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TSMYEQVDTNTADPVAGSRIDPVLARSWLLVNGAHGDRFESAAHSRADIVVLDIEDAVAPKDKHAARDNA VRWFGDGNADWVRINGFGTPWWADDLAMLADSPVGGVMLAMVESVDHVTETAKRLPNVPIVALVETARGL ERINEIAAAKGTFRLAFGIGDFRRDTGFGEDPATLAYARSRFTIAARAAGLPSAIDGPTIGSNALKLIEA TAVSAEFGMTGKICLSPDQCPVVNEGLSPSQDEIVWAKEFFAEFARDGGEIRNGSDLPRIARATKILDLA RAYGIEVSDFEDEPVHMPAPTDTYHY*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3075c | - | - | 100% (307) | hypothetical protein Rv3075c |
| M. tuberculosis H37Rv | Rv2498c | citE | 8e-22 | 36.21% (243) | citrate (Pro-3S)-lyase beta subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3102c | - | 1e-178 | 100.00% (307) | hypothetical protein Mb3102c |
| M. gilvum PYR-GCK | Mflv_4009 | - | 1e-140 | 80.72% (306) | HpcH/HpaI aldolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4737 | - | 4e-59 | 42.75% (269) | putative citrate lyase/aldolase |
| M. marinum M | MMAR_1583 | citE_2 | 1e-155 | 87.58% (306) | citrate lyase beta subunit, CitE_2 |
| M. avium 104 | MAV_3981 | - | 1e-146 | 83.99% (306) | HpcH/HpaI aldolase/citrate lyase family protein, putative |
| M. smegmatis MC2 155 | MSMEG_2667 | - | 1e-139 | 82.15% (297) | HpcH/HpaI aldolase/citrate lyase family protein, putative |
| M. thermoresistible (build 8) | TH_0719 | - | 2e-21 | 30.57% (265) | HpcH/HpaI aldolase/citrate lyase family protein |
| M. ulcerans Agy99 | MUL_3451 | citE_2 | 1e-154 | 86.93% (306) | citrate lyase beta subunit, CitE_2 |
| M. vanbaalenii PYR-1 | Mvan_2378 | - | 1e-144 | 82.03% (306) | HpcH/HpaI aldolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4009|M.gilvum_PYR-GCK ------MYDQSFGEAAFGE-QGQRIDPVLARSWLLVNGAHYERFQAAAHS
Mvan_2378|M.vanbaalenii_PYR-1 ------MYEQNFSESAFGE-QGQRIDPVLARSWLLVNGSHYDRFQAAAHS
Rv3075c|M.tuberculosis_H37Rv ---MTSMYEQVDTNTADPV-AGSRIDPVLARSWLLVNGAHGDRFESAAHS
Mb3102c|M.bovis_AF2122/97 ---MTSMYEQVDTNTADPV-AGSRIDPVLARSWLLVNGAHGDRFESAAHS
MMAR_1583|M.marinum_M MAAEQAMYEQVNSYVVDPADVGSRIDPVLARSWLLVNGTHADRFQAASHS
MUL_3451|M.ulcerans_Agy99 MAAEQAMYEQVNSYVVDPADVGSRIDPVLARSWLLVNGTHADRFQAASHS
MAV_3981|M.avium_104 ------MYEQVNSSAAEPDDIGSRIDPVLARSWLLVNGTHPDRFQSAVDS
MSMEG_2667|M.smegmatis_MC2_155 ------MYDQPIHDPDPSASPGFRIDPVLARSWLLVNGAQYERFAPASRS
MAB_4737|M.abscessus_ATCC_1997 ------------------------MNSKVSRSWLLMNPSREASLEAAIAS
TH_0719|M.thermoresistible__bu -----------------------MDLSAVGPAWLFCPADRPERFEKAAAA
