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MYTISINGTQLTFDDQGLDNGPAILLLTGWGHDHRAYDEILPYLVPHHRVIRMDWRGHGLDRTPVADFGP AEQFSDIIGLLNALSVRSFVPVAHAHAGWTALELADRLGTTRVPAVMLVDLIMTAAPPEFLQGIRAFRDP MGWQSSRLEFLRAWLAGSDNAAVNRHIRSEMGGFGFDVWARAGRVIEDAYVTWGSPMSRMEKMAEPPHVH HIFCTRERTGYDDLHDEFQHRNPWFSYKRLNGATHFPQLELPARVAEEVLGLLKAAGGNH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4679 | - | - | 100% (270) | putative dioxygenase |
| M. abscessus ATCC 19977 | MAB_0303 | - | 1e-87 | 56.44% (264) | putative dioxygenase (1H-3-hydroxy-4-oxoquinaldine |
| M. abscessus ATCC 19977 | MAB_4522c | - | 8e-08 | 29.27% (123) | epoxide hydrolase EphF |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1154c | bpoB | 1e-06 | 31.07% (103) | peroxidase BpoB |
| M. gilvum PYR-GCK | Mflv_1348 | - | 3e-09 | 30.43% (115) | 3-oxoadipate enol-lactonase |
| M. tuberculosis H37Rv | Rv1123c | bpoB | 1e-06 | 31.07% (103) | peroxidase BpoB |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-05 | 35.00% (60) | short chain dehydrogenase |
| M. marinum M | MMAR_4337 | bpoB | 5e-08 | 32.56% (129) | peroxidase BpoB |
| M. avium 104 | MAV_1254 | - | 3e-06 | 29.27% (123) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_1897 | pcaD | 8e-08 | 30.36% (112) | 3-oxoadipate enol-lactonase |
| M. thermoresistible (build 8) | TH_4323 | - | 2e-07 | 32.53% (83) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0147 | bpoB | 1e-06 | 31.78% (129) | peroxidase BpoB |
| M. vanbaalenii PYR-1 | Mvan_2912 | - | 5e-08 | 23.91% (276) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00862|M.leprae_Br4923 ------------MPATQSIHKVPHQFVESPDGVRLAIYQSGQ----PEGP
TH_4323|M.thermoresistible__bu --------------------MATEHFIDSSGGVRIAAYEEGN----PDGP
Mflv_1348|M.gilvum_PYR-GCK -----------------------------MSAVDVHVIESGL----PDGP
MSMEG_1897|M.smegmatis_MC2_155 -----------------------------MSSVAVHHVVTGR----SDGP
Mb1154c|M.bovis_AF2122/97 MTIWRVPSKVTSGPVSAVSSSPQAVAFSGARGITLVADEWNRGAAAADRP
Rv1123c|M.tuberculosis_H37Rv MTIWRVPSKVTSGPVSAVSSSPQAVAFSGARGITLVADEWNRGAAAADRP
MMAR_4337|M.marinum_M --------------MSAMSNNPRTVEFSGTEGITLVADEWNRDTAASGRP
MUL_0147|M.ulcerans_Agy99 --------------MSAMSNNPRTVEFSGTEGITLVADEWNRDTAASGRP
MAV_1254|M.avium_104 ------------------------MEFAGVDGITLVADEWNRGSDGAGRP
Mvan_2912|M.vanbaalenii_PYR-1 --------------------MHDDVKYLDLHGDRVAYREAGQ------GP
MAB_4679|M.abscessus_ATCC_1997 ------------------------MYTISINGTQLTFDDQGLD----NGP
. : . *
MLBr_00862|M.leprae_Br4923 AIVLVHGFPDSHVLWDGVVPLLAKR-FRIVRYDNRGVGQSSVPKPVSAYT
TH_4323|M.thermoresistible__bu TVVLVHGWPDSHVVWDSVAPLLADR-FRIIRYDNRGVGRTTAPRRVADHT
Mflv_1348|M.gilvum_PYR-GCK AVVLSNSLGATHRMWDAQLDALERR-FRVLRYDTRGHGASPVPD--GPYS
MSMEG_1897|M.smegmatis_MC2_155 AVVFSNSLGSTHRMWDPQLAAFEER-FRVVRYDTRGHGQSPVPE--GPYT
Mb1154c|M.bovis_AF2122/97 TILMLHGGGQNRFSWKNTGQILADEGHHVVALDTRGPGDSDRAPG-ADYA
Rv1123c|M.tuberculosis_H37Rv TILMLHGGGQNRFSWKNTGQILADEGHHVVALDTRGPGDSDRAPG-ADYA
MMAR_4337|M.marinum_M TILMLHGGGQNRFSWKNTGQILADTGLHVIALDTRGHGDSDRAPD-ADYA
MUL_0147|M.ulcerans_Agy99 TILMLHGGCQNRFSWKNTGQILADTGLHVIALDTRGHGDSDRAPD-ADYA
MAV_1254|M.avium_104 SILMLHGGGQNRFSWKNTGQTLADEGLHVVALDSRGHGDSDRSPQ-ADYQ
Mvan_2912|M.vanbaalenii_PYR-1 AVLLIHGMGGSSLTWKALLPHLATR-YRVIAPDLLGHGQSDKPRG--DYS
MAB_4679|M.abscessus_ATCC_1997 AILLLTGWGHDHRAYDEILPYLVPH-HRVIRMDWRGHGLDRTPVA--DFG
:::: . :. : ::: * * * . .
