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TAATTLRIENKPHLSGQAVGLVGAGRMGTGIGLCLLRQGAKLRVIANKDRSGTNELIDHGATESRSLAEL ADGCAVVVLSLPSSAQVENVCGQDGGLFGALSQGAVVLDTTTAWPQSTIALAQQAGALGIRFVDAPVTRS PEHARQGALNSMLGCTGDFRGLIDVVSAYSATITRVGPVGSAHQMKIVYNAMTMGISAVVAEACQLAASM DVDLHTLRSIVSMGSTNSGIFQKITEYLLEEDTTVLSISLENAAKDIRLAVDAAAENKLSLRSLAAASET YQEACRAGLADKTLPNLATHSQKATRPELG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4878c | - | - | 100% (311) | 3-hydroxyisobutyrate dehydrogenase/ 6-phosphogluconate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4486 | - | 2e-13 | 25.70% (284) | 3-hydroxyisobutyrate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1220 | - | 9e-12 | 25.98% (204) | dehydrogenase/reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0793 | - | 1e-13 | 25.69% (218) | dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_2480 | - | 1e-18 | 31.13% (212) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | Rv0770 | - | 2e-14 | 26.15% (218) | dehydrogenase/reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4926 | - | 8e-16 | 28.43% (204) | dehydrogenase/reductase |
| M. avium 104 | MAV_1928 | - | 3e-16 | 26.84% (272) | 6-phosphogluconate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5477 | - | 6e-23 | 26.91% (249) | 2-hydroxy-3-oxopropionate reductase |
| M. thermoresistible (build 8) | TH_2512 | - | 7e-12 | 24.63% (268) | PUTATIVE 6-phosphogluconate dehydrogenase, NAD-binding |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 7e-08 | 24.06% (212) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. vanbaalenii PYR-1 | Mvan_0536 | - | 6e-16 | 24.91% (281) | 6-phosphogluconate dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0793|M.bovis_AF2122/97 ----------MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRV
Rv0770|M.tuberculosis_H37Rv ----------MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRV
MMAR_4926|M.marinum_M ----------MSEH---PKLGYIGLGNQGAPMAKRLLDWPGGLVVYDVRA
Mflv_2480|M.gilvum_PYR-GCK ---------------MS-AVGFVGAGRMGAPMVERLVQAGHEVRVLGRSA
MAV_1928|M.avium_104 ---------------MAGIVGFLGAGQLGEPMVERLIDAGHDVLVYARRE
TH_2512|M.thermoresistible__bu -----------------MRVGFIGLGSQGGPMARRIAENGYETTLWARRA
MSMEG_5477|M.smegmatis_MC2_155 ----------------MSTIAFIGLGIMGSPMAVNLVKAGHTVKGYNRSP
MUL_0835|M.ulcerans_Agy99 -------------MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVP
Mvan_0536|M.vanbaalenii_PYR-1 ----------------MRRVGVIGLGGMGSALAASLLATDHYVVCFDIRP
MAB_4878c|M.abscessus_ATCC_199 MTAATTLRIENKPHLSGQAVGLVGAGRMGTGIGLCLLRQGAKLRVIANKD
:. :* * * : :
Mb0793|M.bovis_AF2122/97 EA-MAPFVEGGATAAASVSDVAE-ADIISITVFDDAQVSSVIT-ADNGLA
Rv0770|M.tuberculosis_H37Rv EA-MAPFVEGGATAAASVSDVAE-ADIISITVFDDAQVSSVIT-ADNGLA
MMAR_4926|M.marinum_M EA-MTPLAEAGASAAASVAEVAG-ADIISVTVLNDAQVREVIT-GANGLA
Mflv_2480|M.gilvum_PYR-GCK EK-RSAIAGLGATAVATTAEVSGGADVVIVCVFTDDQVAELCL-DGD-LV
MAV_1928|M.avium_104 EA-RHRLESKGANLAASVADLARGSDVLISCLFSDAQLRETGL-GPDGFV
TH_2512|M.thermoresistible__bu AT-LEPFADTPAKTAGSPAELGAASDLVCLCVVGDDDVREVLY-GDTGVL
MSMEG_5477|M.smegmatis_MC2_155 HR-TADLVAAGGTAADSIADAVDGAEIVAVMVPDSPDVTEVLT-ADGGVF
MUL_0835|M.ulcerans_Agy99 AA-ASATAAKGATMFDSAAEAVARADVVITMLPNG---AVVKR-CYAEVL
Mvan_0536|M.vanbaalenii_PYR-1 DV-LRPIVELGAEAAADARELAGACDVVLTFLPGPSQVLEVALGSERGVL
MAB_4878c|M.abscessus_ATCC_199 RSGTNELIDHGATESRSLAELADGCAVVVLSLPSSAQVENVCG-QDGGLF
. : . :: : .
