPVVNEGLSPSQDEIVWAKEFFAEFARDGGEI-------
Mflv_4009|M.gilvum_PYR-GCK MTGKICLTPEQCLTVNEGLSPSAEEIAWAKEFFVEFERDGGEI-------
Mvan_2378|M.vanbaalenii_PYR-1 MTGKICLTPEQCPTVNEGLSPSAEEITWAKEFFVEFERDGGEI-------
MAB_4737|M.abscessus_ATCC_1997 MTGKLALRSSDADTINTGLSPSDEDVSWAQDFVDRFNSQGGKP-------
MAV_5074|M.avium_104 FGGKLCIHPCQVAPVNSQFSPSIEEQAWARKVMAAGSGNGAR------TV
MSMEG_6298|M.smegmatis_MC2_155 FGGKQVIHPSQIASVAGAFVTSDAEIDWARAVDAAFSAAEAEGVSSIRLA
TH_0719|M.thermoresistible__bu FDAKVAIHPTQVAVIREGYTPTPDQVRWARHVLAAARDERGVF-----QF
: .* : . : : .: : **: . .
MMAR_1583|M.marinum_M -RNGSDLPRIARATKILDLARAYGIEASDFE--DEPVHSPAPTDTYHY
MUL_3451|M.ulcerans_Agy99 -RNGSDLPRIARATKILDLARAYGIEASDFE--DEPVHSPAPTDTYHY
Mb3102c|M.bovis_AF2122/97 -RNGSDLPRIARATKILDLARAYGIEVSDFE--DEPVHMPAPTDTYHY
Rv3075c|M.tuberculosis_H37Rv -RNGSDLPRIARATKILDLARAYGIEVSDFE--DEPVHMPAPTDTYHY
Mflv_4009|M.gilvum_PYR-GCK -RNGSDLPRIARANKILELARAYGIEPSEFDDVDEPTHIPAPSDTYHY
Mvan_2378|M.vanbaalenii_PYR-1 -RNGSDLPRIARATKILDLARAYGIEPSDFDDVDEPAHIPAPSDTYHY
MAB_4737|M.abscessus_ATCC_1997 -KDGSDLPRLNRARIILERARMLGLITP--------------------
MAV_5074|M.avium_104 DGCMVDKPVVDRAARILARAQGLTSP----------------------
MSMEG_6298|M.smegmatis_MC2_155 DGTFVDYPVAQRARAILAGAR---------------------------
TH_0719|M.thermoresistible__bu EGIMVDAPVLRRAERIVQLAPDPGR-----------------------
* * ** *: *