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VTAPAYRPRRTTLAVPGSSQKMIDKAKTLPADEVFLDLEDAVAAPAKVEARRRIAEALNAPGWSGQLLSV RVNDWTTEWTYADLVEIVSRAGANIDNILLPKVTAASHVTALDLLLTQLERSHGLQVGAIGIQAQIENAE GLTNIDAIASASPRMRSLVFGPADFMASLGMRTLVVGEQPPGYDGEAYHHVLMTILVAARAHGIDAIDGP YLKVRDVDAFRTAAARSAALGFDGKWVLHPAQIEAGNEIFSPRQDDYDRAELILDAYEWHTSVAGGARGA VMLGDEMIDEASRKMALVIAGKGRAAGMARQAAPYEPPTG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1369 | - | - | 100% (320) | citrate lyase beta chain |
| M. abscessus ATCC 19977 | MAB_4737 | - | 4e-15 | 31.09% (238) | putative citrate lyase/aldolase |
| M. abscessus ATCC 19977 | MAB_4378c | - | 2e-12 | 25.90% (278) | putative citrate lyase beta subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2526c | citE | 3e-17 | 28.57% (259) | citrate (Pro-3S)-lyase beta subunit |
| M. gilvum PYR-GCK | Mflv_2209 | - | 1e-134 | 76.11% (314) | Citryl-CoA lyase |
| M. tuberculosis H37Rv | Rv2498c | citE | 3e-17 | 28.57% (259) | citrate (Pro-3S)-lyase beta subunit |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4158 | citE_1 | 1e-20 | 28.38% (296) | citrate (pro-3s)-lyase (beta subunit) CitE_1 |
| M. avium 104 | MAV_0343 | - | 2e-54 | 41.10% (292) | malyl-CoA lyase |
| M. smegmatis MC2 155 | MSMEG_5064 | - | 1e-130 | 73.57% (314) | malyl-CoA lyase |
| M. thermoresistible (build 8) | TH_3034 | - | 1e-127 | 73.53% (306) | PUTATIVE Citrate (pro-3S)-lyase |
| M. ulcerans Agy99 | MUL_4021 | citE_1 | 4e-20 | 28.04% (296) | citrate (pro-3s)-lyase (beta subunit) CitE_1 |
| M. vanbaalenii PYR-1 | Mvan_4487 | - | 1e-133 | 75.87% (315) | citrate (pro-3S)-lyase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5064|M.smegmatis_MC2_155 -MENTYRPRRTCLSVPGSSAKMIEKAKTLPADQVFLDLEDAVAADAKAQA
TH_3034|M.thermoresistible__bu --------------VPGSSAKMIAKAKTLPADQVFLDLEDAVAPDAKAEA
Mflv_2209|M.gilvum_PYR-GCK -MENRYRPRRTCLSVPGSSEKMIQKAKALPADEVFLDLEDAVAAEAKDEA
Mvan_4487|M.vanbaalenii_PYR-1 -MENRYRPRRTCLSVPGSSAKMIQKAKTLPADEVFLDLEDAVAPGAKEQA
MAB_1369|M.abscessus_ATCC_1997 MTAPAYRPRRTTLAVPGSSQKMIDKAKTLPADEVFLDLEDAVAAPAKVEA
MAV_0343|M.avium_104 ---MTQLLRRSELAVPASNDNMFDKAAGCGADLVFLDLEDAVPPAFKEES
Mb2526c|M.bovis_AF2122/97 --MNLRAAGPGWLFCPADRPERFAKAAAA-ADVVILDLEDGVAEAQKPAA
Rv2498c|M.tuberculosis_H37Rv --MNLRAAGPGWLFCPADRPERFAKAAAA-ADVVILDLEDGVAEAQKPAA
MMAR_4158|M.marinum_M ----MKPIPRSLLFTPATKTQHYLTAAAVHAEALILDLEDSVAPRDKAQA