. :. :**: : : * :
Mflv_4009|M.gilvum_PYR-GCK R-ADIVVLDIEDAVAPKDKAAARANVVRWLGEGHADWVRVNGFGTEWWAG
Mvan_2378|M.vanbaalenii_PYR-1 R-ADIVVLDIEDAVAPKDKAAARANVTRWFGEGHDDWVRINGFGTEWWAG
Rv3075c|M.tuberculosis_H37Rv R-ADIVVLDIEDAVAPKDKHAARDNAVRWFGDGNADWVRINGFGTPWWAD
Mb3102c|M.bovis_AF2122/97 R-ADIVVLDIEDAVAPKDKHAARDNAVRWFGDGNADWVRINGFGTPWWAD
MMAR_1583|M.marinum_M R-ADIVVLDIEDAVAPKDKGSARDNVVHWLGDGNADWVRINGFGTPWWAD
MUL_3451|M.ulcerans_Agy99 R-ADIVVVDIEDAVAPKDKGSARDNVVHWLGDGNADWVRINGFGTPWWAD
MAV_3981|M.avium_104 R-ADIVVFDIEDAVAPKDKNAARDNVVSWLRAGNVDWVRINGFGTPWWAD
MSMEG_2667|M.smegmatis_MC2_155 R-ADIVILDIEDAVAPKDKAAARDNVVRWLSEGNTDWVRVNGFGTPWWAD
MAB_4737|M.abscessus_ATCC_1997 TNADEVILDLEDAVAPNEKEPARGRVLEYLNSGGNAWVRVNDASSDFWSA
TH_0719|M.thermoresistible__bu A--DVVILDLEDGVAAKDRPAAREALLSTPLDPARTVVRVNPAGTADHRL
* *:.*:**.**.::: .** **:* .:
Mflv_4009|M.gilvum_PYR-GCK DLEMLAGTS-VGGVMLAMVESVDHVTETAKRLP-GVPIVALVETARGLER
Mvan_2378|M.vanbaalenii_PYR-1 DLEMLAGTS-VGGVMLAMVESVDHVTETVKRLP-GVPIVALVETARGLER
Rv3075c|M.tuberculosis_H37Rv DLAMLADSP-VGGVMLAMVESVDHVTETAKRLP-NVPIVALVETARGLER
Mb3102c|M.bovis_AF2122/97 DLAMLADSP-VGGVMLAMVESVDHVTETAKRLP-NVPIVALVETARGLER
MMAR_1583|M.marinum_M DIAILAGSS-VGGVMLAMVESVDHVTETARRLP-NVPIVALVETARGLER
MUL_3451|M.ulcerans_Agy99 DIAILAGSS-VGGVMLAMVESVDHVTETARRLP-NVPIVALVETARGLER
MAV_3981|M.avium_104 DLTALAGTP-VGGVMLAMVESVDHVTETAKRLP-DVPIVALVETARGLER
MSMEG_2667|M.smegmatis_MC2_155 DLDTLKGTS-VGGIMLAMVESVDHVTETANRLP-DVPIVALVETARGLER
MAB_4737|M.abscessus_ATCC_1997 DCRALADARGLKGVVLAKTEGGNHMWDTSNRLGGETPVIALIETARGLSR
TH_0719|M.thermoresistible__bu DLDALTRTP-YRTVMLAKTDAAEQVRALA-----PLQVVVLIETPLGALN
* * : ::** .:. ::: ::.*:**. * .
Mflv_4009|M.gilvum_PYR-GCK ITEIAAAKGTFRLAFGIGDFRRDTG-------FGGDALTLAYTRSRFTIA
Mvan_2378|M.vanbaalenii_PYR-1 INEIASAKGTFRLAFGIGDFRRDTG-------FGDNPMTLAYARSRFTIA
Rv3075c|M.tuberculosis_H37Rv INEIAAAKGTFRLAFGIGDFRRDTG-------FGEDPATLAYARSRFTIA
Mb3102c|M.bovis_AF2122/97 INEIAAAKGTFRLAFGIGDFRRDTG-------FGEDPATLAYARSRFTIA
MMAR_1583|M.marinum_M ITEIASAKGTFRLAFGIGDFRRDTG-------FGEDATTLAYARSRFTIA
MUL_3451|M.ulcerans_Agy99 ITEIASAKGTFRLAFGIGDFRRDTG-------FGKDATTLAYARSRFTIA
MAV_3981|M.avium_104 ITEIAATKGTFRLAFGIGDFRRDTG-------FGEDPATLAYTRSRFTIA
MSMEG_2667|M.smegmatis_MC2_155 ITEIAATKGTFRLAFGIGDFRRDTG-------FGENPATLAYARSRFTIA