Mb0793|M.bovis_AF2122/97 THAKPGTIVAIHSTIADTTAVDLAEKLKPQGIHIVDAPGSGGAAAAAKGE
Rv0770|M.tuberculosis_H37Rv THAKPGTIVAIHSTIADTTAVDLAEKLKPQGIHIVDAPVSGGAAAAAKGE
MMAR_4926|M.marinum_M AHARAGTIIAIHSTISDTTAEELARELRPRGIHVIDAPVSGGAGAASKGQ
Mflv_2480|M.gilvum_PYR-GCK TSMSAGATLVLHTTGSPRTAQSVAEK--FPHVAVVDAPVSGGPHDIAAGN
MAV_1928|M.avium_104 ANAKPGAVLVSHTTGNLSTLEALRDSS-ATPPVILDGPVSGTADDIAAGK
TH_2512|M.thermoresistible__bu AGLAPGGVVAIHSTVHPDTCREISEKAAAQQVSVIDAPVSGGGPAVEEGK
MSMEG_5477|M.smegmatis_MC2_155 ASAAPGTLIIDFSSIRPDVSMDLAKQAADHDLRLIDAPVSGGEIGAKNAA
MUL_0835|M.ulcerans_Agy99 PAARSGALFIDSSTISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGT
Mvan_0536|M.vanbaalenii_PYR-1 AGLADGAALLDMSTCNPEVAAIIGQAYDAAGRRFVDCPVSR-----KAPN
MAB_4878c|M.abscessus_ATCC_199 GALSQGAVVLDTTTAWPQSTIALAQQAGALGIRFVDAPVTRSPEHARQGA
* . :: : :* * :
Mb0793|M.bovis_AF2122/97 LAVMVGADDEAFQRIKEPFSRWASLLIHAGEPGAGTRMKLARNMLTFVSY
Rv0770|M.tuberculosis_H37Rv LAVMVGADDEAFQRIKEPFSRWASLLIHAGEPGAGTRMKLARNMLTFVSY
MMAR_4926|M.marinum_M LATMVGAGDDVFARVKEPFSCWASLVVHAGPPGAGTRMKLARNMLTFTIY
Mflv_2480|M.gilvum_PYR-GCK VTLFVGGAQDVLARIRPVLGAYGDPILHAGDTGAGQLVKLVNNTMFAAQI
MAV_1928|M.avium_104 LTVLLGGPTDAVAAVTPILAAYADPVVATGELGTALALKLINNLLFAANA
TH_2512|M.thermoresistible__bu LLVMVGGDEEVVERCRPVFASYADPIVHLGPLGSGQVTKILNNLLFTANL
MSMEG_5477|M.smegmatis_MC2_155 LSIMIGGADEDVSRAMPVLEAVGKTIVHVGPNGAGQTVKAANQLIVAGNI
MUL_0835|M.ulcerans_Agy99 LAFMVGGDQSALAQARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQ
Mvan_0536|M.vanbaalenii_PYR-1 MTVLVGGPSGVLGPDADVLAAVSRTLVYCGQRGAGYATKLLNQHIKYSWY
MAB_4878c|M.abscessus_ATCC_199 LNSMLG-CTGDFRGLIDVVSAYSATITRVGPVGSAHQMKIVYNAMTMGIS
: ::* . . . : * *:. * : :
Mb0793|M.bovis_AF2122/97 AAAAEAQRLAEACGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPMEPAD
Rv0770|M.tuberculosis_H37Rv AAAAEAQRLAEACGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPMEPAD
MMAR_4926|M.marinum_M AAVGEAWKLAEASGVNLQDLGNVVRHTDKLTSGAGSIMFRDNTKDLEPGH