MUL_4021|M.ulcerans_Agy99 ----MKPIPRSLLFTPATKTQHYLTAAAVHAEALILDLEDSVAPRDKAQA
*. : .* *: ::*****.*. * :
MSMEG_5064|M.smegmatis_MC2_155 RTQVAVALAEDGWAGQLRGVRVNDWTTPWTYSDVIEVVSTAGAHLDLIVL
TH_3034|M.thermoresistible__bu RTRVAAALAEDGWGDQMRGVRVNDWSTPWTHSDVIEVVSAAGAHLDIIVL
Mflv_2209|M.gilvum_PYR-GCK RQRVAQALAEPGWGDQLRGVRVNDWTTPWTHADIIEVMARAGASLDIVVL
Mvan_4487|M.vanbaalenii_PYR-1 RGQVAAALAEPGWAGQLRGVRVNDWTTPWTHSDIIEVVARAGASLDIVVL
MAB_1369|M.abscessus_ATCC_1997 RRRIAEALNAPGWSGQLLSVRVNDWTTEWTYADLVEIVSRAGANIDNILL
MAV_0343|M.avium_104 RGKAISALNDLDWGRTARAVRINGLDTPWCHDDLIEVVTAAGRNLDTVII
Mb2526c|M.bovis_AF2122/97 R----NALRDTPLDPERTVVRINAGGTADQARDLEALAG-TAYT--TVML
Rv2498c|M.tuberculosis_H37Rv R----NALRDTPLDPERTVVRINAGGTADQARDLEALAG-TAYT--TVML
MMAR_4158|M.marinum_M RRDALNFLCTTTPAKTMAAIRVNAPDTLDGWRDLTALLD-SAADPDFLML
MUL_4021|M.ulcerans_Agy99 RRDALNFLCTTTPAKTMAAIRVNAPDTLDGWRDLTALLD-SAADPDFLML
* * :*:* * *: : :. :::
MSMEG_5064|M.smegmatis_MC2_155 PKVTDVSHVHALDLLLTQLEQTHGLPVGRIGIEPQIEDALGLTNVEAIAA
TH_3034|M.thermoresistible__bu PKVTDVSHIHALDLLLSQLEVQHGLPVGRIGIEAQIENAQGLTNIDAIAA
Mflv_2209|M.gilvum_PYR-GCK PKVTDVSHVHALDLLLSQLEATHDLPPGRIGIEAQIEDARGLTHIDAIAS
Mvan_4487|M.vanbaalenii_PYR-1 PKVTDASHVHALDLLLSQLEATHGLPLGRIGIEAQIEDAKGLTNVDAIAS
MAB_1369|M.abscessus_ATCC_1997 PKVTAASHVTALDLLLTQLERSHGLQVGAIGIQAQIENAEGLTNIDAIAS
MAV_0343|M.avium_104 PKARRARDVWWVDVLLSQLEAKLNLG-NKIRLEVLIEEVEGLANAEEIAV
Mb2526c|M.bovis_AF2122/97 PKAESAAQV-----IELAPRD-------VIALVETARGAVCAAEIAAADP
Rv2498c|M.tuberculosis_H37Rv PKAESAAQV-----IELAPRD-------VIALVETARGAVCAAEIAAADP
MMAR_4158|M.marinum_M PKVQSAAEIGLVKRLLRQSQK-------TTRLIATAESAVVAANPDCALD
MUL_4021|M.ulcerans_Agy99 PKVQSAAEIGLVKRLLRQSQK-------TTRLIATAETAVVAANPDCALD
**. . .: : . : . . :.
MSMEG_5064|M.smegmatis_MC2_155 G-PRVQALVLGPGDMAASLRMRTLEVGGQPDGYDIGDAHHHVLMRILIAA
TH_3034|M.thermoresistible__bu A-PRVQALVLGPADLMASLNMRTLVVGEQPEGYDVGDAYHHVLMRILIAA
Mflv_2209|M.gilvum_PYR-GCK A-PRVQALVLGPADLMASLNMRTLVVGEQPEGYDVGDAYHHVLMRILIAA
Mvan_4487|M.vanbaalenii_PYR-1 A-PRVQALVLGPADLMASLNMRTLEVGEQPEGYTEGDAYHHVLMRILVAA
MAB_1369|M.abscessus_ATCC_1997 ASPRMRSLVFGPADFMASLGMRTLVVGEQPPGYD-GEAYHHVLMTILVAA
MAV_0343|M.avium_104 ASPRLDALIFGVGDFSLSQGAR-VDTNFVPLGEYPGDFWQYARNKVIVAA
Mb2526c|M.bovis_AF2122/97 ----TVGMMWGAEDLIATLGGSSSRRADGA----YRDVARHVRSTILLAA
Rv2498c|M.tuberculosis_H37Rv ----TVGMMWGAEDLIATLGGSSSRRADGA----YRDVARHVRSTILLAA
