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MNRSQSADDQVAEAWRRHRPYLVNLAYQMLGDIGDAEDVAQEAFLRLSAAGDIDDVRGWLTVVASRLCLD QLRSARARHERPGDVGEQPAPPRFDPADRITLDDEVRTALLEVLRRLSPGERVSFVLHDVFGVPFEAIAQ TVGRPVGTCRQLARRARAKFVAAQPKLNTVGAAEHQRVTEKFITACANGDLAGLAAVLDPTVWGVGTVLA DPAPPPQVNHGPDAVATNLLRYLWPDVTLVGGPAGAPVLLAFSRRRLFAVIVLSIRDARVVKIEAIADPA ARSAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0164 | sigI | - | 100% (285) | RNA polymerase sigma factor SigI |
| M. avium 104 | MAV_2018 | - | 3e-34 | 39.11% (271) | RNA polymerase ECF-subfamily protein sigma factor |
| M. avium 104 | MAV_2475 | - | 1e-33 | 35.34% (283) | RNA polymerase sigma factor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1221 | sigI | 4e-63 | 49.65% (284) | RNA polymerase sigma factor SigI |
| M. gilvum PYR-GCK | Mflv_4852 | - | 3e-37 | 36.45% (299) | RNA polymerase sigma factor SigJ |
| M. tuberculosis H37Rv | Rv1189 | sigI | 4e-63 | 49.65% (284) | RNA polymerase sigma factor SigI |
| M. leprae Br4923 | MLBr_01448 | - | 2e-11 | 32.37% (139) | RNA polymerase sigma factor SigC |
| M. abscessus ATCC 19977 | MAB_2999c | sigI | 1e-104 | 67.93% (290) | RNA polymerase sigma factor SigI |
| M. marinum M | MMAR_3687 | - | 5e-35 | 37.50% (288) | alternative RNA polymerase sigma factor SigJ-like protein |
| M. smegmatis MC2 155 | MSMEG_1666 | - | 1e-32 | 34.40% (282) | RNA polymerase sigma factor SigJ |
| M. thermoresistible (build 8) | TH_1142 | - | 5e-30 | 32.99% (288) | RNA polymerase sigma factor, sigma-70 family protein |
| M. ulcerans Agy99 | MUL_3630 | - | 3e-35 | 37.50% (288) | alternative RNA polymerase sigma factor SigJ- like |
| M. vanbaalenii PYR-1 | Mvan_1575 | - | 2e-35 | 42.73% (220) | RNA polymerase sigma factor SigJ |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0164|M.avium_104 -------------MNRSQSADDQVAEAWRRHRPYLVNLAYQMLGDIGDAE
MAB_2999c|M.abscessus_ATCC_199 -------------MSSSSTHDALVTAAWREHYPYLVNLAYQMLGDIGDAE
Mb1221|M.bovis_AF2122/97 -----------------MSQHDPVSAAWRAHRAYLVDLAFRMVGDIGVAE
Rv1189|M.tuberculosis_H37Rv -----------------MSQHDPVSAAWRAHRAYLVDLAFRMVGDIGVAE
Mflv_4852|M.gilvum_PYR-GCK --------MPHGGIYTRRMTASARVAEFEQMRPHLLSVAYRLTGTVADAE
Mvan_1575|M.vanbaalenii_PYR-1 ------------------MTTSARVGEFEQLRPHLLSVAYRLTGTLADAE
MSMEG_1666|M.smegmatis_MC2_155 ------------------MTTAARTDQFEALRPHLLAVAYRLTGTYADAE
TH_1142|M.thermoresistible__bu ----------MTGSGAPSARGDEHAERFTHLRPLLFTIAYEILGSATEAD
MMAR_3687|M.marinum_M ------------------MTDPALLARFQAARPRLGALAYRMLGSLADAE
MUL_3630|M.ulcerans_Agy99 ------------------MTDPALLARFQAARPRLGALAYRMLGSLADAE
MLBr_01448|M.leprae_Br4923 MIASSGDEAVTDLALAAARGSKRALEAFIKATQQDVWRFVAYLSDVGNAD
: . *:
MAV_0164|M.avium_104 DVAQEAFLRLSA-----AGD--IDDVRGWLTVVASRLCLDQLRSARARHE
MAB_2999c|M.abscessus_ATCC_199 DAVQEAFVRLAR-----AEETEIDEPRAWLSVVVGRLCLDQLRSARMRRE
Mb1221|M.bovis_AF2122/97 DMVQEAFSRLLR-----APVGDIDDERGWLIVVTSRLCLDHIKSASTRRE
Rv1189|M.tuberculosis_H37Rv DMVQEAFSRLLR-----APVGDIDDERGWLIVVTSRLCLDHIKSASTRRE
Mflv_4852|M.gilvum_PYR-GCK DIVQDAWLRWSTH-----RGAAVEDLKAWLTTVVSRLALDKLRSAAHRRE
Mvan_1575|M.vanbaalenii_PYR-1 DIVQDAWLRWEAN-----SATVIEDLKAWLTTVVSRLALDRLRSAAHRRE
MSMEG_1666|M.smegmatis_MC2_155 DIVQEAWIRWAG------QEAPIENLQAWLTTVVSRLGLDRLRSAAHRRE
TH_1142|M.thermoresistible__bu DVLQESYLRWAEV-----DLAAVRDTKSYLAKLVSRQALNALRAGARRRE
MMAR_3687|M.marinum_M DVVQEAWLRLNATTDRPQGAQELVNLDAWLTTVVARLCLNLLRDRRGRGR
MUL_3630|M.ulcerans_Agy99 DVVQEAWLRLNATTDRPEGAQELVNLDAWLTTVVARLCLNLLRDRRGRGR
MLBr_01448|M.leprae_Br4923 DLTQETFLRAIG---AIERFSGHSSGRTWLLAIARRVVADHIRRAQTRPR
* *::: * . :* :. * : :: * .