Mflv_2480|M.gilvum_PYR-GCK GLVAEGVRLGARFGVDEGALLNALTHGSAQSRALSMIASAG---------
MAV_1928|M.avium_104 QLLASAAQLGTQLGIDPDVLLSTLQVCSANSNAAAHAHRIG---------
TH_2512|M.thermoresistible__bu GSALSTLELGESLGIPRVKLAEVLNGGSATSKALGSISVFGG--------
MSMEG_5477|M.smegmatis_MC2_155 ALLAEAIIFLEAYGVDTTAAVKVLGGGLAGSAVLDQKAQKMLDRSFDPGF
MUL_0835|M.ulcerans_Agy99 IAIGEAFVLAENLGLDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPAN
Mvan_0536|M.vanbaalenii_PYR-1 LASAEALLIAEAMGLNAGDVADAIAECSGGDSGLTTAAAYFR--------
MAB_4878c|M.abscessus_ATCC_199 AVVAEACQLAASMDVDLHTLRSIVSMGSTNSGIFQKITEYLL--------
. : .: . :
Mb0793|M.bovis_AF2122/97 PLRPLLEHTRGLG--EKDLSLALALGEVVSVDLPLAQLALQRLAAGLGVP
Rv0770|M.tuberculosis_H37Rv PLRPLLEHTRGLG--EKDLSLALALGEVVSVDLPLAQLALQRLAAGLGVP
MMAR_4926|M.marinum_M FLYDGFVHARDLG--EKDLGLALALGEALSVDLPLARLALERLAPGLGVP
Mflv_2480|M.gilvum_PYR-GCK SAETFISRVGEFI--GKDVAVVRRTVADLGGTLGDLEPLVN---------
MAV_1928|M.avium_104 GMDRFTELAGPFL--RKDIAACREAAAEAGVDLGLLGTAVREGPLTLDDR
TH_2512|M.thermoresistible__bu TVEGLAPIAGALL--QKDVRHAANIAASASVPEGTVFTVADTALT-----
MSMEG_5477|M.smegmatis_MC2_155 RIELHHKDLGILTNAAREAGVVTPIGAAVAQLMASARINGDGALDHSGLF
MUL_0835|M.ulcerans_Agy99 NDFKPGFATALMN---KDLGLAMDAVTSTASAAPLGSHAAEIYAKFATDH
Mvan_0536|M.vanbaalenii_PYR-1 HDTESVRNRAPASTITKDSALAERMATNAGIRSRTLEPVVDFFQSVAASE
MAB_4878c|M.abscessus_ATCC_199 -EEDTTVLSISLENAAKDIRLAVDAAAENKLSLRSLAAASETYQEACRAG
::
Mb0793|M.bovis_AF2122/97 HPDTEPAKET-----------------
Rv0770|M.tuberculosis_H37Rv HPDTEPAKET-----------------
MMAR_4926|M.marinum_M HTQKDA---------------------
Mflv_2480|M.gilvum_PYR-GCK AVAP-----------------------
MAV_1928|M.avium_104 AAGQN----------------------
TH_2512|M.thermoresistible__bu AMGHARR--------------------
MSMEG_5477|M.smegmatis_MC2_155 RTIAKLSGASTEPGSSNTKERP-----
MUL_0835|M.ulcerans_Agy99 ADQDFSAVIEMLRGS------------
Mvan_0536|M.vanbaalenii_PYR-1 FRDRAYPESTELLQRIRSMPPKSTSTP
MAB_4878c|M.abscessus_ATCC_199 LADKTLPNLATHSQKATRPELG-----