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PHGGIYTRRMTASARVAEFEQMRPHLLSVAYRLTGTVADAEDIVQDAWLRWSTHRGAAVEDLKAWLTTVV SRLALDKLRSAAHRRETYVGEWLPEPVVTGLDGRDPLSALVADEDARFAAMVVLENLTPDQRVAFVLHDG FAVPFSAIAEVLGTSTQAARQLASRARRAVSSAPPPAADHAEVVGKLLAAMASGDLTAVVSLLHPDVTFT GDSNRRAPTAARVIRGSDKVARFLLGLGAKYGPERLLAGSELGLVNGELGVYSPGADATPDAPRIMPRIQ ALAVRDGLVVAIYDVANPDKFTASPLAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4852 | - | - | 100% (309) | RNA polymerase sigma factor SigJ |
| M. gilvum PYR-GCK | Mflv_1927 | - | 6e-48 | 37.63% (295) | ECF subfamily RNA polymerase sigma-24 factor |
| M. gilvum PYR-GCK | Mflv_1191 | - | 5e-32 | 40.09% (222) | ECF subfamily RNA polymerase sigma-24 factor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3361c | sigJ | 1e-111 | 68.92% (296) | RNA polymerase sigma factor SigJ |
| M. tuberculosis H37Rv | Rv3328c | sigJ | 1e-110 | 68.92% (296) | RNA polymerase sigma factor SigJ |
| M. leprae Br4923 | MLBr_01076 | sigE | 2e-06 | 27.88% (165) | RNA polymerase sigma factor SigE |
| M. abscessus ATCC 19977 | MAB_3678c | - | 1e-105 | 66.78% (298) | RNA polymerase sigma factor SigJ |
| M. marinum M | MMAR_1196 | sigJ | 1e-109 | 69.73% (294) | alternative RNA polymerase sigma factor SigJ |
| M. avium 104 | MAV_4301 | - | 1e-115 | 68.51% (308) | RNA polymerase sigma factor SigJ |
| M. smegmatis MC2 155 | MSMEG_1666 | - | 1e-116 | 69.23% (299) | RNA polymerase sigma factor SigJ |
| M. thermoresistible (build 8) | TH_1142 | - | 9e-47 | 36.90% (290) | RNA polymerase sigma factor, sigma-70 family protein |
| M. ulcerans Agy99 | MUL_3630 | - | 7e-44 | 40.73% (302) | alternative RNA polymerase sigma factor SigJ- like |
| M. vanbaalenii PYR-1 | Mvan_1575 | - | 1e-136 | 81.14% (297) | RNA polymerase sigma factor SigJ |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4852|M.gilvum_PYR-GCK ------MPHGGIYTRRMTASARVAEFEQMRPHLLSVAYRLTGTVADAEDI
Mvan_1575|M.vanbaalenii_PYR-1 ----------------MTTSARVGEFEQLRPHLLSVAYRLTGTLADAEDI
Mb3361c|M.bovis_AF2122/97 --------------------MEVSEFEALRQHLMSVAYRLTGTVADAEDI
Rv3328c|M.tuberculosis_H37Rv --------------------MEVSEFEALRQHLMSVAYRLTGTVADAEDI
MAV_4301|M.avium_104 MSLVSLTPGPMAYARFMTSAQQVSEFESLRPHLMSVAYRLTGTVADAEDI
MMAR_1196|M.marinum_M --------------MAVLGAQAASTFESLRPHLMSVAYRLTGTVADAEDI
MSMEG_1666|M.smegmatis_MC2_155 ----------------MTTAARTDQFEALRPHLLAVAYRLTGTYADAEDI
MAB_3678c|M.abscessus_ATCC_199 --------------MVVRAGDRTDEFEALRPRLQAVAYRLTGSVADAEDI
MUL_3630|M.ulcerans_Agy99 ----------------MTDPALLARFQAARPRLGALAYRMLGSLADAEDV
TH_1142|M.thermoresistible__bu --------MTGSGAPSARGDEHAERFTHLRPLLFTIAYEILGSATEADDV