MLBr_00862|M.leprae_Br4923 MTRFADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGASDRVASFT
TH_4323|M.thermoresistible__bu MARYADDFGAVIDALAPGQRVHVLAHDWGSAGVWEYLARPEAEDRIASFT
Mflv_1348|M.gilvum_PYR-GCK IDDLADDVVGILDRR-----------------------------------
MSMEG_1897|M.smegmatis_MC2_155 IDDLADDVVALLDTL-----------------------------------
Mb1154c|M.bovis_AF2122/97 VETPTTDVLHVVEAIG----------------------------------
Rv1123c|M.tuberculosis_H37Rv VETPTTDVLHVVEAIG----------------------------------
MMAR_4337|M.marinum_M IETLTSDILHVLDAIG----------------------------------
MUL_0147|M.ulcerans_Agy99 IETLTSDIRHVLDAIG----------------------------------
MAV_1254|M.avium_104 IETLTADVLRVLDAIG----------------------------------
Mvan_2912|M.vanbaalenii_PYR-1 LGAFAVWLRDLLDLLG----------------------------------
MAB_4679|M.abscessus_ATCC_1997 PAEQFSDIIGLLNALS----------------------------------
. :::
MLBr_00862|M.leprae_Br4923 SVSGPSQDQLVDYILSGLRRPWRPRTF-ARAVSQLFRLTYMVLFSIPVLV
TH_4323|M.thermoresistible__bu SVSGPSGDHLARYVLDGLAAPYRPRRF-LRSLTQLLRLSYMGFFSIPVLA
Mflv_1348|M.gilvum_PYR-GCK ---GIDTAHLVGLSLGGMTAMRVAARN-PDRVNRMVLLCTAAELAP----
MSMEG_1897|M.smegmatis_MC2_155 ---GIERAHVVGLSLGGMTAMRLSARN-PQRVDRIALLCTATHLPP----
Mb1154c|M.bovis_AF2122/97 -----RRVVVVEASMGGLTGILVAERAGPQTVNGLVLVDVVPRYEK----
Rv1123c|M.tuberculosis_H37Rv -----RRVVVVEASMGGLTGILVAERAGPQTVNGLVLVDVVPRYEK----
MMAR_4337|M.marinum_M -----RPVVLIGASMGGLTGILVADSAGPDRVTGLVLVDVVPKYEK----
MUL_0147|M.ulcerans_Agy99 -----RPVVLIGASMGGLTGILVADSAGPDRVTGLVLVDVVPKYEK----
MAV_1254|M.avium_104 -----RPVTIIGASMGGLTGILAAHRAGPAKVTRLVLVDVVPRFEK----
Mvan_2912|M.vanbaalenii_PYR-1 ----IARVTLVGHSLGGGVAMQFVHQH-PDYCERLVLISSGGLGPELG--
MAB_4679|M.abscessus_ATCC_1997 ----VRSFVPVAHAHAGWTALELADRLGTTRVPAVMLVDLIMTAAPP---
* : :
MLBr_00862|M.leprae_Br4923 PMVLWIALSSATIR-RTMVDNISTDQIHHSATLARDAAHSVKTYPANYFR
TH_4323|M.thermoresistible__bu PLLVRGVLSKALRRSLRLRDGVPADRLHHSDTFAADAARSIKVYGANFLR
Mflv_1348|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1897|M.smegmatis_MC2_155 --------------------------------------------------
Mb1154c|M.bovis_AF2122/97 --------------------------------------------------
Rv1123c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4337|M.marinum_M --------------------------------------------------
MUL_0147|M.ulcerans_Agy99 --------------------------------------------------
MAV_1254|M.avium_104 --------------------------------------------------
Mvan_2912|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4679|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AFSGRRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIK
TH_4323|M.thermoresistible__bu TLRHARTDH---FVRVPVQLIVNTRDPYVRPHVYDETDRWVSRLWRRDIK
Mflv_1348|M.gilvum_PYR-GCK ------------------------------------AQAWTDR-------
MSMEG_1897|M.smegmatis_MC2_155 ------------------------------------SSAWTER-------
Mb1154c|M.bovis_AF2122/97 -----------------------------------EGNARIRDFMLGNID
Rv1123c|M.tuberculosis_H37Rv -----------------------------------EGNARIRDFMLGNID