MAV_0164|M.avium_104 RPG--DVGEQPAPPRF----DPADRITLDDEVRTALLEVLRRLSPGERVS
MAB_2999c|M.abscessus_ATCC_199 RTGVASVVESAAPLHVPAVTDPADRVTLDDEVRGALLEVLRSLSPGERVA
Mb1221|M.bovis_AF2122/97 RPQ--DIAAWHDGDASVSSVDPADRVTLDDEVRLALLIMLERLGPAERVV
Rv1189|M.tuberculosis_H37Rv RPQ--DIAAWHDGDASVSSVDPADRVTLDDEVRLALLIMLERLGPAERVV
Mflv_4852|M.gilvum_PYR-GCK TYVG--EWLPEPVVTGLDGRDPLSALVADEDARFAAMVVLENLTPDQRVA
Mvan_1575|M.vanbaalenii_PYR-1 TYVG--EWLPEPVVTGFDGVDPLASVVAGEDARFAAMVVLENLTPDQRVA
MSMEG_1666|M.smegmatis_MC2_155 SYYG--EWLPEPVVTGIDGNDPLNAVVAGEDARFAAMVVLEQLSPDQRVA
TH_1142|M.thermoresistible__bu DYVG--PWLPEPLL--LEERDASADVVLAESVSMAMMVVLESLTPDERAV
MMAR_3687|M.marinum_M EELV--GQLPDPIVDGVAAFDPEHHAMLADAVGLALFVVLDTLAPAERLA
MUL_3630|M.ulcerans_Agy99 EELV--GQLPDPIVDGVAAFDPEHHAMLADAVGLALFVVLDTLAPAERLA
MLBr_01448|M.leprae_Br4923 TTFD---GYPERMLN-------ADRHARGFEDLVEVTTMIANLATEQREA
:: * . :*
MAV_0164|M.avium_104 FVLHDVFGVPFEAIAQTVGRPVGTCRQLARRARAKFVAAQPKLNTVGAAE
MAB_2999c|M.abscessus_ATCC_199 FVLHDVFAVPFEEIASTVGRPVGTCRQLARRARTRFQQSAARSTDVTGAE
Mb1221|M.bovis_AF2122/97 FVLHEIFGLPYQQIATTIGSQASTCRQLAHRARRKINESR-IAASVEPAQ
Rv1189|M.tuberculosis_H37Rv FVLHEIFGLPYQQIATTIGSQASTCRQLAHRARRKINESR-IAASVEPAQ
Mflv_4852|M.gilvum_PYR-GCK FVLHDGFAVPFSAIAEVLGTSTQAARQLASRARRAVSSAP---PPAAD--
Mvan_1575|M.vanbaalenii_PYR-1 FVLHDGFAVPFAEIAEVLGSSPESARQLASRARRAASAAP---PPADE--
MSMEG_1666|M.smegmatis_MC2_155 FVLYDGFGVPFPDIADVLGVSAASARQLASRARRAVADAP---PPVDDNT
TH_1142|M.thermoresistible__bu FVLREVFGFEYGEIATTVGKSVTAVRQIAHRARSHVHARRKRFEPVDPEV
MMAR_3687|M.marinum_M FVLHDVFAVPFDQIAPILERTPEATRKLASRARRRIERAEP-FPDRDLCA
MUL_3630|M.ulcerans_Agy99 FVLHDVFAVPFDQIAPILERTPEATRKLASRARRRIERAEP-FPDRDLCA
MLBr_01448|M.leprae_Br4923 LLLTQLLGLPYADAAAVCGCPVGTIRSRVARAR-----------------
::* : :.. : * : *. . ***
MAV_0164|M.avium_104 HQRVTEKFITACANGDLAGLAAVLDPTVWGVGTVLADPAPPPQVNHGPDA
MAB_2999c|M.abscessus_ATCC_199 HQQLIEKFVTACAQGDLTGLMAVLDPGVWGVGTILGDPAPPPQVNRGRTD
Mb1221|M.bovis_AF2122/97 HRVVTRAFIEACSNGDLDTLLEVLDPGVAG-----EIDARKGVVVVGADR
Rv1189|M.tuberculosis_H37Rv HRVVTRAFIEACSNGDLDTLLEVLDPGVAG-----EIDARKGVVVVGADR