MLBr_01076|M.leprae_Br4923 ---------MGDGIGMEREGRWTGNTQCPLRVVPGDESPTLDGRASPEDL
: . :..:*:
Mflv_4852|M.gilvum_PYR-GCK VQDAWLRWSTHRG-----AAVEDLKAWLTTVVSRLALDKLRSAAHRRETY
Mvan_1575|M.vanbaalenii_PYR-1 VQDAWLRWEANSA-----TVIEDLKAWLTTVVSRLALDRLRSAAHRRETY
Mb3361c|M.bovis_AF2122/97 VQEAWLRWDSQDT------VIADPRAWLTTVVSRLGLDKLRSAAHRRETY
Rv3328c|M.tuberculosis_H37Rv VQEAWLRWDSPDT------VIADPRAWLTTVVSRLGLDKLRSAAHRRETY
MAV_4301|M.avium_104 VQDAWLRWHGQDG------AITDLRAWLTTVVSRLGLDRLRSATHRRETY
MMAR_1196|M.marinum_M VQEAWLRWDAAPGR----DDVADLRAWLTTVVSRLGLDKLRSAARRRETY
MSMEG_1666|M.smegmatis_MC2_155 VQEAWIRWAGQEA------PIENLQAWLTTVVSRLGLDRLRSAAHRRESY
MAB_3678c|M.abscessus_ATCC_199 VQDAWLRLYSTTA------EIEDLAAWLTTVVSRLGLDRLRSAVYRRETY
MUL_3630|M.ulcerans_Agy99 VQEAWLRLNATTDRPEGAQELVNLDAWLTTVVARLCLNLLRDRRGRGREE
TH_1142|M.thermoresistible__bu LQESYLRWAEVDLA-----AVRDTKSYLAKLVSRQALNALRAGARRREDY
MLBr_01076|M.leprae_Br4923 IITNLLSPTIMSHP-----PPSRDDDWVEPFDALQGTAVFDATGDKATMP
: : :: . : : :
Mflv_4852|M.gilvum_PYR-GCK VGEWLPEPVVTGLD---GRDPLSALVADEDARFAAMVVLENLTPDQRVAF
Mvan_1575|M.vanbaalenii_PYR-1 VGEWLPEPVVTGFD---GVDPLASVVAGEDARFAAMVVLENLTPDQRVAF
Mb3361c|M.bovis_AF2122/97 TGTWLPEPVVTGLD---ATDPLAAVVAAEDARFAAMVVLERLRPDQRVAF
Rv3328c|M.tuberculosis_H37Rv TGTWLPEPVVTGLD---ATDPLAAVVAAEDARFAAMVVLERLRPDQRVAF
MAV_4301|M.avium_104 TGNWLPEPVVTGLGPHSGADPLAAVVAGEDARFAAMVVLERLSPDQRVAF
MMAR_1196|M.marinum_M TGHWLPEPVVTGLGDAGGADPLSAVVAAEDARFAVMVVLERLSPDQRVAF
MSMEG_1666|M.smegmatis_MC2_155 YGEWLPEPVVTGID---GNDPLNAVVAGEDARFAAMVVLEQLSPDQRVAF
MAB_3678c|M.abscessus_ATCC_199 VGEWLPEPVVTGLD---GDDPLAALVASEDARFAAMVVLDRLAPDQRVAF
MUL_3630|M.ulcerans_Agy99 LVGQLPDPIVDGVA---AFDPEHHAMLADAVGLALFVVLDTLAPAERLAF
TH_1142|M.thermoresistible__bu VGPWLPEPLLLEER-----DASADVVLAESVSMAMMVVLESLTPDERAVF
MLBr_01076|M.leprae_Br4923 SWEELVRQHAARVY------WLAYRLSGNQHDAEDLTQETFIRVFRSVQN
* : : :. : .
Mflv_4852|M.gilvum_PYR-GCK VLHDGFAVPFSAIAEVLGTSTQAARQLASRARRAVSSAP-----PPAADH
Mvan_1575|M.vanbaalenii_PYR-1 VLHDGFAVPFAEIAEVLGSSPESARQLASRARRAASAAP-----PPADEH
Mb3361c|M.bovis_AF2122/97 VLHDGFAVPFAEVAEVLGTSEAAARQLASRARKAVTAQPALISGDPDPAH
Rv3328c|M.tuberculosis_H37Rv VLHDGFAVPFAEVAEVLGTSEAAARQLASRARKAVTAQPALISGDPDPAH
MAV_4301|M.avium_104 VLHDGFAVPFSEVAEVLGTSEAAARQLASRARKVVSAQP---PPEPDPSH
MMAR_1196|M.marinum_M VLHDGFAMPFAEVAGVIGASEAAARQLASRARKAVAAAP---PPQPDPTH
MSMEG_1666|M.smegmatis_MC2_155 VLYDGFGVPFPDIADVLGVSAASARQLASRARRAVADAP---PPVDDNTH
MAB_3678c|M.abscessus_ATCC_199 VLHDGFSVPFKQIADILGISDAAARQLASRARRMVTATP---EPVADAEH
MUL_3630|M.ulcerans_Agy99 VLHDVFAVPFDQIAPILERTPEATRKLASRARRRIERAEP-FPDRDLCAQ
TH_1142|M.thermoresistible__bu VLREVFGFEYGEIATTVGKSVTAVRQIAHRARSHVHARRKRFEPVDPEVS