MMAR_4337|M.marinum_M -----------------------------------DGSARIRDFMFTNLH
MUL_0147|M.ulcerans_Agy99 -----------------------------------DGSARIRDFMFTNLH
MAV_1254|M.avium_104 -----------------------------------DGSARIRDFMISGLD
Mvan_2912|M.vanbaalenii_PYR-1 -----------------------------------RSLRLLSTPG-----
MAB_4679|M.abscessus_ATCC_1997 -----------------------------------EFLQGIRAFR-----
MLBr_00862|M.leprae_Br4923 AGHFSPMSHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTLV
TH_4323|M.thermoresistible__bu AGHWSPMSHPQVLATAVTELADHLAGAPAGRALLRAQVGRPREYFGDMLV
Mflv_1348|M.gilvum_PYR-GCK --------AAAVRAGGAESVAPAVIARWFTLSHLETHPAE-RAEWVDMIA
MSMEG_1897|M.smegmatis_MC2_155 --------AAAVRTHGSAAVAESVVGRWFTPGFLAADPGR-KAAYQQMIA
Mb1154c|M.bovis_AF2122/97 G--FGSLEEAADAVAEYLPHRDKPRSPEGLKRNLRLRDGRWHWHWDPAMM
Rv1123c|M.tuberculosis_H37Rv G--FGSLEEAADAVAEYLPHRDKPRSPEGLKRNLRLRDGRWHWHWDPAMM
MMAR_4337|M.marinum_M G--FATLEEAADAVATYLPHRTKPRSPEGLKKNLRLRDGRWYWHWDPAMM
MUL_0147|M.ulcerans_Agy99 G--FATLEEAADAVATYLPHRTKPRSPEGLKKNLRLRDGRWYWHWDPAMM
MAV_1254|M.avium_104 G--FDSLEQAADAVAAYLPYRSKPRSPEGLKKNLRLRDGRWYWHWDPAFM
Mvan_2912|M.vanbaalenii_PYR-1 ----IELLLPVAAAPSVVAVGERVRSWLGARGLASPEVGETWNAYASLSD
MAB_4679|M.abscessus_ATCC_1997 ----DPMGWQSSRLEFLRAWLAGSDNAAVNRHIRSEMGGFGFDVWARAGR
. :
MLBr_00862|M.leprae_Br4923 SVTGAGSGIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVASGGVAYA
TH_4323|M.thermoresistible__bu AITGAGGGIGRETALAFAREGAEVIVSDIDEATAKDTAAEIAARGGVAHA
Mflv_1348|M.gilvum_PYR-GCK ATPAEG----------YASCCEAIAELDLREQLPTITAPTLAIAG-----
MSMEG_1897|M.smegmatis_MC2_155 ATPAEG----------YAGCCEAIAALDLRADLARITAPTLAIAG-----
Mb1154c|M.bovis_AF2122/97 TAPGHD---------------PQLRTENFERAAMGLTIPVLLIRGKLS--
Rv1123c|M.tuberculosis_H37Rv TAPGHD---------------PQLRTENFERAAMGLTIPVLLIRGKLS--
MMAR_4337|M.marinum_M TAPGDD---------------PELRTENFERAAMNLTIPILLIRGKLS--
MUL_0147|M.ulcerans_Agy99 TAPGDD---------------PELRTENFERAAMNLTIPILLIRGKLS--
MAV_1254|M.avium_104 TKPGDD---------------PELRTESFEQAAKNLSIPVLLIRGKLS--
Mvan_2912|M.vanbaalenii_PYR-1 PQTRTAFLR----TLRSVVDAQGQAVSALNRLHFTLGLPTLLIWGDQD--
MAB_4679|M.abscessus_ATCC_1997 VIEDAY-------------VTWGSPMSRMEKMAEPPHVHHIFCTRERTG-
: :
MLBr_00862|M.leprae_Br4923 YALDVSDAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDR
TH_4323|M.thermoresistible__bu YQLDVSDAAAVDRFADEVCARHGVPDIVVNNAGIGHAGRFLDTPRDQWDR
Mflv_1348|M.gilvum_PYR-GCK ----------------------------ADDP---------ATPPAKLEQ
MSMEG_1897|M.smegmatis_MC2_155 ----------------------------TDDP---------ATPPDRLAE
Mb1154c|M.bovis_AF2122/97 ----------------------------------------DVVSSDGARD
Rv1123c|M.tuberculosis_H37Rv ----------------------------------------DVVSSDGARD
MMAR_4337|M.marinum_M ----------------------------------------DVVSSEGVQD
MUL_0147|M.ulcerans_Agy99 ----------------------------------------DVVTSEGVQD
MAV_1254|M.avium_104 ----------------------------------------DVVSPEGVRH
Mvan_2912|M.vanbaalenii_PYR-1 ----------------------------------------RLIPPAHGEA
MAB_4679|M.abscessus_ATCC_1997 -------------------------------------------YDDLHDE