MMAR_4158|M.marinum_M P-RLVDAVIFGSADMAADLGAEPS-----------AAVVRHARSTILSHA
MUL_4021|M.ulcerans_Agy99 P-RLVDAVIFGSADMAADLGAEPS-----------AAVVRHARSTILSHA
.:: * *: ::. :: *
MSMEG_5064|M.smegmatis_MC2_155 RAHGINAIDGPYVKVRDVEGFRRVAGRSAALGYDGKWVLHPDQIAAGNEI
TH_3034|M.thermoresistible__bu RTHGIAAIDGPFLQIRDVEAFRRVAARSAALGYDGKWVLHPDQIAAGNEV
Mflv_2209|M.gilvum_PYR-GCK RANGIAAIDGPFLKVRDVEAFRRVAGRSAALGYDGKWVLHPDQIEAGNEI
Mvan_4487|M.vanbaalenii_PYR-1 RANGIAAIDGPYLKVRDVASFRRVAGRSAALGYDGKWVLHPDQIEAGNEI
MAB_1369|M.abscessus_ATCC_1997 RAHGIDAIDGPYLKVRDVDAFRTAAARSAALGFDGKWVLHPAQIEAGNEI
MAV_0343|M.avium_104 RIAGIDAIDAPYPDYRDLAGYERDARRAALMGYTGKWAIHPDQVPVANRV
Mb2526c|M.bovis_AF2122/97 SAFGRLALDAVHLDILDVEGLQEEARDAAAVGFDVTVCIHPSQIPVVRKA
Rv2498c|M.tuberculosis_H37Rv SAFGRLALDAVHLDILDVEGLQEEARDAAAVGFDVTVCIHPSQIPVVRKA
MMAR_4158|M.marinum_M AAAKIPVIDAPFFDIDDIPGLRQAVREAVAEGFAGKAAIHPDHVALINSG
MUL_4021|M.ulcerans_Agy99 AAAKIPVIDAPFFDIDDIPGLRQAVREAVAEGFAGKAAIHPDHVALINSG
.:*. . . *: . . . :. *: . :** :: .
MSMEG_5064|M.smegmatis_MC2_155 FAPRQKDYDHAELILEAYEWHTSQAGGARGAVMLGDEMIDEASRKMALVI
TH_3034|M.thermoresistible__bu FSPRQEDYNHAELILEAYEWYTSQAGGARGAAMLGDEMIDEASRKMALVI
Mflv_2209|M.gilvum_PYR-GCK FSPRQQDYDHAELLLEAYEWHTSRAGGARGAVMLGDEMIDEASRKMALVI
Mvan_4487|M.vanbaalenii_PYR-1 FSPRQQAYDHAELILEAYEWHTSQAGGARGAVMLGDEMIDEASRKMALVI
MAB_1369|M.abscessus_ATCC_1997 FSPRQDDYDRAELILDAYEWHTSVAGGARGAVMLGDEMIDEASRKMALVI
MAV_0343|M.avium_104 YAPTADEIARAEANLAAYREAESNG---RGAVGVNGVLVDAAHVKMAQQT
Mb2526c|M.bovis_AF2122/97 YRPSHEKLAWARRVLAASRSE-------RGAFAFEGQMVDSPVLTHAETM
Rv2498c|M.tuberculosis_H37Rv YRPSHEKLAWARRVLAASRSE-------RGAFAFEGQMVDSPVLTHAETM
MMAR_4158|M.marinum_M FLPGQSEINWAREVLKSAQAG-------AGSVG--GRMVDEAMARRARGI
MUL_4021|M.ulcerans_Agy99 FLPGQSEINWAREVLKSAQAG-------PGSVG--GRMVDEAMARRARGI
: * . *. * : . *: . ::* . *
MSMEG_5064|M.smegmatis_MC2_155 AAKGRAAGLSRTGERFRPPA-
TH_3034|M.thermoresistible__bu AAKGRAAGMTRTGGRFQPPS-
Mflv_2209|M.gilvum_PYR-GCK AGKGRAAGMTRTGERFVPPG-
Mvan_4487|M.vanbaalenii_PYR-1 AGKGRAAGMQRTGEGFRPPS-
MAB_1369|M.abscessus_ATCC_1997 AGKGRAAGMARQAAPYEPPTG
MAV_0343|M.avium_104 LAR--AALINGTGGSNDR---
Mb2526c|M.bovis_AF2122/97 LRRAGEATSE-----------
Rv2498c|M.tuberculosis_H37Rv LRRAGEATSE-----------
MMAR_4158|M.marinum_M LARAQGVNEEEPCMS------
MUL_4021|M.ulcerans_Agy99 LARAQGVNEEEPCMS------
: .