MAB_4737|M.abscessus_ATCC_1997 VHDIAAARPCFRIAFGVNDYTLDIG-------VDQDPLALAYSRSQLVVA
TH_0719|M.thermoresistible__bu VVESARADNAVAVMWGAEDLFAVTGGTDNRNPDGSYRDVARHVRSQSLLA
: : * : . : :* * * . . : **: :*
Mflv_4009|M.gilvum_PYR-GCK AKAAHLPSAIDGPTVGSSALKLSEATAVSAEFGMTGKICLTPEQCLTVNE
Mvan_2378|M.vanbaalenii_PYR-1 AKAAHLPSAIDGPTVGSSALRLSEATAVSAEFGMTGKICLTPEQCPTVNE
Rv3075c|M.tuberculosis_H37Rv ARAAGLPSAIDGPTIGSNALKLIEATAVSAEFGMTGKICLSPDQCPVVNE
Mb3102c|M.bovis_AF2122/97 ARAAGLPSAIDGPTIGSNALKLIEATAVSAEFGMTGKICLSPDQCPVVNE
MMAR_1583|M.marinum_M AKAAGLPSAIDGPTIGSNPLKLIEASAVSVEFGMTGKICLSPEQCAVVNE
MUL_3451|M.ulcerans_Agy99 AKAAGLPSAIDGPTIGSNPLKLIEASAVSVEFGMTGKICLSPEQCAVVNE
MAV_3981|M.avium_104 SKAADLPSAIDGPTIGSNPLKLIEATAVSTQFGMTGKICLTPDQCSVVNE
MSMEG_2667|M.smegmatis_MC2_155 AKAAHLPSAIDGPTVGSSPLKLAEATAVSAEFGMTGKICLTPDQCPTVNE
MAB_4737|M.abscessus_ATCC_1997 SRAAHIPGPIDGPTR--DPAELPEAVSLTRRMGMTGKLALRSSDADTINT
TH_0719|M.thermoresistible__bu AKAHGRLALDSVYLDIKDLDGLRAEVDDAVAVGFDAKVAIHPTQVAVIRE
::* . . . * : .*: .*:.: . : .:.
Mflv_4009|M.gilvum_PYR-GCK GLSPSAEEIAWAKEFFVEFERDGGEIRNG---SDLPRIARANKILELARA
Mvan_2378|M.vanbaalenii_PYR-1 GLSPSAEEITWAKEFFVEFERDGGEIRNG---SDLPRIARATKILDLARA
Rv3075c|M.tuberculosis_H37Rv GLSPSQDEIVWAKEFFAEFARDGGEIRNG---SDLPRIARATKILDLARA
Mb3102c|M.bovis_AF2122/97 GLSPSQDEIVWAKEFFAEFARDGGEIRNG---SDLPRIARATKILDLARA
MMAR_1583|M.marinum_M GLSPSQDEIGWAKEFFAEFERDGGEIRNG---SDLPRIARATKILDLARA
MUL_3451|M.ulcerans_Agy99 GLSPSQDEIGWAKEFFAEFERDGGEIRNG---SDLPRIARATKILDLARA
MAV_3981|M.avium_104 GLSPSQDEIAWAKEFFAEFERDGGEIRNG---SDLPRIARATKILELARA
MSMEG_2667|M.smegmatis_MC2_155 GLSPSQDEISWAKEFFAEFQRDGGEIRNG---SDLPRIARANKILDLARA
MAB_4737|M.abscessus_ATCC_1997 GLSPSDEDVSWAQDFVDRFNSQGGKPKDG---SDLPRLNRARIILERARM
TH_0719|M.thermoresistible__bu GYTPTPDQVRWARHVLAAARDERGVFQFEGIMVDAPVLRRAERIVQLAPD
* :*: ::: **:... : * : * * : ** *:: *
Mflv_4009|M.gilvum_PYR-GCK YGIEPSEFDDVDEPTHIPAPSDTYHY
Mvan_2378|M.vanbaalenii_PYR-1 YGIEPSDFDDVDEPAHIPAPSDTYHY
Rv3075c|M.tuberculosis_H37Rv YGIEVSDFEDEP--VHMPAPTDTYHY
Mb3102c|M.bovis_AF2122/97 YGIEVSDFEDEP--VHMPAPTDTYHY
MMAR_1583|M.marinum_M YGIEASDFEDEP--VHSPAPTDTYHY
MUL_3451|M.ulcerans_Agy99 YGIEASDFEDEP--VHSPAPTDTYHY
MAV_3981|M.avium_104 YGIEALDIDEEER-DHSPAPSDTYHY
MSMEG_2667|M.smegmatis_MC2_155 YGIHEPEYSNDDP-DHVPAPSDTYHY
MAB_4737|M.abscessus_ATCC_1997 LGLITP--------------------
TH_0719|M.thermoresistible__bu PGR-----------------------
*