MLBr_00862|M.leprae_Br4923 VLAVNLGGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTS
TH_4323|M.thermoresistible__bu VLEVNLGGVVNGCRAFAPRLVERGTGGHIVNIASMASYAPLQSLNAYCTS
Mflv_1348|M.gilvum_PYR-GCK IVSAIPG----------ARLLVVDGAAHLANAEQPEQITPAIIEHL--EQ
MSMEG_1897|M.smegmatis_MC2_155 ITAAVRG----------ARLVQVTPGAHLANVEQADAITPTLLEHLGTEQ
Mb1154c|M.bovis_AF2122/97 FLAKVPN----------AEFVELSNAGRTAAGDDNDAFTDVVVDFVRRLS
Rv1123c|M.tuberculosis_H37Rv FLAKVPN----------AEFVELSNAGRTAAGDDNDAFTDVVVDFVRRLS
MMAR_4337|M.marinum_M FLDKVPH----------AEFVELSNAGHTAAGDDNDAFTEVVVDFVKRRA
MUL_0147|M.ulcerans_Agy99 FLDKVPH----------AEFVELSNAGHTAAGDDNDAFTEVVVDFVKRRA
MAV_1254|M.avium_104 FLATVPR----------AEFVELSNAGHTAAGDDNDAFSDAVVAFVKRR-
Mvan_2912|M.vanbaalenii_PYR-1 AHAALPG----------SRLVILPAVGHFPQVEAPLAVADTLDDFIANSS
MAB_4679|M.abscessus_ATCC_1997 FQHRNPW----------FSYKRLNGATHFPQLELPARVAEEVLGLLKAAG
: :
MLBr_00862|M.leprae_Br4923 KAATYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERV
TH_4323|M.thermoresistible__bu KAAVYMFSDCLRAELDSAGIMLTTICPSTVNTNIIGSTRFNAPDGLDDVV
Mflv_1348|M.gilvum_PYR-GCK R-------------------------------------------------
MSMEG_1897|M.smegmatis_MC2_155 S-------------------------------------------------
Mb1154c|M.bovis_AF2122/97 --------------------------------------------------
Rv1123c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4337|M.marinum_M ATG-----------------------------------------------
MUL_0147|M.ulcerans_Agy99 ATG-----------------------------------------------
MAV_1254|M.avium_104 --------------------------------------------------
Mvan_2912|M.vanbaalenii_PYR-1 PWHGPPRHADHAEAD-----------------------------------
MAB_4679|M.abscessus_ATCC_1997 GNH-----------------------------------------------
MLBr_00862|M.leprae_Br4923 RDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISR
TH_4323|M.thermoresistible__bu DTRREQLQKLFALRRFGPDKAAKAIVSAVKQNKPIRPVMPEAYFVYGVSR
Mflv_1348|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1897|M.smegmatis_MC2_155 --------------------------------------------------
Mb1154c|M.bovis_AF2122/97 --------------------------------------------------
Rv1123c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4337|M.marinum_M --------------------------------------------------
MUL_0147|M.ulcerans_Agy99 --------------------------------------------------
MAV_1254|M.avium_104 --------------------------------------------------
Mvan_2912|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4679|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 VLPQVLRSTARIRVI
TH_4323|M.thermoresistible__bu VLPQALRSTARGRVL
Mflv_1348|M.gilvum_PYR-GCK ---------------
MSMEG_1897|M.smegmatis_MC2_155 ---------------
Mb1154c|M.bovis_AF2122/97 ---------------
Rv1123c|M.tuberculosis_H37Rv ---------------
MMAR_4337|M.marinum_M ---------------
MUL_0147|M.ulcerans_Agy99 ---------------
MAV_1254|M.avium_104 ---------------
Mvan_2912|M.vanbaalenii_PYR-1 ---------------
MAB_4679|M.abscessus_ATCC_1997 ---------------