Mflv_4852|M.gilvum_PYR-GCK HAEVVGKLLAAMASGDLTAVVSLLHPDVTFTGDSNRRAPTAARVIRGSDK
Mvan_1575|M.vanbaalenii_PYR-1 HAEVVGKLLAAMASGDLTEVVAVLHPDVTFTGDSNRRAPTAARVIHGSDK
MSMEG_1666|M.smegmatis_MC2_155 HNEIAGALMAALAAGDMDGVVRLLHPDVTFTGDSNRKAPTAPRVIHGPEK
TH_1142|M.thermoresistible__bu SMEITERFLTAASTGDMDGLLAMLAPDATWTADGGGKATAARRPIVGAEK
MMAR_3687|M.marinum_M QREVVDAFFAAGRSGNFERLVSVLHPDVVLRGDFGPNTPRFR--AQGAAT
MUL_3630|M.ulcerans_Agy99 QREVVDAFFAAGRSGNFERLVSVLHPDVVLRGDFGPNTPRFR--AQGAAT
MLBr_01448|M.leprae_Br4923 -----DALLADTEHNHLTG-------------------------------
:. ..:
MAV_0164|M.avium_104 VATNLLRYLW-------------PDVTLVGGP-AGAPVLLAFSRRRLFAV
MAB_2999c|M.abscessus_ATCC_199 VATNLLVYLG-------------PGATLVGGP-FGQPVLLAFTQRRLFAV
Mb1221|M.bovis_AF2122/97 VGPTILRHWSH------------PATVLVAQPVCGQPAVLAFVNRALAGV
Rv1189|M.tuberculosis_H37Rv VGPTILRHWSH------------PATVLVAQPVCGQPAVLAFVNRALAGV
Mflv_4852|M.gilvum_PYR-GCK VARFLLGLGAKYGPERLLAGSELGLVNGELGVYSPGADATPDAPRIMPRI
Mvan_1575|M.vanbaalenii_PYR-1 VARFLLGLARRYGEQRFFGSGVLGMVNGELGVYTMGAPATEDAPAIAPRI
MSMEG_1666|M.smegmatis_MC2_155 VARFLFGLARRYGPN-WLAGAQLALINGELGTYTPGAPAGDGYPELLPRI
TH_1142|M.thermoresistible__bu VAAVILGIFR--------AGQRLPDVRIETAIYNCAPAVVVYSRDNLEGV
MMAR_3687|M.marinum_M VAKLAR----------SYAGPERTVLN---ALVNGAAGAVISISEQASAV
MUL_3630|M.ulcerans_Agy99 VAKLAR----------SYAGPERTVLN---TLVNGAAGAVISISEQASAV
MLBr_01448|M.leprae_Br4923 --------------------------------------------------
MAV_0164|M.avium_104 IVLSIRDARVVKIEAIADP-------AARSAG---
MAB_2999c|M.abscessus_ATCC_199 VTLTVREGLVLKIEATADP-------AARGR----
Mb1221|M.bovis_AF2122/97 LALSIEAGKITKIHVLVQPSTLDPLRAELGGG---
Rv1189|M.tuberculosis_H37Rv LALSIEAGKITKIHVLVQPSTLDPLRAELGGG---
Mflv_4852|M.gilvum_PYR-GCK QALAVRDGLVVAIYDVANPDKFTASPLAR------
Mvan_1575|M.vanbaalenii_PYR-1 QALTVHRGQVVAIYDIANPDKFTASPLR-------
MSMEG_1666|M.smegmatis_MC2_155 TAMTVRDGKVCAVWDVANPDKFTGSPLGTAVRRP-
TH_1142|M.thermoresistible__bu FTVEVVDGRITHFYAVRNPEKLAAVDTPRQISR--
MMAR_3687|M.marinum_M MGFLVRNGRIAAIDVLADPQRIATLDISGLSGPGG
MUL_3630|M.ulcerans_Agy99 MRFLVRNGRIAAIDVLADPQRIATLDISGLSGPGG
MLBr_01448|M.leprae_Br4923 -----------------------------------