MLBr_01076|M.leprae_Br4923 YQPGTFEGWLHRITTNLFLD-----MVRRRARIRMDALP-----------
* :: : : ***
Mflv_4852|M.gilvum_PYR-GCK AEVVGKLLAAMASGDLTAVVSLLHPDVTFTGDSNRRAPTAARVIRGSDKV
Mvan_1575|M.vanbaalenii_PYR-1 AEVVGKLLAAMASGDLTEVVAVLHPDVTFTGDSNRRAPTAARVIHGSDKV
Mb3361c|M.bovis_AF2122/97 NEVVGRLMAAMAAGDLDTVVSLLHPDVTFTGDSNGKAPTAVRAVRGSDKV
Rv3328c|M.tuberculosis_H37Rv NEVVGRLMAAMAAGDLDTVVSLLHPDVTFTGDSNGKAPTAVRAVRGSDKV
MAV_4301|M.avium_104 DEVVGQLMAAMAAGNLEAVVALLHPDVMFTGDSNGKAPTAVQVIHGADKV
MMAR_1196|M.marinum_M NEVVGRLMAAMASGDLHSVVSLLHPDVTFTGDANGRAPTAARVICGADKV
MSMEG_1666|M.smegmatis_MC2_155 NEIAGALMAALAAGDMDGVVRLLHPDVTFTGDSNRKAPTAPRVIHGPEKV
MAB_3678c|M.abscessus_ATCC_199 NEVVGELLEALMSGSVEAVVRLLHPDVTMTGDSDGKAPTAVRVIHGPDKV
MUL_3630|M.ulcerans_Agy99 REVVDAFFAAGRSGNFERLVSVLHPDVVLRGDFGPNTPRFR--AQGAATV
TH_1142|M.thermoresistible__bu MEITERFLTAASTGDMDGLLAMLAPDATWTADGGGKATAARRPIVGAEKV
MLBr_01076|M.leprae_Br4923 -DDYDRVPADEPNPEQIYHDSRLGPDLQAALDSLPPEFRAAVVLCDIEGL
: . . * ** * . :
Mflv_4852|M.gilvum_PYR-GCK ARFLLGLGAKYGPERLLAGSELGLVNGELGVYSPGADATPDAPRIMPRIQ
Mvan_1575|M.vanbaalenii_PYR-1 ARFLLGLARRYGEQRFFGSGVLGMVNGELGVYTMGAPATEDAPAIAPRIQ
Mb3361c|M.bovis_AF2122/97 VRFILGLVQRYGP-GLFGANQLALVNGELGAYTAGLPGVDGYRAMAPRIT
Rv3328c|M.tuberculosis_H37Rv VRFILGLVQRYGP-GLFGANQLALVNGELGAYTAGLPGVDGYRAMAPRIT
MAV_4301|M.avium_104 VRFMLGLARRYGP-GFYSAYQLGLVNGELGIYTAGLPGGDGYREMCPRIM
MMAR_1196|M.marinum_M ARFMLGLARRYGP-AFYTANQLALVNGELGSYTLGTAGDGGHWAMLPRIT
MSMEG_1666|M.smegmatis_MC2_155 ARFLFGLARRYGP-NWLAGAQLALINGELGTYTPGAPAGDGYPELLPRIT
MAB_3678c|M.abscessus_ATCC_199 ARFLLGLMERYGP-QMTQAINPALVNGQFGMYLTETDTDPNFRPVLPRVS
MUL_3630|M.ulcerans_Agy99 AKLARSYAGPERT------VLNTLVNGAAGAVIS-------ISEQASAVM
TH_1142|M.thermoresistible__bu AAVILGIFRAGQR--------LPDVRIETAIYNCAPAVVVYSRDNLEGVF
MLBr_01076|M.leprae_Br4923 SYEEIGAT----------------LGVKLGTVRSRIHR--GRQALRDYLL
. : . :
Mflv_4852|M.gilvum_PYR-GCK ALAVRDGLVVAIYDVANPDKFTASPLAR--------------
Mvan_1575|M.vanbaalenii_PYR-1 ALTVHRGQVVAIYDIANPDKFTASPLR---------------
Mb3361c|M.bovis_AF2122/97 AITVRDGKVCALWDIANPDKFTGSPLKERRAQPTGRGRHHRN
Rv3328c|M.tuberculosis_H37Rv AITVRDGKVCALWDIANPDKFTGSPLKERRAQPTGRGRHHRN
MAV_4301|M.avium_104 AMTVREGKVCALWDIANPDKFTGSPL--------GR------
MMAR_1196|M.marinum_M AMTVRDGKVCALWDIANPDKFSGSPLRDLVG-----------
MSMEG_1666|M.smegmatis_MC2_155 AMTVRDGKVCAVWDVANPDKFTGSPLGTAVRRP---------
MAB_3678c|M.abscessus_ATCC_199 AFTVRDGRVLAVWDVSNPDKFSGTPLREA-------------
MUL_3630|M.ulcerans_Agy99 RFLVRNGRIAAIDVLADPQRIATLDISGLSGPGG--------
TH_1142|M.thermoresistible__bu TVEVVDGRITHFYAVRNPEKLAAVDTPRQISR----------
MLBr_01076|M.leprae_Br4923 TAHPRDGATTDATHVKSA------------------------
* : ..